I had a rough start with benzaclin. When I initially began using it my face was so dry it felt like paper. My skin was so crusty and itchy. After three weeks of consistent use regardless of how drying it was, my face adjusted to the medication and I can now use it exactly as prescribed which is twice daily. I usually apply it once at around 9ish in the morning and again around 8pm in the evening and then I leave it on overnight. Since I started using benzaclin I have seen a huge reduction in blemishes.