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  1. I have been on accutane for 67 days now, at 40mg/day and I weigh 49 kg (108 pounds). Started with mild to moderate acne, and I feel like it’s worse now than it had been before I had started accutane. Bleh. I’m still breaking out pretty consistently around my jaw (cystic) and chin (white heads/normal pimples) area. Dryness isn’t bad at alllll. My skin is only dry after a pimple is popped and it starts to heal. Lips are dry, but not too bad at all either! I use blistex a few times a day and I am set. I wash my hair once every week/week and a half or so, but could probably go a month without washing my hair, so that’s a plus lol. The back pain is terrible though. Apart from minor dryness and bad back pain, some other side effects I have had recently were teeny tiny blister like bumps on my lips that stayed for about 3 days, then they disappeared. My left eye was swollen and sore for a day, then became normal again. I also went 7 weeks without my period, so I am not sure what’s going on with that. Honestly, my time on accutane thus far hasn’t been that bad at all. I know I'm only about 2 months in, but I feel like I’ll never stop breaking out. I always take my medicine right after I eat really fatty foods to maximize the absorption. I have had stretches of a few days where I am not breaking out at all, then it starts all over again. I hope this actually works:(
  2. I began to struggle with acne when I was about 15 years old. During my senior year of high school, I was started on my first dose of Accutane, which was successful in clearing my acne. However, I had to stop taking the medication after 5 months because I was experiencing severe irritability and depression. I experienced terrible panic attacks for the next four years, and my acne returned, full force. During my senior year of college, I reluctantly chose to go on Accutane once again. “It’s a lower dose, so your side effects will be controlled.” These were the words spoken to me by every doctor I encountered. No one warned me that what would result months afterward would be my own personal hell. Once again, I had to stop taking this medication after 5 months, because I began to develop fatigue and migraines that were out of control. I had vision problems, and began seeing stars and spots in my periphery. I began to lose balance and I lost interest in things that I loved. My anxiety began to become off the charts, and depression began to sink in deeper and darker than it had ever been. Perhaps the worst side effect has been numbness and tingling and this prickly, almost cold-like, sensation down the left side of my body. It begins in my head and makes its way all the way to my foot. It has been constant since I stopped taking the medication. My headaches have been out of control, and I have about 3 migraines a week. I used to run half marathons and workout every day, and now I am lucky if I can get up to do yoga or go on a walk. I eat healthy, and I have seen 7 doctors in the past 5 months. Each doctor keeps diagnosing me with “Chronic atypical migraine.” My MRI showed nothing and my blood tests come back completely normal. But I can guarantee that something is not normal. I am fighting every day to find what it means to be “Normal” again. I am tired, I have headaches daily, I am anxious, I experience severe numbness and tingling, and I feel as if I have lost a lot of my zeal for life. I am writing this to see if there are any fellow friends out there who have also suffered from bizarre symptoms with no diagnosis? I do not know if Accutane is linked to these symptoms, but I truly do feel as if it plays a huge role. If you have experienced these things, PLEASE impart your knowledge or advice to me. Anything helps. Cheers and blessings!
  3. My doctor recently prescribed me with Accutane to help deal with mild acne that appears on the sides of my jaw, after noticing that Tactupump wasn't able to get rid of the aforementioned acne. I was informed of the side effects of Accutane, and depression was mentioned (though my doctor said it wasn't common). Feeling a bit anxious of a drug that could possibly affect my brain, I did a bit of research into the cognitive side effects of Accutane and ended up with conflicted results. A forum post on this website mentions that Accutane does indeed cause brain damage with several sources included: https://acne.org/messageboard/topic/376677-accutane-causes-brain-damage/ The forum post above says the following about the drug: 37% of dermatologists say that Accutane may cause mental illnesses Mildly affects the part of the brain that mainly controls decision-making and emotion Causes memory issues in mice Causes depression in mice In the last paragraph, the poster makes a claim that signs of Traumatic Brain Injury are evident, based on what other users post, though I take this with a grain of salt. I have also found a few articles that say that Accutane doesn't affect the brain at all, and even possibly improves brain function: ncbi.nlm.nih.gov/pubmed/21545542 The article above states that Accutane has no negative effects on adults and children. ncbi.nlm.nih.gov/pmc/articles/PMC4473493/ The article above says it's not sure whether there's a link with mental illnesses. https://ncbi.nlm.nih.gov/pmc/articles/PMC3360864/ The article above says that they found improvements in cognitive abilities upon doing a study on participants aged 16 and over. So now I'm lost. Does Accutane actually cause damage to the brain? (edit: Grammar + Bolding)
  4. Title says it all, I'm actually pretty concerned about it. As I've been a long term Differin user 2-3 years and I started getting visual snow, tight scalp muscles, dry eyes and other side effects that Accutane users seem to get. I can find one case study about someone developing intracranial hypertension from Adapalene: https://www.ncbi.nlm.nih.gov/pubmed/18562850 I can't find the full article anymore for some reason.
