I tried doxycycline and it didn't do anything for me. I had to be sure to take with food, otherwise it made me really sick feeling. It was awful. Anyways, I'm taking spironolactone now and find it is more effective for me (also doing dan's regimen). But, everyone is different so antibiotics may work for some and not for others. My acne is more hormonally related, which is why the spironolactone is more effective at treating it. Hopefully the doxycycline will work for you. Best of luck to