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Posts posted by Keffco

  1. Well, there might be many reasons for it but one of them could be high levels of hormones. When you have sex, your body produces a lot of testosterone which in turn can stimulate oil production through the sebaceous glands. If you think of it, some of the adverse effects of testosterone supplementation include acne and oily skin....That would be my theory, especially when you think that your acne is hormonal.

  2. Thanks guys for your replies!

    X3Kell3X: Well, pure emu oils has been reported to have anti-inflammatory, antibacterial, and moisturizing properties and many people who tried it noticed that it significantly reduces red marks and scars. It is claimed to be non-comedogenic....but I am a bit scared of applying it to my face, as it is oil....

    Raimundo: I read the thread you posted, thanks again for your help. Some people have great results with it and others break out....that only confirms that everyone's skin reacts differently to different substances....Well, I have been on Accutane and now my skin is clear but a bit more sensitive than before so I have to be a little more careful what I use....and since you also have sensitive skin and emu oil broke you out I think I might not use it....I think I will just practice my patience and stick to my regimen that has been working great. I don't want to break out as it will only result in extra red marks....it's not that easy to make choices, is it? all those sacrifices!!! lol :)

  3. Hey, it really depends on the person. I was on Accutane almost 6 months ago and I never had the IB...I was one of the lucky ones...But half of the people usually get the IB which, according to my dermatologist, is dose related. She said that people on low dose experience the IB later than people on a high dose....which makes sense...more drug in your system would bring to the surface existing pimples faster...but it should happen anytime between week 2-8.

  4. I am glad it helped! Well, as I said, these are just numbers and usually the length of the treatment is longer than calculated (so the cummulative dose is higher). This in turn gives a better chance of 'cure'. I was on accutane myself, 6 months ago. I was taking 80mg/day for the first month and then 120mg/day for the remaining 4. I weigh only about 65 kg....so my daily and cummulative dose was MUCH higher than recommended. But it was so worth it...I am 6 months post tane and, knock on wood, CLEAR!

    Again, all the best with your course and keep us updated!

  5. Hey there! I am glad that the regimen is working for you but I have to agree with Chirish that 300mg of zinc daily is a VERY high amount. Zinc is essential and beneficial at doses below 100 mg a day. Everything above that is considered as a toxic dose and can have side effects when taken long term, such as gastrointestinal irritation, vomiting, adverse changes in HDL/LDL cholesterol ratios. I am not trying to scare you or anything, just want yto warn you of the possible consequences of high-zinc intake.

    But again, happy it has worked for you

  6. Hey there! I am not a dermatologist but I study Pharmacology at uni, so dealing with different drugs pretty much every day.

    The typical Isotretinoin daily dosage should be between 0.5mg-2.0mg per kg of body weight. Thus, you weighing 165 lbs (which is about 75kg) should be taking between 37.5mg and 150mg. Since you're taking 80mg/day this dosage is perfect as it equals to just a bit more than 1mg/kg of your body weight. Anything above that, would just increase the risk of side effects, and is only used in severe cases.

    The cumulative dose of Accutane ranges between 120mg-150mg per kg of body weight. Therefore, you weighing about 75kg should aim to reach a dose between 9000mg-11 250mg.

    Assuming that you are going achieve the mean cumulative dose of 10 000mg and will continue to take 80mg/day, you should finish your course in about 125 days, which is 4 months and 5 days.

    Saying that, the above calculations are just set numbers and your dermatologist will adjust the daily dose and the cumulative dose (length of treatment) to your individual case.

    Hope this helps and good luck with the treatment!

  7. Hey everyone! I noticed that some of you are curious about the causes of depression from a scientific point of view. I am not a doctor, but a Pharmacology student so I am studying a lot about mental illness, such as depression and its treatment. Although it is extremely difficult to explain the pathology of depression, I will try to do it using simple terms so people who have never done any science in their lives could at least have a general idea.

