About this blog

Entries in this blog


MIAMI - The plan had been to remove only part of the large growth distending Marlie Casseus' upper

face and leave the rest for future surgeries, but the operation went so well that doctors just kept


Marie Casseus before surgery

By the time they had tied off the last of about 2,500 stitches, surgeons had opened the 14-year-old

Haitian girl's face like a book and excised 9 pounds of jelly-like fibrous tissue, bone fragments,

teeth and fluid, doctors reported Friday.

With titanium mesh, they constructed a new framework for her facial features, which, lacking the

support of the underlying growth, would have collapsed into an empty cavity.

Surgeons, who began the operation early Wednesday and completed it nearly a day later, formed an

upper lip, reduced the size of her overstretched mouth by 70 percent and - having been surprised to

find her nasal septum intact - reopened her crushed nostrils with plastic "trumpets."

She lost 40 percent of her blood during surgery at the University of Miami/Jackson Memorial Medical

Center's Holtz Children's Hospital, and received six units of replacement blood.

After surgery she looks like the picture below

Marlie has McCune-Albright syndrome, a genetic condition that includes the uneven bone growth of

polysostic fibrous dysplasia, and endocrine abnormalities.

The condition affects much of her bone structure and could return to her face, doctors cautioned.

She appeared to be growing normally for the first few years of her life, but by age 9, the mass had

so distorted her face that she quit school.

By the time she came to Miami 10 weeks ago, she could barely breathe.

McCune Albright Syndrome


It is possible that the main title of the report McCune Albright Syndrome is not the name you

expected. Please check the synonyms listing to find the alternate name(s) and disorder

subdivision(s) covered by this report.



Albright Syndrome

Osteitis Fibrosa Disseminata

Polyostotic, Fibrous Dysplasia


Precocious Puberty with Polyostotic Fibrosis and Abnormal Pigmentation


Disorder Subdivisions


General Discussion

McCune-Albright Syndrome (MAS) is a rare multisystem disorder characterized by (1) replacement of

normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); (2) patches of

abnormal skin pigmentation (i.e., areas of light-brown skin cafe-au-lait spots with jagged borders);

abnormalities in the glands that regulate the body's rate of growth, its sexual development, and

certain other metabolic functions (multiple endocrine dysfunction). Depending on the number and

location of the skeletal abnormalities, mobility may be impaired, as well as vision and/or hearing,

and the individual may experience substantial pain. Malfunctioning endocrine glands can result in

the development of secondary sexual characteristics at an age younger than normal (precocious


McCune-Albright Syndrome is the result of a genetic change (mutation) that occurs randomly, for no

apparent reason (sporadic). In individuals with the disorder, this sporadic genetic mutation is

present in only some of the body's cells (mosaic pattern). The symptoms and physical characteristics

associated with the disorder vary greatly from case to case, depending upon the specific body cells

and tissues that are affected by the genetic mutation. This mutation occurs after fertilization

(postzygotic somatic mutation). It is not inherited from the parents.

The range of severity of the disorder is very broad: some children are diagnosed in early infancy

with obvious anomalies of bone and increased hormone production by one or more of the endocrine

glands; others show no evidence of bone, skin or endocrine malfunction in childhood and may enter

puberty at an appropriate age.


Stress Management is more than anger management and relaxation. It is self management. There are

many different ways to manage stress. I have compiled the various stress management techniques that

are simple and most effective to follow and practice. Please feel free to use as many as you can,

keeping an open mind, so you can have a collection of techniques that are the most effective for


Feel Good about your Self

Take Care of your Body

Develop the Right Attitude

Develop the Right Environment

Short Tips for Busy People

1. Feel Good about your Self

If you want to bring down your level of stress level in a matter of minutes, these techniques will

help you. Use them as needed to feel better quickly; practice them regularly over time and gain even

greater benefits.

Deep Breathing from the Abdomen


Having a dose of Laughter

Progressive Muscular Relaxation

Listening to light music

Practicing Yoga

Aerobic Exercises

Creative Visualization

2. Take Care of Body

Have six to eight hours of regular sleep

Exercise regularly

Develop a Hobby

Have healthy Sex Life

3. Develop the Right Attitude

Attitude plays a great role in managing stress. Much of your experience of stress has a lot to do

with your attitude and the way you perceive your life's events. Here are some resources to help you

maintain a stress-relieving attitude.

Let go your Ego

Have a Optimistic approach to life

Do not react under pressure

Stop Worrying about things not in your control

Accept that everything cannot be perfect

Find an opportunity in every problem

Say good things to your self

Have a health sense of humour

4. Develop the Right Environment

Having ambiance and pleasant environment make stress management very easy. Your physical and

emotional surroundings can impact your stress levels in subtle but significant ways. Here are

several ways you can change your atmosphere and less your stress.

Clutter free home, office and working desk

Green and Clean surrounding

Light instrumental music

Motivational Posters

Words of Wisdom

5. Short Tips for Busy People

Busy People add a lot of stress to their already stressed life. People who may have more stressors

in their lives is because they have more activity in their lives, and less time to devote to stress

management. If you're a busy person, these resources can help you to manage stress efficiently in a

short amount of time, and eliminate some of what's causing you stress in the first place.

Time Management Tips

Communication Skills

Listening Skills

Managing Priorities

Enhancing Team Work

Enhancing People Skills

The Acne.org Regimen
The Acne.org Regimen
Product & Treatment
Support Forums