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  1. Hello. I'm a 32 year old male too and I've had mild-to-moderate acne since I was ~14 (face, chest, back). However, now I'm mostly clear (like 95 % clear face, 80 % cheast/back). What worked for me was low-dose long-term doxycycline. It's an antibiotic, but I take only 20-25 mg twice a day which is a subantimicrobial dose (100 mg would be the norm) so it shouldn't have much of an antibiotic effect but instead it helps with inflammation (or some other way). I've been using it for 1,5 year
  2. Hello all, I've recently seen an improvement in my acne (28y, mild acne) after taking vitamin B5 (pantothenic acid) 500 mg/d. Today I learned that melatonin is made from Coenzyme A (which is made from B5) and I thought of this thread. Leung (PMID 7476595) suggested B5 deficiency might be involved in the pathogenesis of acne (certainly seems to be in my case) and that the deficiency might be caused by increased production of sex hormones in puberty (which are made from CoA thus depleting B5).