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under_tow last won the day on April 12

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  1. Some discussion here, from research: https://ggenereux.blog/discussion/topic/depletion-rate/
  2. Yes retinoic acid is not back converted to retinol or retinyl, and all that retinoic acid isn't going to be excreted quickly, so the dosage that we take in accutane prescription gets to do a lot of damage. All beta-carotene and retins, need to be converted to RA to excrete. So accutane is on top of all the retins stored already in the liver, fat tissues, and beta carotene throughout the body, which takes years to get down. Would create a nice bottleneck. Body is smart though, studies show the
  3. That sucks, but makes sense, calcium is leeched from bone and teeth to buffer the acidity of retinoic acid, that free calcium is dumped into the soft tissues, accutane loves the cartilage, ligaments, tendons... Some studies show that palmitate is actively turned to 13-cis-retinoic (accutane) before it is excreted, so it is going to have accutane like side effects, that most likely would contribute to the ligament problem. Problem good you have stopped it. Circulating Endogenous Retino
  4. Yep the hypothesis is you become a super-converter of beta carotene, when carotene cleaves you get two retinols. Studies have shown that the liver can hold about 2 years worth of vitamin A, when zero VA is coming in. I suspect anyone with acne has two years worth of retins stored in their liver, and all the dietary vitamin A coming in after storage is full, starts the cascade to auto-immunes, acne, etc... Being a beta-carotene super converter would help this process along even quicker.
  5. The theory/hypothesis is overload with beta-carotene, and it cascades out of control, meaning increased retinol -> retinoic acid. You end up in VA overload. Few people on Grant's forum have DNA tested positive for this scenario using 23andMe. This happens without accutane, and most likely what happened to all us pre-accutane. We were all messed up before we took accutane, accutane just makes the VA overload worse.
  6. I think bco1 is only associated with converting beta-carotene to the retins*, so this wouldn't affect retin* metabolism pathways. " ...reading up on the negative feedback loop that should control the amount of beta carotene entering body. ISX is a transcription suppressor that is stimulated by retinoic acid and suppresses transcription of SCARB1 (main protein receptor allowing carotenoid absorption) & BCO1 (enzyme that cleaves carotenoids into retinal). Therefore if there is plenty of R
  7. Those I just my symptoms(most of them common), everyone is different. https://en.wikipedia.org/wiki/Hypervitaminosis_A#Signs_and_symptoms Lists on the sexual sides, that I hope would benefit from depleting VA: https://nutritionrestored.com/blog-forum/topic/poison-vitamin-a-lowers-testosterone-and-damages-the-testes-testicles/ I am not claiming it will get better, the only way to tell if it will help you, is to put in the time. There is no cost, just the effort of
  8. Hey @cnb30 I have all skin related issues; yellow discoloration, redness, excessive dryness/flaking, excessive sebum oil, plugged pores, dandruff, hair shedding, etc.. I did not get mental and sexual sides, like many have reported, I suspect that they were very minor for me. If I got those with the skin issues, I probably would not be here anymore... Seeing less shrinkage on the low VA diet, more nocturnal wood, and libido is strong. I hope the benefits continue, root
  9. Hey, thanks for the additional info. This is still a work in progress theory, so there will be those against and those for testing, those points have come up lots. Some people are seeing progress doing low VA, that have either been on isotretinoin or just consumed to much carotenoids or pre-formed VA. Jury is still out, but hopefully people will find these posts and make there own informed decisions. I am close to 6months and will report at one year how things have proceeded.
  10. Hair mineral analysis can be very helpful, balancing Zinc is important for retinol binding protein(RBP) Doing this with a zero vitamin A diet will speed up the healing. Vitamin A - Accutane is fat soluble, it won't come out of storage in liver and tissues until it stops coming in. Takes about 1-2yrs to deplete vitamin A down to baseline with zero coming in.
  11. Accutane is active vitamin A, taken in toxic amounts: Symptoms of chronic vitamin A toxicity include: blurry vision or other vision changes swelling of the bones bone pain poor appetite dizziness nausea and vomiting sensitivity to sunlight dry, rough skin itchy or peeling skin cracked fingernails skin cracks at the corners of your mouth mouth ulcers yellowed skin (jaundice) hair loss respirat
  12. Keep the vegetables pale or white and of root form and you should get results. white cabbage, parsnips, celery root, white cauliflower, onions, garlic, etc. Peeled apple, peeled pears, white fruits can be OK as well, depending on symptoms. Short or long water fasts are very good at removing stored vitamin A.
  13. The problem is that the only food that has basically zero VA is white rice. All other foods contain precursors(carotenoids); Cryptoxanthin, Lutein, Zeaxanthin, Lycopene, etc... hundreds of different kinds. Example, removing wheat is not about removing gluten, its about removing glyphosate and lutein/zeaxanthin. Those two carotenoids are potent VA agitators, and Roundup blocks VA breakdown. Unless you eat only white rice for 3 meals a day, you have vitamin A coming in, fruits, veggs,
  14. Vitamin A decreases bile output, this makes the body absorb less vitamin A and D to protect us. https://nutritionrestored.com/blog-forum/topic/gallbladders-cholecystitis-cholelithiasis-caused-by-excess-poison-vitamin-a-and-the-body-tries-not-to-absorb-it-and-vitamin-d-from-the-diet/ Iron/ferritin overload or deficiency could be caused by excess vitamin A https://nutritionrestored.com/blog-forum/topic/iron-overload-and-or-deficiency-are-two-states-that-are-likely-aggravated-by-pois
  15. Very tough to avoid with the vast amount of chemical names used for vitamin A types. Some are using just regular high oleic safflower oil with a good vitamin E mixed in. Vitamin A 3-Dehydroretinol, Antixerophthalmic Vitamin, Axerophtholum, Dehydroretinol, Oleovitamin A, Retinoids, Retinol, Retinol Acetate, Retinol Palmitate, Retinyl Acetate, Retinyl Palmitate, Vitamin A Acetate, Vitamin A Palmitate Retinyl palmitate, retinol, retinaldehyde, adapalene, tretinoin, isotretin