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Can you become immune to topicals?

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I haven't been breaking out for six months.....until now. I've gotten about 5 big pimples (not all at once) this past month. I'm on Clindagel and Azelex. These new pimples are big, but not quite cysts. They HURT, too. Some are underneath my skin. Is it possible that Clindagel just stopped working? I don't see my derm for almost 3 weeks and I need advice! I'm getting so depressed, and I'm sick of icing my zits all the time :(

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