- Last Month
I have acne scars on my face similar to what you have. Mine are clustered together running in a linear pattern above my facial hair on my left cheek. They are about 10 in total scattered randomly along the linear line. I also have 4 on my right cheek forming a bit of a circle. There are other smaller less noticeable pockmarks scattered around my cheeks, temples and forehead.
The sad truth is your acne scars are here to stay. Mine improved a little with time. I feel they are less deep as the skin tries to remodel itself over the years.
Your scars are not so bad, so I wouldn't try to treat them. It can make them a lot worse even if you consult with a highly recommended plastic surgeon or dermatologist. You have to learn to accept these scars. Best of luck.
2 hours ago, Sniffy said:
The Wound care market is huge and the potential is being recognised. Research teams coming from every angle now to crack that elusive scarring problem millions suffer. Its a very interesting time the next couple years.
FS2 showing promise at preventing scar tissue. I hope FS2 offers genuine results and a go to cream that becomes a household name for preventing everyday wounds from forming into scars.
They still are using very different wording to Polarityte. Take it as it comes i suppose they dont want to be using terms like regeneration or scarless healing right now. They are focusing on stopping scar tissue forming at all from fresh wounds and to lessen existing scars with just cream application and they did say it doesnt hinder healing with fresh wounds so in that sense it is allowing normal skin to heal and appear as normal skin again. I just havent seen enough pre clinical results for FS2 to get too excited.
Others have to go through years of viral or microbial infections. The wounds heal with scarring forming pits, raised skin, uneven texture or depressions. Acne, chicken pox and folliculitis are very common skin conditions that heal with extensive scarring for some individuals. There are other not so common skin conditions that also do this too.
Our bodies can heal without scarring however evolution switched this off for all mammals. It's a fast and easy repair preventing further infection. However, scarring is not ideal and creates more problems than anything. Scarring is also thought of preventing regeneration of limbs.
The medical community used to not give too much importance to scars and thought of them as a blessing. The body can close or repair wounds naturally, so its easy for them to operate on individuals.
Since the mid 1900s, body image become increasingly important however. Nowadays, it has reached unprecedented levels. Females must look perfect. There is a whole market out there generating billions on beauty products. For many, scars are imperfections and will go to great extent to cover them up. Cosmetic surgery has also reached unprecedented levels. Males also feel the pressure to look their best. Transgenderism is also a new reality. Tons of money are thrown away by women to improve the appearance of stretchmarks.
It was a matter of time before researchers would try to find a way to promote scarless wound healing than scarring. Many people have extensive scarring which cannot be addressed by any of the traditional cosmetic procedures or make up. Scars not only look ugly but they can also hinder movement in some cases and cause so many other problems.
Burn victims are quite impacted. Also, other human organs heal with scarring resulting in decreased organ function and possible failure again. This is why finding a functional solution to scarring has become more important than ever.
In Quebec City, they are already developing similar technology to polarity to help burn victims. The article is in french though. Just saying that the people behind SkinTE are just trying to market an idea already in use by others. The researchers behind this work at a prestigious canadian university, Laval University.
The article says that for just under 2$ dollars, a doctor can take a skin biopsy out of normal skin (only few skin cells needed) and grow normal skin in a lab in just under a few days. The skin is then grafted on open wounds. The same skin can be glued also and the skin will regenerate.
Pictured on the left is a man who was burned on over 90% of his body with boiling water. The burn scars are not that noticeable.
Seems to me that canadian researchers are really ahead when it comes to scarless healing.
1 hour ago, mjg713 said:
I thought Polarity was supposed to release their final results after this weekend after some sought of conference they had?6 hours ago, damnBOY said:On 01/10/2018 at 5:16 PM, nikki_gargin said:
video from birchbiomed last week. They say they want to release fs2 in cream topical form maybe next year.
3 hours ago, nikki_gargin said:If you read what I said, I said I don’t think skinte is applicable for acne scars because most acne scars aren’t full thickness. And like you said, no surgeon will cut out full thickness skin that isn’t damaged.
surgical and burn scars are different and therefore improvement is possible with skinte. Scars don’t have 3 layers. Just one block. So in that regard skinte is regeneration and cosmetically better than scar tissue. But proberly not cosmetically or functionally better than acne scars.
