Frage

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  1. @guitarman01 No, it was not the doxycycline that had anti-aging and epigenetic effects. They genetically engineered mice using a "OSKM polycystronic cassette" process that allowed those mice to express the OSKM genetic factors, OCT4 SOX2 KLF4 MYC, when doxycycline was exposed to them. Normally, doxycycline will do no such thing. The best part about this study, and why the people at the salk institute and others in this field believe this could be in clinical trials in the next 10 years, is that this method showed that OSKM factors can modulate epigenetic topography without inducing a pluripotent state. Cause yeah, tumors and stuff. So basically, they made the epigenome of old cells appear like one year old cells without changing that cells assigned type (it did not become pluripotent). If researchers can figure out how to replicate this process for humans, without using a polycystonic cassete method of course, well thats the end goal. And if PAS is epigenetic it could be very beneficial for us. I've heard about the growth arrest possibilities of accutane, especially to those who took it during development. That includes me. But I currently look like an aids patient post accutane. Terrible thin wrinkly skin, facial fat changes, dark circles under eyes, dry skin. Happened nearly overnight for me when I had a crash of sorts. Don't know why some people get this and others don't, but it's not all that uncommon among pfs and pas people. So in some ways PAS can make you look young, in other ways it can age you quickly. Its going to be a long time until we fully understand this disease and why these things exactly happen. I think all we need to know though is the general idea of what has happened to us, and then look for treatments that broadly correct that. What I mean is that, we don't need to know every detail if we know enough about the root cause. If we know that pfs is at the root epigenetic or apoptosis related, then we don't need to know all the details to get benefit from OSKM factors treatments. This is the benefit of a lot of SENS technology I've been looking into. At the same time, that technology may be years away. It might be that insight about the details of our disease are found that allow us to use conventional treatments before then. But I haven't found many conventional treatments that might correct the root cause of our issues (being epigenetic, apoptosis, immune related). And this is because most of conventional treatments require intimate knowledge of tons of metabolic pathways, or other feedback systems, or something other. And we can never hope to understand every singe effect accutane has had on us. So at most, I think most conventional medicines can only help correct downstream effects. And I know I haven't defined "conventional treatments" well, but hopefully my point makes it across. Pretty much what I'm doing above Also , a good starter about genetics is the book, The Epigenetics Revolution - by Nessa Carey. You can find it on Library Genesis: http://libgen.io/
  2. Fresh out of the world of anti-aging, I found these studies particularly interesting to our predicament because of the epigenetic nature that we could be in. Heres an article: http://longevityfacts.com/regenerative-reprogramming-aging-researchers/ The study the article refers: http://sci-hub.la/http://circres.ahajournals.org/content/122/1/128.full The mouse study:https://sci-hub.la/10.1016/j.cell.2016.11.052 Basically, some researchers were able to "modulate epigenetic topography" by inducing yamanaka factors, genes associated with inducing pluripotency, in specific ways and times. Food for thought, but maybe lacking practical relevance. They used genetically modified mice that would express these yamanaka factors when exposed to doxycycline. One day though
  3. Interesting video: might help in managing symptoms. I wonder how it works, but I'm too brain dead today to look into it much further. Haven't been able to really sleep in days. Fuck this disease https://www.youtube.com/watch?v=n2IHbHTqjLo Edit: I guess theres just something alluring to me about injecting a solution of pig brain peptides into my deltoid? Ha! Edit2: And then again, a few users who tried cerebrolysin in this longecity forum, had some very severe reactions to this drug. Reactions that actually kind of share some similarities to PAS interestingly. (Disassociation, 0 libido, brain fog, anhedonia, insomnia). One guy in the thread claims to have got the same sides from ssri use, which brings pssd into my mind. Oh boy. Well, thought I'd at least add that addendum before knocking myself out with benadryl. http://www.longecity.org/forum/topic/65682-cerebrolysin-adverse-effects-advice/
  4. Another pfs guy, Kentucky, also seems to have recovered to a good level: http://solvepfs.com/viewtopic.php?f=5&t=1865&p=29415&hilit=kentucky#p29415 A guy named BP7667 over at propeciahelp only had very slight improvement. The procedure he had though seems alot different from the others mentioned: http://www.propeciahelp.com/forum/viewtopic.php?f=5&t=5387&start=260 (Less volume of stem cells Intravenously) Theres others who have claimed results over on that site too. Of course the only thing stopping people from doing this is the cost. Around 20k to do the whole thing in panama. But this is the most promising thing I have seen, by far. If I had 20k I'd do this in a heart beat. And I think I plan to. Is this sane? Obviously I'm convinced. Jesus people these feats seem like miracles What about people on this thread? I see its been discussed a lot. Even people on pheonixrising have had success with this, to an extent. Edit: Why is there such little information around about Neil Riordan and this company? Then theres this stuff that screams scam:
