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  1. Acne Psychological Impact

    Forums Personal logs

    Hi Everyone. Could you share your struggle in facing acne, Ive been told SO UGLY by one of my colleague and that is just saddening..
  2. Hi fellow humans. I would just like to share my thoughts on Accutane and tell a little bit about my experience on it so hopefully I can help any others considering taking it! I've been off of accutane for a little over 3 years now. I pursued taking accutane because I was dealing with a moderate amount of cystic acne on my face at the time (mainly in cheek pockets and on my forehead). My main goal was to take it, deal with whatever side effects that came with it, and get rid of my acne for good! I will try to make this as short and sweet as possible. I started it when I was 21, my dermatologist started me at 20 mg and eventually he had increased my dosage to 120 mg over time because it wasn't working all that well. Around 3-4 months in I began to get a scalp condition known as sebheorric dermatitis, followed by anxiety. These 2 things, which I've never dealt with before, really started to hinder me on a day to day basis. As well as the usual side effects (dry irritated skin, chapped lips, peeling hands, etc). I was working construction at the time and it was extremely hard to deal with in the summer time on these pills. I still continued my dosage and figured everything was going to be better once I was clear! Around the 5 month period, my anxiety was at indescribable levels. I was crippled by it and I eventually got depressed. I was once a kid in general good spirits that could hold a conversation with anyone to eventually being in a place where I couldn't eat and my thoughts were so out of control it was a task just making it through the day. So around this time, a friend had given me Xanax to help with the anxiety (which I've always stayed away from) but it was really helping me eat and relax in the afternoon. I started to self medicate and it was providing me relief, so I figured screw it I'll hang in there and my skin should be completely clear soon so I'll be done with this stuff for good! Well, around the 6-7 month period I got completely sick of it. I was barely holding myself together for a while and figured it would be best to stop. So I stopped taking any pills, about 2 days later while I was home I entered a psychosis. I started to get my sense of smell and taste back and I could not calm down at all! I ended up doing and saying some outlandish things I would never have done if I was in control which in-term landed me in the hospital for a week. In the hospital they put me on a medication called seraquil to help with the psychosis which made things even worse. Lets just say it took long time to recover from this situation let alone just dealing with the mistakes I made while I was in a manic state. I didn't hurt anyone or commit any serious crimes, but I definitely bugged out. I was texting a girl I used to talk to crazy things, freaking out on my friends and my parents. It took a good year of 'just living' for me to process what happened and move on. Fast forward to now; I deal with some joint pain and mainly hair loss (which is 100% related to the sb and accutane). I try not to regret anything, but if I could have just simply not taken it, I would have avoided a whole lot of stress and disturbance to my health and well being. Knowing now that a lot of acne when you are young is related to hormones and diet I could have reversed it in a much more healthy manner. So please, if you are young and have acne, and even if you are desperate to clear it up, start with your diet before anything. There is tons of evidence out there how a plant-based diet and good gut health is related to clear skin. There is no magic pill to get rid of acne! I know there are success stories out there and everyone has a different experience with it, but I just wanted to give my 2 cents. Take my advice and hold on to your health. Accutane is poison! Good luck to you guys and hopefully you can clear up your skin without taking a drug that was originally used as a chemo-treatment! Peace & love.
  3. Everything is in the google document, I've expanded it below. I think I am 100% cured, no longer get anxious or brainfog, sexually I feel the best I ever have, though things like joint health and injuries obviously didn't magically heal, but I have done a lot of PT and my body responds positively to it, though they aren't as good as pre-accutane. Anyway, I'm gonna leave this here and get on with my life. A selfish part of me wants to delete this account and never come back, because there aren't many positive memories here, but I will probably check every month or two but most questions are answered in this post. For brain fog, I strongly recommend meditation, I feel my focus is stronger then its ever been, though the supplements will help with that as well. I didn't recommend meditation that strongly below, because I hadn't started it yet and didn't realise how beneficial it was. And with that said, hope what I've written below helps you and au revoir! https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# Curing PRSD Hey, I am a 22 year old who suffered from Accutanes side effects since I was 16, and I think I am cured, though for me while sexual dysfunction was the side effect that made me notice accutane had affected me, it was not the only side effect. The route to curing my own side effects was by using nutrition and supplements, to undo the damage accutane did to my brain. Personally I believe Accutane causes its negative side effects by changing brain metabolism and causing a degree of brain damage. The brain damage is not caused by outright irreparable cell death, because the main place where cell death occurs is in the hippocampus, where neurogenesis can occur anyway and most of the damage can be reversed. The problem is that accutane also inhibits neurogenesis, so for some people, they suffer this brain damage quite severely, while others get back on their feet pretty quickly and don’t even regret taking it. Now as a disclaimer, I only took accutane for 9 weeks at 2x40mg per day, which was enough to give me no feeling in my penis for 2 months, and several years of not being aroused and not being attracted to any person irl at all, though with porn I could masterbate, though I was very insecure if I would actually be able to perform under pressure, and avoided any situation where anything might happen. I developed social anxiety, I lost my passion for all my subjects, competitiveness for sport and academics, couldn’t concentrate or focus, and lost most hope and ambition for my future. I wasn’t completely