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Accutane (isotretinoin)
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Brand: Accutane

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Accutane (isotretinoin)


Active Ingredients:
Isotretinoin in 10-mg, 20-mg and 40-mg soft gelatin capsules.

Inactive Ingredients:
Beeswax, butylated hydroxyanisole, edetate disodium, hydrogenated Soybean oil">soybean oil flakes, hydrogenated vegetable oil, and Soybean oil">soybean oil. Gelatin capsules contain glycerin and parabens (methyl and propyl), with the following dye systems: 10 mg - iron oxide (red) and titanium dioxide; 20 mg - FD&C Red No. 3, FD&C Blue No. 1, and titanium dioxide; 40 mg - FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide.

Items marked with red have tested a 3 or above (out of 5) in comedogenic (pore-clogging) testing.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.

Accutane (isotretinoin)

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Accutane (isotretinoin)

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I had to go to the ER
Reviewed on June 23, 2016

This is by far the worst acne drug I've taken. I think I most likely had an allergic reaction to the medication. I ended up vomiting 6+ times in less than 4 hrs. I went to the ER and they tried to give me medication to stop the reaction, and really strong nausea meds that are typically given to chemo patients... I still couldn't hold down anything, including water. I started having breathing problems and they ended up having to give me a steroid shot so I wouldn't go into anaphylactic shock. However, this is an extreme case, and many people have had success with accutane so I'll give it 2 stars. Just... Proceed with caution

Works for acne but makes you gain weight
Reviewed on June 18, 2016

I have been taking Roaccutane for 3 months now and it has certainly helped my acne significantly - mine is hormonally related (started in my 30's after coming off the pill) and can give nasty cysts on my neck and jaw area but I have had none since starting. I am in my mid 40's (female) and also have low progesterone - handled with non-synthetic progesterone and hypothyroidism treated with Novothyral . Each work brilliantly in their own right.

However, I have, since starting Roaccutane. gained 4 - 5 kilos (already) - this is probably down to the fact that my digestive system does not seem to be working very well (pellet like stool and not very regular). However, this frustrates me. I am doing as much exercise (and the same type) as before I started. I follow a pretty strict food regime because of my slow metabolism (5/2 or 4/3 - more the latter) although on my days off, i do enjoya little wine (is this the culprit?). Can someone please advise whether this is normal? I don't want to hear that I am 'eating more', 'eating the wrong things', doing less exercise - as this is not the case. Nothing in my diet or regime has changed and I was happily around 65 kgs for years (I am 1.75)

Weight gain is not stipulated anywhere as a side-effect.....but it certainly is and should be. I just hope when I've finished my 5 month course that I will not be 10 kgs heavier!! - then I'm really not sure it's worth taking the Roaccutane, as my skin was only moderately bad when I started.

Any tips on what to do?

by ZitsSuck21 on 06/23/2016 11:58
Hey, add in a decent probiotic and fermented foods for the IBS. Drink bone broth too. You may have candida so you might need to do some candida cleansing before adding in probiotics if you have a strange reaction too them. Best wishes
Please listen to me
Reviewed on June 17, 2016

I have just finished my 5 months of Accutane and feel I owe it to acne sufferers everywhere and to say that please, just give Accutane a go. I have never been more confident in myself as Accutane has drastically cleared up my skin to the point it is absolutely unnoticeable i even had acne. I am back to being me again, and i know you can feel the same. The worst that could happen would be that you don't like the side effects enough to stop taking the medication. For me it's a life changing medication with only positive results. Please don't listen to people talking badly of the drug as if your acne has you feeling low, it is a miracle cure.

And remember no one looks at you the way you do. People see the bigger picture - not just your skin. Sure they will notice you have acne, but anyone who has not suffered themselves would not see it as disgusting, they will see a bit of redness. And the people who have suffered will only sympathize with your situation. And i mean this in the nicest possible way but no one cares about your apperance - they care about theirs much like you only care about your own. So smile, live through it, and trust me. Try accutane.