  5. Anyone see this: Mel Gibson and Dr. Neil Riordan talk about mesenchymal stem cells and their success in treating things from physical injuries, to autoimmune diseases, to autism, to even more. Some of the pfs guys have had Adipose stem cells from their body fat injected into them through IV and miraculously saw significant improvement. Joetz did, Brazilliandude did. What ever happened to this? edit: I see now, like anything else, adipose stem cell therapy has had varying success for pfs. Still, I feel like almost everyone whos tried it has seen some benefit. And I'm unaware of anyone who has had mesenchymal stem cell therapy. Will have to think about this more.
  6. @Kitte Good luck Kasia. Fasting has helped some in the past and is something that interests me. Here's a study where a fasting mimicking diet was shown to regenerate beta cells in the pancreas: http://www.cell.com/cell/abstract/S0092-8674(17)30130-7. This could be a potential cure for diabetics, even type one diabetics. Crazy. A suggestion though, maybe start with a 4 day fast first before jumping into a 21 day fast. It would both be safer and maybe as effective. It seems the benefits of a fast come during the re-feeding after the fasting period. During this period there is stem cell generation and HDAC inhibitors like butyrate that hit relevant molar levels and all kinds of promising regenerative things. I know I need to look more into this, but a 21 day fast is a long time without giving your body nutrients.
  7. Yo mods. I know gladiatoro is an accutane victim as well, but this behavior is just ridiculously idiotic and unhelpful. He's on this forum talking about how he could beat up better and fuck better than anyone here. Does he not realize that this thread is full of people with physical and sexual disability due to this drug? For some people, whatever woopass he could dish out would be a minor nuisance compared to what these victims deal with daily. I don't care if he was born being an idiot like this or if accutane has fried his brain and driven him mad, please take charge against this moron.
  8. @Dubya_B apoptosis. Haven't heard of that one. How does that theory go? I'm afraid a large reason industries like big pharma have this dangerous corruption, despite being filled with a lot of people who mean well, is because of how they are set up. Research is expensive, drugs need to make money, anything out of the norm is doubted, and as long as someone is not significantly effected by the industry, they have no reason to investigate further. Most people just assume all is well, or atleast close to it. Maybe even among experts who know these things, what would you do about it? One day it may be that science prevails. Good science by inquisitive minds who are able to see what others have seen, but think what others never thought. But it will require a fundamental change in how the pharma industry works. Maybe even governmental change as well. Hope I get to see it, but I have my doubts too. Just read this in a book, could this kind of apoptosis prove a problem to us? " In the rich parts of our planet the diseases that kill most of us are chronic. They take a long time to develop and often they take a long time to kill us when they do. Take heart disease, for example – if someone survives the initial heart attack they don’t necessarily ever go back to having a totally healthy heart again. During the attack some of the heart muscle cells (cardiomyocytes) may become starved of oxygen and die. We might imagine this would be no problem, as surely the heart can create replacement cells? After all, if we donate blood, our bone marrow can make more red blood cells. Similarly, we have to do an awful lot of damage to the liver before it stops being able to regenerate and repair itself. But the heart is different. Cardiomyocytes are referred to as ‘terminally differentiated’ – they have gone right to the bottom of Waddington’s hill and are stuck in a particular trough. Unlike bone marrow or liver, the heart doesn’t have an accessible reservoir of less specialised cells (cardiac stem cells) that could turn into new cardiomyocytes. So, the long-term problem that follows a heart attack is that our bodies can’t make new cardiac muscle cells. The body does the only thing it can and replaces the dead cardiomyocytes with connective tissue, and the heart never beats in quite the same way it did before. Similar things happen in so many diseases – the insulin-secreting cells that are lost when teenagers develop type 1 diabetes, the brain cells that are lost in Alzheimer’s disease, the cartilage producing cells that disappear during osteoarthritis – the list goes on and on. It would be great if we could replace these with new cells, identical to our own. This way we wouldn’t have to deal with all the rejection issues that make organ transplants such a challenge, or with the lack of availability of donors. Using stem cells in this way is referred to as therapeutic cloning; creating cells identical to a specific individual in order to treat a disease."
