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  1. I have the same problem as well. I'm going stop taking the Spironolactone 50mg today and through the week. I've only been taking it a couple of weeks, but am sure that is why my bladder hurts, especially when I pee. It's definitely not a bladder infection or a UTI. I've had too many of those in the past and remember the symptoms. This is different. It's a sharp pain, not a burning sensation. If I push on the lower portion of the bladder while I'm peeing it helps a bit. After I feel better I will