ForumsAcne and its treatm...General acne discus...Valtrex! Notifications Clear all Valtrex! Jenjen 77 MemberMember1(@jenjen77) Posted : 12/15/2016 11:05 am Eek. I had a horrible canker sore yesterday so I took a valtrex and lysine. I woke up this am with a pimple and my skin has been pretty clear lately.Wondering if either the lysine or valtrex could cause acne?! Quote Jenjen 77 MemberMember1(@jenjen77) Posted : 01/11/2017 11:27 am Anyone? Quotenicmic 62 MemberMember467(@nicmic62) Posted : 01/13/2017 2:46 pm I doubt what you took is the cause.Pimples don't pop out that quickly. Usually it takes about a week or so for the pimple to come to the surface. Quote Adeel 2111 MemberMember32(@adeel2111) Posted : 01/13/2017 3:30 pm Try vaseline, better and safer imo. Quote Exning MemberMember32(@exning) Posted : 01/14/2017 7:38 pm I doubt its the cause as well, unless maybe youre allergic to a filler they added? Lysine usually helps some for acne, its just an amino acid Quote