- Last Week
Maybe it wasnt bacteria. This is what I mean, or have been looking at.
Could be wrong though.
Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary studyantifungal medication during pregnancy may affect the masculinization of male offspring.
Like all azole antifungal agents, ketoconazole works principally by inhibition of .... Ketoconazole is anantifungal imidazole that inhibits androgen biosynthesis at ...by E Campione - 2016 - Related articlesApr 29, 2016 - Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate ...This is the first evidence of a direct and strong fungistatic activity of ATRA
23 hours ago, ACCUiTy_drANE said:
7. If vitamin A is at the root of autoimmune illness, how does this fit into the idea that microbial transplants can both cure and induce a number of autoimmune diseases in mice? Does bacteria make the liver grow or something?
Except i'm not looking at bacteria atm, but what it evolved to.
Maybe it was never bacteria.
"the diversity of the microbiota on the cheek and the back was significantly increased after acne treatments"
Eukaryotes represent a tiny minority of all living things. However, due to their generally much larger size, their collective worldwide biomass is estimated to be about equal to that of prokaryotes.[The interrelationship between endogenous microbiota, the immune system, and tissue regenerationis an area of intense research due to its potential therapeutic applications. ... The culture of these bacteria yielded a strain of Pseudomonas capable of inducing progressive tissue degeneration.The mechanism by which neonate tissues adapt to the formidable challenge of ..... the gut, TLR activation by commensals was required to promote tissue repair ...
- Last Month
I would say the amounts of vitamin a are so small in the diet compared to what Accutane was (which might have equated to around 100k iu to 40 mg isotretinoin just looking at weights, but Accutane being a more potent version)
That avoiding vitamin a in the diet is pointless, minus eating liver.
I could also say that I could experimentally induce a lot of the Accutane side effects by taking the wrong supplements that are further agonists to Accutanes many possible modes of action.
And guess what it might have to do with Accutane at this point?
Absolutely nothing. Meaning Accutane might be long gone.
You can see a side effect profile or correlations with many drugs and supplements that have nothing to do with retinoids.
Maybe the fact that they might be a similar type of poison of you want to call it that, with a trickle down effect to the host organism or unavoidable damage or stress that the person must recover from.
Just a update, i've backed off of Bacillus based supplements for now as well, as they might be further antagonists like Accutane.
For me Testosterone has not correlated with symptoms of muscular weakness or paralysis.
Just had it tested a couple days ago. im 35 btw.
Testosterone, Serum 581 ng/dL 264 - 916
Has anyone looked into prostatitis or had symptoms that could relate?
Maybe inflammation that spreads like a cancer.
sinuses,lungs, gi tract,mouth, bladder, brain.
symptoms of Prostatitis (don’t wish it on my worst enemy) – Feeling the need to urinate constantly even though you don’t have to, pain in the the testicles and the entire pelvic region, a burning fire/ pain in the anus, almost complete loss of libido and serious ED problems.
Been a little bit. I'll be real brief what im currently looking at.
Im done with supplementing vitamin k2 directly. Although there is alot of positive research on k2, I believe it can become just like any other nutrient and feed the wrong bacteria. Meaning pathogens. There is evidence of this.
But im not done with this so to speak because im looking at the bacteria itself that produces k2.
Also other Bacilli species such as Bacillus coagulans and Bacillus Clausii.
The main focus will be on Bacillus subtilis for now.
These are more newly available as supplements.
As for Lions Mane I see it as a fungus that's capable of altering the microbiome and/or mycobiome.
Alterations can happen fast. Within a matter of days.
What happens if things continue to shift in the wrong direction?
Death and Disease.
To give you a glimpse of what im talking about.
Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity
Shifts in the microbiome impact tissue repair, regeneration
- August 26, 2016
- Stowers Institute for Medical Research
A definitive link between the makeup of the microbiome, the host immune response, and an organism’s ability to heal itself has been confirmed by scientists.
As for the other.
- More Than a Month
noOn 4/22/2018 at 3:34 AM, brendan452 said:
Has anyone tested for biotin deficiency and been found to be deficient if just one of you could confirm for me
Biotin is something that is produced by bacteria though, just like some other nutrients.
