No, you shouldn't use epiduo while on accutane. It would be too irritating and might interfere with healing. A gentle cleanser and a simple moisturizer should do.

Thanks, that's a relief! Applying the epiduo each evening is a pain!

You can spot treat.

What Oceanic said! I think people try to compound treatments hoping for faster/better results but realistically, accutane is a very strong medication and you should just let it do its thing. In fact, since starting accutane I only use my cetaphil cleanser at night time and only wash with water in the shower in the mornings.

Good luck!