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  1. Day 4

    Blogs Accutane

    Day 4 of taking 40mg of accutane each day Side effects: Patches of dry skin- especially around nose/ itchy skin around nose Tired but unsure if thats because I'm not sleeping enough and waking up early Slight muscle pain Also felt a bit sick when I took the pills but again, unsure if that is because I had a coffee an hour before I took them. Skin hasn't got any worse yet but has got slightly more oily (apart from the dry patches)
  2. I used accutane for about 6 months and then finished and now my acne has come back. I heard from my dermatologist that it’s common and would need to do another round. Since my acne is not as bad as it first was, she prescribed me 40mg of accutane and to take it every Monday, Wednesday and Friday. I have suffered with acne since I was in 7th grade and now am close to 22. I have VERY oily skin and when I went on accutane, it was a dream. Not having to blot every 30 min and touch up was amazing. Unfortunately after having a break from it, my oily skin has come back. Now taking accutane 3 Times a week, my skin is still oily. I am planning to go to the Philippines in the summer and it is very hot and humid and I don’t want to have to blot every half hour. Is there anyone who has taken the same amount and has had their oily sebum reduced? Pls let me know, I’m sure I’m not the only one wondering. Thanks!
  3. Ok so idk if anyone will care to read this but Hii! if you’re on here I’m assuming you’re going through a similarly hard time and I wish you the best and hope you find what works for you soon! ok backstory I have had acne since I was 13, I have it on my face (rarely on my cheeks though), and on my back and chest (though I am better at dealing with that for some reason) after years I came to the realization my acne was hormonal. I get painful “blind pimples” and whit heads, the worst of it is around my chin/jaw. I did everything suggested, including ridiculous things like oatmeal to the face only one thing worked, doxycycline, and for a year I was clear and it was as wonderful as I thought it would be...i think that is why it was so hard when it came back. I tried everything I could for the 10 months following it’s awful return. Unfortunately, spironolactone was last and did not work. So, well, here we are, the end of the road. I never wanted to go on accutane, but I’m 21 now, nothing else worked, and my level of self confidence is lower than the bottom of the Atlantic Ocean. So, i give in and i hope it will take the one course and never come back so i can finally move on with my damn life! Month 1 day 7 So not much has happened...I think my face is starting to feel a little drier. I’m still dealing with a really bad hormonal breakout. I knew it was coming but it sucks that it corresponds with the first week of this medication. *little rant ~ My worst nightmare happened yesterday! Since my acne is around my chin, i have trouble eating. Sometimes the painful under pressure spots will pop due to the chewing (ugh horrible I know) it had never happened in public but I was always terrified that it would. Well...Yesterday. Was. That. Day. We went to the beach and at least it was the end of the day when we got food. When I got into the back of the car I saw it. In the mirror. The horror. It was really sunny so I saw the light reflect off the bead of blood and nasty that had popped on side of my chin. I spent the hour long journey home covering my face with the sleeve of my sweatshirt, then holding my bag in front of my face so my friends wouldnt notice. (Im realizing now how dumb I must’ve looked like picture it...gets out car *voice muffled by large bag covering face* “great day guys! Really fun... What? Why do I have a bag covering my face? Uh well...Why don’t you have a bag in front of your face? huh?! I gotta go!”) man it was the fucking worst, I hit a new low I’m desperate for this to end it ruined my otherwise nice day Respectfully, Bag-Face Lady. (That is my new name)
  4. Hello everyone! I have been taking accutane since 21 February. I weight 88 kg. Now I am on 50 mg a day. I did the bloodwork and i have high bilirubin, 49.3 µmol/L. Is this a common side effect? Should I stop taking accutane? Thanks.
  5. Hello, lovely people of this website!My name is Marissa and I'm 17. I just made this account today. I thought it would be hella cool to start a blog so I can keep track of my progress (or lack thereof), spread information/be a reference for people new to Accutane, and hopefully make some friends on here. So here I am. Nice to meet you.Some background:So I actually started Accutane last month (4/27/18) - I'm on my 25th day today (5/21/18). I've never had great skin, but around age 15-16 it started getting worse and worse, especially after I got a Mirena IUD in April of last year. I finally went to see a dermatologist and I tried a million different creams and antibiotics but nothing worked. I was desperate to get on Accutane because I figured it's my last hope. I would literally cry almost every other day after seeing myself in the mirror. I felt hopeless and I got hella depressed over it.The ProcessGetting on Accutane was an entire struggle and a half for me.If you're a guy, obtaining Accutane is fine and dandy, but if you're female it's a tremendous pain in the ass. If you're reading this, you probably know all the excessive steps you have to take before you can get on it; waiting 30 days, giving 2 negative prego tests, blah blah blah. In my case, on top of all that, because I have a history of depression, my doctor wouldn't allow me to go on it until I had the written consent of another doctor saying that I'm stable enough to take it. There's been found to be a slight risk of depression, but other studies contradict this finding, saying there's no risk.Regardless, my dermatologist didn't want a teenage suicide on his hands so I had to do it. It was a long, incredibly discouraging process because I didn't have a psychologist or a psychiatrist at the time. Eventually, though, I got my Primary doctor to write it. Then, the problem was the price. it was $450. $450. When I heard that price I immediately knew i wasn't getting on it. It was a sad day. HOWEVER, I was able to talk to my dermatologist office and they ended up sending it through a smaller, family-owned pharmacy that cut the price down to $130. Still a lot to pay every month, but it's possible. FINALLY, finally, I popped the first pill. I can not explain the excitement, relief, and hope I felt the day I took the prescription home. Things finally seemed to be working out. This post is getting pretty long so I'm going to start a new one that goes into more detail about my experience so far along with some pictures.:) Thanks for reading!-Mari$$a
  6. 5/21 - cream follow up

    Blogs Accutane Process

    it's been about 2 months since i last updated my progress. it has been hard to use this cream in a consistant manner. there were a few weeks i completely forgot to use it. Now, i'm trying to get into the habit of using it every day instead of every other day like when i first started. my skin has gotten so much better. i'm not red like i use to be with accutane and my scar redness has gone down. i still have scars but they're not so prominent now. very pleased with my results!
