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  1. My main point is don't avoid it and vitamin A, because Isotretinoin is not vitamin A, and infact can cause vitamin A deficiency. Isotretinoin-Induced Night Blindness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533586/ Oral isotretinoin, neuropathy and hypovitaminosis A https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2230.2008.03171.x The second link has case studies which suggests between Vitamin A deficiency pre treatment and suffering depression due to accutane, and by supplementing vitamin A mid treatment helped. Beta-carotene is safer than straight vitamin A supplementation, so while I used vitamin A myself, BC is probs safer because it is only converted if your body recognises a need for vitamin A (though it is possible isotretinoin reduces conversion because it fucks with the body in mysterious ways, in that case Beta Carotene would just act as an antioxidant)
  2. I've recently talked to others who’s PRSD makes mine pale in comparison, despite the fact that it was still completely life changing. I fantasised about suicide, but I guess I could still live if I lowered my expectations low enough, such as by dropping out of Uni and accepting I would never have a sexual relationship, and that I would never be particularly happy or successful, etc... while post recovery, I I think I can now achieve a good life, going to Uni, dating, having fulfilling relationships, etc. However, for others, it affects them a LOT harsher than it did me, and so for promising a cure, I feel like a fraud. I'm going to leave it up, because I know it can still help SOME people regain control of their life, and I am sure its on the right track, but for some people, whos symptoms are much more severe than myself, it may not bring much respite. https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# Summary of treatment: Immediately post accutane when symptoms begin to surface, start taking -1000iu Vitamin E. If Isotretinoin is causing brain damage, the antioxidant effect of vitE can reduce that. -Plenty of beta carotene. It is impossible to overdose on vit A though BC, because your body will stop converting to vitamin A if you already have vitamin A. Keep in mind Vitamin A is very different to Isotretinoin, and it is common to suffer vitamin A deficiency post accutane. Beta Carotene is also an antioxidant. -10,000IU of Vitamin D, and vitamin K as well. Retinoids can cause deficiencies in Vitamin D, and vitamin K can help bone health and also regulate those fat soluble vitamins -Creatine and Zinc. They are both neuroprotective and increase neuroplasticity, and they also increase testosterone. -Fish Oil. Improves recovery from brain injuries, as it improve neuroplasticity as well -300mg/day of Magnesium. Some people report lower blood levels of magnesium post-accutane, and that has a range of mental and physical side effects, ranging from concentration issues, depression, erectile dysfunction, anxiety, muscle pains and cramps, erratic energy, moodiness, headaches, insomnia and frequent waking. Also neuroprotective I guess this is a starter pack nutrition wise, for stabilizing PRSD, and for me it got me back on my feet, cleared a fair bit of brain fog, and gave me a semblance of normalcy. Perhaps because I’d forgotten what is was like to be normal, for a time I thought I was normal, but honestly I’m not there yet. Physically I am pretty good, but still get some old man injuries even though I’m young. I can get erections fine when masturbating, but suffer ED sometimes when with women, which suggests that its more mental than physical. Mentally, even though I am happy, can concentrate somewhat, I can forgive myself and and can deal with anxiety much better, I’m not 100%. At the same time I think that on the mental side I can continue to improve through practicing mindfulness meditation, and so hope to get back to 100%. Anyway, I just wanted to be honest with everything on my end, because while I have made good progress with my treatment, I am by no means cured/100%, and I am sorry if I misled anyone. I personally don't know if getting back to 100% is entirely feasible, but I am back at Uni, running 2-3 times per week, doing well in the gym, though I have to exercise caution when exercising (pain=no gain). Lastly I know that while my PRSD was/is the shittest thing in my life, and I wish everyday I had never taken it, for others it is much worse, so I apologise if my treatment doesn't help. I still think its the best treatment currently around, everything is safe and backed by studies... However it is still severely lacking, so sorry. I don't have much more to say. Good luck everyone.
