1. Last Week
  2. On 7/9/2016 at 4:46 PM, eph95 said:

    Every few months I come back to this thread to take a look and see how people are doing. And it's quite sad to see, but the majority of people are wasting their time and going the wrong way about it. If you want to cure your Isotretinoin side effects, it's actually quite simple. I see so many people, talking about different theories on how Isotretinoin causes negative side effects and health issues after ceasing the drug. I am quite shocked to see people are actually still talking about DHT levels and how this is one of the mechanisms by which Isotretinoin damages the body. There is also the copper theory, amongst many others. But everyone is wrong! People seem to over complicate things. 

    if you really want to cure your depression, suicidal thoughts, mood swings, erectile dysfunction, low libido, fatigue and all the rest then please. Don't listen to most people on this thread.

    the key to repairing the chemotherapy damage from Isotretinoin. Is by addressing your gut. The way accutane causes all these health problems is because it is a very powerful agent, it wipes out all the bacteria in your gut (that's the good bacteria too). You need to replenish your healthy gut flora. There is a Reason why the gut is called "the second brain", it's because it produces 90% of the bodies serotonin. Isotretinoin also weakens the gut lining and causes crippling candidiasis. The only way to cure yourself is to take a combination of natural antifungals and probiotics . If anyone wants any more info then email me henthornedward@yahoo.co.uk

    have a good day everyone and don't give up.

    Cheers,

    ed, Oxford, United Kingdom.

    I still remember this post. sounds like BS right? is it? 

    Not to shift gears because submitting 23andme data is a good idea or no brainer,
    but keep this in mind as well.
  3. On 8/13/2018 at 6:56 PM, Dubya_B said:

    There's one very easy  way to find out if many of us share this polymorphism. If you do have 23andMe data, please upload it and take part in the propeciahelp GWAS.

    Yes. Easy enough to do if you already have the kit. if not 100 bucks for 23andme is a good investment.

    Speaking of 100 bucks, 
    it would be nice to see someone else get this test I just posted if you think this could be "product of your environment" based as much as genetics. which i think it could be both.
    Meaning what you consumed (Drug), altered your microbial environment.
    Shifts that continue to go in the wrong direction.

    It would be good to verify this isnt flagging with someone else.
    if you have a nearby quest diagnostics, it will cost you 90 dollars through walkinlabs.

    On 8/10/2018 at 1:27 PM, guitarman01 said:

    CANDIDA ALBICANS AB TXC
    (IGG,IGA,IGM)
    C.ALBICANS IGG 1.3 H
    C.ALBICANS IGA 1.4 H
    C.ALBICANS IGM 1.1 H

  4. Along with 23andme (which i've looked at pretty extensively myself), one thing i'm curious about is if our genes could predict some of our microbiome composition and or vice versa.

    Im actually more curious of this atm, which I plan to get the most comprehensive version of this test as soon as I have some more information.

    https://shop.ubiome.com/pages/explorer-plus

    • comprehensive access to your entire microbiome, including viruses and fungi
    • Functional metagenomics information, such as insights into what key metabolites and vitamins your bacteria are synthesizing for you
    • More comprehensive probiotic bacteria
    • Downloadable raw data for every organism detected in your sample

    Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

    https://www.dovepress.com/association-between-leptin-gene-rs7799039-polymorphism-and-lipid-profi-peer-reviewed-article-TCRM



     
  5. Last Month
  6. Not sure about this yet. But every single antibody was above normal. Not by alot though. 
    You see it's also found in a percentage of the normal population.