  7. Hi, recently ive developed keratosis pilaris and acne (after an accutane course) so i went to the derm and he gave me clindamycin and urea. Its been a month and i still have like 6 tiny pimples on my cheeks , blackheads and whiteheads on my nose and some underskin puss in areas where I had acne. I see my derm in 3 days and i was thinking on asking him for a tretinoin cream. The last time I went to the dermatologist he did not want to give me something stronger because he said my acne was not so bad but now it's worse . What should I ask him to prescribe me?
  8. Background Story: I classify my acne situation as mild to moderate acne. I'm a teenager (14 years old) and find my acne becoming uncomfortable for me and slightly unsettling. I am planning on seeing a dermatologist for my situation. I have not tried much options for my acne except for a face cleanser (neutrogena) which I have been using twice a day for 6 weeks now. I have heard of Accutane (Isotretinoin) and feel like it might be a great option for me. I'm worried that when seeing my dermatologist, I have not had much experience with more alternatives for my face, and the dermatologist will decide to not prescribe me Accutane (Isotretinoin). I have suffered with acne since age 12 and determined Accutane will treatment me with a 90% chance of success. If I understand the side affects and let my dermatologist know I feel more comfortable using Accutane as an alternative, will they prescribe Accutane as a treatment depending on my situation or is it required for me to try other alternatives over the course of 2-3 years in order for me to start Accutane? Other similar questions: 1. Is it required for me to try every option for my acne in order for a dermatologist to prescribe Accutane (Isotretinoin) as a treatment? 2. Can a dermatologist prescribe Accutane (Isotretinoin) if a patient is uncooperative in trying alternatives? 3. Will a dermatologist prescribe Accutane (Isotretinoin) if a patient feels more comfortable going that route?
  9. Hi. I was taking 20 mg a day of accutane, but my hair was already starting to fall off. So i stopped. I only took 18 pills. When is it safe for me to start using topicals again?
  10. Hi guys, first of all, sorry for my English, I´m from spain. I took isotretinoin for 6-7 months I do not remember well, I think 40 mg per day, during the treatment I had the typical symptoms of dryness, the problem is that 2 years later I still suffer from dryness. My skin is very dry and my eyes bother me a lot. The eyes is what worries me most I think it has affected my meibomian gland. I would like to know if someone has gone through a similar situation and can give me some advice to return to normality. I wish I had never taken accutane, I prefer acne and oily skin to this dryness. Sorry my English!! Thanks for reading and I await your stories.
  11. Hi all, A little bit about my situation: I’ve never had horrible skin, just a few hormonal breakouts every now and then. I started birth control about 3 years ago and about a year in I started getting horrible side effects (weight gain, breakouts, greasiness, anxiety, etc) so 2 months ago I decided to stop taking the pill and all the side effects went away except my breakouts which turned into a raging case of nodular acne. Since I’ve tried literally every topical and oral medication for severe acne my dermatologist is insisting I try accutane, however, I know I need to be on some type of birth control in order to take it. My question is, if I go on birth control for my round of accutane then stop a month after the accutane is over, will my face start breaking out again due to hormones or will the accutane have been strong enough to prevent hormonal acne?
  12. Hi All, Has anyone checked Vitamin A levels after taking Accutane?
  13. Hi fellow humans. I would just like to share my thoughts on Accutane and tell a little bit about my experience on it so hopefully I can help any others considering taking it! I've been off of accutane for a little over 3 years now. I pursued taking accutane because I was dealing with a moderate amount of cystic acne on my face at the time (mainly in cheek pockets and on my forehead). My main goal was to take it, deal with whatever side effects that came with it, and get rid of my acne for good! I will try to make this as short and sweet as possible. I started it when I was 21, my dermatologist started me at 20 mg and eventually he had increased my dosage to 120 mg over time because it wasn't working all that well. Around 3-4 months in I began to get a scalp condition known as sebheorric dermatitis, followed by anxiety. These 2 things, which I've never dealt with before, really started to hinder me on a day to day basis. As well as the usual side effects (dry irritated skin, chapped lips, peeling hands, etc). I was working construction at the time and it was extremely hard to deal with in the summer time on these pills. I still continued my dosage and figured everything was going to be better once I was clear! Around the 5 month period, my anxiety was at indescribable levels. I was crippled by it and I eventually got depressed. I was once a kid in general good spirits that could hold a conversation with anyone to eventually being in a place where I couldn't eat and my thoughts were so out of control it was a task just making it through the day. So around this time, a friend had given me Xanax to help with the anxiety (which I've always stayed away from) but it was really helping me eat and relax in the afternoon. I started to self medicate and it was providing me relief, so I figured screw it I'll hang in there and my skin should be completely clear soon so I'll be done with this stuff for good! Well, around the 6-7 month period I got completely sick of it. I was barely holding myself together for a while and figured it would be best to stop. So I stopped taking any pills, about 2 days later while I was home I entered a psychosis. I started to get my sense of smell and taste back and I could not calm down at all! I ended up doing and saying some outlandish things I would never have done if I was in control which in-term landed me in the hospital for a week. In the hospital they put me on a medication called seraquil to help with the psychosis which made things even worse. Lets just say it took long time to recover from this situation let alone just dealing with the mistakes I made while I was in a manic state. I didn't hurt anyone or commit any serious crimes, but I definitely bugged out. I was texting a girl I used to talk to crazy things, freaking out on my friends and my parents. It took a good year of 'just living' for me to process what happened and move on. Fast forward to now; I deal with some joint pain and mainly hair loss (which is 100% related to the sb and accutane). I try not to regret anything, but if I could have just simply not taken it, I would have avoided a whole lot of stress and disturbance to my health and well being. Knowing now that a lot of acne when you are young is related to hormones and diet I could have reversed it in a much more healthy manner. So please, if you are young and have acne, and even if you are desperate to clear it up, start with your diet before anything. There is tons of evidence out there how a plant-based diet and good gut health is related to clear skin. There is no magic pill to get rid of acne! I know there are success stories out there and everyone has a different experience with it, but I just wanted to give my 2 cents. Take my advice and hold on to your health. Accutane is poison! Good luck to you guys and hopefully you can clear up your skin without taking a drug that was originally used as a chemo-treatment! Peace & love.