On 11/01/2018 at 10:09 PM, JhonnyBravo said:
I'm a 30 yr old fella and I would like to know what medical treatment / procedure I must partake in order to get rid of these white underskin pimples that cannot be squeezed. I have had these since I was a teenager and still remain unchanged. I was wondering if i can poke them with a sterile needle or where can I go to be removed by a doctor and how is this procedure called so I can do a search on the internet. Also does this desease have a name because I could not find explanations for my particular case.
Thank you!On 30/07/2018 at 6:47 PM, Banana8008 said:
I too have had the same similar white bumps on my skin since I was a teen. I seem to notice more of them here and there. I've tried several different things to attempt at ridding these pesky white spots, of course nothing seems to work. I have them on my back, chest, and a few on my neck and jawline. I've been told it's a few different things: some sort of clogged pores, oil trapped under the skin, and scars. Still waiting to see a dermatologist so I can find out what the heck these really are, they drive me absolutely nuts and they make me feel so self conscious.
There's no treatments out there that make scars totally disappear. You could pay a tons of money to resurface the skin with a bunch of ablative lasers. It might improve their appearance. The raised ones can be flattened with steroid injections but they will never disappear. Laser resurfacing can make everything a lot worse and steroid injections might shrink the scars to the point of forming pits on the skin instead. Therefore, finding experienced doctors is always recommended.
When an injury happens to the skin, the body tries to repair it fast, It doesn't care about aesthetics or the appearance of the healed injury. Some people don't get scars at all while others do. It's all genetics. When an injury happens including acne lesions, the body responds by either closing the wound with too much collagen forming a thick raised scar or not enough collagen creating pits or depressions on the skin. Anything that looks like depressions on the skin are classified as atrophic scars.
The scars shown on the picture can be anything from the following:
1) atrophic macules: these are scars left behind from healed cysts and nodules on the body. Initially, the scars are red, pink or purple and slowly turn ivory white over the years. They are generally flat but some may have a slightly sunken appearance on the skin as there is too little collagen. They are generally a darker color in the beginning because of all the blood vessels that are being regenerated underneath as the lesions heal. This is also known as hyperpigmentation that fades over time.
2) Papular acne scars or papular hypertrophic scarring: these are small slightly raised white scars that are soft to the touch and have a wrinkly appearance. They are formed due to loss of elastic fibers on the skin. They resemble whiteheads or small pimples that haven't fully evolved. They also go by other names like mid dermal elastolysis, follicular macular atrophy or perifollicular elastolysis. They are definitely scars. The body seems to flatten them over time as it tries to repair the missing elastic fibers but they never totally disappear. However, literature seems to suggest that after a few years, they disappear. I still have them for many years. They are related to another similar skin condition known as anetoderma. Anetoderma however happens spontaneously.
3) Hypertrophic scars: these are normal scars that everybody gets after a deep wound has healed. They are raised and lumpy with an excess amount of collagen, no hair follicles and no sweat glands. They might be painful in the beginning as the body tries to repair damaged neurons. Over the years, they become less lumpy and turn white. If the zit was large enough to create a deep wound, the end result will be a white raised scar.
Not much can be done for them today. Ablative lasers burn the scar tissue, go deep enough and the body responds by creating more collagen. This can create more scar tissue in the process. Non-ablative lasers don't go deep enough to provide great improvement on this type of scarring. Micro-needling stimulates collagen raising sunken scars. Raised scars can be flattened with steroid injections. This is the best treatments we have for scars currently. They also costs a fortune. Most health insurance plans don't cover the costs as it is considered cosmetic surgery.
We need to be patient and wait for a miracle solution that will make scars vanish one day.
- More Than a Month
36 minutes ago, nikki_gargin said:
are people seriously going to try and make it? Lol
On 09/09/2018 at 7:27 PM, 91baby said:
yes i think so, im not saying they dont work but in my case they're just not worth it. Most my scarring is shallow and widespread. Yes im starting to think its been the way to go for me the whole time. Wish i started peeling earlier. I actually wanted to peel with tca but the downtime is just not do-able for me at the moment so glycolic it is! Thank you that means a lot, hopefully cuter soon haha!
I'm on my 5th glycolic peel in 5 weeks so im thinking later on this week ill post some pictures to show my progress
I also suffered from cystic acne when I was a teenager and in my 20s. My face had many scabs, redness that took years to resolve and hundreds of cysts. Girls would often refuse to kiss me probably fearing of touching those cysts. My face hopefully cleared but now I have a few small pits on my cheeks, what we call ice picks.
