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  1. ★Why does the DAILY use of SmartPhones cause PAIN in the HANDS and other parts of the body?★ Many users who touch the screens of SmartPhones for long periods feel a BURNING or ITCHING sensation on the TIPS of their FINGERS. The regular use of SmartPhones for months and years can even cause deformities in the nails of their fingers. The daily or regular use of SmartPhones causes PAIN in the HANDS of users because the low-voltage ELECTRICAL IMPULSES of their SmartPhones CONTINUOUSLY TRAVEL through the NERVES of their fingers and ALL other PARTS of their BODIES till the ELECTRICAL IMPULSES finally reach the EARTH through their FEET!! The PAIN is caused by the excessive stimulation and exhaustion of the NERVES, which can produce weakness and tiredness in the whole body. The PAIN can SPREAD to the wrists, arms, shoulders, back, neck, head, chest, waist, legs, feet and other parts and organs of their bodies! There can be an attack of PARALYSIS in the fingers, hands, arms, etc, even without a stroke which is associated with the presence of blood clots in the brain! When the NERVES in and around the bones are affected, ARTHRITIS and other bone diseases can occur. ★ALL the Organs like HEART are Affected★ As the NERVES are present in the whole body, ELECTRICAL IMPULSES from SmartPhones adversely affect the health of various organs. The HEART too is affected by the ELECTRICAL IMPULSES of SmartPhones travelling through its NERVES, which can cause arrhythmic beats, palpitations, heart failure, and even a cardiac arrest becomes possible without any blockage in any coronary artery! Constant ACHES & PAINS in the body can cause sleeplessness, headaches, depression, eye problems like blurred vision, etc. ★Other SYMPTOMS & DISEASES caused by SmartPhones★ ELECTRICAL IMPULSES of SmartPhones can also affect the lungs, kidneys, bladder, liver, stomach, intestines, pancreas, muscles, membranes, ears, nose, mouth and tongue, teeth, blood, blood vessels, lymph, lymph glands, etc, which can cause problems and diseases of these organs. ELECTRICAL IMPULSES of SmartPhones can also cause skin and hair problems, as there are NERVES in the skin and around hair roots. CANCER: Besides the low-voltage ELECTRICAL IMPULSES, the RADIATION from the SmartPhones is known to cause many other problems like CANCER in the persons who use their SmartPhones for many hours daily. ★★★You should NOT use your mobile phone or tablet when its battery is being charged. Holding and using mobiles and tablets, during the time of RECHARGING their batteries, is much MORE HARMFUL for HEALTH. When we use them during RECHARGING, more ENERGY (electricity) passes through our bodies constantly, which can HARM the heart, brain, other organs and tissues. The BATTERY CHARGER should be SWITCHED OFF or disconnected when we use the mobiles and tablets. ★We must STOP the EXCESSIVE use of SmartPhones!★ Forward this message to your friends and relatives, as this information can save millions of SmartPhone users from PAIN and suffering.
  2. Hi, I was wondering if anyone has been through the same thing and could help. I’ve never had great skin, and as a teenager always had mild acne, but once I got to 18 it evened out to the point where it had minimal impact on my everyday life. I’m 24 now, and around May/June my skin got so bad - moderate to severe acne - on areas of my face I’d never got spots before - with big painful cysts. I went to my doctor and was prescribed Epiduo which I eagerly used too much off and ended up with a chemical burn on my face. (I think almost anyone who has used this has done the same) It was so painful I couldn’t even wash my face. I slowly figured out how to use Epiduo best - every other night to get used to it - only a tiny amount - and eliminating all other harsh products from my regime. I’m now using it every night and using Avene cicalfate cream on areas that get dry or irritated. I’ve now been using Epiduo for two months and two weeks ago I was also prescribed an oral antibiotic to take alongside it. Currently my skin is terrible. I have been getting more breakouts instead of less, some areas of my face are extremely dry and painful whilst my t-zone is suddenly really greasy and oily which I’ve never had before. Also my scars and hyperpigmintation are dark and obvious regardless of any make up I put on to cover it. I started a new job two weeks ago too, Thinking if I was occupied and busy I would not have as much time to obsess over my skin and get depressed. But it has done the opposite I now feel anxious and panicky - have no idea how to get out of the job as I doubt anyone would understand the extreme impact my skin is having on me. It’s a really high pressure job in a law firm - and I’m guessing the stress may also be adding to my skin. And then I catch a glimpse of myself in the mirror and feel sick. I then feel so angry and frustrated and hate myself. And he spots hurt so even if I avoid all reflections I can feel them all day - with some of them giving me headaches. I have a blood test tomorrow to test for PCOS and my doctor said if I have it there will be more treatment options and it may explain my mental health difficulties. My worry is the test will be negative and I’m stuck with what I’ve got. If nothing works soon I don’t know what I’m going to do. I keep thinking about hurting myself and suicide (several times everyday) perhaps as the only way to escape. If I leave my job I’ll feel like a failure and probably get quite depressed but if I stay im going to continue getting so anxious and stressed (over job and skin) that something bad is gonna happen to me. Please, I just need someone to help me or I don’t know if I can cope.
  3. Hi there to whoever will read this! im almost a 21 years old female suffering from acne of my face, back and chest. I have been dealing with this problem for the past 5-6 years and it has become increasingly unbearable for me to deal with it. During my teen years, my acne did not effect my mental health that much. However I am in college now and earlier this year, I had a flare up which led to significant damage to my self esteem and symptoms of intense depression. I'm currently using adapalene gel and benzoyl peroxide combo to treat my acne. Earlier I only used to use BP but I have incorporated adapalene after seeing a dermatologist a month ago. I'm on my fifth week of the treatment and I'm breaking out almost everday. I feel scared and stressed and exhausted after continuously living with acne. Everyday I wake up in gear and the first thing I do is check my face in the mirror to see if I have any overly concering pimples. My stress and anxiety also makes me pop up pimples which almost always make them worse and I find my self in a cycle of self hatred. I am worried about my mental health but unfortunately there is no where I can get help from. I don't want to go to therapy. I don't think I can afford it. I barely go to college once a week due to my acne and I can see myself become more and more mentally ill. My acne is disrupting my life and I have no clue what to do. I have tried every treatment that I could afford and there is no one I can talk to about this with. I'm so exhausted that I want to give. I just want to stop everything.