All the best, Ben

by Charles Marcus on 06/18/2016 06:30
hello! I'm a 20-year-old male and I'm on my second week of taking Isonoin/accutane. I'm not seeing yet any improvement on my skin, just want to know if, how long will it take to see improvements. Thanks!
by Aliste24 on 07/13/2016 10:20
You will only see major improvement a month or so after the trial has ended. My dermatologist used to say this every visit and it did indeed come true, I'm afraid there's no instant cure
The best there is
Reviewed on June 16, 2016

I went on Accutane about a year ago and I had moderate to severe acne before starting my treatment. I also had moderate acne on my back chest and shoulders. I took a generic isotretinoin capsule once a day of I think 400 mg (maybe I can't really remember) for 6 months. It was quite a pain to start, I'm female and my doctor required I take birth control during the entire course of treatment even though I was abstinent the entire time. I had to get a hormone implant called nexplanon a month before I could start the treatment and since I might have to have my wisdom teeth out while I was taking it I had to do that too before I could start. But after all that it did work really well, my acne was completely gone by the time I finished the 6 months. My skin was very dry and I did have a few side effects, I had dry skin, nose and eyes for almost the entire 6 months plus a few months after I stopped taking it. I did not have any severe side effects and had no complications.

Now almost a year after taking the drug, I still get pimples occationally but it's very mild, I still have some minimal scarring from before I took the drug but to my knowledge it was not supposed to fix that at all just prevent any further scarring. The acne on my shoulders, chest and back is completely gone and has not come back at all.

I would recommend this drug, even though it was a bit of a hassle to start and had some scary possible side effects, my acne is almost completely gone and I'm very happy with my skin. I wish you luck if you have acne!

by dou on 06/27/2016 13:18
I'm so scared to be acne is not severe but few pimples.i want To try for month if I see I can't handle it I will stop the medicine I will opt for so the moment I haven't got spots,I used an acid months ago on my skin which I had to stop because it had made my face burnt So I give a go and see. But when did u notice an improvement in your face?
Trip to Hell
Reviewed on June 15, 2016

I was so excited to try this after 30 years with acne. I've never had any side effect to any medication and never been on antidepressants or had mental health issues. From the reviews I read I got the impression most people were fine on it, that the main problem was that it might not work, and that a few people who had bad effects had caused it to be prescribed more carefully than was maybe helpful for acne sufferers. I was started on only 20mg and told that would be put up to 40 and 60. By about day 2 I noticed my thoughts were harder to stop than normal, eg I would find it hard to switch off at night, and I woke up from vivid dreams (thoughts still persistently going on in the background) and found it hard to get back to sleep. I had read about this from other reviews who just persisted with treatment so thought that was to be expected and carried on. After about a week I had hardly any dryness on that dose but could tell that my skin was becoming less acne prone - it just felt un-itchy and after suffering from acne for as long as I have I can generally feel when my skin is in a state where I'm liable to break out or not, and the isotretinoin was obviously doing its job, but I kept bursting into tears. By day 9, my skin was clear, but I was in hell. I could only see the bad things about my life, which were blown out of all proportion to a psychotic degree, I was constantly crying, there was no hope, I didn't see anything positive in life or feel the same about my family, and the back of my brain felt like it was coated with tar. I was missing sleep and had lost my appetite. The thought of raising the dose even higher and being on it for months more was unthinkable. There seemed to be no guarantees that this mental change would not be permanent to some degree (I could find studies that showed depression and brain changes after taking it, but none that showed the depression and brain changes as having then gone away after say a few months of stopping treatment, which I would have expected the drug companies might do if it was possible) and the two people I know who have taken accutane don't get spots but are miserable - one is constantly having headaches and is just generally unhealthy and the other is depressed. So I stopped and thankfully the stuff is out of my system (6 weeks ago). I guess we're all different and you can't tell what your response will be.

Reviewed on June 13, 2016

I hope my review will be helpful to anyone.

So I have been on 30 mg per day dose, which is the minimal dose for my weight, I am 58 kg, it makes about 0.5mg/kg.

I have stubborn acne on my jaw that would never leave no matter what I tried.

I have been on isotretinoin for 1 months- I have lots of break outs, since the begining of treatment, the whole month, it is very depressing.

I am trying to stay positive and patient, but I didnt have a break from increased zits since I started the drug.