I would like to try TCA cross. The biggest ones are 1-2 mm wide, particularly my left cheek has about 7 of them clustered together and they are quite visible. If I can at least improve these, then I believe I can tackle the other 3 clustered together on my right cheek. There are a few others scattered around my cheeks but are smaller than 1 mm, looking like large pores. I don't really care about those because my skin has very visible pores. Let's face it, nobody has perfect skin.
The worse of my acne was mostly on my thighs, sides of my back, shoulders, upper arms, upper buttocks and jawline. I have a lot of raised hypertrophic scarring, white pigmentation and small soft raised white spots on those body parts. I am conscious of taking off my shirt in public. My sides of my back, upper arms and shoulders are littered with these disgusting white raised scars as if I was burned by tiny acid droplets. In some places it looks like chicken skin. My jawline also has white raised spots which are prominent after shaving. There's not much right now to fix my scars.
My cystic body acne came and went in 3 phases. The first phase was when I was a teenager, very red tender nodules that healed with prominent scarring. The second phase began when I entered adulthood around 18, worse nodules that scabbed over. The last phase was in my early to late twenties, mostly smaller pustules that would come to a head. I believe it was all related to stress from school and very bad sleeping patterns. Lots of pain both physical and emotional from these stupid things.
I was prescribed a ton of medications but never went on Accutane for fears of going impotent and bald. I tried home treatments, different diets and a lot of different washes. I had mixed results. I just entered my thirties now, I can say my skin has almost cleared on my body but I have extensive scarring. I also have recurrent folliculitis from shaving or friction which makes everything a whole lot worse.
I hate acne and it took a lot from me. As a completely healthy individual, the last you want is to have a battle with your skin and enjoy life to the fullest. I only hope that someday acne will no longer affect us with its disfiguring scarring and disgusting pimples. I wear my scars with pride.
I can finally say I won the battle with my skin. I am starting to tackle the folliculitis as well.
54 minutes ago, FromScarredtoFree said:
I spoke to Dr. Sun and he was very nice and friendly. He told me he plans to include scarring in the clinical trials. Whether that means he will create a scar in a patient like some clinical trials do or allow people with preexisting scars to join is unknown at this point however. He also talked to me about the burn scars on his arms and how he understands the pain we go through which I didn't expect. I think for someone to go through the effort to cure scarring they have to understand what we go through because it seems like people with cancer or Aids have it worse. Also some unrelated good new that I found is while approval rates for drugs is very low (14%) approval rates for devices is much higher (60-90%) depending on what sort of Device it is classified. Sunogel isn't a life or death device (except maybe in burn victims) nor it is a permanent implant so it's likely it will be a Category II device putting it at a high chance of success if it shows efficacy. We should all endeavor to support Dr Sun as he seems to be the closest this form has ever gotten to an answer. Another interesting thing to note is that Dr. Sun put the whole recipe of his hydrogel in his last paper. To all the super desperate people, you can always make the hydrogel yourself and let us know how it works. XD
Skinte has fallen into even deeper problems it seems as one of their officials was caught doing shady business in other companies. Also Mark Cuban from shark tank admitted he's selling short on it which doesn't help their publicity. But they plan to release clinical results at some sort of a convention soon if anyone is still following them.
They seem to be still going on however and about to publish new results in a few days. Hopefully, then we can finally figure out what they actually are. Investors are slowly pulling out. A year has passed since clinical trials begun so those wounds it was tested on should be healed up and a little red. I do believe their method can truly replace skin grafting one day but they can't do much about scarring. However, they face stiff competition from upcoming 3D skin bio-printing start-ups who are using similar methods.
Sunogel looked promising from the start because Dr. Sun tried to develop something for scars for such a long time. In previous tries, he failed while partnering with other researchers. He went on his own and seems to have developed something to minimize or eliminate scars however we only have a pic of a finger cut to judge. Small cuts heal nicely with barely any visible scarring. Clinical trials should start hopefully next year as planned.
There are a few anti scarring drugs currently in clinical trials. FS2 is currently in phase 2 clinical trials in North America. The drug which can be injected, taken orally or used as a topical is believed to reduce existing scars and to eliminate new scars from forming. In the UK, OLX101 is in phase 1 clinical trials and phase 2 in South Korea. The makers behind this drug claim to have found a way to inhibit the processes that keep existing scars from going. SCX-001 is in phase 1 in Canada. It is a nefopam based scar cream said to reduce scarring. All these drugs seem to be targeting hypertrophic scarring and not necessarily atrophic acne scars. These drugs can take up to a decade to be marketed.