  5. It's been a few weeks since I last updated this blog, so be prepared for a long one! Right now, without hopefully jinxing it, I have no actives on my face!! It's by no means clear however, unfortunately still some quite persistent lumps from previous spots that just won't go down . I also have A LOT of hyperpigmentation and a few scars so definitely not looking clear by any means. But I honestly can't believe this right now, after just 4 weeks I've reached a point where I am going a good few days without getting a cluster of new spots. Before roaccutane I would usually get about 3-4 new spots a day so this is a real difference. I did notice a bit of a purge in the first 2 weeks with a cluster of cysts quite suddenly popping up around my mouth and a few on one of cheeks - the ones on the cheeks being the persistent ones that won't fully go down (). But since then I've still been getting spots but just not the same quantity and going a few days between them popping up. In terms of side effects, my skin certainly isn't oily anymore. Before starting the medication, I would have said my skin wasn't even that oily but now that I'm producing so little of it I realise I was wrong hahah. And my makeup lasts really well all day!! However, I wouldn't say my face is particularly dry. After washing my face, if I were to leave it for half an hour without moisturising, I would notice dry patches on my chin but that's about it. I've been using the Clinique moisture surge collection which I really recommend, pricey but good at battling the dryness! My lips are pretty dry though. I apply the La Roche Posay Cicaplast lip balm which I really like. I apply it in the morning, then usually sometime half way through the day and then a thick layer at night before going to bed. So only applying 3-4 times a day max, but I have split my lip twice since starting roaccutane. My hair is now going days between washes. Right now, I washed my hair 4 days ago and have been to the gym twice in that time, sweating a fair bit, and it still no grease to be seen (for reference I washed my hair every other day before starting). I began getting a dull ache in my lower back about 2 weeks ago, which I noticed whilst running. Since that happened I have been taking an omega 3, 6 and 9 supplement everyday and today I was at the gym doing bursts of sprinting on the treadmill and didn't notice any aches. That's pretty much it on the side effects, my mood has been pretty positive, no stress as uni is finished for summer and generally happy about the progress being made. I also had my dermatologist appointment last week. My skin wasn't actually looking too good last week at the appointment (always happens) but I spoke to her about how I'm doing good with the side effects but obviously want some more progress, so she's upped me to 30mg!! I'm pretty excited about upping my dose but also slightly nervous that I'll see another purge, which I know will disappoint me given how good it's looking right now. I'm also going on holiday next week to see family so I'm reaaaally hoping it doesn't happen. Oh, I got my blood test done last week also, and found out my cholesterol is high, but still within standard limits (5.2) so I'm trying to keep to a low fat, healthy diet as up until last week my diet consisted of a lot of pizza and chocolate, so sad times :((( Well I think that's it for the update. I'll try to update more frequently as this was a lonnnng post, soz about that. Let's hope for more progress at the next one!!
  6. Blogging my Accutane journey. I started Accutane two weeks ago. I started on 20mg per day for the first week and am now on 40mg per day. I will track my progress and let you know how I am dealing with the side effects. Find my blog here: http://nak-on.blogspot.com/search/label/On Accutane
  7. Hello, I've had acne since I was about 18, and at that time, I experimented with a ton of different OTC treatments and washes, most of which only made things worse and irritated my face. About a year ago, I finally decided to go to the dermatologist and was prescribed antibiotics. Prior to that, I was washing my face with 10% benzoyl peroxide in the morning, which I soon realized was simply not enough. The antibiotics made a huge difference, but I was still getting clogged pores that would be red bumps, they just wouldn't get inflamed and sore or come to a head. I started adapalene on my own in January after a concern that I might be starting to develop resistance to the antibiotics.
  8. Hello! i recently began taking isotretinoin, 40 mg a day (just over a week ago). I didn’t notice any side effects until two days ago, but it was just the cracked lips. Last night, after feeling fine all day, I suddenly started shivering uncontrollably, and nothing I did helped me get warm. I took a shower, put on extra layers, and got under several blankets, but I couldn’t stop shivering. I also felt extremely sore. My whole back was sore, and the muscles in my legs, chest, and shoulder were too. After a few hours, i started to get really hot. I don’t have a thermometer so I can’t confirm whether I had a fever, but that’s exactly what usually happens when I do. The achy muscles have persisted to today. I’m confused though, because I have no other symptoms of a cold or the flu. No congestion, sore throat, vomiting, etc. So I guess I’m just wondering whether this could at all be related to the isotretinoin? And if so, is it something which would go away after a few days, or is it something to be worried about? Thanks!
