Epiduo + Salicylic Acid? in Over-the-counter acne medications and products Posted August 17, 2015 I wouldn't recommend it, because it's not just that Epiduo can mix with the ingredients and be irritating, it's that Epiduo is making your skin more sensitive to the ingredients (that's how I see it at least). Before I would go to the dermatologist to get a chemical peel they would tell me to not use Epiduo for a few days before and after my appointment, because it would make my skin too sensitive. Of course they would probably tell you to stay clear from any topicals, but my point is that they make your skin sensitive, so it's not good to use too many at the same time. Like I said it really depends on the percentage of Salicylic Acid too. And unfortunately I have no knowledge of bee venom and how that might be irritating as well.