I have read enough though that in a case of dysbiosis bacteria can "steal" and repurpose some nutrients for further growth.
So maybe there is a catch 22 where even though you need some nutrients, supplementation might do more harm than good.
As you have mentioned this quite a few times yourself.
Curtis Huttenhower, Ph.D. (Harvard School of Public Health) states, “It appears that bacteria can pinch hit for each other. It matters whether the metabolic function is present, not which microbial species provides it.”
You could be looking at the very cause of acne as it relates to the microbiome and inflammatory response.
I'm just going to pick things up right where I left off and will use this forum to put down thoughts and research.
How Accutane, A Cancer And Acne Drug, Threatened My Life
By tomshearerhealth |Posted on Aug 27, 2017
This is what im looking at. I will probably get this tested at some point in the near future. I'm sure this will be something that could evolve with time.
it reminds me of the 23andme of microbiome testing. Im not sure if this is available outside of the states.
From just one gut sample, you get a comprehensive breakdown of your microbiome, how it’s functioning, and how it compares to others.
Not only that, you can test multiple body sites. It gets more pricey though.
Sample all five sites: your gut, mouth, nose, genitals and skin.
Learn about all five microbiome sites.
You find some correlations among us or some bacteria populations that have drastically changed compared to a healthy control group, and there might be part of your answer.
Why might this be important? We took a drug that killed antibiotic resistant bacteria.
Antibiotic Use In Young Mice Linked To Inflammatory DiseaseDisrupting the early development of a healthy gut microbiome can do serious — yet reversible — damage, a study finds.
Researchers have long known that childhood antibiotic use can impede the normal growth and development of gut bacteria. This, in turn, affects the function of the immune system ― around 70 percent of which is contained in the gut.
The gut is home to trillions of bacteria that play a crucial role in our physical and mental health, including the digestive system, brain and immune system. One side effect of antibiotics is that they can indiscriminately kill off important strains of healthy bacteria alongside the bad bacteria they aim to target.
5 hours ago, hatetane said:
Has anyone looked at this?
I have been looking at central nervous system treatments and healing - has anyone got ideas about this?
I have literally just been looking at this.
Maybe it's something we can look into as a group.
I'll get back to you.
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestinehttps://www.cell.com/immunity/fulltext/S1074-7613(15)00392-1
4 hours ago, Colinboko said:
If I can remember correctly @guitarman01 Mayo measures it in nmol/l and gives you your actual measurement. I wish you could find your results
I know my results. I will get another copy of the test and screenshot it or see if I can get the format viewable online.
0.07 considered positive according to Mayo. It said considered positive according to their interpretation.
AChR Ganglionic Neuronal Antibody
Negative results do not exclude autoimmune gastrointestinal dysmotility or cancer.
Yes you cant compare quest to mayo, the labs are different, the numbers are different . the numbers do not coincide.
I thought quest would be the easiest test to get or approved over the mayo test.
In the future id look into one of the following,
Autoimmune Gastrointestinal Dysmotility Evaluation, Serum
Autoimmune Dysautonomia Evaluation, Serum
1 hour ago, Colinboko said:
Gastric dysmotility? Check
Orthostatic hypotension? Check
I think its safe to say gastric dysmotility has been confirmed for me.
Not only with this test but also CT Scan. I might actually present this acetylcholine test result to a gastro dr next, before another neurologist.
Orthostatic hypotension has been disproven at least for myself through tilt table testing
This doesn't mean I don't get light headed. Or used to.52 minutes ago, Nemesisbrady said:
gerd inflamed esophagus
14 hours ago, Nemesisbrady said:
so ima avoid a
and ur gunna try a?
That paper discredits vitamin a being classified as a vitamin, but a toxin instead. Pretty radical idea.
We dont need anything that graphic of that last pic please. That is a serious nosebleed though.14 hours ago, macleod said:
I referenced a medical journal about a boy in India who lost all night vision while on Accutane. The doctors took him off and treated with 200,000iu vitamin A for a few months, and he made a full recovery.1 hour ago, Colinboko said:
2 hours ago, macleod said:
Why are you so worried about being clocked rather than common sense and practicality?