    Test Name In Range Out Of Range Reference Range Lab
    CANDIDA ALBICANS AB TXC
    (IGG,IGA,IGM)
    C.ALBICANS IGG 1.3 H
    C.ALBICANS IGA 1.4 H
    C.ALBICANS IGM 1.1 H
    REFERENCE RANGE: <1.0
     INTERPRETIVE CRITERIA:
     <1.0 Antibody not detected
     > or = 1.0 Antibody detected
    Systemic candidiasis is often characterized by
    markedly elevated levels of IgG, IgA, and IgM
    recognizing Candida. However, interpretation of
    Candida antibody levels is complicated by
    detection of antibodies in 20-30% of healthy
    individuals, and blunted antibody responses in
    immunocompromised patients at risk for systemic
    candidiasis. Candida antibody results should be
    considered within the context of clinical findings
    and results from other relevant laboratory tests,
    such as Candida antigen detection and/or culture.
    This test was performed using a kit that has not
    been cleared or approved by the FDA. The analytical

  7. we will see. maybe there has never been a targeted approach.
    im not looking at a all in one "candida" supplement.
    As a actual drug I could reference 100mg of fluconazole per day for 3 weeks.
    im looking at something similar to sibo, instead with fungus.
    Im not looking at candida specifically but its cousins or close relations as well.
    Example, saccharomyces cerevisiae. A commensal yeast since birth, can become pathogenic.
    im looking at something that is isolated or contained to the lower gi tract but still causes a systemic response.


     

  8. On 6/25/2018 at 7:23 PM, guitarman01 said:
    Antifungal properties of selective serotonin reuptake ... - Oxford Journals
    by C Lass-Flörl - ‎2001 - ‎Cited by 66 - ‎Related articles
    In conclusion, our in vitro studies clearly demonstrate antifungal effects of SSRIs. Animal studies are needed to evaluate the potential role of these psychotropic ...
     

    In Vitro Analysis of Finasteride Activity against Candida albicans ...

    aac.asm.org/content/58/10/5855.full.pdf
    by AA Chavez-Dozal - ‎2014 - ‎Cited by 12 - ‎Related articles
    May 16, 2014 - clinical utility of finasteride in the prevention of urinary candidiasis is ... with standardantifungal drugs, and finasteride is one of several.
     

    Fungistatic activity of all-trans retinoic acid against Aspergillus ...

    by E Campione - ‎2016 - ‎Related articles
    Apr 29, 2016 - Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate ...
    So maybe you suppress something. But what comes back? With a vengeance. Sparks a immune response.
    Inflammation. This could constrict blood flow.
    Maybe thats why some have found temporary relief taking again what might have harmed them in the first place. But then maybe they end up even worse then they started.

    Its been awhile since ive gotten any tests.
    But im getting one tonight. Just in case.
    im actually looking for a immune response coming from the gi tract.
    There's no other way to possibly test this atm.
     

    Candida albicans Antibodies(IgG, IgA, IgM) (30440) - Quest Diagnostics

    www.questdiagnostics.com › For Physicians & Hospitals › Test Center
    Candida albicans Antibodies (IgG, IgA, IgM) Test Code 30440 CPT Code(s) 86628 (x3) Preferred Specimen(s) 1 mL serum Minimum Volume 0.2 mL Transport ...



     
  9. UCLA scientists identify a new way to activate stem cells to make hair grow

    Mirabai Vogt-James | August 14, 2017
    http://newsroom.ucla.edu/releases/ucla-scientists-identify-a-new-way-to-activate-stem-cells-to-make-hair-grow


    In this study, Christofk and Lowry, of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, found that hair follicle stem cell metabolism is different from other cells of the skin. Cellular metabolism involves the breakdown of the nutrients needed for cells to divide, make energy and respond to their environment. The process of metabolism uses enzymes that alter these nutrients to produce “metabolites.” As hair follicle stem cells consume the nutrient glucose — a form of sugar — from the bloodstream, they process the glucose to eventually produce a metabolite called pyruvate. The cells then can either send pyruvate to their mitochondria — the part of the cell that creates energy — or can convert pyruvate into another metabolite called lactate.

    The research team first blocked the production of lactate genetically in mice and showed that this prevented hair follicle stem cell activation. Conversely, in collaboration with the Rutter lab at University of Utah, they increased lactate production genetically in the mice and this accelerated hair follicle stem cell activation, increasing the hair cycle.
  10. Still a very popular drug as you can see.
    Hopefully this will also mean continued research.
    For anyone praising the drug, yea I was there once too.
    (I just think those posts in this spot might be in the wrong place. We all know what Accutane can do)
    Even thought about taking a second course after some zits came back.