antisocial, and still had a few friends, male and female, but only because my brain wouldn’t really care if it was female and if there was zero chance of being aroused, there was zero chance of being anxious as well Accutane What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." Anxiety, Depression and the Hippocampus After taking Accutane, I suffered depression and anxiety, and so far from normal that I went to a psychologist and explained my symptoms, and went there several times, and while I considered antidepressants, I never took them. On Accutane forums, many people are depressed, and so many have taken SSRIs, and many people feel much better having taken them. They still do not feel 100%, but while on them they regain a lot of feeling and emotion that they have missed, antidepressants obviously have their own side effects so it is not always worthwhile. There is much research showing there are natural ways to stimulate neurogenesis in the hippocampus, that does not risk the side effects of antidepressants Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. https://www.ncbi.nlm.nih.gov/pubmed/16425236 “The hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.” This study basically states the reason SSRIs work again depression is because they upregulate hippocampal neurogenesis Ventral hippocampal lesions affect anxiety but not spatial learning. https://www.ncbi.nlm.nih.gov/pubmed/12642189 Rats with cytotoxic ventral hippocampal lesions which removed approximately 50% of the hippocampus (including dentate gyrus) starting from the temporal pole, displayed a reduction in freezing behaviour following the delivery of an unsignalled footshock in an operant chamber. This was more plausibly a result of reduced susceptibility to fear than a result of a lesion-induced increase in general motor activity. There was no consistent difference between sham and lesioned animals in spontaneous locomotor activity, or locomotion following acute or chronic treatment with amphetamine. In contrast, ventral hippocampal lesioned animals were quicker to pass from the black to the white box during a modified version of the light/dark exploration test, and were quicker to begin eating during tests of hyponeophagia. Furthermore, rats with ventral hippocampal lesions defecated less than their sham counterparts both during open field testing and in extinction sessions following contextual conditioning. In contrast to these clear lesion effects, there were no signs of any spatial learning impairment either in the watermaze or on the elevated T-maze. Taken together these results suggest that the ventral hippocampus may play a role in a brain system (or systems) associated with fear and/or anxiety, and provide further evidence for a distinct specialisation of function along the septotemporal axis of the hippocampus. Anxiety and hippocampus volume in the rat. https://www.ncbi.nlm.nih.gov/pubmed/16192979 In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxiety-related behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. The studies above show that hippocampal volume, which is the most common measure of neurogenesis and neuroplasticity, are very accurate in determining whether someone suffers from depression and generalised anxiety disorder, and also the severity of the mental illness. Hippocampal volume is also an accurate predictor of how well someone will recover from a brain injury, or how well they will cope when faced with a stressful situation. The cure is focussed in restoring neuroplasticity and hippocampal growth (aka promoting neurogenesis, they are all basically the same thing), and while following the routine your brain should regain this ability to heal itself and over several months a close to full recovery should be within reach. As a bonus, the depression and anxiety also being suffered should be much reduced after following the protocol Effects of Hippocampal atrophy/ negative changes in brain metabolism Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/ “In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients’ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs—both the trauma-exposed and unexposed members—had significantly smaller hippocampi than non-PTSD pairs.” here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/ The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or maybe the worse his mental state before the injury happened, the worse his recovery will be, rather than simply being optimistic improves outcomes. In this we see that accutane, in mant ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane’s sides. That is because they can help treat some of accutanes sides in specific instances, because SSRIs can promote neuroplasticity, though it doesn’t cut through to the heart of the issue, and it means you can’t stop taking SSRIs. Now we established that hippocampal atrophy is the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally and safely, without the need to put your health under any further risks Stimulating hippocampal growth/neurogenesis/neuroplasticity First line of treatment is just some nutritional supplements Nutritional treatment for acute and chronic traumatic brain injury patients. https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related "omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a TBI" Dietary supplement creatine protects against traumatic brain injury. http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/ Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/ Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. https://www.ncbi.nlm.nih.gov/pubmed/14695924 COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group. Changing diet Long-term effects of a ketogenic diet in obese patients http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania" Lifestyle choices and activities Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/ Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least. Mindfulness-based stress reduction (MBSR) improves long-term mental fatigue after stroke or traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/22794665 “CONCLUSION: The results from the present study show that MBSR may be a promising non-pharmacological treatment for mental fatigue after a stroke or TBI.