  9. Isn't this more epigenetic guys? Theres people who have took one pill and then the next day have full blown pfs. Depression, brainfog, etc. Something happened in that short time period that turned a perfectly healthy person into a chronic sufferer of countless symptoms. Gut isn't the cause of this, but definitely another damaged area. If the 19th century was the era of evolution, and the 20th century the age of DNA, then the 21st century is the era of epigenetics. Is there any other cellular memory that could explain the persistent radical changes that has happened to some of us? Its unfortunate that epigenetic treatments are in such an infancy. I want to look into other diseases that are using epigenetic ideas as treatments, even if there just therapeutic treatments, but there is such little information as to what has happened to us. How could we possibly approach a cure when we have nearly zero data? Wish I had money to throw around. Wish I had a lot of things. Like a time machine. All I know is I can't wait for more studies to come out. And I feel like I have to keep trying things, it's like how I cope, but I've become scared of anything that interacts with the 5ar or androgen receptor. Even the glycine I've been using. Don't want to make myself any worse. Its got to be epigenetic right? The new Milan study is looking at specifically epigenetic effects AND the Baylor study is. http://www.pfsfoundation.org/news/possible-epigenetic-changes-pfs-patients-focus-new-clinical-study/ http://www.pfsfoundation.org/news/clinical-study-of-post-finasteride-syndrome-launched-at-baylor-college-of-medicine/
  10. PFS people have. Here for example:http://www.propeciahelp.com/forum/viewtopic.php?f=4&t=11372 But I think most PFS people have low progesterone, as the melcangi study identifies.
  11. @guitarman01 The second guy I mention went by the name of quantumfaith over on solvepfs. http://solvepfs.com/viewtopic.php?f=3&t=1213 The first guy I couldn't find where I read it. I could be misremembering because I know I thought I read that a long time ago. Found out the administrator of propeciahelp, mew, had a case of gastroenteritis. Although, his experience was much different from mine. http://www.propeciahelp.com/forum/viewtopic.php?f=1&t=10145 I need to calm myself down and wait and see. Edit: @Iamme. year post tane
  12. Yeah, bandaids.Thats almost all I'm in search of at the moment. Safe supplements and medications that make life a bit better while research continues on this disease. I am sure I will be seeing a doctor or two regarding this in the near future. Yet it has been my experience that most doctors are nearly useless when it comes to even treating the symptoms of our condition. I was hoping someone had kinda already been there done that on this topic and had a suggestion or two. LDN? Dopamine blockers? Part of me has a feeling its going to be hard finding a doctor who might have some good insight into these gastrointestinal problems and accutane.