    Then some things started to happen probably within a year of finishing my course.
    The first real sign that something abnormal was going on was probably the total diffuse hair loss that spanned the entire body. 
    Also the facial flushing, headaches, feelings of warmth in my head( inflammation?) trouble concentrating.

    For some the acne is so severe no cream is going to do a thing.
    The problem must be fixed internally.
    At least even the drug companies might be looking for alternatives.


    Isotretinoin Drugs Market Expected To Reach USD 1567.1 Million with Major Players Mylan N.V. (US), Ranbaxy Laboratories Inc, a SUN PHARMA company. (India) and Teva Pharmaceuticals USA by 2023

    https://www.openpr.com/news/1132596/Isotretinoin-Drugs-Market-Expected-To-Reach-USD-1567-1-Million-with-Major-Players-Mylan-N-V-US-Ranbaxy-Laboratories-Inc-a-SUN-PHARMA-company-India-and-Teva-Pharmaceuticals-USA-by-2023.html

    The Global Isotretinoin Drugs Market has been evaluated as steadily growing market and it is expected that the market will continue to grow similarly in the near future. Increasing prevalence of various skin disorders, genetic disorders and cancer are major driving forces for the market. The market for isotretinoin drugs was around US$ 1257.0 million in 2016 and is expected to reach US$ 1567.1 million which is projected to grow at a CAGR of 3.2% by 2023.

    Isotretinoin drugs causes some serious side effects such as birth defects and depression. To avoid these kind of situation, drug manufacturers are focusing more on new drug development. Due to strict regulatory policies, all the top players are trying to improve the efficacy and safety of isotretinoin drug.

  11. More Than a Month
  12. On 7/15/2018 at 10:11 AM, Devolution said:
    On 7/14/2018 at 1:24 PM, guitarman01 said:

    This looks like a fairly new method of testing. I wonder how easy this test would be to come by.

    I know Dr. Healy was asking people to get it done to see if people with PSSD have SFN but i think its quite expensive, 300 or so for the test. Be interesting all the same if it is covered by insurance.
    300 sounds cheap actually. Unless you meant 3,000.

    btw regarding tests.
    a recap. 
    you had someone show some low grade brain inflammation going on from a Mayo clinic analyzed PET head scan.
    @Babis
    he also tested positive for a pretty rare antibody.
    acetylcholine ganglionic neuronal antibody.
    So did I.
    I tried looking into this a little bit. No local drs are familiar with it. Even including a nero at UW Madison.
    This can also affect the gastro system.
    it basically could be a autoimmune attack on the nervous system.
    Don't quote me on that.
    Getting to a place like Mayo is prob a good idea. After you have some type of case built up or maybe some idea of what might be going on.
    I might try in the future, I dont have insurance atm.

    switching gears been looking at a couple things
    a hormone that seems to regulate alot
    somatostatin.
    inhibits digestion?

    Somatostatin - Wikipedia

    Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary ...

    Gastrointestinal system[edit]

     

    on the other side of the spectrum. 
    Lactic Acid

    1. Increases Testosterone
    2. Increases Human Growth Hormone
    3. Is Used as Fuel

    Special cells called “Leydig” use lactic acid to suck up cholesterol and convert it into testosterone.
    Without lactic acid... your body refuses  to do any of the exciting things such as producing more testosterone, growth hormone and energy.

    its also a powerful antibiotic thats looking to replace "antibiotics"
    you can find it in things like palmolive antibacterial soap. 


    Brain metabolism[edit]

    Although glucose is usually assumed to be the main energy source for living tissues, there are some indications that it is lactate, and not glucose, that is preferentially metabolized by neurons in the brain of several mammalian species 

    lactic acid is also produced by some commensal bacteria

  13. On 7/11/2018 at 7:21 PM, Devolution said:

    has anyone on this forum ever got a skin biopsy to test thier small fibers?