If it is an IB, how long does it usually lasts?

by S33kingS0lution on 06/22/2016 06:08
My lasted 3months. Worst initial breakout. Worse than my acne before i started.
Does what it promise
Reviewed on April 30, 2016

I took it mainly for scarring though my facial acne was a little worse than mild-moderate with monthly cysts*can't really call mild when having cysts).Acne on back was extensive but again,no bad lesions.Just the average pustules and papules.Has been on accutane for over two months and seeing less acne as time goes by.My back is almost clear and my face and arms get little weekly zits.But the truth is the skin peeling due to the excessive drying made my scars worse.

Giving it a 4 stars now and will give it 5 once I get clear and continue to be that way.

Reviewed on June 8, 2016

Took it for 6months left with indented scarrings. I never get scars before accutane no matter how big my zit was wether i pop it or not, it never left a scar. But every pimple i got during my course left dents. I don't know if i'm gonna keep getting them but accutane is my biggest regret. I should've tried other options. If you're planning to go on accutane, pls don't risk it. You may or may not get the results you want. You can't be sure. I'm having a lot of gas and constipation as well.

by TinaSI on 07/15/2016 18:53
Have you been picking on your skin while on the drug? If you do ANYTHING to your face it will likely leave a scar.
by S33kingS0lution on 08/05/2017 15:35
My dermatologist gave me facials and injected steroid on my cystic acne while I was on accutane. I suspected that the ones she injected are those that left scars.
Worked For Me!
Reviewed on June 2, 2016

There is a higher ratio of people leaving negative reviews on accutane than positive reviews because many people who reaped the benefits don't come back to write " it worked for me" , but here I am to say " IT WORKED".

My dermatologist had been encouraging me to take accutane for years now but I was scared from reading all the negative reviews ,so I resorted to natural methods ( which did not work to the magnitude I desired). After finally giving up, I gave it a shot and luckily for me I experienced the common side-effects which go away after discontinuing the drug.

I was 19 years old when I took the drug, female, 5'4, weighed around 120 ( for the people who care about stats). Did not take birth control because I didn't want any extra drugs circulating my system especially when accutane is a strong drug on its own. Avoiding pregnancy was not an issue for me so my doctor was lenient about this. I took Accutane - 30 mg for the first two month. Epuris- 40 mg for the other 4 months. I started in May 2015 and ended in November 2015.

The type of acne I had was related to unbalanced hormones, stress, poor diet- all factors which I had a hard time fixing due to being a full time university student. Stress and poor diet was unavoidable in my case no matter how hard I tried. Problematic areas for me were my cheeks and sometimes forehead, it was not flaming red acne all over my face. I was still able to cover it up with makeup but vanity was not my reason to take it. It was very painful, I would get cysts on my cheeks and back ( had been suffering from bacne for 6 years now).

During the first month, I felt the common side effects of dry lips, dry skin, aching back. The most problematic side effect for me was the back aches and the knees cracking so I asked my doctor to switch me to another brand Epuris which alleviated some of the back pain.

For the remainder of the treatment, the dryness was my pressing issue. No matter how much lip balm I used , they always felt chapped and dry. My skin was very dry so I constantly moisturized with Ponds. I also had a very dry scalp causing me to have dandruff but that quickly went away when I started using mustard oil before shampooing almost 3 times a week. The mustard oil REALLY HELPED keep the scalp dryness at bay. Most days I wouldnt have aches but few days I would experience bach aches. I was also very keen on applying sunscreen twice a day, your skin becomes very sensitive.

In terms of grooming, I stopped waxing my face, eyebrows, stopped laser and electrolysis treatments for a year total. Threading was the best way to go. If you opt for this, please let your person know so they can be slow and careful with your skin.

My acne started disappearing right away when I started taking away with a flare up during the 4 month. It wasn't a severe flare up , a few pimple on the lower right side of my cheek but at that point it felt like alot because I had gotten used to my new skin. The flare up cleared in a week and a half. Ever since I have been clear and only get a few small pimples here and there, those are usually related to poor skin care, like leaving my makeup on overnight.

