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Unusual Spironolactone Issues

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I'm having some issues on Spironolactone.

Today is my 30th day taking it. I started on 25mg and went up to 50mg about 2 1/2 weeks ago. My initial breakout was not going away, so my doctor added 200mg Doxycycline.

My skin was looking a LOT better......smoother, less cysts. Then, about last Wednesday, BAM. Cysts. I have 7 of them right now. They're not going away, and I'm getting a couple new ones. I haven't changed anything major, so I don't understand what's happening.

Has anyone else experienced this? Should I just wait it out (I know it's early in the treatment)? Or should I go up a dose? This is really freaking me out..........

(I'm calling my dermatologist tomorrow, but I just thought I'd ask for opinions first).

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I experienced an initial breakout out 2-3 weeks into starting Spiro. I also started Doxy during the IB. Doxy took about 2+ weeks to calm the inflammation. I haven't had a cyst since the IB. However, you did up your dose, so think of this last round of cysts potentially your IB from the dosage change. Where are you in your cycle? Do you have any food sensitivities, dairy, caffeine, gluten, etc? Hang in there 30 days was definitely a tough time for me. I'm 50 days on 50 mg and have to say I

m glad I hung in there even when I felt it wasn't working.

12/30/2013- Started Spironolactone 50mg then up to 75mg with Yas
2/2015 stopped BCP due to Aphasia/Migraines
2/2015 Spiro upped  to 100mg no BCP
1/2016 Spiro upped  to 125mg no BCP

2/2016- starting Berberine 500mg 3x day

Daily skin care routine from Makeup Artists Choice

MUAC Mandelic Acid Cleanser

MUAC Mandelic Acid Toner
BP Dan's
Cerave PM- mix in Dan's AHA at night

Exfoliation- MUAC Mandelic and Lactic Acid Peels


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It takes a very long time for spiro to build up in your system and begin working. Some people see success very early in treatment, but this is definitely the exception to the rule. When I was prescribed spiro, I was told not to expect significant improvement for at least 4-6 months. Unfortunately, after about 8 months of beign on 125mg of spiro, I was showing no impovement. Now I am on isotretinoin and I am finally improving. I think my situation reflects a small minority of people who take spiro though, so waiting it out is the best bet. It is very unlikely that spiro is worsening the situation more than doing nothing at all. It could however, be a resistance to the doxy, especially if you've taken it in the past.

My Accutane log (with pictures): Holy Isotretinoin Batman It's another Accutane Log!

26 y/o female- approx. 54kg

Absorica -40 mg, 1 daily, December 26, 2013 - February, 25, 2014

Absorica - 60 mg, 1 daily. February 26, 2014 - July 6th 

Probiotic - 1 daily

Fish oil supplement w/ vit D - 1 daily



Cetaphil cleanser

Food Grade Rose water - Toner

La Roche Posay Mineral Water Spray

Vichy 50+ Capital Soleil Cream for Sensitive Skin



Cetaphil Cleanser

Food grade Rose Water - Toner

Ziana (tretinoin/clinda combo) August, 2014 - Current

La Roche Posay Mineral Water Spray

Aveeno Positively Radiant intensive night cream

Cerave Facial Moisturizing Lotion- PM

Avene Cicalfate (as needed)

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