    I will start with some background info to refresh your memory:

    I am sure that you are familiar with neurons (or nerve cells) that send impulses to conduct information. There are millions of neurons in the brain that transfer information by releasing chemicals from one neuron to another. You could think of it as the “domino effectâ€, each domino piece representing a neuron and collapsing dominoes would be the signal. Also, our brain has a special area called the mood centre, where all the signals sent determine whether we feel happy, sad, scared, etc. The chemicals that are released, called neurotransmitters, include dopamine, noradrenaline and serotonin. SEROTONIN is the principal neurotransmitter that determines mood. High levels of serotonin result in elevated mood (happiness, energy, motivation, etc.)….briefly, SEROTONIN=HAPPY and vice versa….NO SEROTONIN=SAD. As an example, people who take ecstasy are happy and loving everything, this being due to the fact that the pill acts directly on the serotonin neurons, making them release more and more serotonin------HAPPINESS!

    O.K., so now that I explained the basics, the rest will be much easier to explain (I hope). There are many theories of depression but the most common one is the “Monoamine Theoryâ€â€¦I know the name might sound scary but in principle it is a fairly straightforward theory. It states that low levels of “mood transmitters†like SEROTONIN, are responsible for depression and high levels of them make us feel happy. Patients with depression are found to have much lower levels of serotonin in mood brain area compared to healthy individuals.

    So, how can serotonin levels be LOW and cause DEPRESSION? Well, there could be quite a few possibilities:

    1. Neurons that are responsible for producing and releasing serotonin are damaged/do not function

    2. Neurons are healthy but no serotonin is produced because some precursors (substances needed to make it) or enzymes are missing/low (“making†of serotonin is a few step process that needs other substances as well)

    3. Serotonin is produced but it is metabolized or “recycled†back to the neuron too quickly so it has no time to act

    4. Serotonin is produced and released by the first neuron but it cannot activate 2nd neuron (if we look at the domino analogy, you could think of the 2 dominoes placed too far apart).

    5. …….others…….

    Saying that, people who have genetic predisposition to depression have a very high chance of being affected by one of the 4 points mentioned above without any significant stimulus, for example some of the serotonin neurons might not function already.

    However, people could become depressed due to external stimuli, such as stress. STRESS, for example, could be responsible for damaging serotonin neurons or depleting essential substances needed for making serotonin. Certain drugs, not only the abused ones, such as marijuana, but also clinical ones could affect serotonin transmission in the mood centre in the brain. Isotretinoin (Accutane) is THOUGHT, but NOT YET PROVED to decrease the levels of serotonin, which could result in depression. That is one of the proposed theories for Accutane-induced depression but there might be many other factors much more relevant. It still remains a mystery.

    I hope I did not write too much and that the text helped you at least a bit in understanding the complex science behind depression. As I said, other theories might be possible as well but the depletion of serotonin theory is most widely used and accepted. I tried to make it much more simple so the text does not contain too much detail or scientific words (just saying it for the Science people out there :))

  8. The only moisturizers that I found were 100% non-comedogenic were the ones produced by Vichy, Avene and La Roche Posay. You can only get them in pharmacies (in Europe). I used Vichy Aqualia Thermal when I was on Accutane and now post-tane and it always gave me perfect moisture and NEVER broke me out. I've tried Avene Hydrance Optimale and La Roche Posay Hydraphase and they also were nice moisturizers and never broke me out but they were to 'light' for me during my tane course.

    Sadly, before I was using Olay complete as well as Lancome Hydrix for men....and they broke me out after a few days of use, despite they were ment to be oil free and non -comedogenic.... Then again, everone is different but I know lots of people using Vichy/Avene/La Roche Posay with great results.

    All the best!

