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Eek. I had a horrible canker sore yesterday so I took a valtrex and lysine. I woke up this am with a pimple and my skin has been pretty clear lately. 

Wondering if either the lysine or valtrex could cause acne?! 

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I doubt what you took is the cause. 

Pimples don't pop out that quickly. Usually it takes about a week or so for the pimple to come to the surface.

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I doubt its the cause as well, unless maybe youre allergic to a filler they added? Lysine usually helps some for acne, its just an amino acid

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