    This looks like a fairly new method of testing. I wonder how easy this test would be to come by.
    Maybe more so in a university or clinic setting. Not sure if its standardized, covered by insurance?
    Something to look into.  


    speaking of skin. what is normally found on the surface looking at the microbiome?
    could a biopsy reveal this as well?

    The Normal Bacterial Flora of Humans 
    http://textbookofbacteriology.net/normalflora.html


    Prop.acnes_colonies.jpeg
    Figure 4. Colonies of Propionibacterium acnes, found on skin and the conjunctiva.

  14. @MonsterDiesel
    on the topic of k2. You look into this thread and later find out that this person had taken Accutane previously as well and seemed to have a extreme reaction to k2.
    Weird Reaction to Vitamin K2
    https://www.longecity.org/forum/topic/68130-weird-reaction-to-vitamin-k2/
     

    6 hours ago, Devolution said:

    My skin keeps burning, getting pins and needles

    Yes as well.
    emg was neg.
    On 7/7/2018 at 4:04 AM, Biggest Brother said:

    We did this meiobian gland therapy which massaged the glands with heat to help push the blocked oil out

    This almost makes me think there is muscle involvement which might include blood flow.
    As to something being "choked out" from blood flow to gland function.
  15. On 7/8/2018 at 5:06 PM, Caprisunny said:

    I often read accutane can speed up MPB but how does this work?

    I had diffuse hair loss everywhere (entire body), not just the scalp.
    On 7/9/2018 at 5:07 AM, childofsungod said:

    According to a recent ultrasound they are both at around the 10ml mark, whilst the average is 20ml.

    What was the follow up? they didnt find any issues with blood flow?
    oh wait they did.
    you have a left sided varicocele that was found on ultrasound?
    11 hours ago, MonsterDiesel said:

    I've been getting really bad cramps anytime i take vitamin d

    Yea I did too. 
    I have looked extensively into vitamin k2 as the long chain form synthesized from bacteria.
    So now im looking at the bacteria itself.
    supplementing vitamin k might not make sense. 
    it might not be how it works in nature.

  16. On 7/6/2018 at 3:17 PM, Dubya_B said:

    alteration of conjunctival flora

    Accutane.
    alteration of skin flora
    probably including alteration of scalp flora
    alteration of sinus flora, including ears, nose, throat
    probably alteration in GI tract, including colon.

    This is a study id be concerned about.
    Even on low dose.
    see how this is from 2018?
    Trust a drug from the seventies?
     

    Low-dose isotretinoin therapy and blood lipid abnormality: A case series with sixty patients.

    Sarkar T, Sarkar S, Patra A.

    J Family Med Prim Care. 2018 Jan-Feb;7(1):171-174. doi: 10.4103/jfmpc.jfmpc_104_16.

     

    The Future of Vascular Biology and Medicine | Circulation

    circ.ahajournals.org/content/133/25/2603
    by S Kinlay - ‎2016 - ‎Cited by 8 - ‎Related articles
    Jun 21, 2016 - During the past several decades, landmark discoveries in the field of vascular biologyhave evolved our understanding of the biology of blood ...


     

     
  17. On 7/1/2018 at 1:29 PM, marshl1 said:

    Yes they could see the floaters after dilating my pupils and performing a simple slit lamp test. They were floating around inside the vitreous
    I have floaters. I am going to get this test when I get a chance to confirm the floaters are of the same nature. (you would think this could be a lawsuit if provable and not mentioned in the pamphlet.) 
    Something like this is also what sparks further studies.
    there are still plenty of ongoing studies on isotretinoin and similar.


    Speaking of floaters and various eye problems
    who has vision problems? dryness, irritation, light sensitivity, problems with night vision, eye floaters
    BUT still has 20/20 vision?
    anyone?
    Do you have astigmatism?
    Do you wear contacts?

    A side note if you wear contacts.
    Clean & Clear might help.
    Its a unique lens solutions that contains hydrogen peroxide.
    This will help kill unwanted pathogens that could easily build up on your contacts.
     