  9. Hey Acne.org, I'm a 17 year old male who finished a 6 month 40 mg/day course of accutane about a year ago. While on the accutane, I didn't really have any issues, but the problems started after I stopped. Ever since I stopped, it felt like my entire life has been turned upside down, and I started experiencing horrible side effects which are as follows: -Hair loss: I've always had thick and curly hair, but shortly after stopping accutane, I noticed my hair started falling out in droves (mainly in the shower). The hair loss has slowed since then, but it hasn't shown any signs of improving, and my hair is noticeably thinner. -Stomach problems: I never really feel "hungry" anymore, my stomach just hurts, and I eat to alleviate the pain. When I do eat, I'm never satisfied after finishing, and it feels like my metabolism has slowed down greatly. It also feels like foods have lost their taste for me. -Back pain: I used to be extremely active, doing lots of body weight exercises, but I started having horrible back pain towards the end of the accutane treatment. Anytime I would bend over or twist in either direction I would experience a very sharp pain in my lower back. This has gotten better, but only after I cut back significantly with my exercise. -Cold hands: After stopping, it's as if my body's ability to warm itself reduced dramatically. My hands are always EXTREMELY cold, and I've become very intolerant to cold weather. Whenever I exercise, I don't really feel that "hot" and I'm not satisfied stepping into an air conditioned room on a hot day like I used to be. This one seems to be unique, as I haven't read of anyone else with this side effect. -Eye strain: My eyes are red 24/7 since stopping, and I'll often get headaches after low exposure time to screens. I used to be able to look at screens nonstop for hours at a time without any issues whatsoever, and now I can barely keep my eyes on my monitor for half an hour without getting a headache. -Sexual health: My libido went down like crazy in the months following accutane. I went from masturbating twice a day to once a week, and I don't really feel attraction towards females like I used to. -Mental health: This is the worst out of all the side effects I've listed. Ever since stopping, I've had ZERO drive to do the things I used to love doing. I used to always keep myself busy when I had nothing to do, but now I'm passionate about literally nothing, and I lack the mental energy to keep myself occupied when I'm bored. I feel as if I've lost my soul entirely, and I don't know what to do about it. Also, I don't ever feel genuine happiness like I used to. The memories I had before accutane were filled with joy, but now it's as if I'm living in a world of black and white, and the "happiness" I feel nowadays is nothing compared to what I used to feel. So is there anything I can do to get my life back on track? Or am I just another doomed statistic?
  10. So because I read it's good for acne I order some niacin. 500 mg. All of the other ones were without the 'flush' and I read you need the flush or it won't really work... So I took it tonight. O.M.F.G The side effects. The flushing, hot hot skin, stomach cramping, nausea, dizziness, could barely breathe... It felt like I was dying for a few minutes and I've been on some strong medications before. It's been about half an hour since and my skin is still super hot. My face also feel puffy. And my arms are super itchy and hot too. I feel like I need an ice bath. 500 mg is obviously way too much. Maybe I should try 100? Also does it have to be one that has 'the flush?' All the other ones from this store are 'non-flush'.
  11. Everything is in the google document, I've expanded it below. I think I am 100% cured, no longer get anxious or brainfog, sexually I feel the best I ever have, though things like joint health and injuries obviously didn't magically heal, but I have done a lot of PT and my body responds positively to it, though they aren't as good as pre-accutane. Anyway, I'm gonna leave this here and get on with my life. A selfish part of me wants to delete this account and never come back, because there aren't many positive memories here, but I will probably check every month or two but most questions are answered in this post. For brain fog, I strongly recommend meditation, I feel my focus is stronger then its ever been, though the supplements will help with that as well. I didn't recommend meditation that strongly below, because I hadn't started it yet and didn't realise how beneficial it was. And with that said, hope what I've written below helps you and au revoir! https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# Curing PRSD Hey, I am a 22 year old who suffered from Accutanes side effects since I was 16, and I think I am cured, though for me while sexual dysfunction was the side effect that made me notice accutane had affected me, it was not the only side effect. The route to curing my own side effects was by using nutrition and supplements, to undo the damage accutane did to my brain. Personally I believe Accutane causes its negative side effects by changing brain metabolism and causing a degree of brain damage. The brain damage is not caused by outright irreparable cell death, because the main place where cell death occurs is in the hippocampus, where neurogenesis can occur anyway and most of the damage can be reversed. The problem is that accutane also inhibits neurogenesis, so for some people, they suffer this brain damage quite severely, while others get back on their feet pretty quickly and don’t even regret taking it. Now as a disclaimer, I only took accutane for 9 weeks at 2x40mg per day, which was enough to give me no feeling in my penis for 2 months, and several years of not being aroused and not being attracted to any person irl at all, though with porn I could masterbate, though I was very insecure if I would actually be able to perform under pressure, and avoided any situation where anything might happen. I developed social anxiety, I lost my passion for all my subjects, competitiveness for sport and academics, couldn’t concentrate or focus, and lost most hope and ambition for my future. I wasn’t completely antisocial, and still had a few friends, male and female, but only because my brain wouldn’t really care if it was female and if there was zero chance of being aroused, there was zero chance of being anxious as well Accutane What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." Anxiety, Depression and the Hippocampus After taking