  3. I too wouldn't recommend Accutane. While the risk isn't great, there certainly is a risk of long term side effects. While I wasn't told these potential side-effects before I went on it, I was told it may affect my growth. I was already 16 years old and 6'4, so I didn't mind, but at 13 it would certainly be something to consider. Lastly, for some people this is worth taking, I have several friends who took it and don't regret it, but they all had very severe acne. Personally I regret taking it Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Associationhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage.
  4. Not really, I did start getting a bit of acne back, so I occasionally get a few pimples, but I am always pretty dry so I moisturise these days, or my skin gets kinda flaky, especially after hot showers
  5. Isotretinoin (cis-13 retinoic acid) usually composes of ~2% of the retinoids in your body. During treatment it composes of 98+% of the retinoids in your body, as you are taking it at 100x your usual vitamin A dose. This is how it hijacks retinol metabolism
  6. Creatine and zinc would be the best safe/accessible supplements going by your theory.
  7. The specific retinoid poisoning Isotretinoin induces has been shown to cause Vitamin A deficiency, not vitamin A toxicity. Isotretinoin-Induced Night Blindness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533586/ That is why I megadosed it as my first attempt in treating long term accutane sides. The first week I felt good, thought more must be better, and ended up poisoning myself. So don't megadose, however taking a normal dose is fine, and avoiding it would be counterproductive I think. I looked into it a few years ago, and it seemed that isotretinoin attaches to all your retinoid receptors, changing their usual function which causes tonnes of changes in your body. By having some vitamin a available it reduces those effects, but too much vitamin a affects other fat-soluable vitamins, among other adverse effects Retinoic Acid Restores Adult Hippocampal Neurogenesis and Reverses Spatial Memory Deficit in Vitamin A Deprived Rats http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003487 "A dysfunction of retinoid hippocampal signaling pathway has been involved in the appearance of affective and cognitive disorders. However, the underlying neurobiological mechanisms remain unknown. Hippocampal granule neurons are generated throughout life and are involved in emotion and memory. Here, we investigated the effects of vitamin A deficiency (VAD) on neurogenesis and memory and the ability of retinoic acid (RA) treatment to prevent VAD-induced impairments. Adult retinoid-deficient rats were generated by a vitamin A-free diet from weaning in order to allow a normal development. The effects of VAD and/or RA administration were examined on hippocampal neurogenesis, retinoid target genes such as neurotrophin receptors and spatial reference memory measured in the water maze. Long-term VAD decreased neurogenesis and led to memory deficits. More importantly, these effects were reversed by 4 weeks of RA treatment. These beneficial effects may be in part related to an up-regulation of retinoid-mediated molecular events, such as the expression of the neurotrophin receptor TrkA. We have demonstrated for the first time that the effect of vitamin A deficient diet on the level of hippoccampal neurogenesis is reversible and that RA treatment is important for the maintenance of the hippocampal plasticity and function." basically says VAD impacts neurogenisis. Because having isotretinion can cause VAD, avoiding vit A can exacerbate the neg sides of accutane Vitamin A and Retinoids as Mitochondrial Toxicants https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452429/ "It has been shown that retinoids possess an ability to alter cell cycle and to induce apoptosis in some experimental models. It was published that the treatment of adult mice with 13-cis-retinoic acid at 1 mg/kg·day−1 (a clinical dose commonly applied in the treatment of nodular acne) for 1–6 weeks suppressed hippocampal cell division (neurogenesis) and, consequently, decreased capacity to learn in behavioral task [133]. Accordingly, Sakai et al. demonstrated increased cell loss in the hippocampus of mice treated for 3 weeks with 13-cis-retinoic acid at 1 mg/kg·day−1 [134]. The mechanism by which 13-cis-retinoic acid altered neurogenesis and induced cell death in mice hippocampus is not clear, but it has been reported that this retinoid may trigger apoptosis through activation of caspase-3 and by modulating bcl2 and p53 gene expression in melanoma cells [135]. Reinforcing the finding that a retinoid may induce negative consequences to hippocampal function, it was reported that vitamin A supplementation with retinol palmitate induced anxiety-like behavior in adult rats [63]. Anxiety is a behavior closely related to alterations in the function of hippocampus and significantly decreases human life quality [136–138]. Furthermore, studies in humans demonstrated that the use of 13-cis-retinoic acid (as treatment to nodular acne) decreased metabolism in orbitofrontal cortex, a region associated with depression [119]. Indeed, there is a strong body of evidence showing that 13-cis-retinoic acid (isotretinoin) induced depression and increased both suicide ideation and suicide rates among some patients under such treatment [120–124]. However, it remains to be elucidated whether there is a causal link between bioenergetics impairment and neuronal dysfunction that leads to detrimental alteration in human behavior." Basically says what we know, that accutane fucks up the brain. Says the same can happen with vitamin A under very high doses, so don't megadose Obligatory plug for my hippocampal/brain theory of accutane side effects, check my research and whatever on this thread https://www.acne.org/messageboard/topic/377887-curing-post-accutane-syndrome-post-retinoid-sexual-disorder-is-a-part-of-that/?tab=comments#comment-3595283 good luck everyone!
