I'm on Spironolactone and Minocycline, have been for at least a year. It's worked really well and I'm pretty happy with my skin at the moment. Next week, (going on holiday to celebrate end of school) I'll be drinking a lot, so I'm just wondering how alcohol will react with my meds... I've heard that drinking alcohol can 'inactivate' antibiotics like minocycline. Is this true? Do you think my skin will flare up again? Or maybe should I just not take them for a week?