Accutane, I suffered depression and anxiety, and so far from normal that I went to a psychologist and explained my symptoms, and went there several times, and while I considered antidepressants, I never took them. On Accutane forums, many people are depressed, and so many have taken SSRIs, and many people feel much better having taken them. They still do not feel 100%, but while on them they regain a lot of feeling and emotion that they have missed, antidepressants obviously have their own side effects so it is not always worthwhile. There is much research showing there are natural ways to stimulate neurogenesis in the hippocampus, that does not risk the side effects of antidepressants Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. https://www.ncbi.nlm.nih.gov/pubmed/16425236 “The hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.” This study basically states the reason SSRIs work again depression is because they upregulate hippocampal neurogenesis Ventral hippocampal lesions affect anxiety but not spatial learning. https://www.ncbi.nlm.nih.gov/pubmed/12642189 Rats with cytotoxic ventral hippocampal lesions which removed approximately 50% of the hippocampus (including dentate gyrus) starting from the temporal pole, displayed a reduction in freezing behaviour following the delivery of an unsignalled footshock in an operant chamber. This was more plausibly a result of reduced susceptibility to fear than a result of a lesion-induced increase in general motor activity. There was no consistent difference between sham and lesioned animals in spontaneous locomotor activity, or locomotion following acute or chronic treatment with amphetamine. In contrast, ventral hippocampal lesioned animals were quicker to pass from the black to the white box during a modified version of the light/dark exploration test, and were quicker to begin eating during tests of hyponeophagia. Furthermore, rats with ventral hippocampal lesions defecated less than their sham counterparts both during open field testing and in extinction sessions following contextual conditioning. In contrast to these clear lesion effects, there were no signs of any spatial learning impairment either in the watermaze or on the elevated T-maze. Taken together these results suggest that the ventral hippocampus may play a role in a brain system (or systems) associated with fear and/or anxiety, and provide further evidence for a distinct specialisation of function along the septotemporal axis of the hippocampus. Anxiety and hippocampus volume in the rat. https://www.ncbi.nlm.nih.gov/pubmed/16192979 In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxiety-related behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. The studies above show that hippocampal volume, which is the most common measure of neurogenesis and neuroplasticity, are very accurate in determining whether someone suffers from depression and generalised anxiety disorder, and also the severity of the mental illness. Hippocampal volume is also an accurate predictor of how well someone will recover from a brain injury, or how well they will cope when faced with a stressful situation. The cure is focussed in restoring neuroplasticity and hippocampal growth (aka promoting neurogenesis, they are all basically the same thing), and while following the routine your brain should regain this ability to heal itself and over several months a close to full recovery should be within reach. As a bonus, the depression and anxiety also being suffered should be much reduced after following the protocol Effects of Hippocampal atrophy/ negative changes in brain metabolism Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/ “In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients’ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs—both the trauma-exposed and unexposed members—had significantly smaller hippocampi than non-PTSD pairs.” here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/ The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or maybe the worse his mental state before the injury happened, the worse his recovery will be, rather than simply being optimistic improves outcomes. In this we see that accutane, in mant ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane’s sides. That is because they can help treat some of accutanes sides in specific instances, because SSRIs can promote neuroplasticity, though it doesn’t cut through to the heart of the issue, and it means you can’t stop taking SSRIs. Now we established that hippocampal atrophy is the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally and safely, without the need to put your health under any further risks Stimulating hippocampal growth/neurogenesis/neuroplasticity First line of treatment is just some nutritional supplements Nutritional treatment for acute and chronic traumatic brain injury patients. https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related "omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a TBI" Dietary supplement creatine protects against traumatic brain injury. http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/ Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/ Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. https://www.ncbi.nlm.nih.gov/pubmed/14695924 COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group. Changing diet Long-term effects of a ketogenic diet in obese patients http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania" Lifestyle choices and activities Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/ Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least. Mindfulness-based stress reduction (MBSR) improves long-term mental fatigue after stroke or traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/22794665 “CONCLUSION: The results from the present study show that MBSR may be a promising non-pharmacological treatment for mental fatigue after a stroke or TBI.