ForumsAcne and its treatm...Prescription acne m...When Does Accutane ... Notifications Clear all When Does Accutane Really Kick In? Waterpolo player MemberMember0(@waterpolo-player) Posted : 04/30/2013 3:26 pm I'm on week 8, 20mg a day. Seeing small improvments, but when's it going to start really kicking in? Quoteauroranora MemberMember0(@auroranora) Posted : 04/30/2013 3:59 pm my first time on accutane it took about 3 months... hang in there- its worth it! just keep telling yourself that x Quote