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mariovitali last won the day on August 1 2018

mariovitali had the most liked content!

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About mariovitali

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    Data Science, Machine Learning

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  1. @guitarman01 @TrueJustice @tanedout I think that you will find this interesting : How Liver and Gut issues and Vitamin K are related : https://www.s4me.info/threads/the-microbiome-hypothesis-lipkins-collaborative-part-1-simon-mcgrath-blog.5029/#post-94110
  2. Hey Guys, Sorry for not being around too much, i wanted to post here a quick update. I will be presenting my work in London this coming September to a team of Researchers. I will try to convince them to focus their attention to the Liver. As a summary of what i've been finding over the past 3 months. -I confirm the importance of Gut. Even though i was not looking too much at this, Gut *is* very important. -Given the latest findings of Lipkin et. al, we see Phospholipid metabolism alte
  3. @guitarman01 @Dubya_B @TrueJustice @hatetane I believe i know the full mechanism of what is going on. So i am asking you who i tagged or anyone else reading this : If i am ready to suggest a way to get people out of this mess and to have it evaluate it by Medical professionals : 1) What do i do 2) Where do i speak about this FWIW, My belief is that no one will listen and really look at this. Looking forward to your thoughts / suggestions. PS : Lion's Mane may be a 5AR Inhibitor. No
  4. @guitarman01 This chart paints the picture quite well i believe :
  5. @hatetane Thank you, much appreciated. Regarding David Healy : We spoke through E-Mails many times and i cannot say anything but nice words about him. I also wanted to give you all a short update. I have very positive feedback from 3 Professors of Medicine, mentioning this work as "very interesting". I do not believe that at this point it is necessary to say who these Professors are. But the fact that not one of them suggested that whatever i write on a 33-page document is nonsense but
  6. I am homozygous. The software i use , i created it using Python and what it does is that it summarizes SNPs found in many 23andme DNA files. Here are the results (all numbers are percentages) : {'snp': 'rs9934438', 'homozygous': 18.97, 'heterozygous': 46.55, 'not_in_chip': 0.0, 'no_mutation': 34.48} Given that the MAF of this SNP is 35.58% we wish to know if these results are statistically significant. I will get back to you for this. An example of a "good catch" regarding Vitamin K are
  7. @guitarman01 This is a copy/paste from my Cohort for these two Genes : {'snp': 'rs7412', 'homozygous': 0.0, 'heterozygous': 12.07, 'not_in_chip': 0.0, 'no_mutation': 87.93} {'snp': 'rs429358', 'homozygous': 3.45, 'heterozygous': 24.14, 'not_in_chip': 3.45, 'no_mutation': 68.97} APOE has been mentioned here : http://forums.phoenixrising.me/index.php?threads/unfolded-protein-response-and-a-possible-treatment-for-cfs.37244/page-80#post-710648
  8. @TrueJustice I believe that the fact that you feel better during Alcohol consumption is because Alcohol induces P450 (tells your Liver to work faster). However in the long run -as you know- Alcohol creates problems. It is possible that you will feel even better by consuming Gin . This is so because we have a synergistic effect of Alcohol and Pronthyacinidins from Juniper Berries used to make the distinctive taste of Gin (Hypothesis). Note that i am not suggesting that you or anyone else sho
  9. @guitarman01 According to the hypothesis, Vitamin K is very important. However there are many more pathways that need to be looked at. What we are dealing with is a vicious cycle of Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress and impaired Phagocytosis (list not inclusive). FWIW : We are very close in a full Recovery of a Woman in her 40s having ME/CFS for 25 years along with severe Neurological Issues. Her DNA Data have been forwarded to a well-known ME/CFS Researcher for ev
  10. @guitarman01 Sorry for not being around too much, have your flu passed or you continually have low-grade fever?
  11. @guitarman01 @tanedout @TrueJustice New Fibroscan of ME/CFS Patient with moderate to severe Fibrosis (f2 to f3). Please check your Liver with a Fibroscan test.
  12. GOOD :-) This is the first step towards Recovery @guitarman01 !! Question : Where you getting sick every year after you got Post-Accutane? Why do other people get sick every single year? This is the natural thing to happen, it is not natural to never get the flu. Recall that many ME/CFS Patients (i would also expect many Accutane Users) stop getting the flu after they got sick. This has nothing to do with an "over active immune system". This is because N-Linked Glycosylation is work
  13. I had the bloating side effect and also i was feeling less hungry. How much are you taking? Also, have i looked at your DNA Data?
  14. Which of course can be prevented / reversed with K2 : https://www.nutraceuticalbusinessreview.com/technical/article_page/Vitamin_K2_MK7_prevention_and_treatment_of_arterial_calcification/123944
  15. @guitarman01 I have no doubt that the Gut may be heavily involved. But we cannot underestimate the importance of having a Liver in good working order. For example, if N-Linked Gluycosylation has been affected, Gut Lining is affected as the body cannot produce it in significant amounts, This leads to Gut permeability and as a result toxin load through the Gut. We need to block as many "holes" in the system as possible. Having a Fibroscan and assessing any damage is a very important step to a