“ The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848393/ “Effect size estimates suggest that mindfulness-based therapy was moderately effective for improving anxiety (Hedges’ g = 0.63) and mood symptoms (Hedges’ g = 0.59) from pre to post-treatment in the overall sample. In patients with anxiety and mood disorders, this intervention was associated with effect sizes (Hedges’ g) of 0.97 and 0.95 for improving anxiety and mood symptoms, respectively. These effect sizes were robust, unrelated to publication year or number of treatment sessions, and were maintained over follow-up.” Larger hippocampal dimensions in meditation practitioners: differential effects in women and men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351565/ “Descriptively, left and right hippocampal volumes were larger, on average, in male meditators compared to male controls; they were also larger in female meditators compared to female controls (see Table Table1).1). The group-by-sex interaction was significant for the left hippocampus (p = 0.002) but not for the right hippocampus (p = 0.46). Conducting post hoc comparisons separately within males and females, left hippocampal volumes were significantly larger in male meditators than male controls (p = 0.02) as well as in female meditators than female controls (p = 0.046). Significant meditation effects with respect to right hippocampal volumes were not detectable in males (p = 0.722) or in females (p = 0.291).” Mindfulness meditation improves cognition: evidence of brief mental training. https://www.ncbi.nlm.nih.gov/pubmed/20363650 “ After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.” Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/ Abounding evidence has shown that HBOT promotes neurogenesis. Future investigations need to be extended to models of neurological diseases, including subarachnoid hemorrhage (SAH), cerebral hemorrhage, AD, PD, surgical brain injury (SBI) and autism for cell proliferation, survival and differentiation. Furthermore, studies need to be conducted to explore whether HBOT induced neurogenesis leads to a functional improvement followed by large scale, strictly controlled clinical trials to establish HBOT as a prevention and/or treatment modality for neurological diseases. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. https://www.ncbi.nlm.nih.gov/pubmed/21118604 Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/ Dietary supplement creatine protects against traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/11079535 Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. https://www.ncbi.nlm.nih.gov/pubmed/19741313 Fish oil 3g x2 per day. It has very strong neuroprotective effects, and has been shown to control epilepsy in children. In animals it has been show to increase testosterone and improve sperm count Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Effect of Long-Term Fish Oil Supplementation on Semen Quality and Serum Testosterone Concentrations in Male Dogs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948075/ Effect of dietary fish oil on mouse testosterone level and the distribution of eicosapentaenoic acid-containing phosphatidylcholine in testicular interstitium. https://www.ncbi.nlm.nih.gov/m/pubmed/28955915/ Zinc 30mg elemental/day Has been shown to have neuroprotective effects, improve male hormone profile, and improve liver health. If also taking iron supplements take at a different time of the day, because zinc can hinder iron absorption Zinc status and serum testosterone levels of healthy adults. https://www.ncbi.nlm.nih.gov/pubmed/8875519 Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout. https://www.ncbi.nlm.nih.gov/pubmed/21744023 Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/ Example treatment routine Creatine - increases Dihydrotestosterone (DHT) and testosterone, which is very important for PFS sufferers especially, while also increasing muscle power and improves neuroplasticity Fish Oil - improves joint pain, helps heart disease, reduces seizure incidence and promotes neurogenesis Zinc - increases levels of male hormones and improves neuroplasticity Magnesium - helps with chronic pain, fatigue and insomnia and neuroplasticity Vitamin D: Improves bone health, physical fitness, and improves neuroplasticity Meditation: Allows the body to better regulate stress, has been shown to increase happiness and reduce fatigue from social situations in stroke victims, and promotes neurogenesis. Yoga is also shown to help with mood and neuroplasticity, as well as physical health, so I recommend that if it is available to you CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity Multivitamin - makes me less likely to be malnourished. Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and improves neuroplasticity Ketogenic Diet: Improves body composition, can help ED, has been known to cure depression and anxiety, and improves neuroplasticity. I tried it for a Hyperbaric oxygen therapy: If this therapy is accessible to you I would also take advantage of it, though I haven’t done it. Many studies show it strongly promotes neuroplasticity Olive Oil: Improves hormones, displays neuroprotective effects, helps with constipation and antioxidents, improves wound healing and skin health, helps with depression and anxiety Edit: Olive oil studies Extra virgin olive oil improves learning and memory in SAMP8 mice. https://www.ncbi.nlm.nih.gov/pubmed/21955812 Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724295/ Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats. https://www.ncbi.nlm.nih.gov/pubmed/26168701 Extra-virgin olive oil preserves memory, protects brain against Alzheimer's https://www.sciencedaily.com/releases/2017/06/170621103123.htm It also helps joint pain https://www.ncbi.nlm.nih.gov/pubmed/25294776 Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. Depression and anxiety Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/ Constipation and antioxident profile The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.(only 4ml a day) https://www.ncbi.nlm.nih.gov/pubmed/25238699 Antioxidant activity of olive polyphenols in humans: a review. https://www.ncbi.nlm.nih.gov/pubmed/20209466 Alternative treatment routines Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. https://www.ncbi.nlm.nih.gov/pubmed/18173322 “High-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.” Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. https://www.ncbi.nlm.nih.gov/pubmed/21940440 “Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.” Nootropic agents stimulate neurogenesis. https://www.ncbi.nlm.nih.gov/pubmed/19441945 Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/ Acupuncture stimulation induces neurogenesis in adult brain. https://www.ncbi.nlm.nih.gov/pubmed/24215918 Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/ "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17]. Conclusion Remember, there will be scars remaining from your specific syndrome, but after this cure you will no longer be trying to cure the whole brain fog, erectile dysfunction, depression, anxiety, injury-susceptiblility, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone!
