I started the course 11 days ago -- and I have my fingers crossed!!!! I'm on a strange course for the first month. I'm taking 40 mg every other day for the first two weeks. Then I move up to a 40 mg pill everyday for two days then a day off for a week -- and then three days and a day off until I'm taking one everyday. My derm said this will prevent the initial breakout and control some of the drying effects. SO far so good!!!!