“ The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848393/ “Effect size estimates suggest that mindfulness-based therapy was moderately effective for improving anxiety (Hedges’ g = 0.63) and mood symptoms (Hedges’ g = 0.59) from pre to post-treatment in the overall sample. In patients with anxiety and mood disorders, this intervention was associated with effect sizes (Hedges’ g) of 0.97 and 0.95 for improving anxiety and mood symptoms, respectively. These effect sizes were robust, unrelated to publication year or number of treatment sessions, and were maintained over follow-up.” Larger hippocampal dimensions in meditation practitioners: differential effects in women and men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351565/ “Descriptively, left and right hippocampal volumes were larger, on average, in male meditators compared to male controls; they were also larger in female meditators compared to female controls (see Table Table1).1). The group-by-sex interaction was significant for the left hippocampus (p = 0.002) but not for the right hippocampus (p = 0.46). Conducting post hoc comparisons separately within males and females, left hippocampal volumes were significantly larger in male meditators than male controls (p = 0.02) as well as in female meditators than female controls (p = 0.046). Significant meditation effects with respect to right hippocampal volumes were not detectable in males (p = 0.722) or in females (p = 0.291).” Mindfulness meditation improves cognition: evidence of brief mental training. https://www.ncbi.nlm.nih.gov/pubmed/20363650 “ After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.” Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/ Abounding evidence has shown that HBOT promotes neurogenesis. Future investigations need to be extended to models of neurological diseases, including subarachnoid hemorrhage (SAH), cerebral hemorrhage, AD, PD, surgical brain injury (SBI) and autism for cell proliferation, survival and differentiation. Furthermore, studies need to be conducted to explore whether HBOT induced neurogenesis leads to a functional improvement followed by large scale, strictly controlled clinical trials to establish HBOT as a prevention and/or treatment modality for neurological diseases. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. https://www.ncbi.nlm.nih.gov/pubmed/21118604 Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/ Dietary supplement creatine protects against traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/11079535 Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. https://www.ncbi.nlm.nih.gov/pubmed/19741313 Fish oil 3g x2 per day. It has very strong neuroprotective effects, and has been shown to control epilepsy in children. In animals it has been show to increase testosterone and improve sperm count Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Effect of Long-Term Fish Oil Supplementation on Semen Quality and Serum Testosterone Concentrations in Male Dogs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948075/ Effect of dietary fish oil on mouse testosterone level and the distribution of eicosapentaenoic acid-containing phosphatidylcholine in testicular interstitium. https://www.ncbi.nlm.nih.gov/m/pubmed/28955915/ Zinc 30mg elemental/day Has been shown to have neuroprotective effects, improve male hormone profile, and improve liver health. If also taking iron supplements take at a different time of the day, because zinc can hinder iron absorption Zinc status and serum testosterone levels of healthy adults. https://www.ncbi.nlm.nih.gov/pubmed/8875519 Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout. https://www.ncbi.nlm.nih.gov/pubmed/21744023 Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/ Example treatment routine Creatine - increases Dihydrotestosterone (DHT) and testosterone, which is very important for PFS sufferers especially, while also increasing muscle power and improves neuroplasticity Fish Oil - improves joint pain, helps heart disease, reduces seizure incidence and promotes neurogenesis Zinc - increases levels of male hormones and improves neuroplasticity Magnesium - helps with chronic pain, fatigue and insomnia and neuroplasticity Vitamin D: Improves bone health, physical fitness, and improves neuroplasticity Meditation: Allows the body to better regulate stress, has been shown to increase happiness and reduce fatigue from social situations in stroke victims, and promotes neurogenesis. Yoga is also shown to help with mood and neuroplasticity, as well as physical health, so I recommend that if it is available to you CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity Multivitamin - makes me less likely to be malnourished. Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and improves neuroplasticity Ketogenic Diet: Improves body composition, can help ED, has been known to cure depression and anxiety, and improves neuroplasticity. I tried it for a Hyperbaric oxygen therapy: If this therapy is accessible to you I would also take advantage of it, though I haven’t done it. Many studies show it strongly promotes neuroplasticity Olive Oil: Improves hormones, displays neuroprotective effects, helps with constipation and antioxidents, improves wound healing and skin health, helps with depression and anxiety Edit: Olive oil studies Extra virgin olive oil improves learning and memory in SAMP8 mice. https://www.ncbi.nlm.nih.gov/pubmed/21955812 Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724295/ Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats. https://www.ncbi.nlm.nih.gov/pubmed/26168701 Extra-virgin olive oil preserves memory, protects brain against Alzheimer's https://www.sciencedaily.com/releases/2017/06/170621103123.htm It also helps joint pain https://www.ncbi.nlm.nih.gov/pubmed/25294776 Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. Depression and anxiety Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/ Constipation and antioxident profile The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.(only 4ml a day) https://www.ncbi.nlm.nih.gov/pubmed/25238699 Antioxidant activity of olive polyphenols in humans: a review. https://www.ncbi.nlm.nih.gov/pubmed/20209466 Alternative treatment routines Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. https://www.ncbi.nlm.nih.gov/pubmed/18173322 “High-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.” Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. https://www.ncbi.nlm.nih.gov/pubmed/21940440 “Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.” Nootropic agents stimulate neurogenesis. https://www.ncbi.nlm.nih.gov/pubmed/19441945 Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/ Acupuncture stimulation induces neurogenesis in adult brain. https://www.ncbi.nlm.nih.gov/pubmed/24215918 Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/ "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17]. Conclusion Remember, there will be scars remaining from your specific syndrome, but after this cure you will no longer be trying to cure the whole brain fog, erectile dysfunction, depression, anxiety, injury-susceptiblility, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone!