On 04/09/2018 at 9:07 AM, RandaATX said:
Thank you Anonymouz1 !!!!!
Your story and experience is EXACTLY what I’m going through and I can’t find anything useful. It’s comforting to gain a bit of knowledge while we’re waiting on the dermatology community.
Mine started around age 30 (6 years ago.) I’ve NEVER had bad acne, barely any at all. A few pimples will randomly occur alongside these and I regretfully popped/picked at them so I assumed it was the consequence. But the bumps don’t ever head or have pus, so I assume it’s not traditional acne, but related. I can see hair and healthy pores so that’s a good sign. It flares up in cycles, some go away.
Best I've found is to use sterile tweezers and unclog the pore from underneath, but that sometimes backfires. So I’m going off the assumption that it’s the acne bacteria.
Fingers crossed that there’s soon more research on follicular atrophy (?) and we’ll find some answers and treatment.
Thank you again, you’ve helped me sooo much.
What you describe seems to be related to yet another common skin condition known as keratosis pilaris. Its not acne at all but is due to clogged pores as well. The skin produces too much keratin which blocks the pores resulting in little red, black or white bumps which resemble blackheads, whiteheads or little pimples. Many people have this condition and refer to it as "chicken skin".
The condition doesn't leave scars behind unless you pick at the bumps. Picking makes you more prone to infection. The bumps become bigger and inflamed. Once the skin heals, scars can form and hyperpigmentation can last for months.
Some people change diet and the condition improves while others use topical creams with mixed results.
This is what keratosis pilaris looks like.
This is what mid dermal elastolysis/follicular macular atrophy or perifollicular elastolysis looks like.
All of those terms are commonly used to describe a type of acne body scarring following healed cysts and nodules. Mind you new terms have been recently introduced by dermatologists. Medical literature calls them papular acne scars or papular hypertrophic scars now. Some people have these scars on their jawline and chins. They are rarely found on the face however.
Here's a better picture of what these scars really look like.
These scars are similar to yet another uncommon skin condition known as anetoderma. It looks like this.
In anetoderma, the elastic skin fibers are damaged spontaneously resulting in sunken or raised patches of skin. When stretched, the lesions vanish. It can take years for the lesions to develop. The condition can be progressive, slow or rapid. Scientists have been working hard to find the cause behind this but don't seem to have a clue yet. Anything from an auto-immune reaction to staphylococcus bacteria have been proposed. There are no treatments and a cure seems to be years away.
Follicular macular atrophy is a scarring process following healed nodules and cysts. The healing outcome has similar properties as anetoderma. The elastic fibers of the skin are damaged resulting in raised or sunken patches of skin. These scars are often confused with hypertrophic scarring. The only way to tell is that hypertrophic scars are thick and dense while these scars are soft to the touch and disappear when stretched.
My back is a lot better than the pic I posted above however I've got many of these raised spots like Anymouz1. I have them on the sides of my back, shoulders and upper arms. I've also got some on my thigh and jawline.
Like Anymouz1 suggested, tanning makes them less noticeable but I also suffer from keratosis pilaris on my back. The bumps tend to blend with the acne scars which makes it hard to tell if I have keratosis pilaris or an acne scar. Like Anymouz1 mentioned, some lesions have flattened over time, some have not changed however. Current treatments don't do much. Steroid injections can flatten them. Ablative lasers remove the top layers of the skin, so may remove the loose skin altogether resulting in a smoother skin appearance after healing. I haven't had any treatments myself on these scars.
I've also read that a new treatment using a hyfrecator can burn the loose skin off. The lesions therefore become invisible.
4 hours ago, golfpanther said:
We're working together to hopefully make a video promo for Sunogel. Thus far we haven't gotten too into the weeds, but he remains confident that the product will work, even if it needs optimization at some point.
20 hours ago, FromScarredtoFree said:
I just wanted to add as a grad student it really bothers me when people say that things like Sunogel and Skinte are scams. I work in the biochemistry field and believe me no one goes into it to get rich. Almost everyone that studies something at a graduate level has an extreme amount of passion in their field and genuinely wants to help people. I've seen lots of my peers in business get rich with a bachelors. While studying for a PHD or Masters we are paid a near poverty level wage while we spend our youth studying seemingly obscure medical and research articles and doing boring but intellectually challenging lab work. After getting our credentials we have very little job prospects other than working in a lab or teaching. We are essentially dedicating our lives to a subject. For a scam artist to spend 8+ years in field studying a field and getting PHD is unfeasible to me. I think Dr. Sun is a guy who genuinely wants to help people with scarring and we may have a solution finally after 11 years of this forum.