  4. Hey guys! I'm not sure who, or if anyone will even see this but I really want to share my freaking TRANSFORMATION with others who are going through something similar. I will include photos for reference. For the past 4-5 years I've had severe acne/blackheads/red marks and I missed out on a lot of life from hiding in my house. I went to several estheticians and dermatologists and it felt so hopeless to not see even the slightest results in my favor. I was helpless, it was endless. I have shed a lot of tears, I was constantly feeling shame. I tried EVERYTHING and as some of you know, it became quite expensive. Upwards of 6,000 in fact. Tretinoin, topical antibiotics, oral antibiotics, every vitamin, every natural resource possible, egg white masks, hormone balancers, freaking everything. I thought I must have had something wrong with me. It was a terrible feeling. My most recent facialist told me NO MORE OIL, so my first wave of success was just that: #1. NO OIL Oil free products aren't hard to find, and there are so many good ones! Unfortunately I still was not as clear as I wanted to be, but it was better. #2. NO SILICONE I happened to come across a youtube video about some girl's struggle with acne. She mentioned that silicone was the culprit. Now, silicone comes in MANY different names, but if the word ends in -CONE, run away. Dimethicone, trimethicone, etc. Run. RUN dude. Silicone is in EVERYTHING. Even powder. Ugh. Good luck finding ideal makeup. Thankfully some oil free & silicone makeup DOES exist. I'm currently using Juice Beauty Oil Free moisturizer and bare minerals makeup (but only the ones without silicone!!!!!) It is the enemy. The rest of the factors like water/healthy diet are obviously important too, but I just wanted to share that since I went silicone free, I have also become acne free. Within three weeks, my acne was gone. I am free. I pray for those who still have it, it's one of the hardest things that I've ever been through.
  5. I've struggled with acne since around age 12...I am now 19 and always thought I'd have it all cleared up by now but that is not the case and it's an on going battle that often feels like has no end. I started using foundations and concealers at 13 to cover the problems... I wouldnt even let my own family see me bare faced... In my own house. At age 15 I had enough and started looking into the impact of diet on acne and from that day forward I was drinking a gallon of water a day with amazing results (my face almost completely cleared) but anytime I indulge in any type of sugary, salty processed foods my face suffers greatly. My mood is entirely dependant upon how my face is doing that day and it is so completely exhausting. I haven't left my house without foundation on since I was 12..... That's 7 fucking years. My skin is so pale it holds on to ALL of the hyperpigmentation so even when my face isn't bumpy or textured it's covered in red spots from years upon years of acne, I usually get cystic acne sometimes white heads.... Currently the only thing helping me is organic jojoba oil on my face, gallon of water a day and never eating anything tasty but I still look in the mirror and see a face full of red spots so it's like nothing has changed or ever will and I feel so completely hopeless sometimes I just think it'd be easier to off myself and shed this mortal coil that has caused me so much pain. None of the friends I've had have struggled with acne so they wouldn't understand and I couldn't confide in them anyway because it's a problem I don't want to draw attention to.... Something I hope they'll overlook....thinking of someone other than my boyfriend seeing me without foundation is absolutely mortifying to me and I don't think I could bare it. I'm constantly checking mirrors to see if my makeup is still covering up all the skin on my face sometimes I wish I could just take a knife and slice all the skin off of my own face, this is not living it's merely existing and has made me a hermit and recluse essentially. This is the only place I felt o could vent where someone might understand. I've never had ANYONE to relate to about acne.
  6. Day 1-3

    Blogs A Spot of Bother...

    After a 'spot of bother' (pardon the pun, of course) obtaining my prescription via a very well known highstreet chain (it took 9 working days to get it!) I was hesitant to begin my tablets the day before a big social event. I held off until the Saturday morning and then (with a hearty full English in my belly) took the first 2 20mg pills with a big glass of water and my 'usual' dose of sertraline. Yes, as covered in my 'about me' I am on an anti-depressant, not a high dosage and basically as a result of work pressure/anxiety, low self esteem and a family bereavement over New Year, but I was ordered by my dermatologist (who for the record is LOVELY!) at my first appointment to remain on the drug until after I complete Roaccutane - she said, given the 'horror stories', which I was assured were in some cases exaggerated by the media, it would be better to continue with it than to take me off it ahead of starting. I would agree, better safe than sorry right? So in the run up to this point I also had the fasting blood tests done via my GP which came back with a slightly reduced kidney function but which everyone just put down to dehydration because of the very hot weather in July/August. They will check it on my next test to be sure it was a 'one off'. I also order pregnancy tests from 'Wish' which were cheaper than in the chemist and MUCH cheaper than the £56 they charge privately at the hospital *shocked face* and as expected(!) demonstrated a negative result after peeing on stick in the ladies loo and showing her in her office...surreal... I have the coil! Above - Skin on a REALLY GOOD day - hard to see on image but I as well as papules and pustiles around my jaw line and chin I have A LOT of comedones (blocked pores) all over my face which are the real 'problem' as they eventually become full blown spots and though I keep my face clean and try and unblock pores it is a losing battle... Anyway, so far - 3 days in and nothing major to report, a bit achey this evening and I think my skin is just starting to dry out - I have moisturiser and lip balm ready to go... COME AT ME ROACCUTANE - As a 33 year old woman not sure whether to use anti-acne or anti-aging products - I AM READY FOR YOU!!!
  7. In university during the first few months, I broke out TERRIBLY. And whatever I did, the breakouts wouldn't stop. I tried all kinds of treatments from switching my cleansing routine to using over the counter products, to even trying toothpaste or green tea teabags...all which seem now, in hindsight, to be grave errors because when the breakouts finally cleared up, I was left with atrophic/pitted scars and hyperpigmentation on my cheeks, from under my cheekbones to around just above my chin. My solution was makeup. I treat for my acne still during the day by using Clinique's Acne Solutions All Over Clearing gel under my makeup, and at night I try what I can with Vitamin C/Rosehip oil to heal my hyperpigmentation. But during the day, I learned how to do makeup well and quickly to cover my acne scars, and I soon entered into a relationship with my second boyfriend. Now I feel so much anxiety around him. I always feel like, if I didn't do my makeup well, I probably look disgusting or too powdery. I ALWAYS wear makeup around him and EVERYBODY, including my family. When I don't wear makeup in public, I wear one of those "fashion" germ masks to hide my cheeks. I'm even "in bed" with him, with makeup on. I get so much anxiety when he says that I'm pretty or when he tries to cup my face or anything fond and cute and things that I would LOVE if I didn't feel so fake or so ugly when I'm not fake. I honestly don't really know what to do. I KNOW someone might tell me that he won't mind and to confide in him, and the thing is I KNOW he'll be kind about it but for some reason, I feel so much anxiety about letting ANYONE see my real face now....like I feel sheer panic over that idea. Anyone go through a similar experience? Any advice? Thank you!