  14. I've been on accutane for just over a week. I started on 20mg/day and pretty much the next day i was significantly bloated in the my stomach and face. Since i went up to 40mg/day it seems to have gotten worse, i look like I've gained 4kg or so! Has anyone else had this problem, particularly so early on and how long did it take to go away whilst continuing with the medication?
  15. Hey guys ! so , In february 25th I finished my 9 month course of accutane . It was 9 months full of pain and lots of tears , but I thought that It would all be worth it in the end since I would get rid of that persistent acne forever with only getting a pimple here and there . This "acne free forever" dream of mine lasted for about 2 months and now I´m back to reality. Lately (+ than 2 weeks ago) I´ve been getting small pimples on my forehead , cheeks , chin and especially on the nose . Some of them are like whiteheads , others are just red bumps , but they all have a thing in common - they are annoying af . I think I get at least 3 everyday . Now, my skin does not look as bad as it did before , that´s for sure. I´m not getting cysts or big pimples that take forever to heal ... but I´m afraid that I will . I´m afraid that my skin is slowly returning to the state it was 9 months ago, with cysts and big pimples appearing every week and other smaller pimples appearing everyday. Also , on my last visit to the dermatologist (back in january), she prescribed me tretinoin , to apply 3 times a week after my course ended in order to get rid of any red marks left from acne , which I sort of did . Let´s say I was not very consistent with its usage on the first 2 months after my course ended. I would apply it like 3 times in a week and then on the other 2 weeks I would just be too lazy to apply It and forget about It or I would make up excuses not to use It, like "next week I have a wedding and I don´t want my skin to be peeling , so I´m not going to use It this week" or "I´m gonna travel and I just can´t be bothered to put on creams , so I´m not going to take It with me" . Only at the end of April did I become more serious about applying the tretinoin cream and so I would apply It every week , 3/4 times a week, and I am still doing that (I think i´m gonna start using It every night though). I read It online that some people break out after they start using tretinoin cream and at first I thought that might be the cause of me suddenly breaking out ... but the truth is, I´m not so sure about that anymore. Aren´t my pores supposed to be clear after accutane ? If so , I shouldn´t be experiencing a purge, right ? So ... I don´t really think this breakouts are because of the tretinoin ... but hey ,what do I know ? what do you guys think ? can these breakouts be caused by the tretinoin cream ? any advice or opinions on this are welcome.
  16. Hey guys, I was on accutane from July 2017 to January 2018, it was one of the worst experiences of my life! It broke me out it large cystic painful acne and left my face wreaked with hyperpigmentation and scarring; my face is worse than it was before! It’s now been five months since I completed accutane, I have managed to get the hyper pigmentation down through the use of Mario Badescu’s Gyloic acid cleanser and The Ordinary’s AHA + BHA peeling solution, however my progress has slowed to a halt and my skin hasn’t improved at all in the last month! I’m also starting to break out more (which I expected) but they are just creating even more hyper pigmentation. I have no idea what to do and I wanted to know if anyone could give me tips on reducing hyper pigmentation?? I have attached pics of my skin currently; and if you want to see it before there are pictures in my profile under the posts section. thank you soo much. I really hope someone can help me
  17. Hello, this is my first post on here so bare with me. I am a 20 year old female and I have done 2 courses of Accutane. The first course when I was 17 for 7 months, and the second course I had just finished a month and a half ago and lasted 5 months. My first course I didn’t have any severe side effects, just dryness to the skin and hair. Everything went back to normal once I was off the tane. This time my eyes began to get very dry, they became bloodshot, I took a steroid drop once while I was on the tane and was constantly using eyedrops to keep them moist. I spoke to two different eye doctors and my Dermotologist who all told me that this was just a side effect of the drug and would go back to normal once I discontinued. I was seeing a dry eye specialist when about 4 months into my treatment I noticed the margin of my eyelids were really puffed and swollen, no pain, but very swollen. I went back to the eye doctor and he told me it was just a side effect of the dryness. He told me to start doing warm compresses and lid scrubs. They wanted me to be on the drug for 8 months and I quit after 5 because I was too scared to continue. I also started to lose my hair, eyelashes and eyebrows. That was the breaking point for me. I knew this was not normal. It’s been a month and a half and my eyes are still very dry and VERY red. My eyes used to be my biggest compliment and now I don’t even like making eye contact with people. I felt as if the dry eye specialist wasn’t giving me straight forward answers and wasn’t really helping me. So I decided to get a second opinion. The eye doctor I have last seen evaluated my eyes and immediately told me I have lid margin disease. The protocol I am on now is lid scrubs and cold compresses, he said the warm compresses were making the swelling worse and that I need cold ones to bring the swelling down. Though no one has told me that my Meibomian glands are blocked I was doing lid massages on my own and I had seen some of them were expressing white stuff.. I feel as though my eyes are not making an efficient amount of oil to keep my eyes from being dry.. i am very scared , very worried for my eyes. I would like to know what your guys experiences have been like, how long they have persisted and what have you guys done to treat your eyes after Accutane. I have tried every eyedrops, every compress. Nothing has brought my eyes back to normal. Any input would be helpful even if it’s a bad experience I want to know. I’m so upset I traded my eyes for skin. Had I know the effects it was going to have on my eyes I would have never done this to myself. Be careful on Accutane. Take a low dose if you really need it. I wish I could go back in time. Any advice would be appreciated
  18. I've just finished my 2nd course of accutane a little under a month ago, one of my largest problem areas prior to this was the skin on either side of my nose, I had large, clogged pores which would breakout in cystic acne. Accutane dried out my pores leading me to think this area would no longer be a problem for me but it's been about 3 weeks since I've finished my course and I can feel this area is texturised, I wake up with an oily nose (big problem area) and today my foundation was so oily, something I hadn't experienced in a long time. I don't know what to do to help with this. I did my first face mask today in a long time to try and counteract the oiliness and pores but it seems to have clogged and brought them out even more. I have combination skin although I would say I'm on the more oilier side and my only consistent skin care products right now, are Clinique sun screen, aveeno moisturiser and cetaphil daily cleanser. I've recently started using aloe vera gel which I extract from the plant myself at home as this helped me before accutane. I know i shouldn't even be touching my face anymore but I Can't help it when i can see my pores are enlarged and feel as though small spots are resurfacing, this is mainly around my nose mouth and pore area. Does anyone have any advice to help with this problem?
