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Taking Antibiotics For Years?

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Wont my organism suffer from taking oral antibiotics for years?It is the only option for me,so it seems.I cant go on hormonal treatment or Accutane because of my dry eye(those medications make dry eye syndrome even worse).I am wondering what can happen to me.And which antibiotic is best for a long-term usage?

Recently I got azytromycine but it doesnt work as well as doxycyline and I take it only once a week,maybe thats the reason it doesnt work that well.

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