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  1. I'm on my 2nd round of Accutane (results did not last the first time, but I did have 8 months of clear skin). I am in an extremely dry climate (CO), so my skin is not handling the dryness well. Even without actively taking Accutane, I had dry skin since the first trial, and it's even worse now when taking the meds again. Because I am on it again, my skin is so dry that I get nose bleeds every week, and can barely wear makeup without looking like I have wrinkles, even though it is just dry skin.