  8. Hello, I just kinda wanted to rant. Note: It's 7 am and I haven't slept yet, which is normal for me. But soon or later school will start and just thinking about me want to end it all (Yes, it's extreme). But hear me out. Years and years even when I was bullied for my skin I just kept studying. No matter how ugly I felt, how much I isolated myself because of acne or how bad my depression got I just studied. In hopes of clearing up in a few years and have a future (such a joke). Well I'm 19 now, about to start university (laws) in about 2 months. And every single day terrifies me. I have to make a choice sooner or later. Here is how it is laid out in my head: If I go ... 1.It's torturing myself like I have the past few years. The same routine: Crying while getting ready for school, pretending to be okay, feeling like people are staring at me. Getting home and cry when I remove my make up. Also; Granted with my depression right now I won't be able to concentrate on ANYTHING, right now I'm surviving by sleeping and distracting myself with the internet. One good thing is that studying distracts me, only this time my mental health has gotten so bad I'm actually sure it won't work this time. If I don't go... I'll be a failure for my parents. Hey, I already am but I mean this choice would really make me a failure to them. Other than that I'll just be able to 'live' like I'm doing right now. Hiding, sleeping, internetting and switching day and night like I'm doing right now. I mean, it works (even if it's lonely and painful).. But for a whole year? I don't even want a solution or think about it. I'm just ranting to no one in particular until I hopefully fall asleep. It is hopeless really. I don't even have 1% hope in the future, let alone the upcoming months. I'm just hoping this miserable 'life' miraculously ends somehow. But has anyone experienced the same thing, or is going through something similar? Again, I'm not trying to find a way out. I just want to share things on this platform It's so stupid that I even have to think about this, IT'S SO unfair! Everyone else has to deal with other problems but at least they're able to show up to places and LIVE without having all these mental problems and unsightful faces because of acne (for years!) And it sucks that this has restricted me so much and probably be the end of me, not even being dramatic. Anyways, I'll just stop here before I write more.Thanks for reading if you did.
  9. I’ve been dealing with severe cystic acne for 5 years. I’ve seen a number of dermatologists and holistic doctors. The only thing that helped was birth control but it caused me to gain a substantial amount of weight and had other psychological side effects that were bad enough for me to stop taking it. Doxycycline helped keep it more manageable and I stayed on it for a year. I weened myself off of it a few months ago in hopes of keeping my liver healthy and the acne came back with a vengeance. It mostly affects my cheeks, chin and now my forehead. The cysts are painful, the skin is red and inflamed and itchy. I am so depressed and I don’t know what to do. I don’t want to leave the house, go to work or see anyone. I’m afraid to use makeup or anything on my face at all. I’ve tried veganism, cuttting out all sugar, gluten and dairy. Nothing has helped. I’ve been having suicidal thoughts and I just want to feel normal. Please any advise would be helpful.
  10. I’m new here and honestly pretty messed up to begin with. So I don’t know how to start. Start anything for that matter. Anyway, hi, I’m depressed and suicidal since 16 years old and I’m 21 now. Seems short but hey, life has felt extremely and unnecessarily long over here for some reason. And it sucks. As if I can’t be any more pathetic, here I am trying not to cry again. I’ll just stash that away since there’s no real reason to cry over acne, right? I guess not. Besides my eyes sting like hell whenever I shed the slightest tear. Ah well. Basically, I’m fucked up. I hate talking about myself and I just want to die already but here goes I’ll make it brief and stupid: Personality before age 16 and before acne: Basically a funny, kind, helpful friend who would never hesitate to be in the spotlight just to have fun and make everyone laugh and feel at their happiest in life. Now, at age 15, sure I had started getting one pimple ocassionally but I had used Clearasil and it took care of it. My face had always been clear otherwise. I was... quite simply living the time of my life. And so, after having to move From Germany, depression hit badly because all my friends, family, do way of life disappeared. Unfortunately on top of that, I went to a new high school and honestly, it was terrible. Felt alone. Cold. Suddenly, and i didn’t understand why, I began breaking out on my cheeks, gradually, then my chin and forehead. That’s where the depression got worse. Not to mention getting bullied, made me feel suddenly unlovable and ... disgusting? Like a... monster. Fast forward to today. I had tried probiotics back when it was more severe. And one day I had looked in the mirror and seen that my entire left cheek was clear. But my mother stopped letting me take those because they’re bad for liver yadayada. Sigh. Ah well. it all came back. For about five years now the same acne has been stuck on my face. And..well.. my mother is now an aesthetician and gave me currently a good regimen for moderate acne. Stuff with certain acids that help acne. Been helping and healthy diet during college really helped me. Everything was clearing finally... almost. Then .... I thought it would be okay... it would end. The pain. The feelings...of suicide. death. But no... my twin is like clear now...... I’m not at all. I ask myself... that’s not fair, why? They always touch their damn face. They eat lots of sweets I eat only fruits and vegetables. They complain about being ugly and have no confidence. ...You..fool. Acne is the only shade of black that ever cast me a shadow. I’ve been...so patient. So healthy. So selfless. All i wish for... is for this cursed acne to get lost. It’s getting worse and I disconnect myself so much I’m so alone. I feel nothing....my real self is gone. TL;DR I never had severe cystic acne, but this moderate acne on top of nonstop dry skin and REDNESS... all over my disgusting face... it’s all killing me. I’m mentally unstable, wanting to kill myself just about every day. At the moment, I’m alone cooped up in my room, ruminating that I can’t live a normal life because ACNE? And yet... this monster called acne has officially transformed the wearer into a much more frightening nightmare. I hardly cry anymore. depression did that. But yesterday I broke down. I CAN’T....keep living with this shit. Paranoid...disgusting...hugely delusional. Paranoid of food. Of chemicals. Huge fear of breaking out more. I hate myself and will die with nothing left in my soul but self-disgust. Nothing left in my heart but dead blood. Fuck acne, no one deserves it.