    NIH study shows microbe living on the surface of the eye protects cornea 
    Eye microbiome trains immune cells to fend off pathogens in mice. NIH study shows microbe living on the surface of the eye protects cornea from infection. C. mast is a commensal bacterium living on the surface of the eye. Bugs in your eyes may be a good thing.Jul 11, 2017
  18. 1 hour ago, marshl1 said:

    I have also had several second opinions. I was told by every eye doctor, including the impartial ones that I had vitreous floaters

    so was this a conclusion based on a certain test?
    Or based on described symptoms?
    Could they literally see the floaters after dilating your eyes?
     
  19. 48 minutes ago, marshl1 said:

    Are you saying that you have these eye conditions post accutane?

    I have eye floaters,dry eyes, eye inflammation and light sensitivity.
    Im saying has anyone had their eye floaters formally diagnosed as vitreous floaters?
    This would probably involve dye colored eye drops to dilate the pupils then examine. 

    Do your floaters respond to blinking?

    Finally, whereas most floaters are found in the vitreous fluid, it is important not to overlook another, simpler cause of the problem. You could be suffering from debris in the tear film. Many people, especially those prone to allergies, blepharitis (eyelid inflammation) or styes can accumulate makeup, mucus and other material within their tears. Floaters due to tear-film debris move when you blink, whereas vitreous floaters respond more to eye movements than to blinking.

  20. Anyone had this fully investigated?
    The last one, tear film debris could go hand in hand with dry eyes. I'm also looking at microbial changes on the conjunctiva or mucus membrane that cover the eyes. 

    Floaters

    • Ophthalmic
      • Vitreous syneresis
      • Vitreous haemorrhage
      • Posterior vitreous detachment
      • Retinal detachment
      • Vitritis
      • Tear film debris
  21. Dont waste your time.

    Let me give some examples of a follow up from my last post.

    BACTERIAL INHERITANCE LEADS RESEARCHERS TO RETHINK HEREDITY

    BY DOUGLAS MAIN ON 2/19/15 AT 9:14 AM
    http://www.newsweek.com/bacterial-inheritance-leads-researchers-rethink-heredity-307855

    Now im jumping around here a bit, going back and forth. Im aware of this.
    You see these gene mutations?
    This might tell you what bacteria you may be lacking.
    ive seen this in my own mutations.

    VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases
    http://www.funpecrp.com.br/gmr/year2015/vol14-4/pdf/gmr6188.pdf

    now lets dig a little further from what was just mentioned

    https://www.sciencedirect.com/science/article/pii/S2305050016301257

    Effect of black soybean natto extract (Glycine soja) on reproduction system of hypercholesterolemia male mice
    Black soybean natto extract influenced on reproduction system of male hypercholesterolemic mice by increasing the testosterone level and increasing the density and motility of sperm.
    This is also a vitamin k producing bacteria.

    There's also bacteria that produce carotenoids in the gut, right at the site of absorption.
    same for b12, biotin, folic acid, digestive enzymes.
    Microbes are also responsible for multiple metabolisms.
    Things like glucose, heavy metals, cholesterol.
    Bacteria can Also degrade a form of estrogen that is a powerful endocrine disruptor. 
    example.

    Isolation and characteristics of 17beta-estradiol-degrading Bacillus spp. strains from activated sludge.
    https://www.ncbi.nlm.nih.gov/pubmed/20135340

    Did you know they discovered a fungus that eats plastic? 

    Something that is unexplored to me is individual probiotic strains.
    even strains from the same genus can compete with each other.

    Did you know the p.acnes bacteria might get its origins from the soil?

    "Propionibacteria are commonly found in milk and dairy products, though they have also been extracted from soil."

    There is a probiotic that happens to not fall too far from the acne tree.
     Propionibacterium freudenreichii.

    So your looking at what gets knocked down, like p. acnes. and what went along with it.
    your looking at knocking down bacteria along with fungus from isotretinoin. 
    But then what came back?
    After or during treatment.

