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ACCUiTy_drANE last won the day on December 17 2019

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About ACCUiTy_drANE

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  1. Can you please provide a source that retinoic acid specifically can be stored in the liver for long periods of time? Accutane is a metabolite of Retinol (vitamin A) known as 13-cis-retinoic acid. The body cannot convert retinoic acid back to retinal or retinol. The half-lives of retinoic acid and their associated metabolites are under 30 hours (Wiegland, 1998). I read the ebook and wrote my all my disagreements to the author. All due respect, I believe the book is nonesense. I will provide sev
  2. Long story short, I am trying to do everything I can to run in the opposite direction of aging. Lots of fish oil, low-dose Naltrexone, cardio workouts, intermittent fasting (helps a LOT), various safe antidepressants/herbs with neuroprotective effects (NOT SSRIs), etc. When I say "chemo effects" I am referring to how the drug is documented to work in the body. It is undeniable that the drug exerts effects that mimic aging. That is the reoccurring theme in looking at many of the drug's acti
  3. Long-term issues from exposure to chemotherapy drugs has reached the attention of the medical community. One of the biggest ones that comes to mind is post-chemotherapy cognitive impairment, or "chemo brain." It is thought that the drugs are causing CNS damage, specifically by both degrading the myelin sheath AND impede restoration mechanisms. In other cases, it is thought that hormonal therapy alone (e.g.,Nolvadex for female breast cancer) can cause long-term mental issues. To me, this is telli
  4. That is the single most interesting piece of information I have read regarding this Accutane mess in the past few months! This is the type of science-based discussion we need. Differences in how individuals metabolize drugs has been acknowledged for other drugs (e.g., antidepressants) in the past. However, I have yet to see that discussed for Accutane. From what I understand, All-trans retinoic acid is the "chemo" aspect of Accutane; it's what drives the apoptotic effects of the drug, which as m
  5. In addition to the paper that documented altered brain bloodflow in the orbitfrontal cortex, another paper did show the drug caused brain damage in patients. " In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow.173 Ten of these patients were evaluat
  6. Well, recently IBS has flared up so I have been trying to focus on that. I have also been dealing with anal fissures for some unknown reason (inflammation?). When my IBS was at its best, the main difference was that I was running frequently instead of lifting. So I have recently got back into running, which may have been more important to my health than I once appreciated. Anyway, right now I am taking all of the following: Co Enzyme Q10 Maqui berry extract thanks to dry eye syndrome catchin
  7. Yep. https://www.ncbi.nlm.nih.gov/pubmed/8319203 "Patients taking these drugs [Accutane] often show side effects resembling the symptoms of hypovitaminosis A, namely, night blindness and decreased plasma retinol levels. A dietary vitamin A deficiency is not suspected in these patients; therefore, interference with normal vitamin A metabolism seems likely. The effect of these drugs on two enzymes involved in vitamin A metabolism was investigated. At micromolar concentrations, all three derivati
  8. Yikes, your naturopath was oversimplifying things greatly. . . The devil is in the details, not whether a substance can be broadly categorized as an herb or drug. Just like man-made drugs, herbs have a therapeutic dose, a toxic dose, and an LD50. Many herbs have similar mechanisms of action as man-made drugs: They can be SSRIs, 5-alpha reductase inhibitors, NDMA antagonists, dopamine reuptake inhibitors, opioid agonists, etc. They can also be toxic to various organs depending on the dose or gen
  9. As I tell people on Accutane who get mad at me for sharing factual information about Accutane, I cannot control how people react to new knowledge. The truth simply matters. There is no reason to believe managing brain damage/brain alterations is so grim. We have more treatments for psychiatric problems and TBIs than ever. Also, studies on former alcoholics prove the brain does improve with time, even without special interventions. Yeah, aren't poor people annoying? Why can't they just have
  10. You seem to misunderstand the definition of brain damage. One could sustain an injury in which a rod is lodged into the brain, and he/she could still count to ten. Aside from the story linked in which profound changes occurred (yet he was still somewhat functional), brain damage is not always readily noticed by outsiders. Look at NFL players; a large number of them have brain damage and can still memorize a playbook, socialize, and comprehend numbers. Brain damage usually involves deficits from
  11. Yes, the user names "accustained" and "accutainted" were inspiration to my own name. Clever! In regards to what happened to "accustained," it appears his account has been deactivated. If you Google his screen name you will find a post that says it was edited by him, but the user name of the post is a generic "User511605" with the heading Inactive. That's too bad. It sucks that many people come and go to these boards without a clear resolution. Some people certainly make strides and I believe g
  12. Although that is possible, that is not what the study I posted indicated. The study identified two different pathways Accutane's metabolite acts on, which directly lead to telomerase downregulation. It was a biological (mechanism of action) study. Again, this entirely unsurprising for a drug that treats cancer. So this is the second time someone implied I should watch what I (scientifically) say on here because it may make people lose hope. I am only here to discuss science and evidence-bas
  13. Right! Point being, given Accutane's well-documented pharmacological profile, it's odd that medical professionals are so dismissive of its enduring side effects. We see the same type of persistent/long-term side effects with other chemo drugs. Accutane is not a special snowflake chemo drug; it has a comparable potential for harm. The only difference is that former users of other chemo agents have patient follow-up studies. And perhaps that's what we need (as former Accutane users) to be taken mo
  14. Ask and you shall receive. (Err, doubt and you shall receive. See Cunningham's Law.) This study confirms that Accutane's metabolite down-regulates the telomerase enzyme, which is responsible for maintaining the length of telomeres of cells. (Yes, Accutane is a pro-drug.) The longer the telomeres of a cell are, the more times the cell can divide before self-destructing (apoptosis). Less telomerase activity = shorter telomeres = more cellular death. One counter-argument to this idea
  15. Substantially; almost on par with Adderall. In fact, Naltrexone is used in a commercial weight-loss product. I may actually hit LDN Doctor back up for a prescription for LDN, as in the past few months I have felt neuropathic (?) pain developing in my arms and jaw. I am hoping it is merely a side effect of one of many the supplements I am taking, but I cannot be too sure about that. This "pain" has waxed and waned in previous years (post-Accutane) and I just tried to ignore it. I do not recall