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I've been on Epiduo for a few months now...I think since Sept. Last year. I used it a few years back as a teen & it didn't irritate me & cleared my skin up so good. But now, it still dries my skin out & my acne is less but definitely hasn't cleared up. I'm not sure if they've changed something or what. But (for me) the irritation still continues but not as much. It takes some time. And you can always lessen your amount so it won't be as irritated...

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Hey, at first when I started to use it my face was really dry/red for a week or so. Then, my skin got used to it and it wasn't that bad, it was still red but not as much as first week. I'm on my fourth week also, and it seems like it's still red and dry. It looks like it killed most of my cystic acne but the red marks are still very very appearent. I keep using it... Good luck to you :)

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