Is there a way to determine if the bottle benzoyl peroxide I have is no longer effective? I heard this can happen. I've had a 32 is bottle for about 2 months now but have been on the regimen for almost 2 years. While I have not had full resolution of my acne it has cleared up a lot. I currently have breakouts on my forehead and cheeks and it's spreading and getting worse with no signs of clearing up. Does anyone have any advice?