  19. Hello! I am currently on DAY 23 of Accutane (isotretinoin). MONTH 1: 40mg/daily Can anyone help me with some questions??? Ive heard of the purging phase (and hoping not to get it)....I think I’m experiencing it now. Ugh, it’s just everywhere on my face. its currently 2am and I woke up because my face was bleeding and I now this is disgusting but my pimples were..popping I guess? The puss was just seeping out..yuck! I don’t want that on my pillow, so I got up and had to hold tissue on my face. But now I have neosporin on every pimple and 5 bandaids on my face I can’t even put foundation on it. I hate wearing foundation anyways I guess but man, when my acne is as bad as this, I wanna cover it! I constantly have pimples; whiteheads and under the skin, they’re constantly coming to the surface, I’m also getting blackheads in places I’ve never seen! It’s sore and super SENSITIVE and burns from even unscented face wash or gentle face wash like CeraVe. Dryness is not too bad though. I’ve been drinking water! Anyways, I’m concerned. It looked the tinniest bit better for like a day in the first week, but it’s really only gotten worse since. It’s definitely not better. I hear that I “just need to wait, give it Time, be patient and it’ll be worth it” and stuff but most people see results by now. I see my derm next week an maybe/hopefully he’ll increase dosage because my skin is just being stubborn and gross. ANYONE ELSE EXPERIENCE ANYTHING LIKE THIS? CAN ANYONE HELP? Thanks!!
  20. This is my first time starting a forum! I’ve been on these message boards for weeks now looking for support so thought I’d go for it. I started dealing with a resurgence of acne in September of last year, age 28 (now 29). It was consistently mild and linked to my period. After several months of trying spironolactone, changing my diet, and changing up my skin care, I saw no improvement. It actually got worse. So my dermatologist put me on Tazorac .1% cream every other night and finacea gel mornings. I declined antibiotics because they’ve made me sick in the past. But as the weeks went on, my skin FREAKED OUT. I had a cluster of cysts along my jaw and more appearing on my cheek. My jaw was so swollen I looked like I’d had my wisdom teeth removed. I agreed to go on antibiotics, but they didn’t help much. I changed my morning topical to Aczone gel and upped my dose of antibiotic, and together that seemed to help for a few days, but it didn’t last. I kept reading forums and everyone said Tazorac makes it worse before better, but this just seemed so extreme. I’ve never had acne even close to this bad in my life. I was depressed for weeks. I went back to my dermatologist again and we agreed it was time for Accutane. I started last week at 30 mg 2x/day. I feel like I’m already seeing some improvement, but then I have nights like tonight where I wash my makeup off and I panic because I feel like the cystic ones are itchier than the night before or more tender or more red. It’s an emotional roller coaster. And I think the hardest part is just wishing that I’d never done Tazorac. I look at pictures of my skin when I started and it was nothing like it is now. Just wondering if anyone else had a similar situation and how you’re doing now. I’m hoping to see some light at the end of the tunnel. <3
  21. Hello, I’m planning on getting a tattoo, I’ve been around 5 months into accurate, on a 20mg every other day, the tattoo is to cover a scar, I’m wondering how bad can things go? It’s not an option for me to wait at this time since I have to travel abroad for a year and I the scar is terrible. has anyone gotten a tattoo? It’s in an arm if that helps. I haven’t had any real side effects, the most I’ve had has been dry lips, and they even seem okay when I don’t apply ointment Any input would be great! Thank you or should I ask my tattoo artist?
