ForumsAcne and its treatm...Prescription acne m...Does Spiro Cause An... Notifications Clear all Does Spiro Cause Anyone On Here Muscle Weakness? Does It Go Away. Pookiedoll 80 MemberMember0(@pookiedoll80) Posted : 04/02/2015 2:13 pm Been on it for about 5 weeks. In the last week or 2 I feel like I get this weird sensation in my arms. Not sure if its muscle weakness or what. What could this be and is this a side effect from Spiro? Quotetracy 521 MemberMember144(@tracy521) Posted : 04/02/2015 2:48 pm I would ask your doctor about it. I have been on spiro for over 2 years and never had any of those issues. Quote