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Getting Rid of Your "Acne Enzyme"

Acne sufferers tend to have increased activity of the enzyme 5 alpha reductase, which is responsible for converting testosterone to dihydrotesterone (DHT). DHT is a potent androgen and the primary culprit in the stimulation of oil gland receptors which, if oversensitive to such hormonal input, consequently overproduce oil and hyperkeratinise dermal cells within the pore, resulting in a comedone. Thus in two individuals with identical testosterone levels one may suffer disfiguringly severe acne while the other enjoys flawless skin.

Is there any means for suppressing the enzyme in question, thereby isolating this crucial variable in the physiological sequence of events behind acne formation?

In theory, the less DHT you have the less androgenic overstimulation of the oil glands, and thus the less acne. Lower DHT sufficiently and you eliminate acne. You can achieve this by suppressing activity of the enzyme 5 alpha reductase. Anyone know how to do this?

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See the other post on this issue I just made a couple of minutes ago. A recent study by some big-time dermatologists showed that a potent 5a-reductase type 1 inhibitor had no effect against acne. The reason for the failure is unknown.


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There is a topical product line called Triaxon that helps regrow hair for those suffering from hair loss. It works by controlling or neutralizing the scalp's production of DHT by up to 90%.

I've had success with Triaxon in reversing a slight receding in the front hairline. However, I'm not about to be the first guinea pig to use it on the face for acne for obvious reasons wink.gif

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