  8. A spiel about Olive Oil, its pretty good shit, as is fish oil, and they are both cheap . Extra virgin olive oil improves learning and memory in SAMP8 mice.https://www.ncbi.nlm.nih.gov/pubmed/21955812Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724295/Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats.https://www.ncbi.nlm.nih.gov/pubmed/26168701Extra-virgin olive oil preserves memory, protects brain against Alzheimer'shttps://www.sciencedaily.com/releases/2017/06/170621103123.htmIt also helps joint painhttps://www.ncbi.nlm.nih.gov/pubmed/25294776Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis.fuck this site man, i pressed ctrl-z once it just deleted everything I wrote in the last 30 minutes, and there is no ctrl-y apparently...Depression and anxiety Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Ratshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/Constipation and antioxident profileThe short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.(only 4ml a day)https://www.ncbi.nlm.nih.gov/pubmed/25238699Antioxidant activity of olive polyphenols in humans: a review.https://www.ncbi.nlm.nih.gov/pubmed/20209466Anyway, it was more detail before, but basically is pretty super. Its shown to improve general health, blood pressure, neuroplasticity etc, and is one of the main reasons the Mediterranean diet is healthy. Only need 4ml's a day for noticeable benefits
  9. Sorry for the super late reply. If you can find some vitamin k and a multivitamins that would help, just one a day for a month or two, and on top of that creatine and fish oil will help as well. Vitamin k helps regulate your retinoic acids, and a multi will help replenish any nutrients that have been depleted by the Retinoic acid imbalance. The creatine and fish oil will help repair any ill effects on the brain and mood If you are not too busy try implementing exercise and mindfulness meditation, both of those will help clear the brain fog. Many people naturally recover by themselves, some people are just more vulnerable.

  10. Take vitamin D and K to begin with, that will help rebalance your retinoids. Anxiety is probably one of the main causes, as Accutane completely messes up your stress and sex hormones, so right now your body probably feels a tonne of stress. People who take such a limited dose recover much better, and one of my friends took 80mg for 15 months and he is good now, though it knocked him around for a fair bit.

    One of the ironic things about accutane is it makes your body react poorly to stress, then creates a fuckton of it.