    Id be curious about looking at ubiome in some of us.
    If and when I get these test results, I will be sure to share.

    maybe in the future a bacterial or even fungal deficiency as it relates to human microbials will be so much more important than any vitamin deficiency as you can see just one strain can do so much more than a single nutrient. 

    So this is what I will be exploring for the near future.

     
  22. 21 hours ago, TrueJustice said:

    Its interesting where you’re heading with this school of thought about fungus vs bacteria!!

    What Products are currently available to treat fungus issues? There must be something already available surely - a drug of some sort.

    Even some supplements, “oregano oil” is good for example but that’s not exactly going to be the cure for us, something stronger would be needed.
    The gist of it could be,
    Ive seen antibacterial=anti androgen
    Ive seen antifungal= anti androgen

    Ive seen possible feminism type features in some that could be related to messing with the above.
    (and that doesn't necessarily mean directly.)

    pretty sure Accutane messes with this. "This" meaning the micro and myco biome.

    Your genes could predetermine what your micro/myco biome is composed of.
    Also more susceptible to.

    The key of this school of thought would be,
    what do you knock down? what do you promote?
    is there a sort of gut/skin/mucosal protector missing?

    What hasnt been looked at extensively?




     
  23. @mariovitali
    @Dubya_B
    @ACCUiTy_drANE
    So here we go. Possible correlations.
    This could mean any number of outcomes, or not relate to this at all.
    obviously we have heard of antibiotic resistance,
    what about fungal resistance?
    looking at dysbiosis the definition could fall in line with a microbial imbalance that's not a outright infection.
    This in turn could trigger autoimmunity and inflammation. 
    To me this is at least evidence of possible microbial alterations. 
    That might remain permanent. 

      Antifungal properties of selective serotonin reuptake ... - Oxford Journals
    by C Lass-Flörl - ‎2001 - ‎Cited by 66 - ‎Related articles
    In conclusion, our in vitro studies clearly demonstrate antifungal effects of SSRIs. Animal studies are needed to evaluate the potential role of these psychotropic ...
     

    In Vitro Analysis of Finasteride Activity against Candida albicans ...

    aac.asm.org/content/58/10/5855.full.pdf
    by AA Chavez-Dozal - ‎2014 - ‎Cited by 12 - ‎Related articles
    May 16, 2014 - clinical utility of finasteride in the prevention of urinary candidiasis is ... with standardantifungal drugs, and finasteride is one of several.
     

    Fungistatic activity of all-trans retinoic acid against Aspergillus ...

    by E Campione - ‎2016 - ‎Related articles
    Apr 29, 2016 - Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate ...

    Is it harder to kill fungi in the body than bacteria? If so, why?

    The treatment of fungal diseases is more difficult than those caused by bacteria. Because bacteria are prokaryotes, the makeup of their cells are very different than our own eukaryotic cells ( cells containing membrane-bound organelles) and pharmaceutical products, such as antibiotics, are able to successfully destroy bacteria without harming much our cells, tissues and organs. However, because fungi are eukaryotes, finding a treatment that will kill the fungus and not harm our own cells is more difficult. So most chemical treatments that are harmful to fungi are also toxic to us.
     
  24. On a side note,
    Did you know your eyes have their own microbiome?

  25. @mariovitali
    abnormal immune system reaction.
    Do you think its a overactive immune system or underactive?
    34 minutes ago, Jason3 said:

    TSH is only going to catch really obvious thyroid problems

    I myself have gone as far as a thyroid ultrasound along with above mentioned tests.


    Even during periods of extreme ed, All hormones have tested relatively normal. You could find this in PFS as well.

    5 hours ago, Kolonie said:

    Autonomic Nervous System is broken..


    The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the autonomic nervous system (ANS) and consists of a mesh-like system of neurons that governs the function of the gastrointestinal tract.[1] It is capable of acting independently of the sympathetic and parasympathetic nervous systems, although it may be influenced by them. The ENS is also called the second brain.[
     

    Stress, Sex and the Enteric Nervous System

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003424/
    the largest immune response reservoir of the body

     highly susceptible to microenvironmental changes.