  11. Hi everyone. I'm 24 yo female and have been struggling with my problematic skin since I was 16 which has led me to serious mental health problems. I'm taking antidepressants so I can manage my life somehow but problems with skin haven't gone away which make me question for what it all worth. My skin is oily especially in T zone, I have large pores on my forehead and both cheeks at the side of the nose. Pores are clogged. Texture is rough and I have those small bumps all over my face plus décolleté (pic) from which nothing seems to come out. Exfoliating doesn't help. I have tried everything including tons of products (literally everything recommended), healthy diet, oral contraceptives, different vitamins and herbs etc. There seem to be no way out. Currently I'm on the new pills "Valette" which don't do any job at all, though the doctor told me they're known as those which clear the skin. I feel like I'm alone with such a condition. People say "you don't have acne", yes I don't have red acne but that isn't the only problematic skin condition which a person could have. Always having my pores clogged, always being excessively shiny, it's disgusting. Is there any cure?
  12. Hey. I was recently diagnosed with acne conglobata, which I'm told is a severely inflammatory type of cystic acne. couldn't find much personal logs of this hellish thing and navigating healthcare has been challenging to say the least so I decided to talk about it online in the hope of connecting with people also familiar with it, (which is equally terrifying as it is liberating.) currently waiting to start roaccutane treatment -and learning how to access dermatology healthcare in the UK. Having a miserable time emotionally and physically, trying to stay hopeful, and aiming to document the process. Here is some acne chat for anyone who may find it useful
  13. Acne Psychological Impact

    Forums Personal logs 4 replies

    Hi Everyone. Could you share your struggle in facing acne, Ive been told SO UGLY by one of my colleague and that is just saddening..
  14. Hi fellow humans. I would just like to share my thoughts on Accutane and tell a little bit about my experience on it so hopefully I can help any others considering taking it! I've been off of accutane for a little over 3 years now. I pursued taking accutane because I was dealing with a moderate amount of cystic acne on my face at the time (mainly in cheek pockets and on my forehead). My main goal was to take it, deal with whatever side effects that came with it, and get rid of my acne for good! I will try to make this as short and sweet as possible. I started it when I was 21, my dermatologist started me at 20 mg and eventually he had increased my dosage to 120 mg over time because it wasn't working all that well. Around 3-4 months in I began to get a scalp condition known as sebheorric dermatitis, followed by anxiety. These 2 things, which I've never dealt with before, really started to hinder me on a day to day basis. As well as the usual side effects (dry irritated skin, chapped lips, peeling hands, etc). I was working construction at the time and it was extremely hard to deal with in the summer time on these pills. I still continued my dosage and figured everything was going to be better once I was clear! Around the 5 month period, my anxiety was at indescribable levels. I was crippled by it and I eventually got depressed. I was once a kid in general good spirits that could hold a conversation with anyone to eventually being in a place where I couldn't eat and my thoughts were so out of control it was a task just making it through the day. So around this time, a friend had given me Xanax to help with the anxiety (which I've always stayed away from) but it was really helping me eat and relax in the afternoon. I started to self medicate and it was providing me relief, so I figured screw it I'll hang in there and my skin should be completely clear soon so I'll be done with this stuff for good! Well, around the 6-7 month period I got completely sick of it. I was barely holding myself together for a while and figured it would be best to stop. So I stopped taking any pills, about 2 days later while I was home I entered a psychosis. I started to get my sense of smell and taste back and I could not calm down at all! I ended up doing and saying some outlandish things I would never have done if I was in control which in-term landed me in the hospital for a week. In the hospital they put me on a medication called seraquil to help with the psychosis which made things even worse. Lets just say it took long time to recover from this situation let alone just dealing with the mistakes I made while I was in a manic state. I didn't hurt anyone or commit any serious crimes, but I definitely bugged out. I was texting a girl I used to talk to crazy things, freaking out on my friends and my parents. It took a good year of 'just living' for me to process what happened and move on. Fast forward to now; I deal with some joint pain and mainly hair loss (which is 100% related to the sb and accutane). I try not to regret anything, but if I could have just simply not taken it, I would have avoided a whole lot of stress and disturbance to my health and well being. Knowing now that a lot of acne when you are young is related to hormones and diet I could have reversed it in a much more healthy manner. So please, if you are young and have acne, and even if you are desperate to clear it up, start with your diet before anything. There is tons of evidence out there how a plant-based diet and good gut health is related to clear skin. There is no magic pill to get rid of acne! I know there are success stories out there and everyone has a different experience with it, but I just wanted to give my 2 cents. Take my advice and hold on to your health. Accutane is poison! Good luck to you guys and hopefully you can clear up your skin without taking a drug that was originally used as a chemo-treatment! Peace & love.