  4. Hi I'm a 19 year old girl and have just completed my first year in college. My struggle with acne started when I was in 7th grade but it started to get severe as years passed by. It spread to my back and it is still full of acne marks. It is so bad that you can hardly see any skin.in school I would mostly be this girl with low self confidence and I pretty much turned into an introvert. I would talk less and would always worry that the other person would notice my acne more than my words. So many times I was called names like spotted dear. It's hard to focus on the good things in life when people keep reminding you about your weaknesses. When in school I thought that by the time I would reach college my skin would be clear. I went to so many doctors but every time it turned out to be a waste of my parents' money and time. So many times I felt like killing myself and just end this once and for all but I won't ofc. I'm just tired of people asking me if it's chicken pox on my face. I'm tired of wearing full sleeves even in the hot summer. All I want is a normal life like my friends. You know like start dating but I can't.Acne has cost me a lot of precious years and what not. I'm just tired and this is the first time I have opened up about it. Please tell me how I can I can help myself.
  5. Hi, Recently my skin has been a mess, and I have no idea whats causing it. Ive always had good skin, with a few big pimples here and there, but who doesn't honestly. I have narrowed it down to 3 possible factors, which are stress (broke up with bf during finals season), which resulted in some closed comedones or bumpy texture. To combat this my doctor prescribed adepolene gel .1% (possible factor 2). I have also switched from prozac to zoloft (sertraline) and i have heard this drug can cause acne especially in young women (possible factor 3). Basically, I was wondering if anyone else has experienced acne from zoloft, because the closed comedones I thought were from stress happened about 2 or 3 weeks after I started taking it, and thats around the time side effects begin to show up. Thoughts?
  6. I end every day thinking, well hey now, at least it can't get worse than today. It's all up from here, man. And every new day I am proved wrong. Fourth May '18, New levels of low. Gigantic, inflamed, infected cysts showing zero signs of healing after months.They are just kind of there and persistently painful/unsightly/anxiety-fuelling. Sleeping hurts, smiling hurts, talking hurts, eating hurts. Every day in work customers ask me what's wrong with my face, what's on my face, (or my personal fave), what have you done to your face. Self worth non existent, anxiety levels perpetually through the roof. My skin is doing weird and gross things and I don't know how best to help it heal. My last appointment with a doctor was a major let down. I am working towards being able to pay (a lot) for a private dermatologist. I miss who I was. I don't remember the last morning I woke up when my face didn't THROB. I don't go out unless I have to. I'm trying v hard to be more hopeful.
  7. 24/M First a bit about my acne before my rant. I had cystic acne all of high school which really killed my self esteem and social skills. I was put on antibiotics which cleared things up 100% for about 3 years. 4 months ago after my breakup I started to breakout. I was put on antibiotics yet it seems I've built up immunity to them. My derm put me on accutane. 3 weeks in I had a pretty bad IB, my whole right side of face broke out in cysts. Recently it has cleared up, but some new spots are forming on my other cheek. Side effects include dry lips, dry face, fatigue, joint pain, muscle soreness and maybe depression. Now comes the part where I discuss why I might be depressed. So I went through a really tough breakup about 4 months ago with my ex-girlfriend. She was the love of my life (and still sort of is), yet she couldn't do the distance anymore. She and I were heavy gamers (Which is where we met), and she streams on twitch.tv and is quite big on there. Ever since the breakup I haven't been gaming at all because everything reminds me of her, and I have no friends anymore because she and I met all the friends either from gaming or her twitch channel. Obviously they prefer her over me cause shes gorgeous. I feel like I'm constantly in a competition with her because I know she goes out every week and probably gets hit on my numerous guys. And it's really difficult to deal with because I have no friends to go out with to forget her. Before taking accutane I was feeling optimistic about life and my future for the first time after my breakup. A month in to taking accutane at 40 mg a day, I just feel worthless and I feel like I wont make any friends or find another love. I'm fairly attractive I guess but the accutane is making me so anti social because of how tired it is making me so it's hard to be interesting to others in order to try and make some friends or find another girl. Should I keep taking accutane? I really don't want my acne to return but it feels like I've tried every other treatment. Sorry for the long post.