You are presenting bacterial overgrowth for the millionth time when there are people suffering from severe side effects such as depression and erectile dysfunction.
SIBO? That was a test talked about years ago where we all drank a substance and blew into a bag for 10 minutes. Raise your hand if anyone here tested positive for SIBO?
By all means, get the test, it is one of many people should do if they have insurance.
But, I wonder, how many people here have been on antibiotic courses to no avail? Or have made things worse by taking antibiotics.
I can focus on the facts. On the science. Can you really present any of those posts to a doctor? I definitely cannot.
Do any of your posts have anything in common with knowledgeable docs on the matter, such as Pezzi or Bremmer?
I'm not saying to stop posting, just maybe some direction as to how the science you present relates to us.
I don't quite like being a bully to anyone anymore, and it is not my intention at this stage of my life. If you want to solve the mechanisms of action dilemma (professionals cannot), rather than focus on treating side effects, by all means, but to subject us to it too? Not only us, but all the newbies who stumble on the site with god knows going on with their bodies, looking for solutions.
Sibo was one quick example.
Gut bacteria hold clues to heart health
By AMERICAN HEART ASSOCIATION NEWS
“People are still getting their head around how something in the gut can affect the heart,” Reid said. “One way is the microbes produce molecules that end up in the bloodstream or that affect factors in the bloodstream.”
Such busy little “bugs” may account for much of the individual variation in heart health. Large-scale genetic studies suggest hereditary factors can account for only about 15 percent of cardiovascular risk, meaning environmental causes account for the rest, said cardiologist Stanley Hazen, M.D., Ph.D., chair of the Department of Cellular and Molecular Medicine at the Cleveland Clinic’s Lerner Research Institute.
Next you'll probably tell someone to stop looking into this.
Your not focusing on facts or science.
your focusing on me.
Dr. Pezzi seems pretty damn crazy to me if you actually look into his bio. Doesn't seem very credible to me.
He sounds like the dos equis man.
"I'm not saying to stop posting, just maybe some direction as to how the science you present relates to us."
My response would be why would I take any more time then I already have. I cant make you get it.
Your not a Bully, just a distraction to me.
I think your not the only one that has Guitarman fatigue,
Thats why I am taking a break and will start a new thread.
If I continue to put in any effort and the way I go about things, that seems like the best idea to me.
Maybe more like a blog.
On 4/18/2018 at 3:25 PM, macleod said:
Bacteria dysregulation? Sure, why not. Maybe cause people digestion and bloating issues. But enough to cause people to suffer stroke, erectile dysfunction, or suicidal thoughts? Not likely.
You seem most concerned about redirecting people on here than anything else (thats not based on any sort of fact) and clocking me.
This is one example of Bacteria affecting the brain.
"Brains from patients with Alzheimer's disease show changes in bacterial populations compared with healthy brains"
This is an example of Bacteria affecting androgens.
Antibacterial and Antiandrogen Flavonoids from Sophora flavescens
These compounds exhibited significant antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, S. epidermidis, and Propionibacterium acnes. They also exhibited antiandrogen activities.
(and I literally once again just posted this)
This is Bacteria affecting Vascular function
This is a possible progression that could be brought on by autoimmune gut dysmotility
(just got done posting this as well)Feb 21, 2017 - A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination. Plasma levels of the inactive form of MGP (dephosphorylated-uncarboxylated matrix Gla-protein) were quantified by ELISA and vitamin K2intake was ...
This is what i might do.
I might create my own thread and it will be a person's choice if they choose to listen.
The majority of my posts will no longer be on this particular thread.
Heres an example. This is just some random substance found in nature.
Sophora flavescens is a plant.
Look at the effect it has on bacteria modulation.
Antibacterial and Antiandrogen Flavonoids from Sophora flavescensThese compounds exhibited significant antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, S. epidermidis, and Propionibacterium acnes. They also exhibited antiandrogen activities.
On 4/4/2018 at 10:34 PM, Frage said:
Isn't the biggest mystery to this condition the POST nature of it?
Not surprising to me they are looking into the microbiome with the most recent post finasteride study.