  15. EDIT:*I've recently talked to others who's post accutane syndrome makes mine pale in comparison. For me, it was completely life changing, I thought about ending it, but I could still live. Before recovery, I could still live a life, if I lowered my expectations low enough, dropping out of Uni and accepting I would never have a sexual relationship, and that I would never be particularly happy or successful, while post recovery, I I think I can now achieve a good life, going to Uni and dating, etc. However, for others, it affects them a lot harsher than it did me, and so for promising a cure, I feel like a fraud. I'm going to leave it up, because I know it can still help SOME people regain control of their life, but for plenty of people, who accutane his much harder than myself, it may not bring much respite, and so I apologise for any whom I gave false hope Everything is in the google document, I've expanded it below. I think I am 90% cured, no longer get anxious or brainfog, sexually I'm about 50%, but an optimistic for continued improvement, and though things like joint health and injuries obviously didn't heal, but I have done a lot of PT and my body responds positively to it, though they aren't as good as pre-accutane. Anyway, I'm gonna leave this here and get on with my life. For brain fog, I strongly recommend meditation, I feel my focus is stronger then its ever been, though the supplements will help with that as well. I didn't recommend meditation that strongly below, because I hadn't started it yet and didn't realise how beneficial it was. And with that said, hope what I've written below helps you and au revoir! https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# Curing PRSD Hey, I am a 22 year old who suffered from Accutanes side effects since I was 16, and though for me while sexual dysfunction was the side effect that made me notice accutane had affected me, it was not the only side effect. The route to curing my own side effects was by using nutrition and supplements, to undo the damage accutane did to my brain. Personally I believe Accutane causes its negative side effects by changing brain metabolism and causing a degree of brain damage. The brain damage is not caused by outright irreparable cell death, because the main place where cell death occurs is in the hippocampus, where neurogenesis can occur anyway and most of the damage can be reversed. The problem is that accutane also inhibits neurogenesis, so for some people, they suffer this brain damage quite severely, while others get back on their feet pretty quickly and don’t even regret taking it. Now as a disclaimer, I only took accutane for 9 weeks at 2x40mg per day, which was enough to give me no feeling in my penis for 2 months, and several years of not being aroused and not being attracted to any person irl at all, though with porn I could masterbate, though I was very insecure if I would actually be able to perform under pressure, and avoided any situation where anything might happen. I developed social anxiety, I lost my passion for all my subjects, competitiveness for sport and academics, couldn’t concentrate or focus, and lost most hope and ambition for my future. I wasn’t completely antisocial, and still had a few friends, male and female, but only because my brain wouldn’t really care if it was female and if there was zero chance of being aroused, there was zero chance of being anxious as well Accutane What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." Anxiety, Depression and the Hippocampus After taking Accutane, I suffered depression and anxiety, and so far from normal that I went to a psychologist and explained my symptoms, and went there several times, and while I considered antidepressants, I never took them. On Accutane forums, many people are depressed, and so many have taken SSRIs, and many people feel much better having taken them. They still do not feel 100%, but while on them they regain a lot of feeling and emotion that they have missed, antidepressants obviously have their own side effects so it is not always worthwhile. There is much research showing there are natural ways to stimulate neurogenesis in the hippocampus, that does not risk the side effects of antidepressants Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. https://www.ncbi.nlm.nih.gov/pubmed/16425236 “The hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.” This study basically states the reason SSRIs work again depression is because they upregulate hippocampal neurogenesis Ventral hippocampal lesions affect anxiety but not spatial learning. https://www.ncbi.nlm.nih.gov/pubmed/12642189 Rats with cytotoxic ventral hippocampal lesions which removed approximately 50% of the hippocampus (including dentate gyrus) starting from the temporal pole, displayed a reduction in freezing behaviour following the delivery of an unsignalled footshock in an operant chamber. This was more plausibly a result of reduced susceptibility to fear than a result of a lesion-induced increase in general motor activity. There was no consistent difference between sham and lesioned animals in spontaneous locomotor activity, or locomotion following acute or chronic treatment with amphetamine. In contrast, ventral hippocampal lesioned animals were quicker to pass from the black to the white box during a modified version of the light/dark exploration test, and were quicker to begin eating during tests of hyponeophagia. Furthermore, rats with ventral hippocampal lesions defecated less than their sham counterparts both during open field testing and in extinction sessions following contextual conditioning. In contrast to these clear lesion effects, there were no signs of any spatial learning impairment either in the watermaze or on the elevated T-maze. Taken together these results suggest that the ventral hippocampus may play a role in a brain system (or systems) associated with fear and/or anxiety, and provide further evidence for a distinct specialisation of function along the septotemporal axis of the hippocampus. Anxiety and hippocampus volume in the rat. https://www.ncbi.nlm.nih.gov/pubmed/16192979 In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxiety-related behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. The studies above show that hippocampal volume, which is the most common measure of neurogenesis and neuroplasticity, are very accurate in determining whether someone suffers from depression and generalised anxiety disorder, and also the severity of the mental illness. Hippocampal volume is also an accurate predictor of how well someone will recover from a brain injury, or how well they will cope when faced with a stressful situation. The cure is focussed in restoring neuroplasticity and hippocampal growth (aka promoting neurogenesis, they are all basically the same thing), and while following the routine your brain should regain this ability to heal itself and over several months a close to full recovery should be within reach. As a bonus, the depression and anxiety also being suffered should be much reduced after following the protocol Effects of Hippocampal atrophy/ negative changes in brain metabolism Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/ “In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients’ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs—both the trauma-exposed and unexposed members—had significantly smaller hippocampi than non-PTSD pairs.” here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/ The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or maybe the worse his mental state before the injury happened, the worse his recovery will be, rather than simply being optimistic improves outcomes. In this we see that accutane, in mant ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane’s sides. That is because they can help treat some of accutanes sides in specific instances, because SSRIs can promote neuroplasticity, though it doesn’t cut through to the heart of the issue, and it means you can’t stop taking SSRIs. Now we established that hippocampal atrophy is the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally and safely, without the need to put your health under any further risks Stimulating hippocampal growth/neurogenesis/neuroplasticity First line of treatment is just some nutritional supplements Nutritional treatment for acute and chronic traumatic brain injury patients. https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related "omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a TBI" Dietary supplement creatine protects against traumatic brain injury. http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/ Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/ Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. https://www.ncbi.nlm.nih.gov/pubmed/14695924 COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group. Changing diet Long-term effects of a ketogenic diet in obese patients http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania" Lifestyle choices and activities Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/ Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least. Mindfulness-based stress reduction (MBSR) improves long-term mental fatigue after stroke or traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/22794665 “CONCLUSION: The results from the present study show that MBSR may be a promising non-pharmacological treatment for mental fatigue after a stroke or TBI.