  8. Acne has ruined my life

    Forums Adult acne 19 replies

    Ok. My story so far. I used to have normal skin. Not perfect but so bad i wont look in the mirror. About 8 months ago everything change. Right now is the worst my skin has ever been since I was 17 years old and in high school. Acne is ruining my life. I go to med school, so i have to study, theres no option, but i’m so depressed. All i can think is how horrible look, i dont wanna go back to uni, I dont wanna get out of the house, been to several derms, none has help. A doctor diagnosed me with pcos. I also have facial hair. I feel i look like a man. I feel so disgusting. Lately all I can think about is the fatest easiest way to kill myself. I see no end to this. I’m sick of it. I dont go out anymore, no one’s gonna love looking like this. I wish i could just dissapear. I wish i didnt have to wake up in the morning. I want to die. I cant go on living like this anymore. I ask god everynight why this happened to me and why cant he just kill me in my sleep. I know a lot of people have it worse, but this is important to me. I want to die, please god just let me die
  9. I don't know how many of you heard about the acne no more program(mike Walden). Is it a scam ? Please I want honest reviews about it.
  10. Hi, I have suffered from moderate to severe acne since I was about 16 and am now 21. I have taken doxycycline pills, benzoyl peroxide cream (which I still use on occasion- I am unsure whether it actually helps or is irritating and drying out my skin too much) and now take anti-androgens. I have taken antidepressants for about a year until recently as well. Since January, I have pretty much eliminated dairy products from my diet as I've heard multiple times that it is good for acne. My skin has improved slightly but that may also be due to changing medications and using Lush's Ultrabland cleanser. I have also read that, forgive me if I'm not using the correct term, 'carbohydrates with a high glycaemic index' such as bread, cakes and rice often contribute to acne. I am trying to reduce these in my diet but am finding I now feel very hungry and irritable a lot of the time. I've always followed a pescatarian diet and I don't ever want to eat meat that isn't fish. So what is there left to eat? Fruit, vegetables, eggs, fish, nuts, vegan meat and dairy substitutes? I eat all these things but I think that because of my tall, slim body type I have always been the kind to get very hungry easily and my body is used to me eating a lot of bread and pasta. I don't have a lot of money to buy lots of fancy non-wheat vegan food. Any suggestions of what I can do and is it even worth restricting my diet so much in order to reduce acne?
  11. Hello all who is out there reading this, I’m James, a 23 year old male & I have been suffering from acne since age 11. I’m not quite sure on the exact cause so I’ve come here to hopefully seek some wisdom from maybe those who’ve been in my shoes. Get ready for a bumpy (face of a) ride. Here’s my journey. A brief background on my acne. I’ve tried pretty much all over the counter products. Cleansers Moisturizers Topicals: BP, Salicylic Acid, Clindamycin, Essential Oils Minocycline, Doxycycline, & eventually 6 months of Acutane. All have done there fair share of either helping slightly or damaging my skin. I would say my acne has always been pretty moderate. Anyth region above my eyes has always been crystal clear but my cheeks, chin, & forehead never have been clear. My current regimen includes: VITAMINS & MINERALS & ANTIOXIDANTS: Vitamin A, Vitamin C, Vitamin D, Vitamin E, B-Complex, Fish Oil, Evening Primrose Oil, Zinc, Alpha Lipoic Acid, Magnesium, Beta Sitosterol (active compound in Saw Palmetto), Probiotics, & Fiber capsules. AM: Wash with a gentle gentle cleanser in the morning, use Thayers Witch Hazel (rose water) as a toner with a few drops of Salicylic Acid Moisturize is Aloe Vera gel. Before I head out the door I spray my face with Green Tea water mixed with Thayers. PM: Recently switched to a 3% Sulfur cleanser to help my dead skin cell slow turnover rate. Thayers again as a toner. Also recently switched to Azelaic Acid (20%) as my topical. Lastly I use a Retin-A . I found that Azelaic Acid & Tretinion compliment eachother. MY DIET: This last month I did a full month long colon, liver, & full body detox cleanse to insure my acne wasn’t purely internally based. I am a very health conscience person and happen to be allergic to dairy & gluten so those two factors are already out the window. I stay far from excess sugary foods & hydrogenated oils. Other than that I eat a high fiber/omega-3/omega-6/ diet. Lots of beans, lentils, veggies, avocados, fruit, rolled oats, pumpkin, flax & chia seeds, almonds & cashews. No