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Drug Interactions

Use of this medicine with skin-peeling agents such as salicylic acid, sulfur, tretinoin, or resorcinol can cause excessive skin irritation. Consult your doctor if you take an oral contraceptive, or if you are using any other prescription or nonprescription medication for acne, or if you use medicated cosmetics or abrasive skin cleaners.

Food Interactions

See below.

Disease Interactions

A history of allergy to cinnamon and foods containing benzoic acid increases the chances of developing an allergic skin rash to benzoyl peroxide. Be sure to notify your doctor if you have either of these allergies. Consult your doctor if you have any skin condition other than acne before using benzoyl peroxide.

benzoyl peroxide topical

Pronunciation: BEN zoe ill per OX ide

Brand: Benoxyl 10, Benoxyl 5, Benzac, Benzashave 10, Benzashave 5, Brevoxyl, Desquam-E, Fostex Bar 10%, Fostex Gel 10%, Fostex Wash 10%, Loroxide, Neutrogena Acne Mask, Neutrogena On Spot Acne Treatment, Panoxyl 10, Panoxyl 5, Persa-Gel

What other drugs will affect benzoyl peroxide topical?

• Do not use benzoyl peroxide topical during treatment with tretinoin (Retin-A). The combination could lead to severe skin irritation.

• Do not use other topical prescription or over-the-counter products unless directed to do so by your doctor. They may interfere with your treatment or increase irritation to your skin.

• Avoid using harsh, abrasive, or irritating cleansers, perfumes, or cosmetics on the area you are treating.

• Drugs other than those listed here may also interact with benzoyl peroxide topical. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Avoid combining sunscreen containing PABA and benzoyl peroxide.

Do not use benzoyl peroxide topical during treatment with tretinoin (Altinac, Avita, Renova, Retin-A). The combination could lead to severe skin irritation.

Drug interactions and/or related problems

The following drug interactions and/or related problems have been selected on the basis of their potential clinical significance (possible mechanism in parentheses where appropriate)â€â€not necessarily inclusive ( » = major clinical significance):

Note: Combinations containing any of the following medications, depending on the amount present, may also interact with this medication.

Acne products, topical, or products containing a peeling agent, such as


Salicylic acid


Alcohol-containing products, topical, such as

After-shave lotions


Cosmetics or soaps with a strong drying effect

Shaving creams or lotions or

Hair products, skin-irritating, such as hair permanents or hair removal products or

Isotretinoin or

Products containing lime or spices, topical or

Soaps or cleansers, abrasive (concurrent use with benzoyl peroxide on the same area of the skin may cause a cumulative irritant or drying effect, especially with the application of peeling, desquamating, or abrasive agents, resulting in excessive irritation of the skin. If irritation occurs, the strength or dose of benzoyl peroxide may need to be reduced or application temporarily discontinued until the skin is less sensitive)

Antibiotics, topical, such as clindamycin or erthyromycin or

Retinoids, topical, such as adapalene or tretinoin (although these medications are used in a treatment regimen with benzoyl peroxide for therapeutic effect, their use on the same area of the skin at the same time is not recommended. The oxidizing action of benzoyl peroxide degrades antibiotics over time. A physical incompatibility between the use of the medications and benzoyl peroxide or a change in pH may reduce their efficacy if used simultaneously. When used together for clinical effect, it is recommended that these medications and benzoyl peroxide be used at different times of the day, such as morning and night, to minimize possible skin irritation, unless otherwise directed. If irritation occurs, changes in dose or frequency may be needed until the skin is less sensitive {11} {12} )

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well i did a search and find this:

Antibiotics, such as clindamycin solution (Topicilâ„¢) are best used with benzoyl peroxide or azelaic acid to reduce the chance of antibiotic resistance.

Erythromycin solution (Stiemycinâ„¢), gel (Eryacneâ„¢) - best used with benzoyl peroxide or azelaic acid to reduce the chance of antibiotic resistance



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