“ The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848393/ “Effect size estimates suggest that mindfulness-based therapy was moderately effective for improving anxiety (Hedges’ g = 0.63) and mood symptoms (Hedges’ g = 0.59) from pre to post-treatment in the overall sample. In patients with anxiety and mood disorders, this intervention was associated with effect sizes (Hedges’ g) of 0.97 and 0.95 for improving anxiety and mood symptoms, respectively. These effect sizes were robust, unrelated to publication year or number of treatment sessions, and were maintained over follow-up.” Larger hippocampal dimensions in meditation practitioners: differential effects in women and men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351565/ “Descriptively, left and right hippocampal volumes were larger, on average, in male meditators compared to male controls; they were also larger in female meditators compared to female controls (see Table Table1).1). The group-by-sex interaction was significant for the left hippocampus (p = 0.002) but not for the right hippocampus (p = 0.46). Conducting post hoc comparisons separately within males and females, left hippocampal volumes were significantly larger in male meditators than male controls (p = 0.02) as well as in female meditators than female controls (p = 0.046). Significant meditation effects with respect to right hippocampal volumes were not detectable in males (p = 0.722) or in females (p = 0.291).” Mindfulness meditation improves cognition: evidence of brief mental training. https://www.ncbi.nlm.nih.gov/pubmed/20363650 “ After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.” Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/ Abounding evidence has shown that HBOT promotes neurogenesis. Future investigations need to be extended to models of neurological diseases, including subarachnoid hemorrhage (SAH), cerebral hemorrhage, AD, PD, surgical brain injury (SBI) and autism for cell proliferation, survival and differentiation. Furthermore, studies need to be conducted to explore whether HBOT induced neurogenesis leads to a functional improvement followed by large scale, strictly controlled clinical trials to establish HBOT as a prevention and/or treatment modality for neurological diseases. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. https://www.ncbi.nlm.nih.gov/pubmed/21118604 Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/ Dietary supplement creatine protects against traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/11079535 Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. https://www.ncbi.nlm.nih.gov/pubmed/19741313 Fish oil 3g x2 per day. It has very strong neuroprotective effects, and has been shown to control epilepsy in children. In animals it has been show to increase testosterone and improve sperm count Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Effect of Long-Term Fish Oil Supplementation on Semen Quality and Serum Testosterone Concentrations in Male Dogs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948075/ Effect of dietary fish oil on mouse testosterone level and the distribution of eicosapentaenoic acid-containing phosphatidylcholine in testicular interstitium. https://www.ncbi.nlm.nih.gov/m/pubmed/28955915/ Zinc 30mg elemental/day Has been shown to have neuroprotective effects, improve male hormone profile, and improve liver health. If also taking iron supplements take at a different time of the day, because zinc can hinder iron absorption Zinc status and serum testosterone levels of healthy adults. https://www.ncbi.nlm.nih.gov/pubmed/8875519 Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout. https://www.ncbi.nlm.nih.gov/pubmed/21744023 Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/ Example treatment routine Creatine - increases Dihydrotestosterone (DHT) and testosterone, which is very important for PFS sufferers especially, while also increasing muscle power and improves neuroplasticity Fish Oil - improves joint pain, helps heart disease, reduces seizure incidence and promotes neurogenesis Zinc - increases levels of male hormones and improves neuroplasticity Magnesium - helps with chronic pain, fatigue and insomnia and neuroplasticity Vitamin D: Improves bone health, physical fitness, and improves neuroplasticity Meditation: Allows the body to better regulate stress, has been shown to increase happiness and reduce fatigue from social situations in stroke victims, and promotes neurogenesis. Yoga is also shown to help with mood and neuroplasticity, as well as physical health, so I recommend that if it is available to you CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity Multivitamin - makes me less likely to be malnourished. Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and improves neuroplasticity Ketogenic Diet: Improves body composition, can help ED, has been known to cure depression and anxiety, and improves neuroplasticity. I tried it for a Hyperbaric oxygen therapy: If this therapy is accessible to you I would also take advantage of it, though I haven’t done it. Many studies show it strongly promotes neuroplasticity Olive Oil: Improves hormones, displays neuroprotective effects, helps with constipation and antioxidents, improves wound healing and skin health, helps with depression and anxiety Edit: Olive oil studies Extra virgin olive oil improves learning and memory in SAMP8 mice. https://www.ncbi.nlm.nih.gov/pubmed/21955812 Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724295/ Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats. https://www.ncbi.nlm.nih.gov/pubmed/26168701 Extra-virgin olive oil preserves memory, protects brain against Alzheimer's https://www.sciencedaily.com/releases/2017/06/170621103123.htm It also helps joint pain https://www.ncbi.nlm.nih.gov/pubmed/25294776 Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. Depression and anxiety Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/ Constipation and antioxident profile The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.(only 4ml a day) https://www.ncbi.nlm.nih.gov/pubmed/25238699 Antioxidant activity of olive polyphenols in humans: a review. https://www.ncbi.nlm.nih.gov/pubmed/20209466 Alternative treatment routines Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. https://www.ncbi.nlm.nih.gov/pubmed/18173322 “High-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.” Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. https://www.ncbi.nlm.nih.gov/pubmed/21940440 “Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.” Nootropic agents stimulate neurogenesis. https://www.ncbi.nlm.nih.gov/pubmed/19441945 Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/ Acupuncture stimulation induces neurogenesis in adult brain. https://www.ncbi.nlm.nih.gov/pubmed/24215918 Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/ "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17]. Conclusion Remember, there will be scars remaining from your specific syndrome, but this may help with brain fog, erectile dysfunction, depression, anxiety, injury-susceptiblility, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone! EDIT:*I've recently talked to others who's post accutane syndrome makes mine pale in comparison. For me, it was completely life changing, I thought about ending it, but I could still live. Before recovery, I could still live a life, if I lowered my expectations low enough, dropping out of Uni and accepting I would never have a sexual relationship, and that I would never be particularly happy or successful, while post recovery, I I think I can now achieve a good life, going to Uni and dating, etc. However, for others, it affects them a lot harsher than it did me, life is not liveable in any sense, and so for promising a cure, I feel like a fraud. I'm going to leave it up, because I know it can still help SOME people regain control of their life, but for plenty of people, who accutane his much harder than myself, it may not bring much respite, and so I apologise for any whom I gave false hope, though I still encourage everyone to give it a go
  16. Hi I'm a 19 year old girl and have just completed my first year in college. My struggle with acne started when I was in 7th grade but it started to get severe as years passed by. It spread to my back and it is still full of acne marks. It is so bad that you can hardly see any skin.in school I would mostly be this girl with low self confidence and I pretty much turned into an introvert. I would talk less and would always worry that the other person would notice my acne more than my words. So many times I was called names like spotted dear. It's hard to focus on the good things in life when people keep reminding you about your weaknesses. When in school I thought that by the time I would reach college my skin would be clear. I went to so many doctors but every time it turned out to be a waste of my parents' money and time. So many times I felt like killing myself and just end this once and for all but I won't ofc. I'm just tired of people asking me if it's chicken pox on my face. I'm tired of wearing full sleeves even in the hot summer. All I want is a normal life like my friends. You know like start dating but I can't.Acne has cost me a lot of precious years and what not. I'm just tired and this is the first time I have opened up about it. Please tell me how I can I can help myself.
