Sirius Lee

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About Sirius Lee

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  1. Hypopigmentation - loss of skin colour

    Try DMSO + Rosehip Oil Rosehip oil is very good for evening out the pigmentation issues while DMSO will help penetrate the oil deeper into the skin. Be sure to clean both face and hands before using the DMSO.
  2. Tips for wound healing

    These all help stimulate tissue regeneration and wound healing. Oral supplements Vitamin C Zinc L-lysine Topical applications Comfrey leaf Lugol's Iodine Vaseline
  3. Alternative Treatments and Biohacks for Scar Revision

    An interesting article about using decorin, an anti-fibrosis agent, to prevent scar. (Source: ******* Muscle lacerations - injuries to muscles in which there is tearing of muscle fibres - are common sports injuries. They occur in every sport and can be the result of external forces (for example, when a football player's quadriceps muscles are struck by another player's foot or leg) or internal duress (for example, when hamstring fibres are torn during a sudden acceleration). When a muscle is lacerated, it undergoes a very systematic and unvarying process of repair, sometimes described as 'degeneration and regeneration'. First to occur are the 'necrotic changes' to the lacerated muscle, during which damaged muscle fibres are actively removed by white blood cells. On stage next are the 'satellite cells', which may sound like protoplasm from outer space but are actually strange, almost embryonic cells. Satellite cells are natural components of muscle tissue; in response to an injury they first become somewhat unusual, tube-like cells and then begin to develop the characteristics of full-blown muscle fibres. All muscles possess a connective-tissue 'scaffolding' which supports the overall muscle, and within this scaffolding - at or near the site of the laceration - these 'baby' muscle cells (the satellite cells) do their growing-up. The process is a slow one, requiring many weeks - and does not always lead to full functional recovery of the muscle, especially if the laceration is severe. We should point out that this muscular-regeneration process tends to be spurred on by a chemical called insulin-like growth factor-1 (IGF-1). The amount of IGF-1 in a tissue appears to be directly related to the extent to which regeneration occurs; levels of IGF-1 are increased within the body when extra amounts of human growth hormone are released by the pituitary gland. It is interesting to note that human subjects who are given human growth hormone tend to increase their concentrations of IGF-1 and lose less muscle mass in response to ageing. Laboratory mice treated with IGF-1 age at slower rates (from a muscular-system standpoint) than untreated mice. Enter fibrosis As regeneration of a lacerated muscle is occurring, there is another, simultaneous process at work which actually tends to inhibit full muscular recovery. This process is called fibrosis - the filling in of muscle-tissue space with connective-tissue fibres. Fibrosis usually becomes apparent during the second week after a laceration or other serious muscle injury, and the extent of fibrosis tends to increase thereafter, as the healing process continues. In one sense, fibrosis is a good thing. After all, it fills in empty space in a muscle and knits muscle tissue together, providing a permanent connecting point between various previously disconnected, ripped-up sections of muscle tissue. However, a negative aspect of fibrosis is that connective-tissue fibres can in effect take up space in a muscle which would otherwise be occupied by muscle cells. This makes it difficult for a muscle to regain its normal strength, since the density of muscle cells decreases (bear in mind that connective-tissue fibres can not contract). Another negative aspect of fibrosis is that connective-tissue fibres tend to be stiffer and less resilient than muscle cells. It is more difficult to elongate a thick knot of connective tissue, compared with a group of muscle cells, and connective tissue also tends to be less rubber-band-like - and thus less able to use elastic energy to exert force and produce motion. As a result, muscles with significant fibrosis have less strength and flexibility and operate with less efficiency, compared to normal muscles. Unfortunately, IGF-1 does absolutely nothing to arrest fibrosis. De-activating TGF-beta Fortunately, researchers at the University of Pittsburgh have been working hard to develop ways to control fibrosis. The Pittsburgh scientists realised that fibrosis is stimulated by the overproduction