  22. So there are a lot of threads about the long-term effects of accutane. After going through so many pages and posts about accutane, I wanted to create a thread dedicated solely to trying to figure out what accutane exactly messed up that’s causing all the damage that dermatologists are invalidating, especially the joint pain and cracking.One successful story I came across:The only successful person (I know of) who completely cured his symptoms was a user here who found out his testosterone levels were messed up, and took steroids to fix the issue, which according to him, magically cured him completely. He, however, had different symtomps (sorry I can’t remember, but definitely did not have joint pain). I checked my testosterone levels and some other hormones and they were all normal. His story however gave me hope, and I do believe that if we find out the root of the problem, we’ll be able to find a cure. Don’t give up. I’m hoping that people on this thread will suggest theories/ possible blood tests or any tests to consider that might detect the problem. This is to help each other and help figure out things together.My personal symptoms include: Joint pain/cracking/inflammation Fatigued after eating (intolerance), sometimes even feeling faintBrain fog depressionmemory problemsCold intolerance hair fallRecent/new symptoms: high heart rate TremorsWhat I did/ checked so far and my story:I honestly did almost every test under the sun, it’s ridiculous. Everything turns out to be normal. I did blood tests for my vitamins, testosterone, thyroid, arthritis, Lyme, and celiac/gluten intolerance. I did an X-ray for some of my bone and joints and an MRI as well as an EEG for my brain. I even went crazy and did an EMG for my arms and legs’ muscles and nerves as well as an ECG for my heart. Everything turns out to be normal (except for my iron/ferritin which I’m taking supplements for). I’m currently digging a problem with the arteries (possibly food [temporary] epilepsy) but really nothing the doctors will check for.. In the end I thought of just exercising and living healthily like all the doctors told me (since they don’t believe me anyways me thinking i’m exaggerating). And that’s what i’ve been doing recently. However, my condition is getting worse and nothing is improving, it’s scary. I woke up today not being able to walk because of the left hip/joint pain. I still can’t even lift it or move it without leaning on my right side. It’s been four years since I’ve taken accutane.
  23. Hi , I am on 40 mg of isotretinoin daily and taking 2 capsules of 20mg every morning with a fatty breakfast consisting of peanut butter sandwiches , I also consume 1 capsule of omega 3 fish oil at the same time as my food. I would like to know if I should be taking the isotretinoin tablets with the fish oil or should there be a break in between? I normally take the the fish oil during food and after I finish my breakfast I take my tablets is that a good way of taking the isotretinoin tablets to maximise their consumption? Thanks , Alan.
  24. Everything is in the google document, I've expanded it below. I think I am 100% cured, no longer get anxious or brainfog, sexually I feel the best I ever have, though things like joint health and injuries obviously didn't magically heal, but I have done a lot of PT and my body responds positively to it, though they aren't as good as pre-accutane. Anyway, I'm gonna leave this here and get on with my life. A selfish part of me wants to delete this account and never come back, because there aren't many positive memories here, but I will probably check every month or two but most questions are answered in this post. For brain fog, I strongly recommend meditation, I feel my focus is stronger then its ever been, though the supplements will help with that as well. I didn't recommend meditation that strongly below, because I hadn't started it yet and didn't realise how beneficial it was. And with that said, hope what I've written below helps you and au revoir! https://docs.google.com/document/d/1gGkP_NQ8tmYkOADlG2VuEX17YvQJKgnfcEtgy5_6y7c/edit# Curing PRSD Hey, I am a 22 year old who suffered from Accutanes side effects since I was 16, and I think I am cured, though for me while sexual dysfunction was the side effect that made me notice accutane had affected me, it was not the only side effect. The route to curing my own side effects was by using nutrition and supplements, to undo the damage accutane did to my brain. Personally I believe Accutane causes its negative side effects by changing brain metabolism and causing a degree of brain damage. The brain damage is not caused by outright irreparable cell death, because the main place where cell death occurs is in the hippocampus, where neurogenesis can occur anyway and most of the damage can be reversed. The problem is that accutane also inhibits neurogenesis, so for some people, they suffer this brain damage quite severely, while others get back on their feet pretty quickly and don’t even regret taking it. Now as a disclaimer, I only took accutane for 9 weeks at 2x40mg per day, which was enough to give me no feeling in my penis for 2 months, and several years of not being aroused and not being attracted to any person irl at all, though with porn I could masterbate, though I was very insecure if I would actually be able to perform under pressure, and avoided any situation where anything might happen. I developed social anxiety, I lost my passion for all my subjects, competitiveness for sport and academics, couldn’t concentrate or focus, and lost most hope and ambition for my future. I wasn’t completely antisocial, and still had a few friends, male and female, but only because my brain wouldn’t really care if it was female and if there was zero chance of being aroused, there was zero chance of being anxious as well Accutane What do we know about accutane? Well certainly the people that make it claim to know so little it is scary. All they claim to know is that it causes birth defects, and it somehow causes acne to go away. They also claim it causes no lasting side effects, except the magical disappearance of acne. However, that is because not everyone suffers the same side effects, though the loss of acne is the most common one. The reason for this, is because it inhibits neurogenesis and causes hippocampal atrophy(brain cell death), which results in varying degrees of brain damage. Below or the studies that prove this, further down is how to fix it, which is very possible with the right knowledge Dermatologists' attitudes, prescription, and counseling patterns for isotretinoin: a questionnaire-based study. http://www.ncbi.nlm.nih.gov/pubmed/25689814 "A 25-question survey was emailed to 7,013 dermatologists included in a proprietary database (MBD, Inc.) and anonymous responses were collected. 591 board-certified dermatologists participated. Thirty-seven percent of the responding dermatologists believe that isotretinoin may cause psychiatric disturbances. Dermatologists' opinions on this relationship did not significantly impact prescription practices in patients with history of depression (P=0.056) or in patients being treated with an antidepressant (P=0.118)." Functional brain imaging alterations in acne patients treated with isotretinoin. http://www.ncbi.nlm.nih.gov/pubmed/15863802 "RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. Conclusion: This study suggests that isotretinoin treatment is associated with changes in brain functioning." “A 4-month treatment trial with isotretinoin was associated with a decrease in brain functioning in the orbito-frontal cortex, a brain region implicated in depression.” 