  17. Hi, Recently my skin has been a mess, and I have no idea whats causing it. Ive always had good skin, with a few big pimples here and there, but who doesn't honestly. I have narrowed it down to 3 possible factors, which are stress (broke up with bf during finals season), which resulted in some closed comedones or bumpy texture. To combat this my doctor prescribed adepolene gel .1% (possible factor 2). I have also switched from prozac to zoloft (sertraline) and i have heard this drug can cause acne especially in young women (possible factor 3). Basically, I was wondering if anyone else has experienced acne from zoloft, because the closed comedones I thought were from stress happened about 2 or 3 weeks after I started taking it, and thats around the time side effects begin to show up. Thoughts?
  18. I end every day thinking, well hey now, at least it can't get worse than today. It's all up from here, man. And every new day I am proved wrong. Fourth May '18, New levels of low. Gigantic, inflamed, infected cysts showing zero signs of healing after months.They are just kind of there and persistently painful/unsightly/anxiety-fuelling. Sleeping hurts, smiling hurts, talking hurts, eating hurts. Every day in work customers ask me what's wrong with my face, what's on my face, (or my personal fave), what have you done to your face. Self worth non existent, anxiety levels perpetually through the roof. My skin is doing weird and gross things and I don't know how best to help it heal. My last appointment with a doctor was a major let down. I am working towards being able to pay (a lot) for a private dermatologist. I miss who I was. I don't remember the last morning I woke up when my face didn't THROB. I don't go out unless I have to. I'm trying v hard to be more hopeful.
  19. 24/M First a bit about my acne before my rant. I had cystic acne all of high school which really killed my self esteem and social skills. I was put on antibiotics which cleared things up 100% for about 3 years. 4 months ago after my breakup I started to breakout. I was put on antibiotics yet it seems I've built up immunity to them. My derm put me on accutane. 3 weeks in I had a pretty bad IB, my whole right side of face broke out in cysts. Recently it has cleared up, but some new spots are forming on my other cheek. Side effects include dry lips, dry face, fatigue, joint pain, muscle soreness and maybe depression. Now comes the part where I discuss why I might be depressed. So I went through a really tough breakup about 4 months ago with my ex-girlfriend. She was the love of my life (and still sort of is), yet she couldn't do the distance anymore. She and I were heavy gamers (Which is where we met), and she streams on twitch.tv and is quite big on there. Ever since the breakup I haven't been gaming at all because everything reminds me of her, and I have no friends anymore because she and I met all the friends either from gaming or her twitch channel. Obviously they prefer her over me cause shes gorgeous. I feel like I'm constantly in a competition with her because I know she goes out every week and probably gets hit on my numerous guys. And it's really difficult to deal with because I have no friends to go out with to forget her. Before taking accutane I was feeling optimistic about life and my future for the first time after my breakup. A month in to taking accutane at 40 mg a day, I just feel worthless and I feel like I wont make any friends or find another love. I'm fairly attractive I guess but the accutane is making me so anti social because of how tired it is making me so it's hard to be interesting to others in order to try and make some friends or find another girl. Should I keep taking accutane? I really don't want my acne to return but it feels like I've tried every other treatment. Sorry for the long post.
  20. Acne has ruined my life

    Forums Adult acne 19 replies

    Ok. My story so far. I used to have normal skin. Not perfect but so bad i wont look in the mirror. About 8 months ago everything change. Right now is the worst my skin has ever been since I was 17 years old and in high school. Acne is ruining my life. I go to med school, so i have to study, theres no option, but i’m so depressed. All i can think is how horrible look, i dont wanna go back to uni, I dont wanna get out of the house, been to several derms, none has help. A doctor diagnosed me with pcos. I also have facial hair. I feel i look like a man. I feel so disgusting. Lately all I can think about is the fatest easiest way to kill myself. I see no end to this. I’m sick of it. I dont go out anymore, no one’s gonna love looking like this. I wish i could just dissapear. I wish i didnt have to wake up in the morning. I want to die. I cant go on living like this anymore. I ask god everynight why this happened to me and why cant he just kill me in my sleep. I know a lot of people have it worse, but this is important to me. I want to die, please god just let me die
  21. I don't know how many of you heard about the acne no more program(mike Walden). Is it a scam ? Please I want honest reviews about it.
  22. Hi, I have suffered from moderate to severe acne since I was about 16 and am now 21. I have taken doxycycline pills, benzoyl peroxide cream (which I still use on occasion- I am unsure whether it actually helps or is irritating and drying out my skin too much) and now take anti-androgens. I have taken antidepressants for about a year until recently as well. Since January, I have pretty much eliminated dairy products from my diet as I've heard multiple times that it is good for acne. My skin has improved slightly but that may also be due to changing medications and using Lush's Ultrabland cleanser. I have also read that, forgive me if I'm not using the correct term, 'carbohydrates with a high glycaemic index' such as bread, cakes and rice often contribute to acne. I am trying to reduce these in my diet but am finding I now feel very hungry and irritable a lot of the time. I've always followed a pescatarian diet and I don't ever want to eat meat that isn't fish. So what is there left to eat? Fruit, vegetables, eggs, fish, nuts, vegan meat and dairy substitutes? I eat all these things but I think that because of my tall, slim body type I have always been the kind to get very hungry easily and my body is used to me eating a lot of bread and pasta. I don't have a lot of money to buy lots of fancy non-wheat vegan food. Any suggestions of what I can do and is it even worth restricting my diet so much in order to reduce acne?