  13. Hey, so anyone have stomach issues where it seems like food just doesn't move through your system? Something like gastroparesis? I haven't ate in 2 days, yet my intestines still feel extremely full. It feels like the food I ate days ago is just sitting in my digestive track, hardly moving. I have found a few of the pfs boys having the same problem. It seems the onset of this issue marked a point of worsening of symptoms and continued gut issues. In fact, I have already read one story where a guy had other organ failures after this symptom (that eventually killed him), and another where someone offed himself after getting this symptom (although he had several other debilitating symptoms). This is very disheartening. However, I do remember hearing some on hear who have gut issues. Is this relativity normal with this condition? Any bandaids for it? I got weight to spare but I can only not eat for so long you know. I hope I'm not getting myself all scrambled over this but its seeming like it could be relatively deadly.
  14. Interesting, I actually have the purplish skin condition I see in the pictures of antiphospholipid syndrome. However I have had it my whole life. I think it has got worse though. Also a story for anyone who's interested: I just got back from the hospital the other day, checked into the emergency room with severe abdominal pain and bloating. By far the worst physical pain I've had in my entire life. Doctor says it was viral gastroenteritis, knowing post accutanes association with ibs though, I am definitely worried that this might mark the start of another chronic symptom. Only information I got back from the emergency room doc was that I had a very full stomach, very inflamed small intestine, and slightly elevated white blood cell count. Something else, I have found the opioid pain medications I was prescribed have been very effective at alleviating alot of my mental sides. It has been over 24 hours since I took my last hydrocodone, and while the pain relieving effects seem to have warn off, I still am having things like my tinnitus, depression, anhedonia, poor night vision, etc relieved. I'm wondering if this has to do with allopregnanolone. A guy named Bloom over on the raypeat forum theorizes that these effects from opioids are from there effect on up-regulating the 5ar1 enzyme, thus higher allo levels. He also says this isn't a great longterm solution, which is a little obvious. I'm kinda just talking out loud now so I'll leave it at that.
  15. @Perene "But (and here's an important thing I failed to understand until now) the way I behave and think TODAY might be exactly a result of this side effect." I agree that this could be the case, even likely to be the case. Although, don't let that get to you to much. It is what it is. Psycology 101 makes the assumption that the mind can control the body, but it has been my observation through this post accutane stuff that the body does alot of controlling of the mind. That may sound a little vague but hopefully the idea makes it across. "The accutane treatment stole that choice from me. Did you all get my point? Perhaps (just perhaps) I was not meant to be what I am today, perhaps this "meddling" destroyed my sex life and as a result the fact I am not even complaining IS PRECISELY A CONFIRMATION OF THIS SIDE EFFECT." Yeah, unfortunatley it may be the case that your lack of interest in sex and women, and even your stance on the issue, stems largley from accutane usage. Crazy right? "I never used any other drug (not even to treat this depression) and was able to flush down the toilet that mental imbalance over time. During the treatment I followed all medical advices and didn't even visit the gym for fear of jeopardizing the treatment, spend time outside, etc. I didn't do anything wrong." So are you saying this depression went away on its own after a year? What is this "treatment I followed all medical advices"? "Since it's been established that Accutane causes depression by changing how the brain regulates Dopamine and Serotonin, I have a very, very important question" Don't forget that accutane, if it causes the same syndrome as finasteride, also effects allopregnanolone levels. Heres a study done recently on pfs patients that found a bunch of altered neuroactive steroid levels that you might find interesting: http://sindromepostfinasteride.forumfree.it/?act=Attach&type=post&id=607265999 Pubmed abstract: https://www.ncbi.nlm.nih.gov/pubmed/28408350 I found these threads by the user bloom on the raypeat forum interesting: https://raypeatforum.com/community/threads/post-finasteride-sydnrome-and-the-5ar1-and-2-isoenzymes.19166/#post-266796 Can't come to think otherwise that all these drugs that cause these symptoms being 5aris is not a coincidence. Just learned that progesterone has been one of the more successful treatments over on propeciahelp. Progesterone being rather closely tied to the 5ari enzyme. Yet alot of people have known these things for decades, tried treatments that have supposedly cured or helped others and had no success for them. Can't wait for that Baylor study to come out.