of a chemical called transforming growth factor-beta (TGF-beta). TGF-beta is produced by tissues in response to injury and disease and is the major cause of fibrosis in humans and other animals. The Pittsburgh researchers also knew that decorin - a proteoglycan (a protein with sugar attached) naturally found in the human body - has the ability to de-activate TGF-beta. Decorin has been shown to inhibit fibrosis in the kidney, liver, and lung, so why - the Pennsylvania scientists reasoned - would it not also stop fibres from taking over muscle tissue? In recent research, the Pittsburgh medical team has in fact been able to show that decorin is a powerful anti-fibrotic agent in muscle tissue - and thus that decorin administration has the potential to be an outstandingly effective treatment for muscle injury (Kazumasa, F. et al., 'The Use of An Antifibrosis Agent to Improve Muscle Recovery after Laceration,' The American Journal of Sports Medicine, Vol. 29 (4), pp. 394-402, 2001). In their benchmark study, the Pittsburgh scientists first surgically lacerated the gastrocnemius muscles in both hind legs of 16 laboratory mice. The mice were then divided into four groups with different time points for decorin injections (0, five, 10, and 15 days after laceration). At each time point, four different concentrations of human-recombinant decorin were utilised (0, five, 25, and 50 micrograms in 20 microlitres of saline solution). All animals were sacrificed for evaluation of healing and regeneration two weeks after injections were given. In a separate part of the investigation, 12 mice had their gastrocs similarly lacerated and were given decorin 15 days after the laceration - in the various doses of 0 (control), five, 25, and 50. These mice were checked for fibrosis two weeks after the injections. Mouse myofibroblasts (connective-tissue cells which grow in muscle and can produce fibrosis) were also incubated in vitro with decorin added to the growth media, with TGF-beta added, with both decorin and TGF-beta mixed with the cells, and without either compound. This tissue-culture work revealed that TGF-beta indeed spurred connective-tissue growth, that decorin significantly inhibited it, and that when the two compounds were mixed together decorin had the ability to dramatically reduce TGF-beta's fibrotic powers. Further good news In the living mouse muscles, direct injection of the human-recombinant decorin not only reduced the extent of fibrosis - but also enhanced regeneration of real-live muscle cells. Higher doses of decorin seemed to be best: according to the researchers, using 25 to 50 micrograms resulted in better prevention of fibrosis, compared with five micrograms or control, and the use of 50 micrograms increased the number of regenerating muscle cells in the mouse gastrocs and also broadened the diameters of those regenerating cells, compared with the use of all lower doses. In a unique aspect of the research designed to test the ability of decorin to spur on a lacerated muscle's return to full functionality, mouse gastroc muscles were lacerated, injected with 50 micrograms of decorin or a placebo two weeks later, and then tested for strength two weeks after that. Basically, the researchers were able to demonstrate that the placebo muscles were about 50% as strong as normal mouse gastrocs, whereas the decorin-treated muscles had returned to full strength. Decorin appears to be a powerhouse - with beneficial effects on both muscle regeneration and fibrosis control in muscles which have suffered lacerations. This is exciting news, because muscle damage accounts for a huge proportion of both professional and recreational sports injuries, and yet the standard treatments for muscle damage are obviously inadequate. Rest, for example, promotes regeneration but does nothing to stop fibrosis. Likewise, the standard treatments of ice, heat, whirlpool therapy, compression, elevation, immobilisation, and drugs have various effects on muscle-damage symptoms and muscular inflammation, but it is clear that they are not optimally anti-fibrotic, and they do not maximally enhance regeneration. The treatment of lacerations with decorin - along with the utilisation of an outstanding post-injury muscle-strengthening programme- may prove to be the best-possible way of returning athletes to full activity - and full muscular function - in the shortest-possible time. For their outstanding efforts, the University of Pittsburgh researchers were awarded the prestigious Cabaud Award, given each year by the American Orthopaedic Society for Sports Medicine.
  4. Alternative Treatments and Biohacks for Scar Revision