14 hours ago, FromScarredtoFree said:
Lots of medicine is discovered by mistake and that's a good thing. Costarelis made his breakthrough scar discovery while he was studying hair loss. Penicillin was discovered by mistake and it changed the world. To say that we don't know how accutane works doesn't really make sense. It permanently shrinks sebum glands therefore slowing acne bacteria production.
Are you aware that we already have gene therapy now that is FDA approved? Luxturna is a gene therapy for hereditary blindness that was FDA approved. CRISPR is slowly becoming ready for humans. We don't know everything about genes but we know a lot more than we used to and we learn more everyday.
Also I don't get why people say there is no cure for cancer or baldness. I discussed cancer in my previous post but there are many drugs that are effective in stopping balding and hair transplants are very effective. What do you mean by cure? Do you think there will be a magic pill that will make acne scars disappear? Probably not. Will it be cheap? Also probably not. But I think there will be some sort of solution within 10 years.
Severe acne leaves behind ugly scars and potential disfigurement. Most of us with a bad acne history have scarring to some extent.
Researchers have been trying to get an acne vaccine but they have failed. There's a leading dermatologist in California working on such a vaccine. The vaccine targets not the acne bacteria but rather its by-products which trigger body inflammation and produce pimples. The reason why most of us get acne in the first place is because of inflammation triggered by our own body. Others don't get this inflammation, their body doesn't go into defense mode in the presence of acne bacteria and just get regular blackheads time to time.
Acne products and the acne fighting industry generate millions through false advertising. Why would they invest money to stop acne in the first place. Acne is not life threatening. Most of the population, doesn't have the severe form of it. Only a few of us will get severe acne. Also, scar treatments are now generating millions for many unethical dermatologists and plastic surgeons. Do you think they want some scientists to find a way of restoring scar tissue into the normal basket weave pattern skin with sweat glands and hair?
The only way I believe of getting rid of our acne scars forever is when somebody finds a way of restoring normal skin for burn victims and preventing fibrosis in human organs. Only then can they expand into treating skin scars. This can take years to achieve unfortunately.
Small start ups are already taking baby steps. We have the South Korean company OLIX with OLX101 currently being in clinical trials in the UK. We have Canadian scientists in Vancouver testing out FS2. Both of these products reduce or eliminate hypertrophic scarring as they claim. Scientists have also discovered the FOXN1 gene which is actively involved in producing scar tissue to close up wounds. Cotsarelis and Pilkus published an article on how they found a way to prevent scars. We also have the less talked about SkinTE nowadays which promised so much but left us disappointed. And of course, we have Sunogel which has yet to go into clinical trials. Skin 3D printers are also rolling out.
Modern medicine is certainly more advanced than it was 20 years ago and will only get better. However, we need to take into consideration that a new drug or new technique can take at minimum 10 years before being approved by government health agencies like the FDA around the world. Also, most of the time governments in place will block approval for many new therapies because of ethical, religious or even economic reasons, corruption comes to mind. Exporting these new therapies to other countries also takes years. Many developed countries have also very poor health care.
I can only hope that within 20 years, acne and its scars will be a thing of the past so no one else will have to go through the embarrassment of having cysts and ugly acne scars like most of us have to deal with. I would be a bit too old to care about my acne scars by then.
3D skin printing will soon be a reality replacing current skin grafts. It is still not scarless healing but a step closer.
10 hours ago, FromScarredtoFree said:
I was talking about soft tissue organs but you are right bone also regenerates.
Also another point I wanted to make is what if new technology comes in a few years that isn't "scarless" healing per se. Everyone on this forum agrees that acne scars are a cosmetic problem, so what if a new treatment comes along that can camouflage or or flatten scar tissue to the point that it isn't visible. Personally I had filler done and it worked very well to me to the point where I can't see my scars when I shine a flashlight on my face, but I realize filler might not work for everyone because of tethering, atrophy, fat loss, and other variations. But what if the next big filler can flatten scar tissue or change skin pigmentation. Fillers are one of the biggest beauty trends now and a ton of money is going into research. Also there are so many companies fighting for the top spot and currently researching the next generation of fillers like Juvederm, Restalyn, Beletero Ect. While scarless healing is a great thing to strive for, most people on this forum don't need it because we don't have issues with scars like contractures or lack of sweat glands. Most of the problems are from the cosmetic results of our scars and as such we only need a cosmetic level solution.