  9. Hey there, I was on Accutance for 5 months and I also experienced cracked lips and split sides of my mouth. After trying almost everything, vaseline, chapsitck, etc. I found that only BLISTEX MedPlus worked for me. It healed the cracks and stayed long enough on my lips so I did not have to apply it too often. I also used AVENE Cicalfate restorative cream (recommended by my derm) on my lips and it worked wonderfully at healing them in no time. I applied Cicalfate after shaving as well too soothe my skin, that reduced the redness/irritation. As for flushing, spraying AVENE thermal water on my face helped together with frequent moisturizing.

    Good luck with your course!

  10. Welcome to acne.org. I've been on Accutane for 5 months and I moisturized my face 2-3 times a day with a non-comedogenic, hypoallergenic moisturizer (It was Vichy Aqualia Thermal Rich by the way). My derm told me to moisturize my skin frequently not only to reduce the discomfort (very, very dry skin especially in the last month of treatment) but also to healp the skin heal itself, since moisture is important. I started at day 1, as she recomended, even though my skin was still a bit oily. Now I have nice and CLEAR skin, 6 month post tane (touch wood!)

    I would definitely moisturize with a non-comedogenic moisturizer (for sensitive skin preferably).

    I wish you all the best with your course, and keep us updated!

  11. Hey everyone!

    I am just wondering if any of you had experience with emu oil as a night moisturizer to help reduce red marks. If so, does it work and how long would it take to see improvement (I am aware it will not happen overnight).

    I ordered 3 bottles of pure 100% Australian emu oil yesterday reading great reviews on acne.org and waiting for it to be delivered. I am currently clear and my skin looks very good except for a few tiny red marks here and there. I am 6 months post tane and did not break out at all since then (yay!). My current regimen, washing with Eucerin gentle gel and applying Vichy Aqualia Thermal moisturizer seems to be working well but those few marks are really stubborn. Not that they are very visible but now, after tane, I want to have a perfect skin...if you know what I mean....

    Should I be just patient and stick to my regimen or should I try emu oil? I don't want to break out from it. I know it is non-comedogenic but just the idea of applying oil to your skin kind of scares me.

    Thanks a lot, any comments would be appreciated.

  12. Hey, I am using Vichy Homme Shaving Gel Anti-Skin Irritations. It woks great for me and I have delicate, sensitive skin post-tane. It prevents razor burn, skin redness, and ingrown hair. Plus it helps the razor glide smoothly on the skin. The gel is non comedogenic, oil free, and hypoallergenic. After washing and shaving my face I also spray Avene Thermal water on my face and it really soothes my skin and reduces the redness immediately. Sometimes I use Avene Cicalfate Cream after shaving and it really helps to restores my skin. I highly recommend these products, my skin is now quite sensitive after Accutane but they work great and never made me break out or anything.

  13. Hey! As long as you take Accutane with food, the time when you take it does not really matter. It is, however, important that you take the pill with a fatty meal, as Accutane is lipid soluble and is absorbed best when taken shortly after a meal. Studies show that taking Accutane with food rather than on an empty stomach, increases its absorbtion rate by 80%. And, the more of it is absorbed, the better the effectiveness. Plus, the half life (or half elimination time) of Accutane is 21 hours, which is quite long, meaning that it will take some time to completely remove the drug out of your body.

  14. Hey there! I can only speak from my own experience of taking Accutane (generic). I was on a high dose of Accutane for 5 months (1st month 80mg/day and then 120mg/day the rest), I did not get an IB when I started it, I was one of the lucky ones, I just started clearing from the beginning. Slowly but surely! I did experience dryness, tiredness and some muscle/joint pains but nothing that would make me want to stop the treatment. When my dose was upped to 120 mg/day, the side effects worsened, particularly dry lips and skin, and I was even more and more tired and lacking energy. However, that lasted for about a week, maybe 10 days, after that my body got used to the dose and I did not feel the side effects as much (although the were still there, I think it was more psychological). Again, I did not get a breakout. Well, I did get one or 2 zits on my cheeks but that was about it. Nothing major.

    However, as with every acne treatment, everyone is different and will respond differently to the treatment. I wish you all the best with your course and hope you won't experience more side effects and the flare up once your dose is changed!

