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Lmao. I like your thinking, and a valid point I suppose lol. On a side note.. I really hope that the research done on FAK is just a branch that spawned out of verteporfin research vs being the result of it. This paper makes it seem like we’re going back into research mode instead of validation of verteporfin efficacy. Other than that, the results are pretty good. The size of those wounds are gigantic it seems, like the size of one whole cheek in humans. But for the excision appro

This is a Scarless healing Thread. Please dont waste our time with discussion about Lasers that have a long track record of doing bugger all for scars, any results you see are minimal and probably a result of swelling, I speak from experience. People want to remove their scars not improve them marginally and lose a lot of money in the messy process. The momentum for scarless healing has gathered much more steam the past 5 or so years because of inferior current day treatments. Lasers and ot

if you call me believing in someone's decades of research and being optimistic a delusional bubble, then that's okay. Whatever helps you sleep at night. I still don't understand the point you're trying to prove, if you don't believe in scar less regeneration, why even bother reading this thread and replying negatively to everything, what exactly are you trying to achieve with this? You're interested in researching and discussing but all I see is pessimism and honestly it's very draining.

We 're almost there everyone .... i have dermatitis of eyelids , facial scarring etc ... if this works on humans things will only get better .... everyone scarfree healing will happen sooner rather than later ....

Here are some additional photos that I just took outside today. I didn’t take before photos outside but still thought this might be useful for some people to see what my scar type looks like outside in direct sunlight right cheek right Left left

Whats the point you're trying to prove here these past few days? You came here with this wave of negativity and keep criticizing everything. What are we supposed to do? What does the thread say? "Scarless Healing". That's all we are trying to talk about, discuss future prospects and what not. Everyone here realizes that verteporfin may or may not work. Do you expect us to stay depressed about our situation and not research into future prospect on what may or may not work? Longaker ha

It's happening .... am looking forward to scar free healing being a reality soon <3

"It will take decades" No, it won't: 1) Works on the pigs whose skin is closest to human skin 2) It is already approved by FDA (for eyes) 3) Has big interest from hair loss community

Here I am at two months post-op. Same harsh lighting. I angled the lighting a little more so people could see the left cheek’s scarring a little better. right cheek Right cheek right cheek notes on right cheek: boxcars still present but slightly softer than before. They are kind of hard to see because they are white in the centre and kind of blend in to some degree left cheek left cheek left cheek And because my thread is so lo

https://www.prdistribution.com/news/burn-injury-healed-with-complete-skin-regrowth-in-only-6-days-using-new-stem-cell-drug/1836901 This seems promising, it solved a third degree burn with minimum scar tissue, a third degree burn goes deeper than the dermis. https://www.biospace.com/article/releases/viaderma-lead-product-tetrastem-shows-promise-in-treating-acne-/ It has been previously used for acne as well, and this mentions about skin regeneration and minimising scarring as well

Yeah, I hope we will get som news by the end of september!

How about keeping them to yourself , because ultimately they are people on here that stop living there lives because of the scarring they have in which scar free healing holds the key to changing their lives , who are you to come on here and shit on peoples hopes ? the scientists that are working on these technologies are vastly more qualified to talk about weather they will work on humans or not and not some no one that wants to bring peoples morale down.

I came just in the nick of time to see someone answer in the way i would have too. I think mysharon confuses these upcoming therapies and devices with the current "scar removal" treatments we have that at best work to make scars harder to see or better match ones skin colour.

Ever heard of Latisse? It's FDA-approved for treating glaucoma, but it's actually better known for its off-label use for eyelash growth and thickening. You don't need FDA approval when something is known to work off label. Cytrellis is seeking FDA approval for scars because most doctors don't even know what micro-coring is, much less whether it works for scarring. You're looking at this all wrong. Fraxel/CROSS/etc. are all *scar removal treatments*. Verteporfin is a *wound healing treatm

https://www.docseducation.com/blog/new-research-opens-door-scar-free-cleft-lip-surgery "The Stanford team has moved forward by using the medication on pigs, which have skin more akin to humans, and the results have been similarly dramatic. Patents have been filed to use verteporfin specifically for reducing scar formation" "The results have been similarly dramatic"

You know verteporfin is literally closest thing we have right now for scarless healing, why would it take decades for it to be approved for scars when it is already in use and is approved by FDA for eyes. Pigs are not mice, they are similar to humans, if it works for them there is a big chance that it will work for humans too. You came here just to say that the closest thing we have right now for scarless healing is decades away, so by your logic we will have nothing for decades. Just leave alre

It doesn't work that way, the existing scar has to be excised first. Dealing with acne scars alone is enough, why are you bringing this wave of negativity with you?