When it comes to fillers, they work well for depressed type scars like rolling or boxcar. There is fat loss in rolling scars. Also, there's too little collagen in these atrophic type scars like boxcar or ice picks. Fillers help with these voids and even out the skin. Fillers are however temporary not permanent. They don't work well on ice pick scars. Most of us have ice pick scars. There's a new method right now that has to be approved by the FDA where they inject your own body's collagen to inject into these depressions. They are trying to develop a permanent filler. This might help greatly.
Also, many people with facial acne develop severe body acne on the chest, neck, shoulders, back and upper arms. Acne on these areas tends to be aggressive and widespread. After the pimples heal, the skin is covered by scar tissue mostly hypertrophic or atrophic. Fillers can help for atrophic scars but it doesn't make sense to get fillers on depressed acne scars on your back.
Fillers do nothing on hypertrophic or keloid scars. Keloids tend to cause severe disfigurement, excess hypertrophic scar tissue. Steroid injections flatten hypertrophic scars. Keloids tend to return after being manipulated even worse than before.
For some individuals, acne can leave them disfigured especially if they develop keloids. We can't truly say acne scars are purely cosmetic.
4 hours ago, Rez77 said:
Yeah I talked to a scientist at MIT who works in Tissue Bioengineering.
He said the type of things that would lead to total scar remodeling won't be a reality for another 50 years.
That's what he said and I challenged him talking about all the exciting research and he said this is all research for it to first even be found there would need to be several quantum jumps in terms of finding sources with which to actually generate enough cells from stem cells and they're not even close to doing that yet. And then for it to be developed into a therapeutic device or application would take us way past 2040. He said there are tons of unethical start-ups who are promising all sorts of things but they're just pie in the sky hopes that they'll get enough funding to last through the next decade till they can try and post some new discovery. He even said the ugly truth about hair cloning and regeneration is that its at least 20-30 years away.
I just thought it you guys should hear this from a scientist directly involved in the university level research on skin remodeling. THis at least helps me take a deep breath and stop following this thread which I have been very active in previously. I'm sorry I cannot post something more optimistic but I'm posting what I've heard. Its a tough pill to swallow, but at least it helps me accept my scars and stop wasting the rest of life hoping for something that won't come in time for me to still enjoy my youth, which is already half gone anyway. I've been with this thread since 2007 and now 11 years later with no single improvement whatsoever, its time to realize why and stop hoping. Sometimes its just better to know when to quit. Sorry guys.
You have contributed in the past and sometimes it seemed that your scars caused you a great deal of distress. Accepting them, will help you tremendously.
I agree with you that scarless wound healing can take decades but its not because scientists don't have the capacity right now to do so. As you mentioned, it's because of the time it takes to develop a method, drug or device that can take so long. Clinical trials to product development takes on average 10 years provided the clinical trials don't fail. A lot of time, the clinical trials stop because they don't have the funds to continue.
Scientists are already using gene therapy, as experimental treatments. They are already growing human organs in labs for transplantation. They are using stem cells to cure certain types of diseases in young children. We have come a long way.
Scars are for the most part aesthetic. Its only normal to attempt to find functional cures to disease using tissue engineering first.
I truly believe within the next decade, a topical cream or drug will exist that will improve the overall appearance of scars. Right now, we have none.
Wound healing is complex and still not well understood. What we do know is that scar tissue is the normal outcome of a healed wound. Once the dermis is injured, the new healed skin will not be the same as to pre-injury.
Issue is that fibroblasts tend to fill in the gap in order to close the wound. The faster the wound is healed, the less scar tissue is formed. Once the skin is injured, fibroblast cells begin laying down collagen in a different direction. A scab is formed to protect the wound. Fibroblast cells are few in numbers generally awating for an injury to happen in order to begin repair.
Too much collagen leads to thick scars known as hypertrophic scars. Almost everyone will get this type of scar if the wound is large enough. The fibroblasts turn into granulation tissue over time which fill up the wound. Scar tissue is basically matured granulation tissue lacking hair follicles, melanocytes and sweat glands. If the wound is small, fibroblasts tend to die out and white cells eliminate them by phagocytocis. The regenerated skin would look exactly the same as to pre-injury. Essentially, it seems the body cannot eliminate all these fibroblasts if the wound is large enough. Over time however, the scar might become smaller or significantly fade as the body attempts to reorganize the collagen by eliminating all these fibroblasts.
