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willow569

Differin effectiveness

Thought people might be interested in this. I can't find the link to the study itself, but the summary is interesting.

Study shows Differin Gel works well in combination with systemic or other topical agents

Pharmaceutical News

Published: Monday, 6-Mar-2006

Findings from the M.O.R.E. (Measuring Outcomes in A Real World Experience) Trial presented at the 64th annual meeting of the American Academy of Dermatology (AAD) show that Differin Gel 0.1% is a topical retinoid preparation that, when combined with other acne products, dramatically improves the efficacy of an acne regimen.

The M.O.R.E. Trial was conducted by over 400 dermatologists from across the U.S. to investigate the efficacy of Differin Gel 0.1% as add-on therapy or first-line combination therapy in moderate-to-moderately severe acne. The study also evaluated patient satisfaction and tolerability with Differin Gel 0.1% as part of an acne regimen.

"What's significant about the M.O.R.E. Trial is that many different treatment strategies are represented; therefore the trial is representative of the real world. Differin Gel 0.1%, when combined with many different products, yielded reliable improvements with excellent tolerability and patient satisfaction and can be regarded as an ideal topical retinoid preparation," said John E. Wolf, Jr. MD, Professor and Chairman at Baylor College of Medicine's department of Dermatology and a member of the steering committee for the trial.

Overall, results showed an 86% satisfaction rate among patients treated with Differin Gel 0.1% as part of an acne regimen. A dramatic reduction in comedones and inflammatory lesions (65%) was seen during the 12-week treatment with Differin Gel 0.1%, and Differin Gel 0.1% was very well tolerated by the participants, with less than 6% of subjects reporting any adverse events. The majority of patients (64%) also found Differin Gel 0.1% to be superior to other acne treatments when used in combination therapy.

"The effects of acne can be physically and emotionally scarring and can negatively impact a patient's quality of life. Often, prescribing treatment is challenging because of the differences in efficacy and tolerability among treatments. The M.O.R.E. data provides valuable insights for future approaches to acne treatment," said Dr. Wolf.

http://www.galdermausa.com/

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differin with oral antibiotics did little for me and neither did differin and benzoyl peroxide. However, Differin in combination with Benzamycin Gel worked ok and Differin with Duac gel worked even better

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Another summary of the study with a little more information:

Adapalene Gel Safe, Effective in Combination Therapy for Acne

By Martha Kerr

NEW YORK (Reuters Health) Mar 07 - Adapalene gel 0.1% (Differin, Galderma Laboratories, Inc.) used in combination with either topical or oral antibiotics is safe and effective in the treatment of moderate to moderately severe acne.

Results of a phase IV multicenter trial were presented in San Francisco at the annual meeting of the American Academy of Dermatology. The 12-week study of the topical retinoid gel involved 1,979 patients and more than 400 practicing dermatologists. The dermatologists were given free rein to add other retinoids, benzalkonium chloride and topical or oral antibiotics as needed to patients with hard-to-control acne vulgaris.

Lead investigator Dr. John E. Wolf, Jr., of Baylor College of Medicine in Houston, Texas, announced that adapalene gel 0.1%, as either add-on or first-line therapy, "dramatically improved outcome" in patients with moderate to moderately severe acne.

"Adapalene gel, when combined with many different products, yielded reliable improvements with excellent tolerability and patient satisfaction and can be regarded as an ideal topical retinoid preparation," Dr. Wolf told the Academy.

"It improved all types of acne lesions," Dr. Wolf commented in an interview with Reuters Health.

"Adapalene gel normalizes the improper accumulation of skin cells that plug the pores and effectively keeps them clear. Pores then begin to function normally again," he explained. "Adapalene not only helps to prevent the formation of new acne lesions, but also helps the lesions that are already present. It works by affecting the growth of cells and decreasing swelling and inflammation."

Dr. Wolf said his "primary findings are that adapalene has an excellent safety and tolerability profile, either initially or as add-on therapy. Adherence was very good. This is very important, since no medication works if it stays in the tube."

http://www.medscape.com/viewarticle/525072

or try the Google cache

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Unlike many I did stick to it - despite it making me worse - and am thus in a good position to say that it did nothing for me, other than make my skin pretty dry, which took weeks to stop.

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i really hated differin. using it made my skin worse :\

Although I was the one who posted this study (over a year ago - someone's digging up old threads!), Differin killed my skin - I hated it! I am clear now though (using a different regimen)

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i liked differin when i used it, i think its great for mild acne.

when your acne gets moderate/severe its probably not as effective.

its all relative to your severity of acne and the nature of your acne.

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i liked differin when i used it, i think its great for mild acne.

when your acne gets moderate/severe its probably not as effective.

its all relative to your severity of acne and the nature of your acne.

My acne was very mild (few clogged pores on forehead and nose, and the occasional inflamed chin zit. I never had more than a couple of active spots at a time, and I was often totally clear of inflamed pimples. Differin gave me clusters of inflamed pimples on both sides of my chin.

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