After discontinuing the treatment, my dryness subsided in about 2 months. 2 months post-accutane my lips were back to normal. My skin and scalp were not too dry but wasn't oily either, I'd like to say normal. The back aches still occurred after stopping the treatments but completely stopped after about 6 months. I am clear and pain-free now.

For me it worked really well with side effects that were tolerable and went away after stopping the treatment. I would do it again if I had to ( hopefully I don't have to). If you are able to stick through the side effects, then it will be worth it. At the same time, I want everyone to understand your body chemistry will be different than mine so the severity and types of side effects may be different. I had a positive experience which is why I wanted to share mine with you accutane hopefuls out there. Good luck !

Don't risk it
Reviewed on May 2, 2016

I was on accutane 10mg for 3 weeks. (I'm female, 5'3 and around 126 pounds) Then got moved up to 20mg which I have been taking for a month. My dermatologist appointment is tomorrow,and I'm telling her I'm not taking this medication anymore.

I know this is a very low dose to be on, but my side effects show just how harsh this drug is. I have SEVERE abdominal pain 3-4 times a day with back pain and nausea. I'm so worried, I have no idea what it is but I've never ever had stomach problems before and it's a coincidence how this comes up when I get on accutane..

I have researched this side effect and it's supposedly rare,which doesn't make me feel any better. No amount of clear skin is worth the pain I'm in at the moment. It's a shame because my skin was starting to look like it was improving, but I can't spend every morning dreading the day ahead of me knowing I'll be in agonising pain.

I know what it's like to read the bad reviews on accutane and just think of the clear skin you'll have so you use the whole "it won't happen to me" but honestly, if I could go back a couple of months and someone told me this is what was going to happen, no way would I of taken it. I know accutane has helped so many people clear their skin but many of those same people get health issues years and years later.

This drug should be banned, I wish I never considered it.

Update: I told my dermatologist and she didn't seem shocked at all. She suggested moving me back down to 10mg but didn't seem concerned about the worrying side effects I'm having. I've stopped the medication and I'm going to my family doctor to hopefully get some tests done to put my mind at ease, or potentially find out what's gone wrong. Biggest regret of my life.

Last update: I've had 3 doctors and 2 surgeons examine my stomach. I've had blood tests, and even an ultrasound, but nothing is showing up. I've been off of accutane for almost a month and the pain is still awful. My dermatologist still insists it was not the drug that caused this, but doctors think otherwise. My digestive system has also been effected horribly by this drug, as well as the back pain and nausea continuing..

by danluna97 on 05/31/2016 01:17
I ended up with the same fate. Went to Doctors over and over again in till i got a endoscopy done. I would recommend getting one. Got on antacids back in 2011 and to this day I still have to take them sometimes. Still experience stomach pain sometimes. I know this dosent happened to everyone but I would just be careful you can potentially ruin your stomach. Worst decision I ever made in my life.
by M1997 on 06/26/2016 20:53
I hadn't seen anyone else on here experiencing the same side effect so I assumed I was a very rare case, it was honestly the most pain I've ever been in in my life,and that's on one of the lowest doses! My digestive system seems to have improved but I'm the same where I still get stomach pains and bad back pain every now and again, and I've been off of the drug for almost 2 months. It has helped so many people but in my opinion it's just not worth it, I've been eating dairy free since coming off of accutane and my skin has cleared up like 90% already, I'd recommend giving that a try to anyone before considering going on accutane!!
by dou on 06/27/2016 13:27
How's ur acne after a month?
by hatetane on 07/03/2016 10:28
Very common story. thanks for sharing.
by M1997 on 08/11/2016 10:26
Hi Dou, My acne has prettymuch gone now all I'm dealing with is scarring and the odd spot every now and then (I'm still in my teens). I really recommend everyone to try switching to "LUSH" skincare (or other natural products) and eliminating dairy from their diet for a few months to see if it makes a difference to their skin, the combination of the two has made my skin the best it's been in years. I think people under estimate how bad dairy is for us, the hormones and pus in milk is going to break us out because it's meant for baby cows not the human body!! Just remember to check the ingredients on EVERYTHING because milk can even be found in some brands of crisps ect. Good luck:)