  15. I was on a really high dose Accutane (80mg/day 1st month, 120mg/day 4 months) and I have to say that everything was EXTREMELY dry. However, I managed to establish a regiment with my dermatologist so that my skin felt comfortable. Here is what my derm recommended and what I used (and am still using 6 months post-tane). I live in Europe so I am not sure if you could get it in the US but will list it anyway:

    CLEANSER: Eucerin gentle wash gel---leaves skin very clean and no dryness

    TONER: Avene Thermal water----soothes skin, reduces redness, irritation and leaves the skin smooth

    MOISTURIZER: Vichy Aqualia Thermal Rich----great moisturizer, soaked right in, left my skin soft and glowing with no oily/shiny finish. It is non-comedogenic, oil-free, and hypoallergenic. When in sun, I used Vichy Aqualia Thermal SPF 15, which was nice as well, I never got a sunburn and it was well absorbed into my skin. I hate wearing sunscree because it is always greasy, but Aqualia was just perfect.

    LIPS: I found that only BLISTEX MedPlus worked for me, it healed all the cracks and stayed long enough on my lips so I did not have to reapply it every 5 minutes.

    One more thing I used during my course was Avene Cicalfate Restorative Cream. I put it on my face at night when my skin was very dry, irritated or flaking. And the next morning my skin was looking great. It is a bit heavy so I used it only at night. Sometimes I also used it in the morning after shaving to soothe my skin (which worked great as well) and on my chapped lips (it helped the recovery).

    Well, I did not really moisturize my body. Sometimes I would just use Garnier Extra Dry Skin Body Lotion (the one that smells like maple syrup) and I used L'Oreal Gelee Royale shampoo and conditioner for my hair (it is for very dry hair, it smells of honey, and I used it maybe 2 times a week as my hair was VERY VERY dry and did not have to wash it that often)

    As I mentioned in my other post, I am not a product freak. All of it was recommended by my dermatologist and it worked great. Now I have beautiful clear skin, that looks healthy and makes me look much younger, 6 months post tane. Knock on wood.

    I wish you all he best with your course, keep us updated!

  16. I am sorry that most of you don't like your derms....I don't want to seem rude or anything but I have to say that I love my dermatologist, she is one of the most caring and supporting people I know. I am really lucky I found her....actually, I am really glad that my friend recommended her. She always listens, answers questions, and tries to make you smile. She prescribed me Accutane (generic) and I could not be happier with the results, 6 months after my skin is completely clear and glowing. I wish I saw her earlier though, not just tried to cure my pimples with OTCs that made more damage to my skin than any good. I can't really thank her enough for saving not only my skin but also self-esteem. Then again, I live in Europe (Poland) so the health care system might be a bit different than in the US plus the insurance might be different too. Hope you all find a great dermatologist!

  17. Hey toffeebanoffee! I was on Accutane for 5 months and my skin was very dry and flaky until I found a great skin regimen together with my derm. I started using Avene thermal water after washing my face which worked great in reducing the redness, tightness, and burning. Then I would apply Vichy Aqualia Thermal Rich moisturizer which was also amazing, leaving my skin really soft without looking shiny and oily. Avene moisturizers are non-comedogenic, oil-free, and hypoallergenic. You might give it a try, you can get it in a pharmacy (I know Boots sells it, that's where I was getting mine). Might be a bit pricey but little goes long way and it really works great as a moisturizer. Not sure about make up though....

  18. Hey there! Well, acne is hereditary meaning that if one of your parents had it, you have a greater chance of having it as well. However, you do not inherit scars. Scars form when you do not control your acne and let the cysts damage your skin permanently. So, if you have a good skin regime and are controlling your acne breakouts, not getting inflammed cysts, and most importantly NOT PICKING on them, then the chances are that the scarring will be minimal, if any. Hope that helps. I am not a doctor but I am studying Science at uni.