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice. http://www.ncbi.nlm.nih.gov/pubmed/15251924 “We now show, in a mouse model, that endogenous RA generated by synthetic enzymes in the meninges acts on hippocampal granule neurons, and chronic (3-week) exposure to a clinical dose of 13-cis RA may result in hippocampal cell loss.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387382/ "This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA." Retinoic Acid and Affective Disorders: The Evidence for an Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276716/ "Increased concentrations of homocysteine have also been associated with attacks of violent anger. Isotretinoin administration to human subjects was shown to be associated with increased concentrations of homocysteine, as well as decreases in 5-methyl-tetrahydrofolate, providing a potential metabolic mechanism by which isotretinoin may promote depression." "In the case of patients reported to the Norwegian Medicines Agency, single photon emission computed tomography (SPECT) of the brain was performed in 15 cases who reported lasting neurological symptoms. Altered brain function was seen in all cases involving altered or reduced frontal lobe blood flow. Ten of these patients were evaluated to have organic brain damage." 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. https://www.ncbi.nlm.nih.gov/pubmed/20708044 "13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. . . .We hypothesize that the ability of 13-cis-RA to decrease hypothalamic cell number may contribute to the increased depression-related behaviors observed in mice." Anxiety, Depression and the Hippocampus After taking Accutane, I suffered depression and anxiety, and so far from normal that I went to a psychologist and explained my symptoms, and went there several times, and while I considered antidepressants, I never took them. On Accutane forums, many people are depressed, and so many have taken SSRIs, and many people feel much better having taken them. They still do not feel 100%, but while on them they regain a lot of feeling and emotion that they have missed, antidepressants obviously have their own side effects so it is not always worthwhile. There is much research showing there are natural ways to stimulate neurogenesis in the hippocampus, that does not risk the side effects of antidepressants Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. https://www.ncbi.nlm.nih.gov/pubmed/16425236 “The hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could account for alterations of hippocampal structure as well as function is the regulation of adult neurogenesis. Stress exerts a profound effect on neurogenesis, leading to a rapid and prolonged decrease in the rate of cell proliferation in the adult hippocampus. In contrast, chronic antidepressant treatment up-regulates hippocampal neurogenesis, and could thereby block or reverse the atrophy and damage caused by stress. Recent studies also demonstrate that neurogenesis is required for the actions of antidepressants in behavioral models of depression. This review discusses the literature that has lead to a neurogenic hypothesis of depression and antidepressant action, as well as the molecular and cellular mechanisms that underlie the regulation of adult neurogenesis by stress and antidepressant treatment.” This study basically states the reason SSRIs work again depression is because they upregulate hippocampal neurogenesis Ventral hippocampal lesions affect anxiety but not spatial learning. https://www.ncbi.nlm.nih.gov/pubmed/12642189 Rats with cytotoxic ventral hippocampal lesions which removed approximately 50% of the hippocampus (including dentate gyrus) starting from the temporal pole, displayed a reduction in freezing behaviour following the delivery of an unsignalled footshock in an operant chamber. This was more plausibly a result of reduced susceptibility to fear than a result of a lesion-induced increase in general motor activity. There was no consistent difference between sham and lesioned animals in spontaneous locomotor activity, or locomotion following acute or chronic treatment with amphetamine. In contrast, ventral hippocampal lesioned animals were quicker to pass from the black to the white box during a modified version of the light/dark exploration test, and were quicker to begin eating during tests of hyponeophagia. Furthermore, rats with ventral hippocampal lesions defecated less than their sham counterparts both during open field testing and in extinction sessions following contextual conditioning. In contrast to these clear lesion effects, there were no signs of any spatial learning impairment either in the watermaze or on the elevated T-maze. Taken together these results suggest that the ventral hippocampus may play a role in a brain system (or systems) associated with fear and/or anxiety, and provide further evidence for a distinct specialisation of function along the septotemporal axis of the hippocampus. Anxiety and hippocampus volume in the rat. https://www.ncbi.nlm.nih.gov/pubmed/16192979 In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxiety-related behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. The studies above show that hippocampal volume, which is the most common measure of neurogenesis and neuroplasticity, are very accurate in determining whether someone suffers from depression and generalised anxiety disorder, and also the severity of the mental illness. Hippocampal volume is also an accurate predictor of how well someone will recover from a brain injury, or how well they will cope when faced with a stressful situation. The cure is focussed in restoring neuroplasticity and hippocampal growth (aka promoting neurogenesis, they are all basically the same thing), and while following the routine your brain should regain this ability to heal itself and over several months a close to full recovery should be within reach. As a bonus, the depression and anxiety also being suffered should be much reduced after following the protocol Effects of Hippocampal atrophy/ negative changes in brain metabolism Traumatic brain injury: a disease process, not an event. https://www.ncbi.nlm.nih.gov/m/pubmed/20504161/ “Traumatic brain injury (TBI) is seen by the insurance industry and many health care providers as an "event." Once treated and provided with a brief period of rehabilitation, the perception exists that patients with a TBI require little further treatment and face no lasting effects on the central nervous system or other organ systems. In fact, TBI is a chronic disease process, one that fits the World Health Organization definition as having one or more of the following characteristics: it is permanent, caused by non-reversible pathological alterations, requires special training of the patient for rehabilitation, and/or may require a long period of observation, supervision, or care. TBI increases long-term mortality and reduces life expectancy. It is associated with increased incidences of seizures, sleep disorders, neurodegenerative diseases, neuroendocrine dysregulation, and psychiatric diseases, as well as non-neurological disorders such as sexual dysfunction, bladder and bowel incontinence, and systemic metabolic dysregulation that may arise