For some people, the fibroblasts multiply exceptionally resulting in excess scar tissue. This is considered abnormal healing and a disease. These scars are known as keloids. Some doctors consider keloids as tumors as they multiply abnormally just like cancer cells.
Too little collagen results in atrophic scars. These regularly develop after moderate or severe acne or othe skin diseases. They result in skin depressions.
Modern medicine has developed some methods to elevate the skin depressions by injecting collagen or promoting new collagen by re-injuring the skin. The outcome of the procedures depends on each individual.
Thick scars are injected with steroids which seem to flatten them or laser therapy can burn off some of the repaired excess skin resulting in a flatter smoother scar. However, thick scars tend to regenerate into even thicker layers if they are touched.
Researchers already know that the FOXN1 gene is involved in keratin expression and regulates wound healing. What the researchers found accordingly to the article is that there is higher activity of FOXN1 in healing wounds. Inhibiting the gene might prevent scars altogether. My assumption would be that FOXN1 regulates fibroblasts. More fibroblasts means more scar tissue. Less fibroblasts means less scar tissue. However, our skin heals with the aid of these cells which produce collagen in order to help close wounds. Manipulating FOXN1 might tamper the body's natural healing ability.
Cotsarelis and Plikus found a way to turn fibroblasts into fat tissue or adipose tissue which seemed to signal skin regeneration of hair follicles and sweat glands. The research was published on Jan 2017. There's nothing new to report from them ever since. They had intentions to launch clinical trials but over a year has passed and they seem to be quite silent ever since about their findings. I believe they truly hold the answer to scarless wound healing.
A cream or drug that helps turn existing scar tissue into normal looking skin again is the way to go.
WNT signal pathways control cell growth. Tampering with WNT signal pathways leads to uncontrollable cell progression or proliferation resulting in cell overgrowth and higher chances of abnormal cell growth resulting in cancer.
With all the research going on right now in an attempt to eliminate scarring, we can only hope most that the products being currently tested do not fail like Juvista.
So lets get back on topic. Researchers have found the gene responsible for scar formation in Poland. Take it for what's worth.
39 minutes ago, Anish004 said:who are you to judge how severe my scars are ???come meet me.. i will show u my scars
i dont have any blackheads..i have many moles on face..i dont have ice picks but circular pox scars...AMVC scar and extra stretched pores
this is the reason why i left this thread times ago and join more fine persons on group messages and they are much better than immature people on this thread who just came months ago on this thread and started judging others....there are some peoples who are on this thread and forum for more than 10 years and you guys just keep talkinf about % improvement ...oh i forgot go get fraxel for your % improvement...and dont judge my scars....i dont like them and they appear disfiguring to me thats why i am here..... cant u see thats very good lighting and i have mainly scars on my nose
and my cheek scars only appear in index lighting and this pic is in full lighting
You have at most 1 or 2 ice pick scars which as you said are from chicken pox. Everybody has a chicken pox scar somewhere on their body. These atrophic scars are easy to treat with permanent or temporary fillers and even subcision. You do not get 100% improvement but you can get as much as 90%.
Some people have enlarged pores. This is just genetics. Get over it. It's not disfiguring. It's like having freckles.
AMVC is rare random scarring and not caused by acne or any other skin condition. In fact, it's not scarring at all because there's no fibrosis going on. It seems it's a genetic disorder affecting skin elastin of the face. It is similar to anetoderma which occurs on the body. Even if someone finds a way to regenerate skin, your issue has to do with skin elastin not scar tissue.
Some people develop another type of acne scarring known as follicular macular or perifollicular elastolysis on the body after severe acne. Again, elastic fibers are affected but you also have fibrosis going on.
You have very minimal scarring. Go enjoy life.
33 minutes ago, FreddiHendersson said:@Anish004 Are you kidding me?! Where are your SCARS? Live your life, Bro
You'll find many trolls, others here with low self esteem or serious mental health. All you can do is offer advice and try to help.
I don't believe Anish has severe acne or acne scarring for that matter. All I see is some blackheads that can easily be cleared with some over the counter creams or by a dermatologist. There may be 1 or 2 ice pick scars but those are nothing really to cry over.
2 hours ago, SimpleMutton said:
Let's be honest, there will be no cure at least for 10 years.
I decided to tattoo over my scars in my back and hide them that way.
Every product in development is either still in clinical trials (and take years) or plainly doesn't work for acne scars.
Good luck everybody
With time, the scars get better but that's what severe acne leaves behind. People, especially many parents don't seem to think of the potential disfigurement to the skin it may cause.