    My full recovery advise is:
    "Buy creatine, fish oil, coq10, zinc, multivitamins and a decent protein powder, take the recommended dosages for all of these, and try to meditate for 20 minutes a day"(if its early days take some k2 and vitD as well, that will get your retinoids in check post tane)


    Anyway, even if you are a random healthy male the things I've recommended would only improve your health, all would probs be available if you went to your local discount chemist 
  11. Chronic stress induces persistent changes in global DNA methylation and gene expression in the medial prefrontal cortex, orbitofrontal cortex, and hippocampus. https://www.ncbi.nlm.nih.gov/pubmed/26946265 Chronic stress is associated with a plethora of cognitive symptoms such as emotional dysregulation and impaired executive function that have been attributed to modifications in neuroanatomy in the orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), and hippocampus (HPC)(...)In general, chronic stress induced persistent changes in gene expression in the three brain regions we examined and these changes could be associated with the commonly reported cognitive symptoms. The current study highlights the region- and sex-dependent nature of the brain's response to chronic stress and the difficulty we face when attempting to develop treatment options. https://news.wisc.edu/study-reveals-gene-expression-changes-with-meditation/ “To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice.” Richard J. Davidson . Gene expression is misunderstood. It is basically your body being situational, and adapting on the fly to changing conditions. Chronic stress, changes to diet, etc can affect gene expression. Obviously poisoning ourselves, and the subsequent brain damage, fucking up our stress and sex hormones and their receptors, etc over a long period of time is going to affect gene expression. Gene expression is reversible, its just that its become the default so you need to put effort into getting yourselves out of the rut. (EDIT: 50% of my google doc references hippocampal brain damage, its the main part, and how to start promoting neurogenesis again. I was just saying you can cure other forms of brain damage in addition to it.) Anyway, I need to get up in 3.5 hours for Uni, and I can't rebut every single argument and prove that my cure cures every symptom. I am not going to bother defending this anymore, it takes too much time. If you aren't willing to try the stuff that has the science backing it and is safe because it isn't severe enough and my proposed treatment is too simple and accessible, and is too sourced, legitimate and obvious to actually work, then go maybe up it to an hour of meditation, an hour of yoga daily, and at least 200g of organically grown salad per day, which you ideally saw grow with your own eyes. All meat has to be grass fed, be sourced within 20 miles, and if you don't know the animals name then chance of recovery is halved. Make sure all fish is tested for Mercury, the water you drink is filtered for fluoride. Get rid of all processed food, and cut sugar from your diet completely, except organic fruit. Drink 1 liter of Deep Seawater per day, diluted with 1 liter fresh water. Make sure to avoid margarine like the plague. Take cold showers throughout the year, practice abstinence to avoid spilling vital nutrients and ingraining bad reward circuits in the brain, avoid all external sources of hyperstimulation like computer games and movies, and also artificial light within 2 hours of bed time. Make sure to spend at least 9 hours in bed a day, and don't vary your sleep patterns more than 30 minutes day to day. Make sure to get at least 20 minutes of sunlight a day, though in Summer avoid the middle of the day when the sun is too oppressive However, if you actually are trying to lead a semi-normal life whilst recovering, and want the basics that are scientifically proven to make a difference in your life, then: "Buy creatine, fish oil, coq10, zinc, multivitamins and a decent protein powder, take the recommended dosages for all of these, and try to meditate for 20 minutes a day"(if its early days take some k2 and vitD as well, that will get your retinoids in check post tane) Lastly meditating 20 minutes every day is fucking hard, especially after what accutane does to our brains/concentration. Don't think that shit is easy until you've done it for a week. If you get a week straight in your first 3 months of trying you are better than me, congrats (Sorry flynn, you are actually an awesome and positive part of this community, and many others are too, but I think being here on this thread for 2.5 years has done me a number, and I simply have spent so much time here, and ITT if you want to be heard you kinda have to be persistent and keep shouting over the top of others, and you will probably be buried and forgotten anyway, no matter how much time you put into your message, and I hate it). Good luck everyone!
