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Lots of hair loss ( 40%) , brain fog , isotretinoin fatigue ( Chemo fatigue ) , mild tinnitus left ear and I only took 2500 mg , I stopped by myself and refused to take more even though the doc wanted me to take 9000 mg I bluntly told him to &%$# OFF , I never even had severe acne mild to moderate at best , Unless you have SEVERE ACNE , don't even consider taking this , even then try everything else first. The key to acne is DIET/NUTRITION , you are what you eat. There is a trap waiting for you at the Derms office , DON'T FALL INTO IT.