  12. I'm 20 years old with hormonal acne and I've been taking 25mg Spironolactone for just over a month now and in the past week I've had 2 migraines with auras. I only ever used to get these migraines when I was on birth control for over year, which I am now banned from taking as a result of the health risk. I can understand that the excess estrogen from BC would cause my migraines but as an anti androgen, I don't understand why Spiro is doing the same, especially in such a short amount of time. I know that spiro states that headaches can be a side effect but anyone who's had migraines knows that there's a huge difference between the two! Does anyone have any idea what could be happening? I can't carry on with this medication if I continue to get this side effect so any help would be much appreciated! Update: all my migraines previously to spiro have been hormone related but can the diuretic effect of spiro be causing them? I've been trying to make sure I drink a lot of water but I honestly haven't been keeping track with all the stress of final year at uni! Going to start being thorough with my water intake this week and report back if I notice a difference!
  13. After years of mild-moderate cystic acne that persisted through over two years of antibiotics (doxy, mino, bactrim, etc) and every topical retinoid under the sun, I decided to go on isotretinoin at the age of 22. I am 155 LB male, exercise daily, eat healthy, etc. Majority of my acne is around the chin and mouth, occasionally on the cheeks. Been suffering from it for about 5 years total. Every dermatologist that I have ever seen has recommended accutane due to the limited efficacy of nearly everything else I have tried. I by no means have severe acne. Most people would not say that they consider me to have bad skin. Unfortunately, I am a perfectionist, and I spend way to much time and money trying to control my acne. Recently, I decided to go the accutane route, due to nothing else really working and the continuation of antibiotics not being a healthy option. I did a ridiculous amount of research, and noticed that increasingly dermatologists are prescribing lower, fixed dosages of isotretinoin and obtaining the same results for the patients, albeit in a longer time frame. However, the research I found indicates that this approach minimizes the occurrence and severity of side effects. Naturally, this sounded appealing. I found a dermatologist willing to prescribe along these lines, so I started two days ago. The plan is to stick with 20 MG (possibly edging up to 30 MG to speed the process) for a period of about a year or however long it takes to get to the minimum accumulated dosage. I noticed that there is very little firsthand information about this kind of dosing, so I will be posting weekly about my progress, in case others are trying to find more information about this approach.
  14. I´m on accutane and have taken 300 pills of 20mg. Early on, I experienced getting many tiny, small bumps on my forehead and I dont know why... See my pictures. What are they and will they ever go away? I´ve never had this before and sometimes it´s itchy and red. Kind of looks like small blackheads, but they never disappear.. Also, I just get them in the centre/middle, not the whole forehead. It is driving me crazy and I dont understand why I´m having them since my forehead´s never been my problem-area... And one more thing, this is my second round of accutane, and this was NOT something is had my first time around.
  15. Saw Palmetto

    Forums Hormonal acne 1 reply

    Hi all! 34 year old female with hormonal acne. I started getting cystic acne (only on lower half of face) since about 20 years old. When I turned 31 I started spiro and retin-a. My skin quickly cleared up for the first time since I started having acne. After about 6 months, I stopped the spiro, and only continued with the retin-a. For the proceeding 11 months, my skin was still perfectly clear. August last year I did the Aztec clay mask for the first time in a few years before a concert and a couple days later I broke out worse than I ever have and since then have been battling the cystic hormonal acne since then. Fast forward to a week ago when I started taking standardized saw palmetto. I started with 120mg only once daily... since then I have experienced high anxiety (two panic attacks) and lack of sleep. Im a little nervous about attempting to take the pills twice a day since it might make the anxiety worse... is this anxiety just a side effect “phase” that others have experienced and passed, or could this be just how my body responds to this and will never get better?