alcohol. I drink about 3-4 cups of Green Tea a day as well as 1-2 Spearmint or Chamomile teas at night before bed. I also drink plenty of water (at least 100 fluid ounces per day). I believe I may have Hyperkeratinoisis which is a buildup of protein on the skin that clogs pores with dead skill cells. Add my excess sebum (oil) and it’s a mixture from hell. I do get stressed out but not any more than the average person. I’m a fairly calm & level headed human. Depression has taken its toll on me over the last few years after I’ve seen a dermatologist for about 2.5 years which did nothing. I actually obtain more clear skin by researching for myself and trying more holistic approaches. The best thing a dermatologist offered me was Tretinion which I still use to this day. SIDE NOTE: My acne or at least sebum production goes into overdrive after masturbation. I’ve tested the theory and I have broken out bad masturbating consistent days. Also I’ve held off work about two weeks and yes my skin got better but never fully cleared me up. The most frustrating part of this whole journey to clear skin is the teasing of new practices I implement. I try something new & it works, starts to clear me up then out of no where either backfires or stops working. Some examples of these are... Green Tea. Lost its effectiveness so I bumped up to Matcha green tea which was strong and worked again but slowly diminished strength. Pure Tea Tree Oil (huge clogger of pores). My skin was beautifully clear after dabbing pure Tea Tree Oil on my face daily unless it clogged my pores horrifically. Took 3-4 months to unclog them. Alpha Lipoic Acid. Lost its effectiveness. High Fish Oil intake. Stopped its high effectiveness & to thin out my sebum BP. Always overdried me & made my breakouts worse. It’s like my body becomes immune to all of these wonderful options and just wants to make my facial inflammation worse. There’s a few questions that I am eager to have answered. Such as products I’ve been curious to try but have not yet. So without further ado I’ll fire away. Borage Oil over EPO (evening primrose oil)? Does the higher GLA content really make a huge difference Can eating eggs & almonds truly cause more acne? Topical Spironolactone? Anyone have positive experiences with Azelaic Acid? Anyone have positive experiences switching to Sulfur cleansers? If I’ve tried Beta Sitosterol & it didn’t work should I still bother with Saw Palmetto? Sodium Sulfacetamide & Sulfur Topicals/Lotion effectiveness ? Should I try these Best products for Hyperkeratinosis acne? Best acne bacteria fighting/non-drying/non-comedogenic day time moisturizers? Does it does as if I have hormonal acne? Any advice Alpha Hydroxy Acid products? Very curious to try them out if Azelaic doesn’t pan out well. Thank you so much if you got this far. I hope that some of this info can shed new light to those out there struggling because I know some of these products work well for many acne sufferers. I haven’t found my answer yet but I’m still striving to do so. Keep fighting everyone :)!
  12. NEEM can TOTALLY Destroy BEDBUGS! The blood-sucking BEDBUGS are spreading fast all over the world in places of human habitations. They have become a great nuisance, as It is very difficult to eradicate them with the commonly used method of spraying insecticides. Their bites can cause severe itching, sleeplessness, irritability, depression, anemia and other related problems. Even by using different types of insecticides regularly, I had failed again and again to remove all the BEDBUGS from my room. In desperation, I started using NEEM soap and NEEM detergents to wash my bedsheets, pillow covers, blankets, mosquito net, and also to wash my clothes like the shirts, pants, underwears, banians, nightdresses, caps, socks, handkerchiefs, towels, napkins, etc. Only after I did that, the BEDBUGS DISAPPEARED totally within a few days! I was astonished to find such an easy solution in such a short period. So, it is NOT surprising why the Hindus worship the NEEM TREE as a GODDESS! We can use NEEM SPRAYS to kill and repel bedbugs, mosquitoes, mites, lice, fleas, ticks, cockroaches, ants, flies, etc. Washing our clothes with NEEM soap and NEEM detergents repels these insects. Even if we choose to wash our clothes with other soaps and detergents, we can just dip the clothes in NEEM WATER for some time, then squeeze them and hang them for drying. BATHING with NEEM soap and using NEEM creams and NEEM lotions too can help our bodies to repel bedbugs, mosquitoes, mites and lice, and to prevent diseases like ANEMIA, MALARIA, DENGUE, CHIKUNGUNYA, SCABIES, etc. Let us launch a worldwide campaign against bedbugs, mosquitoes, mites, lice and other insect pests by sending many messages like this one to all our contacts.
