I don't know about this... I have been taking birth control for the past 4 months or so to try to calm my PMDD (mostly severe mood swings and migraines that happen during periods of hormonal ups and downs). I have been taking them straight through, no placebo pills, and hadn't gotten a period for 6 weeks. 3 days after I started taking Accutane, I got my period (for 12 days), AND had 3 migraines in a row! Coincidence??? I really don't think so. I would take all precautions necessary!