They are finding some bacteria protect themselves by forming calcification biofilms.
They are also finding altered bacteria in neurodegenerative diseases.
"Brains from patients with Alzheimer's disease show changes in bacterial populations compared with healthy brains"Anyone that really figures any of this out is going to figure out a hell of a lot more then any post drug disorder.
I think this is something else as well.
Dysautonomia and Gastrointestinal DysmotilitySo if motility problems do develop, this could be a risk factor for SIBO in the long run.
This is where a problem can become multi faceted.
Also looking at IBS symptoms.
"Pimentel et al found abnormal lactulose breath test results in 93/111 (84%) patients with irritable bowel syndrome."
Autoimmune-mediated gut dysmotility puts patients at risk for bacterial overgrowthPublish date: October 4, 2016
Genova Diagnostics offers 2 and 3 hr testings.
Thats good. Here is some more info.
There dosent seem to be any false positives, but there can be false negatives. Unfortunately at a rate of 50 percent.
Testing for Autoimmune Disorders
Dysautonomia and Gastrointestinal Dysmotilityhttps://www.mayomedicallaboratories.com/articles/features/autoimmune/
Mayo Clinic offers autoantibody evaluations that are tailored to detect all currently recognized IgG markers of autoimmune dysautonomia and gastrointestinal (GI) dysmotility. The ganglionic (alpha 3) acetylcholine receptor (AChR) autoantibody is the most commonly detected marker of autoimmune dysautonomia and is sometimes encountered with isolated GI dysmotility. This is the only autoantibody proven to cause dysautonomia, including GI dysmotility. Importantly, cancer is detected in up to 30% of patients with the alpha-3 AChR autoantibody.
Because no more than 50% of patients with idiopathic dysautonomia are seropositive for the ganglionic AChR antibody, even when the dysautonomia is severe and generalized,
Autoimmune GI dysmotility: A new directionhttps://www.mayoclinic.org/medical-professionals/clinical-updates/neurosciences/autoimmune-gi-dysmotility-a-new-direction
Although autonomic disease is typically associated with syncope, neuropathy and sweating problems, chronic gastrointestinal (GI) dysmotility also may be a component. Autoimmune GI dysmotility (AGID) is a newly described clinical entity that is a limited manifestation of autoimmune dysautonomia, and can occur as an idiopathic phenomenon. Signs and symptoms include early satiety, nausea, vomiting, bloating, diarrhea, constipation and involuntary weight loss. The onset may be subacute, and neurological manifestations may or may not be an accompaniment.
1 hour ago, TrueJustice said:
Guitarman- who does one see about these Vascular issues??
It measures or calculates Aortic Pulse Wave Velocity.
It measures Aortic Stiffness and the rate of blood flow.
The Aorta is the main artery of the body, supplying oxygenated blood to the circulatory system.
Its not cheap at 150 bucks.
I should be getting it soon. I will let you know.
What is Pulse Wave Velocity?
Imagine a single health metric able to identify people in their 20’s at increased risk for development of Heart Disease, Stroke and Dementia. What if this health indicator could estimate how long you will live?
- Increased Arterial Stiffness is Superior to Blood Pressure in Predicting Cognitive Decline in Healthy Adults read
- Signs Of Cognitive Decline And Alzheimer’s Can Be Detected In Younger Adults - A new study found a link between increased aortic stiffness and early signs of brain injury, which can potentially lead to Alzheimer’s disease, in healthy, middle-aged adults. read
- Stiffening of the arteries detected in multi-ethnic study of young adults read
- Aortic Pulse Wave Velocity: An Independent Marker of Cardiovascular Risk read
- Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. read
- Arterial Stiffness is a Cause of Cognitive Decline and Dementia read
- Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences read
- Short-Term Aerobic Exercise Reduces Arterial Stiffness in Older Adults With Type 2 Diabetes, Hypertension, and Hypercholesterolemia read
- Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population read
- Arterial stiffness: a new surrogate end point for cardiovascular disease? read
- Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study read
- Reflection Magnitude as a Predictor of Mortality read
- Vascular Stiffness: Its Measurement and Significance for Epidemiologic and Outcome Studies read
- Aortic Pulse Wave Velocity as a Marker of Cardiovascular Risk in Hypertensive Patients read
- Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis read
- The effects of dietary and nutrient interventions on arterial stiffness: a systematic review read
- People who eat high protein foods have lower blood pressure and arterial stiffness read
- Protective effect of chronic garlic intake on elastic properties of aorta in the elderly read
- Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections read
- Postprandial effect of dietary fat quantity and quality on arterial stiffness and wave reflection: a randomised controlled trial read
- Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans read
18 hours ago, TrueJustice said:
I feel like suing them just for eye floaters - I certainly never signed up for any of this shit that’s for sure.
