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An observational study of methionine-bound zinc with antioxidants

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Dermatol Ther. 2010 Jul;23(4):411-8.

An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris.

Sardana K, Garg VK.

Department of Dermatology, Maulana Azad Medical College, Lok Nayak Hospital, Delhi, India.


APC is a novel methionine-based zinc complex with antioxidants that has been used in acne as a nutritional supplement. This is based on the proven role of zinc and antioxidants in improving acne, specially the inflammatory lesions. The objectives of this study are to explore the efficacy, safety, and tolerability of APC in acne patients with mild to moderate facial acne vulgaris. In this exploratory trial, 48 patients were treated with oral APC thrice a day for 3 months followed by a 4-week treatment-free period. At the end of treatment (Week 12), there was a statistically significant improvement in the global acne count (p < 0.05), which began after 8 weeks (p < 0.05). Almost 79% (38/48) of the patients had 80-100% improvement. There was a significant reduction in pustules (8 weeks (p < 0.05) and 12 weeks (p < 0.001)), and papules and closed comedones (8 weeks (p < 0.05) and 12 weeks (p < 0.001)). Only two patients had side effects. The current data indicate that treatment with oral APC thrice daily for 12 weeks in patients with mild to moderate facial acne vulgaris is efficacious and well tolerated. As the onset of action is late, concomitant topical therapy can enhance the results.


-Face Reality Sensitive Skin Cleansing Gel


-MD Formulations AOX Hydrating Gel and/or MD Formulations AOX Lotion (on drier areas)

-Mix a few drops of Niacinamide Gel with Face Reality's SPF 30 for Acne Prone Skin


-Face Reality Silica scrub

-Derm A Gel 2 out of 3 nights, PTR Unwrinkle Peel Pads every 3rd night

-Mix Face Reality Hydrating Emulsion with Metazine Niacinamide Gel

-Face Reality's 2.8% BPO (chin only).

*Spot treat any inflamed lesions with Aczone

*Spot treat clogged pores with 8% mandelic

*Diet: Vitamin C and zinc supplements, avoid dairy, avoid iodine, mimimize sugar and salt, avoid peanuts

I also get facials at Face Reality Acne and Skin Care Clinic every 4-6 wks.

My lengthy log:

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