    The Central Mechanisms of Sexual Function » Sexual Medicine » BUMC

    www.bumc.bu.edu/sexualmedicine/.../the-central-mechanisms-of-sexual-function/
    There has, however, been growing interest in the role of the central nervous system (CNS) in the control of erectile function, and researchers have begun to ...
  26. @Dubya_B
    @ACCUiTy_drANE
    Maybe it wasnt bacteria. This is what I mean, or have been looking at.
    Could be wrong though.
     

    Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study

    antifungal medication during pregnancy may affect the masculinization of male offspring. 
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480178/

     

    Endocrine disrupting effects in vitro of conazole antifungals used as ...

    by MB Kjærstad - ‎2010 - ‎Cited by 88 - ‎Related articles
    Aug 11, 2010 - Widely used conazole antifungals were tested for endocrine disruptive effects ...Androgen Receptor Antagonists/toxicity; Animals; Antifungal ...
    Like all azole antifungal agents, ketoconazole works principally by inhibition of .... Ketoconazole is anantifungal imidazole that inhibits androgen biosynthesis at ...



    Fungistatic activity of all-trans retinoic acid against ... - NCBI - NIH

    by E Campione - ‎2016 - ‎Related articles
    Apr 29, 2016 - Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate ...
    Purpose · ‎Conclusion · ‎Introduction · ‎Results
     
    This is the first evidence of a direct and strong fungistatic activity of ATRA 


     
  27. 23 hours ago, ACCUiTy_drANE said:

    7. If vitamin A is at the root of autoimmune illness, how does this fit into the idea that microbial transplants can both cure and induce a number of autoimmune diseases in mice? Does bacteria make the liver grow or something?

    Not sure how often you frequent the forum, but yes, maybe. 
    Except i'm not looking at bacteria atm, but what it evolved to.
    Maybe it was never bacteria.

    "the diversity of the microbiota on the cheek and the back was significantly increased after acne treatments"

    Eukaryotes

    Eukaryotes represent a tiny minority of all living things.[8] However, due to their generally much larger size, their collective worldwide biomass is estimated to be about equal to that of prokaryotes.[

    Pathogenic shifts in endogenous microbiota impede tissue ... - eLife

    The interrelationship between endogenous microbiota, the immune system, and tissue regenerationis an area of intense research due to its potential therapeutic applications. ... The culture of these bacteria yielded a strain of Pseudomonas capable of inducing progressive tissue degeneration.

    Shifts in the microbiome impact tissue repair, regeneration ...

    https://www.sciencedaily.com/releases/2016/08/160826151746.htm
    Aug 26, 2016 - Shifts in the microbiome impact tissue repair, regeneration. Summary: A definitive link between the makeup of the microbiome, the host immune response, and an organism's ability to heal itself has been confirmed by scientists.

    Role of the Microbiota in Immunity and inflammation - NCBI - NIH

    by Y Belkaid - ‎2014 - ‎Cited by 771 - ‎Related articles
    The mechanism by which neonate tissues adapt to the formidable challenge of ..... the gut, TLR activation by commensals was required to promote tissue repair ...
  28. I would say the amounts of vitamin a are so small in the diet compared to what Accutane was (which might have equated to around 100k iu to 40 mg isotretinoin just looking at weights, but Accutane being a more potent version) 
    That avoiding vitamin a in the diet is pointless, minus eating liver.

    I could also say that I could experimentally induce a lot of the Accutane side effects by taking the wrong supplements that are further agonists to Accutanes many possible modes of action.
    And guess what it might have to do with Accutane at this point?
    Absolutely nothing. Meaning Accutane might be long gone.

    You can see a side effect profile or correlations with many drugs and supplements that have nothing to do with retinoids.
    Maybe the fact that they might be a similar type of poison of you want to call it that, with a trickle down effect to the host organism or unavoidable damage or stress that the person must recover from.

    Just a update, i've backed off of Bacillus based supplements for now as well, as they might be further antagonists like Accutane.



     


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