  12. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? https://www.ncbi.nlm.nih.gov/pubmed/25386668 Chronic fatigue syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-week, randomized, double-blind placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in fatigue impact scale total score (p<0.05) was reported in treated group versus placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p<0.001), CoQ10 (p<0.05), ATP (p<0.05), and citrate synthase (p<0.05) were significantly higher, and lipoperoxides (p<0.05) were significantly lower in blood mononuclear cells of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confer potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. https://www.ncbi.nlm.nih.gov/pubmed/16380690 There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). There is a strong comorbidity between major depression and chronic fatigue syndrome (CFS). The present study has been carried out in order to examine PUFA levels in CFS. In twenty-two CFS patients and 12 normal controls we measured serum PUFA levels using gas chromatography and mass spectrometry. We found that CFS was accompanied by increased levels of omega6 PUFAs, i.e. linoleic acid and arachidonic acid (AA), and mono-unsaturated fatty acids (MUFAs), i.e. oleic acid. The EPA/AA and total omega3/omega6 ratios were significantly lower in CFS patients than in normal controls. The omega3/omega6 ratio was significantly and negatively correlated to the severity of illness and some items of the FibroFatigue scale, i.e. aches and pain, fatigue and failing memory. The severity of illness was significantly and positively correlated to linoleic and arachidonic acid, oleic acid, omega9 fatty acids and one of the saturated fatty acids, i.e. palmitic acid. In CFS subjects, we found significant positive correlations between the omega3/omega6 ratio and lowered serum zinc levels and the lowered mitogen-stimulated CD69 expression on CD3+, CD3+ CD4+, and CD3+ CD8+ T cells, which indicate defects in early T cell activation. The results of this study show that a decreased availability of omega3 PUFAs plays a role in the pathophysiology of CFS and is related to the immune pathophysiology of CFS. The results suggest that patients with CFS should respond favourably to treatment with--amongst other things--omega3 PUFAs, such as EPA and DHA. I believe that the brain damage is correlated with the fatigue as well, as the supplements shown to help the brain also seem to fatigue, at least the ones that have been studied I admit to being a bit frustrated though. Would you not take a treatment because it only has direct evidence to healing only 75% of your sides? It feels like even though i have so much evidence, have literally put in about 1.5k hours at this stage looking into this shit, then someone is always like "What about the copper blood levels? Zinc would interact with that badly" or "I've tried fish oil before and I am not healed, so I know it doesn't work" Anyway google meditation and yoga and their effects on chronic fatigue. The best thing about yoga when compared to other forms of exercise is it seems to help the mind more Isometric yoga improves the fatigue and pain of patients with chronic fatigue syndrome who are resistant to conventional therapy: a randomized, controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269854/ All subjects completed the intervention. The mean POMS fatigue score decreased significantly (from 21.9 ± 7.7 to 13.8 ± 6.7, P < 0.001) after a yoga session. The Chalder’s FS score decreased significantly (from 25.9 ± 6.1 to 19.2 ± 7.5, P = 0.002) in the yoga group, but not in the control group. In addition to the improvement of fatigue, two patients with CFS and fibromyalgia syndrome in the yoga group also reported pain relief. Furthermore, many subjects reported that their bodies became warmer and lighter after practicing isometric yoga. Although there were no serious adverse events in the yoga group, two patients complained of tiredness and one of dizziness after the first yoga session with the instructor. A two-year follow-up case of chronic fatigue syndrome: substantial improvement in personality following a yoga-based lifestyle intervention. https://www.ncbi.nlm.nih.gov/pubmed/25825998 Just 1 dude in this one, but improved a lot "Buy creatine, fish oil, coq10, zinc, multivitamins and a decent protein powder, take the recommended dosages for all of these, and try to meditate for 20 minutes a day" In the case of CFS add yoga as well, though everything else will help too
  13. Here is the google docs with all the extra info again. https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit
  14. These are the potential side effects of brain damage. Many display a number of these symptoms. It wouldn't be a far cry to say nearly all symptoms displayed here branch from the symptoms of brain damage (ie. Lipid levels being affected by the systemic metabolic dysregulation and neuroendocrine due to the brain changes caused by accutane) Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” With no further ado, here is the evidence that accutane causes brain damage. Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." Anyway, at the risk of offending those who are not as lucky as I have been, I want to mention that I have made a full recovery from accutane (or as close to 100% as I can expect), using the safe and pretty cheap(<$300 for 3 months) protocol I outline in here https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit#. I don't get brain fog or social anxiety anymore, my hormones are back in check, ED is gone, but I do have performance anxiety left from bad experiences when it was still there, but I think it is improving steadily. Scars and injuries I picked up when I took Accutane never healed as well, but now I can rehab and manage them a lot easier. Sorry if you try it and it doesn't as much as it helped me. That said, its all based on research and so it should still help a fair bit regardless, even if you don't get back to 100%
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