  16. Just thought everyone should know that Accutane is scientifically proven to cause brain damage, and it is probably the cause of many of the long lasting side effects that people experience. Obviously many come out the other side with little significant long lasting side effects, others do. This is because everyones brain is different, which is why after a concussion some are fine a few days later, while some are never the same, and have mental illness for the rest of their lives. In the end its a roll of the dice, and if you are going to roll, I suggest you at least know the risks first. With no further ado, here is the evidence. Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." These are the potential side effects of brain damage. If you read up on past users, often they display a number of these symptoms Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” If you've taken it already and are displaying negative side effects, I recommend you take a read of this: https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# It's like a brain rehab protocol I've devised and had success with. Its pretty cheap, and much safer then the drugs and diets others have resorted to in the attempt to reclaim control of their lives. It will take a few months to take effect, but its cheap and if you are impatient, you can easily take it alongside other protocols you are trying
  17. I saw an older post from 2006 stating that there are no birth side effects caused by the sperm of male patients taking accutane. So today, 12 years later, i was wondering if there have been any birth defect cases caused by the sperm of male patients using accutane. Anyone know? I have been prescribed accutane and i'm frightened to take it. Thanks
  18. hi , i'm on accutane 30 mg daily for almost 2 months now my acne is starting to improve now, but i suffer from side effects and i need your advices regarding how to manage it. joint pain ,i wake up like a 90 years old woman then it improves through the day but my ankle pain don't improve . i also feel sleepy and dizzy most of the day , i sleep too much now 12 hours a day which is not my usual at all. i have alot of study and i need to go to college daily , i don't have time for this so anyone can help ?
  19. I'm turning 40 in a few months and I still get cystic acne. My skin is incredibly oily. Looking on the bright side, it has helped with the aging process. However my acne (which I believe is hormone based) is so painful and embarrassing. I bet like most long term acne sufferers, I have tried everything, read everything and am doing everything I can to take care of my skin - with zero results. I have been on Doxycycline for like, a year. It worked in the beginning but it's pretty worthless now. I think I'm ready to try Accutane. Has anyone experience premature aging? Because my skin is so oily I don't have any wrinkles, even though I am nearly 40. I'm worried that Accutane with make me age.
  20. this is my last week of my 20mg accutane course and iam experiencing flakes on my scalp should i go off accutane, im really scared is this dandruff?? pls someone has to help ????
  21. I am a 54kg female (early 20’s) with mild/moderate (although annoyingly persistent) acne and my derm has prescribed me 10mg Roaccutane per day as a starting dose. My acne is characterized by mainly closed comedones all over my cheeks and jaw with some cystic which tend to scar very badly. I’ve attached some pictures below of my skin pre-Accutane for reference. Weirdly it seems to be way more severe on my right side, with my left only having a small amount of closed comedones (no cysts). Anyway, the dermatologist seemed to think that 10mg per day would still be effective for my acne/skin type with intentions to bump me up to 20mg in the second month and possibly 40mg the months thereafter depending on my results. I am only on day 4 and so far haven’t really experienced any of the dreaded side effects, apart from noticing that a few more whiteheads are popping up here and there. The good news is that the cysts I had on my cheek pre-Accutane cleared up pretty soon after starting. Usually these would linger for 2, sometimes even 3/4 weeks *sigh* Are there any other low-dosers out there who have seen results on this milder form of treatment? All comments/advice welcomed!!
  22. I’m currently on day 3 of Accutane. I’m going to be taking fish oil, glucosamine/chondroitin/MSM, milk thistle, and calcium supp. I eat quite healthy and drink tons of water, am very active and don’t currently have joint problems but I’m very mindful of the reports of long term joint issues. For anyone reading this who has long term joint pain/other side effects, did you take supplements while on Accutane or only after? Also is there anything you would have changed about your lifestyle (other than not take it) which you feel could have avoided some of the effects?