  13. Just thought everyone should know that Accutane is scientifically proven to cause brain damage, and it is probably the cause of many of the long lasting side effects that people experience. Obviously many come out the other side with little significant long lasting side effects, others do. This is because everyones brain is different, which is why after a concussion some are fine a few days later, while some are never the same, and have mental illness for the rest of their lives. In the end its a roll of the dice, and if you are going to roll, I suggest you at least know the risks first. With no further ado, here is the evidence. Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." These are the potential side effects of brain damage. If you read up on past users, often they display a number of these symptoms Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” If you've taken it already and are displaying negative side effects, I recommend you take a read of this: https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# It's like a brain rehab protocol I've devised and had success with. Its pretty cheap, and much safer then the drugs and diets others have resorted to in the attempt to reclaim control of their lives. It will take a few months to take effect, but its cheap and if you are impatient, you can easily take it alongside other protocols you are trying
  14. On January 5, 2018 I started 40mg of isotretinoin. Before starting I heard bad things about accutane but given my 10+ years of acne and talking to my new dermatologist, I was willing to give it a shot. Immediately the first week I noticed my skin was half as oily as it usually is (my skin is usually very oily to the point where I would have to blot my face 3-4 times a day). For me this was already a huge success. By the end of the first month, I noticed all whitehead have disappeared. However the blackheads on my nose were still surfacing in huge quantities. I was immensely surprised and impressed, this seemed to be a miracle drug with no known side effects. I was angry that my dermatologists for 10 years didn’t talk about it with me sooner. So now going into the second month, most of my blackheads have surfaced, my nose is back to a normal persons, my oil production has also benefited and maybe reached the point of oilyness after a slight sweat. However in the second month is when I began feeling the depression. Everyday I was getting more and more fatigued, my motivation for my job was declining drastically among other things and brain fog was increasing. I am not one for blaming drugs but I have never felt this way before so I couldn’t help but think it was the accutane. I was depressed, and everything lost meaning so I decided to start reevaluating my life before quitting the accutane treatment and going back to acne problems. So the first thing is I went to work and told my boss exactly what I didn’t like about the job (depression gave me the courage to do this because at that point it was like I didn’t even care anymore about the outcome), but she saw my point of view, agreed with the changes that should be made and gave me a new position and promotion! But I didn’t feel back to 100% yet so I changed my diet, I started eating only fruits, nuts, greens and white meat on occasion. That got me back to a little more normal but still not 100% The next thing I did was start going out during the day more (more sunlight, vitamin D) and talking walks, around the park and beach. Again, better but not all the way, so I then reduced technology use to about half, also cutting out any porn in the process. These changes gave me another energy/mood boost. Lastly, I added some supplements to my diet, namely maca root, raw cocoa powder and small quantities of caffeine (about 40mg per day). After making all these changes I still feel slightly more physically tired than pretreatment (staying hydrated helps) but not really depressed anymore. So from my best guess of what happened is that accutane makes it so the state you started the treatment with drops to a lower level, but in reaction to this a user CAN increase their base state through openness and willingness to change their lifestyle for the better. So for anyone beginning to feel depressed on accutane, instead of continuing all your same habits and blaming accutane (which very well may be justified). I instead urge you to use that depression as a catalyst to make positive change in your life, where any depression you may feel from accutane becomes a non-factor. The end. Love Accuchange
  15. Hi everyone It has been a while that I haven't updated my new entry. So, my acne is still coming up on left cheek close to my mouth and two big cyst on my forehead. One in the centre and another one on my right. Before this there were 3 cyst on my forehead and a fews on my both left and right cheeks. All of them left red scars on my face. It makes me feel unhappy. I am losing my confidence. I don't know how does it come up or what causes it. I did apply benzac overnight and on the spot but lately it works less than excellent. Acne does not subsize as fast as it should. It begin to get red and dry then it comes up and left scar. It takes almost 2 or 3 weeks for me to elimiate a cyst. Very curious what happens.
  16. The last couple of days I have come to the conclusion that I will be Forever Alone forever. I'm too late in the dating game and will never marry and barely have a social life all thanks to acne and some other personal issues I had when I was younger. Now I'm just trying to figure out how to accept this and be content while seeing happy clear skinned people everywhere. Some of us are just cursed.