retinal vascular disease, or damage to the retina caused by abnormal blood flow.
Now lets take this a step further.
Retinal vascular fractals and microvascular and macrovascular complicationsThe association of D(f) with proliferative retinopathy, nephropathy, neuropathy, and macrovascular disease (coronary heart disease, stroke, peripheral artery disease) was examined.
This study adds to the evidence that D(f) may have some role as a global measure of retinal vasculature and its association with systemic disease.
Now lets take this even further.
Retinal Vascular Fractals Correlate With Early NeurodegenerationCerebral microvascular disease is associated with dementia. Differences in the topography of the retinal vascular network may be a marker for cerebrovascular disease. ... We measured retinal vascular fractal dimension (Df) as a potential marker of cerebral microvascular disease.Mar 27, 2015
Obviously its alot more then our eyes bothering us.
I have eye floaters. I have neurodegeneration.
As far as fatigue, Im thinking Cardiac Output.
I have a small sag in my heart.
Truejustice said if we ever have our day in court...
Someones going to really need to have their shit together.
If I get more than a hint of some things I can do, I am definitely going after this.
On 4/2/2018 at 12:25 PM, macleod said:
somewhere in between hypermetabolism and toxicity.18 hours ago, macleod said:
to be honest, i can't tell if they are purposely misleading the thread or truly believe in such an elaborate theory of everything...
You are so strange on here sometimes, I question your priorities.
Others should too.
I get the person that posts the most on here is open to the most criticism. I can take criticism.
But you better give me a better answer then "just because" if you are going to go out of your way to criticize me. I have put as much effort into this as anyone.
I can stop posting, and you can thank people like @macleod if I do.
Do you see me going after any of you guys?
I could. That's not what I'm about on here.
People are already fighting enough in real life.
i'm still looking at possible absolute causes that balloon into systemic effects.
triggering auto immunity could be a effect, not a cause.
Or Vice versa. You can see they are still learning about this antibody.
I still think this test could have importance.
but yes a antibody by definition is something provoking an immune response.
So at some point could there be a immune response to everything going on?
Probably. We would just need to see some more of these tests results from a group perspective.
I can think back to @Babis posting about low grade brain inflammation detected on a PET scan. Autoimmune encephalitis?
Autoimmune encephalitis (or autoimmune encephalopathy) is a diverse group of neuro-psychiatric disorders recognized recently[when?], presenting acutely or subacutely with alteration of consciousness, cognitive decline, seizure, and abnormal movements. Associated with systemic autoimmune disorders, CNS autoimmune disorders and paraneoplastic syndromes. Pathogenesis is likely to be mediated by antibodies (Abs) to CNS proteins.
I posted this pretty recently. This antibody testing positive does not guarantee that nervous system dysfunction is autoimmune in nature and it could still flag positive.
(though yes the immune system could be involved)
Ganglionic Acetylcholine Receptor AutoantibodyOncological, Neurological, and Serological Accompaniments
Since incorporating the α3-AChR Ab assay into the standard Mayo Clinic serological evaluation for paraneoplastic autoimmunity in 2005, we have observed that this Ab has broader oncological and neurological associations than originally recognized.
Here are examples of other causes. For example Diabetes not being an autoimmune disease, but still flagging positive for nerve damage from it.
The G-nAChR antibody assay can also identify patients with limited forms of dysmotility, diabetic autonomic neuropathy, or postural tachycardia syndrome.
Other Autonomic Neuropathies Associated with Ganglionic Antibody