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databased

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About databased

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  1. ALA is routinely prescribed for neuropathy. If it's not bioavailable enough to cause effects, no one has proven that. They do often use even larger doses, such as 600mg/day. In mice, ALA was interestingly ineffective when applied topically to reduce skin inflammation, but effective when delivered via feeding. There's a fairly large research effort devoted to EGCG; apparently a large number of researchers do not doubt it has effects in humans. The pill linked to is equivalent to about 3 cups
  2. ALA is routinely prescribed for neuropathy. If it's not bioavailable enough to cause effects, no one has proven that. They do often use even larger doses, such as 600mg/day. In mice, ALA was interestingly ineffective when applied topically to reduce skin inflammation, but effective when delivered via feeding. There's a fairly large research effort devoted to EGCG; apparently a large number of researchers do not doubt it has effects in humans. The pill linked to is equivalent to about 3 cups
  3. Never had zinc worsen acne. Never seen a zinc study that mentioned any initial increase in acne. YMMV, obviously. Don't know of any good studies trying to explore the safety of zinc. It would presumably depend on how much other zinc you're getting from diet, as well. IIRC, 100mg/day has been used in a year-long study of elderly adults.
  4. Revised due to: caffeine's effect on melatonin, and folate's ability to influence light-induced melatonin suppression. Morning EGCG + caffeine along with moving folate intake to evening is about the only significant trick I've discovered in the last couple of years. Recap: Zinc is one of the longest-studied nutrients that correlates with statistically significantly less acne. Some months years ago, I discovered that around 200mg/day of zinc picolinate could, under some circumstances, make m
  5. Possibly relevant, but unconvincing. They appear to be talking about increasing SOD in the (rodent) brain via infrared exposure of the retina. That's nice and interestingly weird, but the brain is pretty isolated from the rest of the body and crammed full of cell types that the skin is not. It seems more exciting to me as evidence that sunlight in the eye still has brain effects that remain undiscovered.
  6. Anything's possible, but I doubt it. And the tanning booth operator should be pretty upset if they find you not wearing the blocking glasses; they don't want to get sued if you get cataracts. :D I too can take zinc and still have acne. And not take any zinc and be clear.
  7. Went through 2 bottles of the stuff. Couldn't see that it had any effect. I doubt it can get where/when it's needed in any quantity by taking it orally. Pineal melatonin, OTOH, goes to the skin cells and stimulates each cell to ramp up production of SOD. If you don't have the SOD right there in the cell that got touched by P. Acnes and started spewing superoxide anions, lots of SOD elsewhere will be no help. IMHO.
  8. I'm not, but would be interested to hear your results. When you're 300 pounds and "juice fasting", you're probably experiencing a drastic calorie reduction. Many people (including Holocaust survivors) have reported improved skin when (essentially to some degree or another) starving. My suspicion is that starving starts to shut down the immune system, and that acne is (yet another) auto-immune disease. It's interesting that Holocaust stories also note a disappearance of tooth and gum problems,
  9. OK, let's think about the massive inroads into cancer cures. Ooops, there aren't any. Well, we can now "cure" childhood leukemia (it's gonna hurt, your life expectancy is not truly restored, and you will have side-effects, but that's as close to a "cure" as we'll probably see). We really haven't made a dent in cancer mortality overall to speak of. For most cancers, metastasis is still essentially fatal. Perhaps you've been deluded by Peggy from Cancer Centers of America talking about how her pan
  10. IIRC, the most recent zinc study required taking zinc 3 times per day, and did not show (statistical, group) improvements until multiple months had elapsed. The dumb answer is, it probably won't matter which you choose, but it's easy to experiment and see if you see any difference.
  11. Ice cream gives me cystic acne. When I spend all day outdoors with my naked eyes in the summer sun, I can eat quite a lot of ice cream (and other "problem" foods) without getting acne. Bright light decreases carb malabsorption. Carb malabsorption interferes with digesting: tryptophan, zinc, Vitamin B. Those nutrients (plus a normal nocturnal melatonin surge) are needed to create anti-oxidants at the cellular level. Acne bacteria brushing against toll-like receptors triggers superoxide anion
  12. Free advice, worth every penny. Spend as many hours as possible each day with your naked eyes in bright sunlight. Living in dim indoor light increases carb malabsorption, keeping you from digesting nutrients you need (tryptophan, Vitamin B, zinc, etc.) to prevent acne.Sleep long and regular hours in total darkness. The goal is being sleepy at bedtime, sleeping 8-9 hours, and awakening totally refreshed and alert (indicative of having had a normal nocturnal melatonin surge). Caffeine in the
  13. Sure. But one can construct good ideas about how a hundred different things can affect any proposed biochemical mechanism of acne. If you can't sort out primary factors from less important factors, then you end up just saying everyone is different so no effective treatment can be proposed for most people. I think the two key findings in acne of the last decade are the discovery that the Trobriand Islanders are utterly acne-free, and the finding bacteria touching toll-like receptors triggers su
  14. It's been shown in rats that estrogen helps suppress pineal melatonin output. My theory is that when estrogen levels dip, you need more light in the eye to suppress daytime melatonin, which is needed to get the big nighttime surge needed to prevent acne. This explains both the acne of menstruation and of menopause. I don't view "hormonal" acne as anything different than just acne; it's just that fluctuating estrogen also influences the same systemic problem that causes almost all acne. Of
  15. No man-made bulb can emulate sunlight very well. All light is produced by electrons falling between different discrete energy levels in their atomic orbits. The sun has an enormous number of different energy levels for electrons to move between; manmade bulbs typically have just a few. Bulbs that are labelled "full spectrum" usually just aren't as obviously color-skewed wrt the sun as cheaper and more common bulbs. Nevertheless, the real problem in indoor lighting is simply getting enough brig
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