    If you haven't already, I encourage you to read Tim Ferriss' The 4-Hour Body. In this day and age, it's hard to differentiate between the gurus and the flukes, but Ferriss comes across as pretty genuine feller. Well, I believe the larger question is why shouldn't you use something that's proven to work (as shown by those who recovered from their illness)? Why must you wait until it receives the blessing from the scientific community? By then, you might just be dead (as in cancer treatment, for example).
  5. Alternative Treatments and Biohacks for Scar Revision

    Okay my bad. I didn't want to turn this thread into a pedantic wasteland full of dry arguments about this and that. Even more, I definitely don't want to make this a full-blown commitment. I just want to have open and fun conversation about alternative methods to treating scars. The joke was to break the ice so to speak to get the ball rolling. But, in hindsight, I admit I'm a XXX (fill in the blank). At any rate, I've been very intrigued by the notion of alternative medicine, especially in regards to cancer. I've personally seen a few cancer survivors beating the game with not surgery or chemo/radiation therapy but with alkaline diet and supplements. That got me thinking about biohacking. We've known for some time through biohack gurus like Tim Ferriss how best to keep our body churning. Most of these hacks don't involve anything synthetic but rather naturally derived substances like everyday foodies and herbs. I can't help but wonder then why even after all the money and time spent by the big pharma in research and manufacturing of cancer drugs, we still don't have a cure. Yet, at the same time, we have people being cured just by using the most basic and primitive means. If that's the case, I think the same logic can be applied to scars as well. Couldn't scars be treated naturally, or rather reverse engineered? Scars that have been treated surgically were never considered satisfactory and, more often than not, it required multiple subsequent treatments. Why not just "dissolve the damn scar"? That's the quest that I'm on. Although I have no clue as to where all this will lead, but you're free to jump on the bandwagon.
  6. Alternative Treatments and Biohacks for Scar Revision

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  7. I would like to dedicate this thread to discussing alternative treatments to scar revision. Anything from holistic approach to biohacks, as well as supplements and exercises...they're all welcome. On the other hand, any and all reference to conventional treatments like subcision, RF microneedling, chemical peels, etc. is not welcome. Please keep this thread clean by taking your agenda (and ego) elsewhere.
  8. They're safe, otherwise I wouldn't have used it on my own face. Moreover, they're effective as far as I can tell. DMSO, in fact, very good in killing cystic acnes because of it anti-inflammatory effect. No inflammation, no zits. You can start out by diluting the DMSO with water, say, 50% and see how you react to it. Anyway, here are some of the research studies documenting their benefits. DMSO Please note that DMSO is all about enhancing cell membrane permeability (that is, allowing the large molecule to be absorbed through the cell membrane). By using DMSO, topicals like Hyaluronic Acid Serum, which normally cannot be absorbed due to its large molecule, can easily penetrate under the skin. OilI haven't had much luck finding any research paper on castor oil's role on scar reduction, even though there are many personal testimonies by individuals who swear that castor oil healed or reduced the appearance of their scars (see the following link):
  9. Asking for advice, depressed

    Uhm...yeah, but you think you can control the depth with the peels? Remember this girl has a very light scar. Just how deep the peel will burn through the skin is, well, anyone's guess. With dermabrasion, however, you can fine-tune the depth quite precisely in order to minimize any unnecessary damage.
  10. Asking for advice, depressed

    ** PLEASE READ CAREFULLY!! I usually don't bother replying unless warranted and this one definitely deserves it. Let me start by regurgitating what I wrote above: I would suggest you GET a derma sanding. Just where did I state that OP should do this at home? How does "get" translated into "self-service"? As far as I know, "get" usually means to "receive something from somebody from somewhere". So doesn't it make sense that I was implying that she should get this from a professional? That is the reason why I posted the video which showed the procedure being done by a dermatologist. This is no different from @beautifulambition giving advice about "getting" filler. Did he then mean that you should inject fillers at home? No. So why do you believe what I've stated is any different?
  11. Please, any suggestions for scar between eyebrows

    If you're looking for professional treatment, you will need BOTOX + FILLER. If you're looking for at-home DIY, then apply DMSO + Serrapeptase 2-3 times a week. I too have a very deep wrinkle that runs down between my eyebrows. They're there all the time, regardless whether I furrow my eyes or not. It's been helping for both acne scars and the furrow.
  12. Tethered nodules after subcision

    If your main concern is to lessen the appearance of the nodules, then I suggest you get filler to elevate the surrounding area to even out with the nodule. If your concern is with the tethering, then you will need to get another subcision--but with filler this time to avoid possible retethering. As such, in order to combat both problems, I would suggest you get SUBCISION + FILLER.
  13. Asking for advice, depressed

    It looks like a very mild form of rolling scar. Unfortunately, they won't go away on their own. I would suggest you get a derma sanding, which will take less than 10 minutes. For more info on derma sanding, check out the following video:
  14. Any suggestions for my acne scars? Pics inside

    No you don't need to wait 6 months. Research indicates that it's safe to combine acne scar revision treatments with Accutane.
  15. Ice pick scars after accutane