Stanford filed patents earlier this year on using Verteporfin for wound healing and hair follicle neogenesis ----https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021021607

This “cosmetic” attitude nonsense is worst , even some drs are like whatever , u got some scars so what , despite the fact there are studies how acne scarring affects life of people and also how others perceive you , its awfull . Once it will be proclaimed medical and medical insurance will have to cover this issue then will see improvement in treating acne scarring

Yup acne is very challenging. You could still scar even if you don’t pop acne. The longer the acne linger your body starts attacking the tissues of the affected areas. You get atrophic depression from collateral damage. It’s trying to kill the excess bacteria. That is why I am a strong believer in eradicating acne asap. You don’t know if you will scar the best thing is to assume you do and stop acne in its tracts. The lesser the time of inflammation. The faster you will recover from this.but the

Yup. we all feel the same way, to varying degrees. Your improvement is vast, and unless you're super close up or in terrible lighting, in a few of the photos they were so much improved I barely saw them they looked like you had full makeup on to be honest. Of course this is probably painful to hear because you (and me) are constantly in bad lighting on the way out, or we see our flaws every day and know it's bs, and not in the best situations, and everyone around us is perfect even people i

Since the damaged tissue is going to be removed, it would make new wounds anyway so I think it shouldn't make a difference. It shouldn't matter if the skin removed was damaged or perfectly normal before, since the healing process will begin from square one.

No never experienced this personally tbh. I would love to gain some fat in my cheeks lol. Yes it’s offensive IMO when acne scar revision is seen as cosmetic. 100% medical. I wish we could get more support for this condition. I even feel uncomfortable saying I have body dysmorphia because this flaw is 100% real and if left untreated has so many ramifications both mental and social. In Australia I believe you can get certain coverage via insurance for certain acne scar procedures

As far as existing scars and verteporfin goes, I really don’t see much reason why it wouldn’t work. Wounds treated with verteporfin heals without scars. That’s the statement right? So just create a wound. How to create a wound? Well yeah you could just excise the scar, stitch together, and add verteporfin, but that’s kinda lame. Sunogel had a bunch of illustrations on how you cut off the existing scar and deploy hydrogel, and bam scarless healing. You can do the same thing ex

I want to try it on myself, but I'm scared of it

So it will take about 2 years to start human trials? Wonder if someone will try it off label if pig studies goes well…

Why would microcoring even need verteporfin, microcoring should work very good on its own.

They'll figure out a treatment protocol but i personally think that microcoring+verteporfin can work well together for striae and acne scars(if verteporfin works). I'm holding off being too excited about this treatment until pig study results are published.

This is a research paper published by some chinese authors in July. It covers everything regarding skin scarring, everything researchers know by far. YAP inhibition, mechanotransduction, WNT inhibition. I honestly believe there are multiple pathways to achieve scarless regeneration. https://www.mdpi.com/2218-273X/11/8/1095/htm

Punch excision was pretty life changing for me tbh. Check out my thread and let me know if you have questions.

science has made very good progress on how healing works. it will not be surprising if we have a treatment for complete skin regeneration in the near future. be positive!

I still check in once in a while.