  23. Hello all who is out there reading this, I’m James, a 23 year old male & I have been suffering from acne since age 11. I’m not quite sure on the exact cause so I’ve come here to hopefully seek some wisdom from maybe those who’ve been in my shoes. Get ready for a bumpy (face of a) ride. Here’s my journey. A brief background on my acne. I’ve tried pretty much all over the counter products. Cleansers Moisturizers Topicals: BP, Salicylic Acid, Clindamycin, Essential Oils Minocycline, Doxycycline, & eventually 6 months of Acutane. All have done there fair share of either helping slightly or damaging my skin. I would say my acne has always been pretty moderate. Anyth region above my eyes has always been crystal clear but my cheeks, chin, & forehead never have been clear. My current regimen includes: VITAMINS & MINERALS & ANTIOXIDANTS: Vitamin A, Vitamin C, Vitamin D, Vitamin E, B-Complex, Fish Oil, Evening Primrose Oil, Zinc, Alpha Lipoic Acid, Magnesium, Beta Sitosterol (active compound in Saw Palmetto), Probiotics, & Fiber capsules. AM: Wash with a gentle gentle cleanser in the morning, use Thayers Witch Hazel (rose water) as a toner with a few drops of Salicylic Acid Moisturize is Aloe Vera gel. Before I head out the door I spray my face with Green Tea water mixed with Thayers. PM: Recently switched to a 3% Sulfur cleanser to help my dead skin cell slow turnover rate. Thayers again as a toner. Also recently switched to Azelaic Acid (20%) as my topical. Lastly I use a Retin-A . I found that Azelaic Acid & Tretinion compliment eachother. MY DIET: This last month I did a full month long colon, liver, & full body detox cleanse to insure my acne wasn’t purely internally based. I am a very health conscience person and happen to be allergic to dairy & gluten so those two factors are already out the window. I stay far from excess sugary foods & hydrogenated oils. Other than that I eat a high fiber/omega-3/omega-6/ diet. Lots of beans, lentils, veggies, avocados, fruit, rolled oats, pumpkin, flax & chia seeds, almonds & cashews. No alcohol. I drink about 3-4 cups of Green Tea a day as well as 1-2 Spearmint or Chamomile teas at night before bed. I also drink plenty of water (at least 100 fluid ounces per day). I believe I may have Hyperkeratinoisis which is a buildup of protein on the skin that clogs pores with dead skill cells. Add my excess sebum (oil) and it’s a mixture from hell. I do get stressed out but not any more than the average person. I’m a fairly calm & level headed human. Depression has taken its toll on me over the last few years after I’ve seen a dermatologist for about 2.5 years which did nothing. I actually obtain more clear skin by researching for myself and trying more holistic approaches. The best thing a dermatologist offered me was Tretinion which I still use to this day. SIDE NOTE: My acne or at least sebum production goes into overdrive after masturbation. I’ve tested the theory and I have broken out bad masturbating consistent days. Also I’ve held off work about two weeks and yes my skin got better but never fully cleared me up. The most frustrating part of this whole journey to clear skin is the teasing of new practices I implement. I try something new & it works, starts to clear me up then out of no where either backfires or stops working. Some examples of these are... Green Tea. Lost its effectiveness so I bumped up to Matcha green tea which was strong and worked again but slowly diminished strength. Pure Tea Tree Oil (huge clogger of pores). My skin was beautifully clear after dabbing pure Tea Tree Oil on my face daily unless it clogged my pores horrifically. Took 3-4 months to unclog them. Alpha Lipoic Acid. Lost its effectiveness. High Fish Oil intake. Stopped its high effectiveness & to thin out my sebum BP. Always overdried me & made my breakouts worse. It’s like my body becomes immune to all of these wonderful options and just wants to make my facial inflammation worse. There’s a few questions that I am eager to have answered. Such as products I’ve been curious to try but have not yet. So without further ado I’ll fire away. Borage Oil over EPO (evening primrose oil)? Does the higher GLA content really make a huge difference Can eating eggs & almonds truly cause more acne? Topical Spironolactone? Anyone have positive experiences with Azelaic Acid? Anyone have positive experiences switching to Sulfur cleansers? If I’ve tried Beta Sitosterol & it didn’t work should I still bother with Saw Palmetto? Sodium Sulfacetamide & Sulfur Topicals/Lotion effectiveness ? Should I try these Best products for Hyperkeratinosis acne? Best acne bacteria fighting/non-drying/non-comedogenic day time moisturizers? Does it does as if I have hormonal acne? Any advice Alpha Hydroxy Acid products? Very curious to try them out if Azelaic doesn’t pan out well. Thank you so much if you got this far. I hope that some of this info can shed new light to those out there struggling because I know some of these products work well for many acne sufferers. I haven’t found my answer yet but I’m still striving to do so. Keep fighting everyone :)!
  24. NEEM can TOTALLY Destroy BEDBUGS! The blood-sucking BEDBUGS are spreading fast all over the world in places of human habitations. They have become a great nuisance, as It is very difficult to eradicate them with the commonly used method of spraying insecticides. Their bites can cause severe itching, sleeplessness, irritability, depression, anemia and other related problems. Even by using different types of insecticides regularly, I had failed again and again to remove all the BEDBUGS from my room. In desperation, I started using NEEM soap and NEEM detergents to wash my bedsheets, pillow covers, blankets, mosquito net, and also to wash my clothes like the shirts, pants, underwears, banians, nightdresses, caps, socks, handkerchiefs, towels, napkins, etc. Only after I did that, the BEDBUGS DISAPPEARED totally within a few days! I was astonished to find such an easy solution in such a short period. So, it is NOT surprising why the Hindus worship the NEEM TREE as a GODDESS! We can use NEEM SPRAYS to kill and repel bedbugs, mosquitoes, mites, lice, fleas, ticks, cockroaches, ants, flies, etc. Washing our clothes with NEEM soap and NEEM detergents repels these insects. Even if we choose to wash our clothes with other soaps and detergents, we can just dip the clothes in NEEM WATER for some time, then squeeze them and hang them for drying. BATHING with NEEM soap and using NEEM creams and NEEM lotions too can help our bodies to repel bedbugs, mosquitoes, mites and lice, and to prevent diseases like ANEMIA, MALARIA, DENGUE, CHIKUNGUNYA, SCABIES, etc. Let us launch a worldwide campaign against bedbugs, mosquitoes, mites, lice and other insect pests by sending many messages like this one to all our contacts.
  25. Just thought everyone should know that Accutane is scientifically proven to cause brain damage, and it is probably the cause of many of the long lasting side effects that people experience. Obviously many come out the other side with little significant long lasting side effects, others do. This is because everyones brain is different, which is why after a concussion some are fine a few days later, while some are never the same, and have mental illness for the rest of their lives. In the end its a roll of the dice, and if you are going to roll, I suggest you at least know the risks first. With no further ado, here is the evidence. Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." These are the potential side effects of brain damage. If you read up on past users, often they display a number of these symptoms Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” If you've taken it already and are displaying negative side effects, I recommend you take a read of this: https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# It's like a brain rehab protocol I've devised and had success with. Its pretty cheap, and much safer then the drugs and diets others have resorted to in the attempt to reclaim control of their lives. It will take a few months to take effect, but its cheap and if you are impatient, you can easily take it alongside other protocols you are trying