and/or persist for months to years post-injury. The purpose of this article is to encourage the classification of TBI as the beginning of an ongoing, perhaps lifelong process, that impacts multiple organ systems and may be disease causative and accelerative. Our intent is not to discourage patients with TBI or their families and caregivers, but rather to emphasize that TBI should be managed as a chronic disease and defined as such by health care and insurance providers. Furthermore, if the chronic nature of TBI is recognized by government and private funding agencies, research can be directed at discovering therapies that may interrupt the disease processes months or even years after the initiating event.” Currently there is no acknowledgement of this from anywhere, which is why mental illness is becoming an epidemic. In a few decades though I think this will become mainstream knowledge Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819093/ “In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients’ trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs—both the trauma-exposed and unexposed members—had significantly smaller hippocampi than non-PTSD pairs.” here is another interesting study about recovering from a TBI, it's basically like the worse the patient thinks his recovery will be, the worse it will be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077969/ The reason for this may be the worse the TBI is, the less likely the patient is optimistic about his recovery, or maybe the worse his mental state before the injury happened, the worse his recovery will be, rather than simply being optimistic improves outcomes. In this we see that accutane, in mant ways, affects us like a chronic bout of stress. It is also why people who use antidepressants feel better, and why you often find people recommending SSRIs to treat accutane’s sides. That is because they can help treat some of accutanes sides in specific instances, because SSRIs can promote neuroplasticity, though it doesn’t cut through to the heart of the issue, and it means you can’t stop taking SSRIs. Now we established that hippocampal atrophy is the cause of many of our symptoms, and that the way antidepressants work is by stimulating neurogenesis, here is how you can improve your recovery naturally and safely, without the need to put your health under any further risks Stimulating hippocampal growth/neurogenesis/neuroplasticity First line of treatment is just some nutritional supplements Nutritional treatment for acute and chronic traumatic brain injury patients. https://www.ncbi.nlm.nih.gov/m/pubmed/24844176/?i=6&from=/24605947/related "omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, zinc, alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients may be helpful in the recovery from a TBI" Dietary supplement creatine protects against traumatic brain injury. http://www.ncbi.nlm.nih.gov/m/pubmed/11079535/ Study supporting Creatine consumption as one of the top supplements for recovering from a TBI, and the one below supports Taurine use as well. Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow. http://www.ncbi.nlm.nih.gov/m/pubmed/27156064/ Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. https://www.ncbi.nlm.nih.gov/pubmed/14695924 COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Table 1 and Figure 2 compare the distribution of children according to the number of seizure attacks per month, before the intervention, after one month, after two months, and after three months of the study. In the intervention group, it is quite obvious that the cases are significantly improving and the number of epileptic attacks per month is decreasing after starting the fish oil supplementation. The percentage of children having zero attacks per month increased from 0% to 57.1% at the end of the third month in the intervention group, while it only reached 2.9% in the control group. Changing diet Long-term effects of a ketogenic diet in obese patients http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ "Beneficial changes in the brain energy profile have been observed in subjects who are on a ketogenic diet (28). This is a significant observation because cerebral hypometabolism is a characteristic feature of those who suffer from depression or mania" Lifestyle choices and activities Meditation effects within the hippocampal complex revealed by voxel-based morphometry and cytoarchitectonic probabilistic mapping http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705194/ Mindfulness Meditation can stimulate hippocampal brain cell growth. A smaller hippocampus is correlated with a poorer recovery from TBIs, in the case of war veterans suffering PTSD at least. Mindfulness-based stress reduction (MBSR) improves long-term mental fatigue after stroke or traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/22794665 “CONCLUSION: The results from the present study show that MBSR may be a promising non-pharmacological treatment for mental fatigue after a stroke or TBI.“ The Effect of Mindfulness-Based Therapy on Anxiety and Depression: A Meta-Analytic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848393/ “Effect size estimates suggest that mindfulness-based therapy was moderately effective for improving anxiety (Hedges’ g = 0.63) and mood symptoms (Hedges’ g = 0.59) from pre to post-treatment in the overall sample. In patients with anxiety and mood disorders, this intervention was associated with effect sizes (Hedges’ g) of 0.97 and 0.95 for improving anxiety and mood symptoms, respectively. These effect sizes were robust, unrelated to publication year or number of treatment sessions, and were maintained over follow-up.” Larger hippocampal dimensions in meditation practitioners: differential effects in women and men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351565/ “Descriptively, left and right hippocampal volumes were larger, on average, in male meditators compared to male controls; they were also larger in female meditators compared to female controls (see Table Table1).1). The group-by-sex interaction was significant for the left hippocampus (p = 0.002) but not for the right hippocampus (p = 0.46). Conducting post hoc comparisons separately within males and females, left hippocampal volumes were significantly larger in male meditators than male controls (p = 0.02) as well as in female meditators than female controls (p = 0.046). Significant meditation effects with respect to right hippocampal volumes were not detectable in males (p = 0.722) or in females (p = 0.291).” Mindfulness meditation improves cognition: evidence of brief mental training. https://www.ncbi.nlm.nih.gov/pubmed/20363650 “ After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators.” Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/ Abounding evidence has shown that HBOT promotes neurogenesis. Future investigations need to be extended to models of neurological diseases, including subarachnoid hemorrhage (SAH), cerebral hemorrhage, AD, PD, surgical brain injury (SBI) and autism for cell proliferation, survival and differentiation. Furthermore, studies need to be conducted to explore whether HBOT induced neurogenesis leads to a functional improvement followed by large scale, strictly controlled clinical trials to establish HBOT as a prevention and/or treatment modality for neurological diseases. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. https://www.ncbi.nlm.nih.gov/pubmed/21118604 Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/ Dietary supplement creatine protects against traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/11079535 Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. https://www.ncbi.nlm.nih.gov/pubmed/19741313 Fish oil 3g x2 per day. It has very strong neuroprotective effects, and has been shown to control epilepsy in children. In animals it has been show to increase testosterone and improve sperm count Fish Oil Intake and Seizure Control in Children with Medically Resistant Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525390/ Effect of Long-Term Fish Oil Supplementation on Semen Quality and Serum Testosterone Concentrations in Male Dogs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948075/ Effect of dietary fish oil on mouse testosterone level and the distribution of eicosapentaenoic acid-containing phosphatidylcholine in testicular interstitium. https://www.ncbi.nlm.nih.gov/m/pubmed/28955915/ Zinc 30mg elemental/day Has been shown to have neuroprotective effects, improve male hormone profile, and improve liver health. If also taking iron supplements take at a different time of the day, because zinc can hinder iron absorption Zinc status and serum testosterone levels of healthy adults. https://www.ncbi.nlm.nih.gov/pubmed/8875519 Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout. https://www.ncbi.nlm.nih.gov/pubmed/21744023 Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. https://www.ncbi.nlm.nih.gov/pubmed/ Example treatment routine Creatine - increases Dihydrotestosterone (DHT) and testosterone, which is very important for PFS sufferers especially, while also increasing muscle power and improves neuroplasticity Fish Oil - improves joint pain, helps heart disease, reduces seizure incidence and promotes neurogenesis Zinc - increases levels of male hormones and improves neuroplasticity Magnesium - helps with chronic pain, fatigue and insomnia and neuroplasticity Vitamin D: Improves bone health, physical fitness, and improves neuroplasticity Meditation: Allows the body to better regulate stress, has been shown to increase happiness and reduce fatigue from social situations in stroke victims, and promotes neurogenesis. Yoga is also shown to help with mood and neuroplasticity, as well as physical health, so I recommend that if it is available to you CoQ10: Improves cardiovascular fitness and heart health, and ALSO improves neuroplasticity Multivitamin - makes me less likely to be malnourished. Taurine: Helps body avoid hypervitaminosis A, improves eyesight, digestion, heart health and improves neuroplasticity Ketogenic Diet: Improves body composition, can help ED, has been known to cure depression and anxiety, and improves neuroplasticity. I tried it for a Hyperbaric oxygen therapy: If this therapy is accessible to you I would also take advantage of it, though I haven’t done it. Many studies show it strongly promotes neuroplasticity Olive Oil: Improves hormones, displays neuroprotective effects, helps with constipation and antioxidents, improves wound healing and skin health, helps with depression and anxiety Edit: Olive oil studies Extra virgin olive oil improves learning and memory in SAMP8 mice. https://www.ncbi.nlm.nih.gov/pubmed/21955812 Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724295/ Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats. https://www.ncbi.nlm.nih.gov/pubmed/26168701 Extra-virgin olive oil preserves memory, protects brain against Alzheimer's https://www.sciencedaily.com/releases/2017/06/170621103123.htm It also helps joint pain https://www.ncbi.nlm.nih.gov/pubmed/25294776 Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. Depression and anxiety Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/ Constipation and antioxident profile The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.(only 4ml a day) https://www.ncbi.nlm.nih.gov/pubmed/25238699 Antioxidant activity of olive polyphenols in humans: a review. https://www.ncbi.nlm.nih.gov/pubmed/20209466 Alternative treatment routines Things that might help, but are on the riskier side and I am unlikely to attempt myself, but possibly would help The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. https://www.ncbi.nlm.nih.gov/pubmed/18173322 “High-frequency stimulation of the AN increases the hippocampal neurogenesis and restores experimentally suppressed neurogenesis. Interventions that increase hippocampal neurogenesis have been associated with enhanced behavioral performance. In this context, it may be possible to use electrical stimulation to treat conditions associated with impairment of hippocampal function.” Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. https://www.ncbi.nlm.nih.gov/pubmed/21940440 “Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.” Nootropic agents stimulate neurogenesis. https://www.ncbi.nlm.nih.gov/pubmed/19441945 Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610200/ Acupuncture stimulation induces neurogenesis in adult brain. https://www.ncbi.nlm.nih.gov/pubmed/24215918 Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055571/ "A strong enhancement of neurogenesis has been observed in various species following experimental ECS treatments [20, 21]. Several studies indicated a close relation between hippocampal function and mood regulation. The observation of an antidepressive-like effect and an upregulation of hippocampal cell proliferation upon experimental ECS raised speculations on the participation of neurogenesis in the antidepressive mode of action. However, evidence for a direct participation of neurogenesis in antidepressive mechanisms still remains to be convincingly demonstrated [17]. Conclusion Remember, there will be scars remaining from your specific syndrome, but after this cure you will no longer be trying to cure the whole brain fog, erectile dysfunction, depression, anxiety, injury-susceptiblility, and the continuous and inevitable deterioration of health that the doctors can't seem to pinpoint the cause of, and instead it will be merely the scars, such as back pain, eye floaters, the occasional sore joint, low T, and unlike before, your body will be able to respond and heal so even those scars may fade a little. Good Luck everyone!
  25. Hello. I recommend you view my other post before reading this one but if not it’s all good. Before I started accutane i had pretty bad facial redness. I fully blame benzoyl peroxide, and my dermatologist. I was prescribed BP at age 12 or 13 and i’d slather that stuff on my face. It has damaged it quite a bit. Anyways i’m on my last month of accutane switching between 80 mg to 120 every other day. My acne is cleared (just a few red spots from previous acne that should go away with time) and i’m happy with the results and only had the side effects like dry skin and what not. Anyways i’m still very concerned with my facial redness as i’ve dealed with it for literally years now. I’m very insecure about it. A few questions i’d love to be answered and you’ll be my hero. Will the redness fade with time? It’s not roasecea is it? Does my skin just need time to heal? Any products that’d help? I drink it’s of water and don’t eat to much junk food. Have fairly good diet probably more on the bad side though. Who does have a good diet at age 16 though hah. And i wash my face every other day (wash w room temp water every day though). But yeah jus pls help me out this is 5 months ago starting accutane this is me currently