  23. Hi everyone, I've done two courses of Accutane in my life time, one long one and then one shorter one a year later to finish it off. (see older posts for details). It's been exactly a year since my last pill and I am noticing some definite side effects just kicking in as of recently. The side effects are annoying but pretty easy to cope with from a day to day basis... Here are the symptoms I've noticed since stopping accutane: Dry eyes Dry skin Tingles (hands, feet, face) Dizziness Tinnitus Ear problems Sinus issues (could be allergies) Dehydration Constipation Some brain fog, feelings of stress too note: theses symptoms usually come in waves and go away. Now I'm not blaming any or all of these on accutane specifically but I just want to know if anyone else has been experiencing something like this? I've had a lot going on in my life this past year so I would like to state I could be completely wrong about these being attributed to accutane, however, I have read some interesting stuff on here that matches my symptoms. Basically now I'm going to start a Topic here where I will post back every Friday for the month of December. I have promised my self all of these symptoms will be gone or I will just learn to deal with it by January, so that is my goal. Also if you have any questions, please ask away. (don't be a negative Nancy either, I'm a positive person and I happen to know a lot about the human body so anyone who's depressed from similar symptoms... It starts with your mindset). Keep in mind that I was never a good English student, so if theses posts are a little ill structured or all over the place, just bare with me because I'm not doing any editing or proof reading. This is a freestyle, yo. Anyways, I have a couple dr. appointments coming up and most of these symptoms subside when I'm staying active, drinking lots of water and eating healthy (10 DAYS BEFORE RESULTS), or if there not subsiding then I'm just not thinking about them, which works for me too. I've read something about liver storage of the drug for years... Here's my thoughts on this... Looking back on my first course, I remember developing weird symptoms a year later... They lasted about 6-8 months about the time of my accutane course. Based on my purely anecdotal "bro" science, I think my liver is storing the drug long term in response to the high doses of it that I received, and right now my liver is purging it from my body. If anyone here's is freaking out because they think Accutane is killing them. Listen to this: It's a strong drug, and you signed up for it. The best thing to do is go see a doctor and tell her your symptoms. If you're experiencing anything serious, like fainting, bloody stool, seizures, then it's time to get concerned. If you're like me and you're feeling "off" mentally and physically, well, you're going to be fine. I'm sick of reading posts all these Negative Nancies in the forums. You have to realize, every time you stress and worry your symptoms are going to multiple 10 fold. This is where your mental strength comes in, and if the strength just isn't there... psychiatry, family, boyfriend/girlfriend, or just make a post here. Just be positive because your mind is a lot more powerful then you think. But, don't take any more drugs of any kind for awhile unless you need it, no SSRI's or any of that crap. If you're staying active often and you haven't been diagnosed with any life threatening condition, you'll be fine. Cheese ball quote: "whether you believe you can or can't, you're right". I think that's how it goes.. Either way, yeah. Anyways I'm going to cut out some common allergens (eggs, wheat, corn, dairy), exercise at least once a day for at least one hour vigorously, drink a shit ton of water, and do the things that make me happy, like guitar, hockey, video games, meditation, spend time with family and friends, dates, ect... And just work on having positive a mindset like your brain is a muscle and everyday is brain day. See you next week.
  24. Hello hello, It has been well over a month since my last post. I think as the tablets become a daily routine and as your skin starts to clear up, you just seem to forget how big of a deal it was when starting on them and therefore forget to update! So lets just recap... Month 1 I was on 20mg a day - had a horrendous breakout (worst I've very had in my life) Month 2 I was upped to 30mg a day - Breakout continued and was not seeing much improvement. I was almost giving up and felt like NOTHING was going to help my acne. I was convinced that acne was just something I was going to have to live with for the rest of my life! I was so down and helpless at this point for about 2/3 weeks. Towards the end of the month, it cleared up significantly and I regained faith in the tablets! Month 3 - Almost 2 weeks ago on Halloween day, I went back to my derm for my monthly check up. Blood test results came back perfect so she upped me to 40mg a day. I have only seen improvement from here on out. I actually cannot believe my eyes! The cluster of painful cystic spots I had on both sides of my jawline have totally vanished.. I currently have 2 or 3 active spots (2 on my cheekbone and one on my chin) and a few bumps here and there and where the cysts used to be, but nothing compared to the 20/30 spots and cysts I had this time 1 month ago. Any spots I get now come and go within a day or two which is AMAZING. I've been left with quite a lot of scars though but I'm not going to worry about them until I'm acne free. I want to treat my acne before treating scars. (Someday I will be smiling in these photos, promise!) Also, I know you're not supposed to but I've drank quite a bit over the last month or two due to my birthday, holidays, halloween bank holiday, etc and the tablets do not effect you when you drink. But my godddd do they make you feel it the next day!! Obviously with the dehydration in your skin caused by the tablets and then the alcohol on top of everything, you get a major headache and feel like no amount of water will make you feel alive again.. so if you're going to drink, maybe drink water in between each alcoholic drink... or more importantly..... just don't drink at all! Side effects: Dry skin Very dry lips Dry irritated eyes Tired almost all of the time - but this could be due to endless college assignments too! These side effects are just part of the parcel and nothing out of the ordinary. They're still totally bearable. I'm going to do a blog shortly on the products I've used and been using because when I was researching before going Roaccutane, I found it hard to find good lists of decent products used to battle acne whilst helping to moisture the skin too. Until then, chin up! x
  25. Hi, ive been on roaccutane just over a month now, my skin was initially not too bad but I went straight into 40mg dosages which for a slim 16 year old male is a lot. So far it has made my skin worse than ever, both my cheeks are covered in spots. I understand that an initial flare is normal - but surely theres something wrong here? Can someone also tell me which products they recommend? I need a good face wash/moisturiser that will stop my dry peeling skin, but also a lip balm, that will properly work and not just rub off all the time. Thanks