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Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris

B Aybey, G Ergenekon, N Hekim, A Yarat, Y Kural, N Onsun

Journal of the European Academy of Dermatology & Venereology

Volume 19 Issue 6 Page 766 - November 2005


Acne vulgaris is a chronic inflammatory disease, and a great

number of factors are believed to take part in its aetiology and

course. Recently, it has been reported that the glutathion

peroxidase enzyme (GSH-Px), which is a part of cell antioxidant

defence system, and selenium, which is the cofactor of this

enzyme, may play a role in the aetiology and pathogenesis of

some dermatological diseases.

Control group

Male + female patients 35.82 ± 10.51

Male patients 34.45 ± 6.87

Female patients 37.36 ± 13.91

Patient group (Acne)

M+F 20.84 ± 7.93

M 21.11 ± 8.43

F 20.49 ± 7.36

We found only three studies that examine the relationship

between acne vulgaris and GSH-Px enzyme activities and selenium

levels8–10 and no studies that demonstrate the relationship

between the severity of acne vulgaris and GSH-Px enzyme

levels. In our study we found significantly lower GSH-Px

enzyme levels in patients with acne vulgaris than in the controls.

We also noticed that, as the severity of the disease increased, the

GSH-Px enzyme levels decreased proportionally, although

there was no of statistically significant difference between the

GSH-Px enzyme levels of the three groups.

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Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment.

Michaelsson G, Edqvist LE

Acta Derm Venereol 1984;64(1):9-14

The glutathione-peroxidase (GSH-Px) activity in erythrocytes was determined in 42 men with severe acne and 47 women with acne--26 of a moderate degree and 21 severe. The male acne patients had significantly lower GSH-Px levels than the controls. The women with acne did not differ significantly from the controls in this respect when patients and controls using oral contraceptives were excluded. Both the female controls and the women with acne using oral contraceptives had significantly higher GSH-Px values than the corresponding groups not using the pill. The pubertal acne girls had the same high GHSH-Px activity as women on oral contraceptives. In an open trial 29 patients were given 0.2 mg of selenium (as Na2Se O3) + 10 mg of tocopheryl succinate for their acne twice daily for 6-12 weeks. A good result was obtained, especially in patients with pustular acne and low GSH-Px activity, and the beneficial effect was usually paralleled by a slow rise of the GSH-Px activity. Some 6-8 weeks after withdrawal of the treatment the GSH-Px values had returned to the pretreatment levels.

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