    Everything is intimidating at first, but ya gotta have balls. Otherwise, you're never going to divorce your lovely scars. There is a ton of YouTube tutorials on TCA Cross. Start out by applying a low concentration to one or two scars. Then increase the strength as you get better and spread it out to the rest of your face. Fortunately, icepick scars are the easiest to treat now, thanks to TCA Cross. Once the pits are filled, then get a erbium laser to even out any surface irregularity. Lastly, every treatment comes with a risk, including hyperpigmentation. Sometimes ya gotta make sacrifice in order to gain something better.
  16. Atrophic Scars

    Well, if you're willing to try something unorthodox, then try my method: Wait!! Try this skin hack before you get your next treatment! I have pretty "ghastly" scars and they have been getting better since I've been using this method. That's all I will say for now. Just know that there are people here who are strictly opposed to anything unconventional so beware if they tell you otherwise. But I leave the choice up to your discretion nonetheless. I'm only here to help on a voluntary basis, not to put a gun to anyone's head. PS. If you have a specific question regarding the above method, send me a PM.
  17. Deep acne scars

    There are distinct boxcars with well-defined edges shown in the first pic. Maybe she could spot test one of those with TCA Cross. Anyway, merely sitting on your hands and speculating what could or could not be ain't going to solve anything (even though some folks come here to do just that).
  18. My acne scars (and questions)

    No, I don't recommend laser in general, and certainly not CO2 in particular. If you must get laser, then consider getting Erbium:YAG laser instead. Laser should only be considered if you have well-defined boxcar edges that remains irregular after receiving other treatments.
  19. Deep acne scars

    Also I might add that you should think out of the box once in a while and not follow everything from a script word for word, even though the consensus around here is often in favor of the latter.
  20. Nothing is working!

    Just curious, but has anyone actually considered the long-term effect of multiple chemical peels--like repeating every couple months for multiple years? According to this article, it claims that it can cause irreparable harm to the body. Just a food for thought.
  21. My acne scars (and questions)

    You mostly have rolling and boxcar scars, which makes you an ideal candidate for subcision. I even see a few tethered scars in the 2nd and 4th pics. However, your scars aren't too deep so I ain't sure how much improvement you will get from subcision, which isn't all that effective on shallow scars. That's not to say it's ineffective, just don't expect to see a huge improvement. I personally would recommend you get Sculptra, which is a collagen-inducing filler. Wait for about a month for it to settle and then get Infini or Intensif, which is radiofrequency microneedling.
  22. Deep acne scars

    I'm gonna go out on a limb and suggest TCA Cross. I recall this guy with very similar scars who detailed his self-administered TCA Cross treatment. They turned out unbelievably good.
  23. I dunno about others but that's what I think. As for the length, it depends on how much cushion there is. Cheeks have the most meat, so you can go as deep as 2.5 mm. The forehead and temple have the least, so it would be ideal to dial the setting down to aroun1.25 mm. Well, TCA can in theory leave you with a serious chemical burn if not handled properly. There have been cases where patients ended up in the emergency room with a serious burn to their face. But these are very rare, so no need to freak out.
  24. Nothing is working!

    Get fillers (I recommend Sculptra over HA). Wait for about a week for the filler to settle. Then go in for Infini or Intensif. But seriously, you have no reason to whine. Your scars are nothing in comparison to that other dude.
  25. Very good suggestion. People should always get filler before Infini IMHO. With subcision, though, they should wait. Otherwise, there's a high risk of disrupting the filler with the needle. The reason for the filler (in my mind at least) is that collagen begets more collagen. This is why the temple and the forehead, areas with the least amount of collagen, pose as the most problematic area. They respond very poorly to any type of treatment. As BA mentioned, the fault of fat atrophy is more to do with the operator than the machine itself. Nobody in their right mind will stick 3.5 mm length needles in your face (well, unless one is an idiot). Also keep in mind that even subcision carries a high risk of fat degradation. If the needle is inserted too deep and hit the fat, there will be atrophy. Be that as it may, we've come a long way from the days of Thermage, which was notorious for leaving patients with fat/volume loss. The needles on the older generation machines would heat up the suface of the skin, thereby causing a thermal injury in a fractional manner much like laser. Infini, on the other hand, has insulated needles that penetrate the skin at variable depths, depending on the area treated and the results desired.