Prevention is the best way to avoid the scarring. As a teenager, your parents might tell you it's just a phase. Accutane has too many side effects. Girls can take birth control but as soon as they stop it, severe acne manifests itself.
The best way to deal with acne is finding a functional cure. It is also in development and can take years. I guess, as a teenager if you have severe acne, you might as well accept the permanent skin scarring or take the Accutane route exposing yourself to other potential side effects to minimize future scarring. For most however Accutane gives them back their life.
I have my back and shoulders covered with these strange white wrinkly looking slightly raised scars that resemble little whiteheads. I also have a few on my jawline, thigh and upper arms. Some are large but most are small. They look better or worse as light conditions change. My face has a few ice pick scars as well.
I am an acne sufferer for close to 25 years. My skin condition has improved and the old scars are less noticeable. New pimples don't leave scars and resolve in about a few weeks with redness gone within a month. I never took Accutane and never went for any scar treatment but my skin condition has caused me great despair and limited me from doing fun activities as a young adult.
My skin is clear now and its the best it's ever been but the scars are a constant reminder of the my acne battle.
FS2 looks promising but let's hope it doesn't fail like Juvista.
4 hours ago, mjg713 said:
Any new information on the research done by Dr. Cotsarelis? Wasn't the method he discovered proven to be 100% effective in preventing scarring?
Seems to me that the medical community has more important things to find a cure for than finding something to minimize or prevent scarring. It's important to note that scarring is a normal healing process and not a disease. It will take time before something comes around that regenerates skin as it was before.
It sucks for us acne sufferers and acne scarred individuals who wished their skin was blemish and scar free.
I have been suffering from back, butt, face, thigh, upper arms and shoulder acne for many years. My skin has gotten better with time however I have a collection of acne scars covering different parts of my body especially tiny white slightly raised spots on my back, thigh, upper arms, shoulders and jawline. If I had a random spot here and there, it wouldn't be a big deal but I have collected a substantial amount of these throughout my cystic acne years.
I really hope FS2 doesn't fail as it seems to have taken the lead over all the others promising scarless healing in fresh wounds. Issue here is that it's a drug and can take time to see it ever being prescribed provided it doesn't fail.
Well, I guess the forum has become silent over the past few days. No news from SkinTE. I looked at Polarity's stock and it has taken quite a plunge which suggests that it may be a huge failure.
I would like to give an update on different anti scarring drugs, creams or devices currently in development to prevent or eliminate scarring.
These products are as follows:
FS2 is currently in phase 2 clinical trials. Mind you almost 50% of all experimental drugs fail at this stage. FS2 is licensed to the University of British Columbia in Canada.
It apparently has the power to eliminate scarring in fresh wounds and improve the appearance of existing scar tissue. It also prevents type 1 diabetes also known as juvenile diabetes. Phase 2 of the clinical trials will help drug developers determine if it improves from 40 to 90% existing scar tissue.
If successful, it can take long for such a drug to be sold.
Initially, they had created another anti scarring drug known as Fibrostop. It passed phase 1 clinical trials but ultimately failed.
ScarX Therapeutics is developing a anti scarring cream known as SCX-001. They are currently in phase 1 clinical trials. Apparently, their product improves scars by up to 50%. They are based in Toronto, Canada. Their product is being developed from Nefopam. Nefopam is a painkiller currently prescribed.
Elastagen based in Sydney, Australia were behind developing a product known as tropoelastin. Elastin is a naturally protein found in the skin which gives skin its elastic nature. They were sold in February to a bigger company known as Allergan, a maker of Botox. Their product is designed to treat stretch marks and acne scars. Allergan has been quite silent about the product ever since they acquired it. There are clinical trials underway.
The developer seems to be lacking the funds to proceed in clinical trials. Sunogel has been discussed on this forum heavily. No need to provide further details.
Α) There is also research that was done which suggest some proteins or molecules help with reducing scarring.
Researchers have found that Decorin, a human protein, reduces hypertrophic scarring if applied on fresh wounds.
Galecto Biotech seems to have developed a product to prevent lung scarring. If successful, it can possibly be used on skin scars.
C) Products currently available that may help with scar reduction.
D) Notable failures
1) Avotermin (Juvista)
Juvista failed in phase 3 clinical trials.
According to this research, inhibition of TGF-β3 reduces scar formation in humans.
In conclusion, we may have too wait a little longer to rid ourselves of acne scars.