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  1. I realize that accutane is a serious drug it can do both wonderful and horrible things to people. I have been doing some research and I have not been able to find my answer. I wonder if the depression side effect of accutane is not so much from the drug but from acne itself. Accutane being such a harsh drug I can understand that it can play with the mind. However when is the depression symptom most prominent? Is it during the initial breakout period or is it throughout the whole course? Most o