  17. im fifteen years old and i hate my acne. its only mild acne for me, but every single damn week new breakouts appear and i cant handle it anymore. im on the verge of breaking down and whenever i try and confront my mom about it she just ignores the fact and tells me that its ‘just a phase’. well, this phase is literally affecting my every day life and self esteem. i cant do anything anymore. i lost all motivation and i HATE how my happiness has to depend on the quality of my skin. i’ve tried everything. from face care routines to those face masks that are suppose to be beneficial for your skin but nothing is working. i dont plan on doing proactiv anytime soon because my friend said that it’ll make my skin oily, dry, and even cause more acne. ive become depressed and cant get out of bed anymore. i was always a morning bird, waking up at seven in the morning, but now it seems like ive just gave up trying on life.
  18. Hello guys, I’m a 19 year old who has severe acne scars caused by cystic, inflammatory acne. After a few years of dealing the pain of having this curse (started at about 13), I finally got put on Accutane (around age 16). While this cleared up all my acne, it came well too late. The damage was already done. I had a bunch of shallow scars left over from the terrible breakouts over the years. Now I’m left with the painful reminder everyday when I look in the mirror. My scars have kept me from going outside my bubble, meeting new people, starting relationships, etc. My life is pretty lonely, depressing, and flat out boring. I constantly obsess over my appearance every day. I suffer from low self-esteem among many things because of my face. And I’m really starting to lose hope. I just wanted you guys to see so maybe you can recommend what treatments would be best or to just give me any helpful advice. Anything would be appreciated. I’m under no delusion that my scars will ever go away completely, but any progress is something I’ll take. I’m on a budget as I’m attending college next fall and I’m currently unemployed, so laser treatments really aren’t an option for me. I’m pretty sure my scars are worse than the majority of people I’ve seen on here posting on this forum.
  19. Hey beautiful people, Hope you are all doing well. <3 I am new to this community, and a little lost on where to start from. I had plans to join a support group for this since forever, but for some reason, couldn’t muster enough courage to. I am battling acne for five years now, and it keeps fluctuating. I’ve tried different dermatologists, and they help to some extent, but my acne keeps coming back. Weirdly enough, it has affected me more than anyone would expect to, to the point of driving me suicidal. I have tried ways of emotional healing and being at peace, but nothing works permanently. No one believes how acne is one of the major contributors to my depression. I have tried therapy and have been on anti-depressants, and they made my situation worse. I can’t seem to see a way out, and I feel I’m just moving blindly, traumatically. People around me don’t really have much acne, and if they do, they cover it up with flawless makeup. I live with an emotionally abusive mom, who doesn’t let me use makeup, so that is out of the option as well. ( Before, someone suggests to get away from her, I’ve already tried, but she wields too much power legally for me to do so. ) Sorry for such a long post. I would love to talk to someone dealing with acne, it might help me to feel less lonely. Sending lots of strength, warmth and love to all of you. <3 Have a lovely day/night. <3
  20. Tell me how you did it. Your acne journey. Since when did you got it? what makes it worse? is it severe or mild? for how long have you been suffering? How have people been treating you? And if you had succeeded, how did you do it? Natural or with the help or medications? Is it cleared 100%? Go on, just tell me everything. Let it all out
  21. Some of guys use this topic as chat and write sometimes completety useless thoughts. Many informations was mentioned dozens time. Whats why we have so many trash pages. Please write only significant revelations, tests and improvements during/after treatment.
  22. Turning 22 next month and still have never kissed a girl or done anything for that matter. The thing is my skin is clear but my confidence is shot from the good 4 years I had severe acne. I just feel so inexperienced at this point that there is no reason to try. 15 year olds have more experience than me.
  23. Hi im thinking about going on accutane, a low dose but the problem is is that I suffer with depression. I’m on medication for it but I’m worried they will say I can’t go on accutane as it’s a side effect that it could get much worse
  24. Hi there guys I was just wondering if someone could tell me what severity of acne I have. I have had acne since I was about 12-13 much worse than it is now. Currently I use epiduo every night with aveeno moisturiser afterwards and I use a black pore mask once a week. However despite this I continue to suffer with large red pimples under the skin that are painful and take a long time to go away. Does anyone have any tips to help get rid of these because they make me extremely unhappy and make me not want to show my face at times. Thanks a lot any help would be appreciated.
  25. Help with my acne please!!

    Blogs Jordan 2 comments

    Hi there guys I was just wondering if someone could tell me what severity of acne I have. I have had acne since I was about 12-13 much worse than it is now. Currently I use epiduo every night with aveeno moisturiser afterwards and I use a black pore mask once a week. However despite this I continue to suffer with large red pimples under the skin that are painful and take a long time to go away. Does anyone have any tips to help get rid of these because they make me extremely unhappy and make me not want to show my face at times. Thanks a lot any help would be appreciated.