  19. Hey there! I've been on a high dose Accutane (80mg/day first month and the 120 mg/4 months) 6 months ago and my skin is clear, fingers crossed (except a FEW TINY red marks which are fading!). I have to say that the dryness was quite uncomfortable but I developed my skin care routine together with my derm that kept the discomfort to minimum. And besides feeling tired a lot and a few muscle aches, I did not experience major side effects.

    Well, I live in Europe so I am not sure if you can get the same products where you live but I will list them anyway! I washed my face with Eucerin gentle wash gel. It soothes the skin and moisturises it as well. Then, I would spray a mist of AVENE Thermal water which was amazing as it reduced all the redness, tightness, and irritation. My dermatologist recomended it and it worked wonders for me, leaving my skin REALLY nice and smooth and not red at all. I would spray it on my face whenever I was getting flushes or redness (especially during winter when it was freezing outside) Next, I would apply VICHY Aqualia Thermal Rich moisturizer which would absorb really quickly, leaving my skin soft and not shiny at all. I would do it in the morning and in the evening. When I was in the sun, I would use Aqualia Thermal SPF 15 which was also great, as I never had a sunburn and my skin felt comfortable.

    Also, twice a week I would use a hydrating mask, Hydraphase from La Roche-Posay, also recommended by my dermatologist, and it would just add extra moisture to my skin. Finally, I would use AVENE Cicalfate cream at night when my skin was very dry and flaking and sometimes after shaving in the morning. This really soothed my skin and speeded up its recovery.

    As for lips, I found that only BLISTEX MedPlus worked for me, as I did not have to use a lot and it stayed on my lips for quite some time. It also healed some of the cracks. I would also put some Cicalfate on my lips from time to time and it REALLY helped a lot.

    Well, sorry for the long post. Believe me, I am not a product freak, these are just products that were recommended by my derm and since I really wanted to have nice and glowing skin, I decided to follow her advice. It might sound expensive to buy all of them but since I did not have to pay anything for my Accutane+Blood work+Derm appointments (as my insurance covered it all) It was not that bad but it really worked great!

    I am still using the Eucerin cleanser, Avene Thermal water, and Aqualia Thermal Moisturizer post-tane and it keeps working! Fingers Crossed! I look much younger, and my skin is soft and plump!

    Wish you all the best with your course! Whichever products you use, just make sure you moisturize a lot. That's what my derm said! It's great you started way before feeling the real dryness!

  20. I was on generic Accutane for almost 6 months and it worked great! I am still clear after 6 months off it, knock on wood, and all I am left with are a few tiny red marks that are fading away!

    Well, I am studying Pharmacology at uni so dealing with drugs pretty much every day. All I can say is that generic drugs have to have the same ACTIVE ingredient as the original formulation, and in case of Accutane it is Isotretinoin. That means generic drugs are identical to the brand name drug when it comes to pharmacodynamics (what the drug does to our body, meaning the dose-effect relationship) and pharmacokinetics (ADME-absorbtion, distribution, metabolism and excretion - thus duration of the effect). Therefore, by definition generics are identical in dose, strength, efficacy, safety and generally route of administration to brand name drugs. The only difference could be the formulation, meaning that some of the generic drugs could have different forms, gelatine capsules vs. pills, and additional/supporting substances such as colourants, fats, etc. The formulation COULD have a SLIGTH effect one the pharmacokinetic properties (such as absorbtion) but this is rarely the case. And of course, the prices for generics are much cheaper than the brand drugs due to the expiry of the patent protection. That was one of the reasons Roche withdrew Accutane from the US market. Before, Accutane was patent protected, meaning that only Roche could use Isotretinoin (the active ingredient) to make the pills and market them. Usually patents are granted for 10-15 years, then the company loses their right to be the exclusive manufacturer. In the past, they had a monopoly over the market due to the patent, thus they could set the price (as there was no other drug available). Now, other companies can use Isotretinoin in oral preparations, making the market more competitive.

    Sorry for writing an essay...but I hope it helps....