I understand your situation @pleasehelp321 but the constant negativity is really harmful for those reading here. It's not all doom and gloom here. It's not right to tell people filler and sub will leave the patient's skin exactly the same that's just not true. If the doctor understands the patient's scar type and recommends the treatment with the skill necessary then it's reasonable that the patient will have improvement. Other factors come into play but to say these treatments don't work is wro

You clearly dont understand what off label use means but anyway thanks for your thoughts. Btw the entire world doesnt wait on the FDA, that's an American problem. An approved drug thats already used safely in humans will not take decades to get the ok that satisfies physicians/dermatologist so Im not sure why you are taking such a pessimistic outlook on all of this. Yes I agree we dont know what the results will be in humans yet but its promising so far and as someone else mentioned th

Sorry but i heard someone say micro-coring has been approved and is a big disappointment, is there a source for this or it's just the pessimism of the poster(as usually happens here). More on why I'm hyped for microcoring, my scars are flat, the only atrophic ones i have are two and i don't really mind them.. Saw the video of the Sperry-bio microcoring system on youtube, contacting the lady who put it up led to her taking the video down(as the device is still in development), though the vid

Well it is fda approved... just not for scarring. That's what makes this even more promising. However, we have to wait and see the pig studies. I mean this is a scientific study conducted by researchers that have spent decades on this. Not some company trying to sell you something. So I don't think it is a scam.

The main concern is both because we got old from waiting so long for scarless healing.

I think the main concern here is getting rid of scars.

Yup it’s deep rolling scar. It think you excision area was huge, is that why this caused? Filler are ideal , look for bellafil. Maybe too much area was excised hence caused a depression but it is a depression with sloping edges. Also it seems like there is tethering still. That is why I always think the lower area for excision the better. You are basically remove a tiny portion of skin permanently so it’s possible that it could create a divot. there are silicon fillers as well if you are i

Under Porcine and human confirmation of diverging trajectories: «These experiments demon- strated that YAP indeed acts as a master regulator of profibrotic differentiation, and that silencing YAP expression could, like FAK inhibition, promote regenerative EGR1 expression while down- regulating collagen and myofibroblast markers« I believe we should see the results of verteporfin, because i think FAKI just downregulates YAP, but it doesnt block it. What is good is that the researches fo

It isn't a complete regeneration, sure. But yes, there's a massive difference with/without it. It should only get better from here I believe.

It should be covered by the state/government entirely, until "meaningful/permanent" progress is achieved, which may be never so coverage should continue. Instead, physical and mental damage is ignored and basically called "cosmetic". The irony is they pretend the physical damage of having chunks of skin missing and the barrier/layers damaged is just cosmetic too. It's easy to do so, so they can ignore it. My family paid for personal insurance at the time and we had to jump through hoops to

I was rewatching se7en a few weeks back and noticed brad pitt had more noticeable scarring in some lights that is not visible in his later films, so clearly had some effective work done besides, even then, his scars were minor. In fact, I think MILD acne scars can actually be a plus in terms of looks sometimes. More character, roughness etc.

I suggest waiting for pig results before though. I think verteporfin would be used and skin would be regenerated in about a month?

Theres defo ppl out there that would try it. Everyone that has acne scars especially severe ones can’t wait to get their hands on some verteporfin. The thing is they need to do it properly.

Big update!! Thank you for this.

I think the reason it felt so rushed to me with the previous dermatologists is that no special lighting was ever used, and rarely were my scars marked (marked only with Dr.Sajic). Having subcision done with Rullan was truly a different experience for me. He really blew my cheeks up with the tumescent anesthesia (more than it's ever been done before), and it felt like he was quite thorough (special lighting was used). I think my subcision was about 20 minutes yesterday. But mind you, at this poin

man you are depressing, Im not blaming you, maybe reality is just that depressing. in which case, why bother wasting time oin this treatment forum? if nothing works, why not just come to terms with it never changing and move on with life.

Yeah, but just exactly how many times did you repeat each procedure? Most people tend to quit only after one procedure when they see little to no improvement. The sad fact is that you need many procedures to see any meaningful improvement. For instance, with TCA, you won't likely see much for the first 4-5 treatments. But persistence will pay off in the end.

I have but then I think of all the people who have it so much worse off than me. Acid burn victims in India, kids who have lost their families in fires and live their lives alone with horrific scars. I figure if they can work through it and some people even do amazing things afterwards, then I should count myself lucky. Other than the scarring I live a privileged life compared to 90% of the world's population so I try to focus on the things I'm thankful for like a roof over my head and food on m