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2 hours ago, Calcified said:

So it says Emma stone was on it for 2 months.

Think I was on it for way too long.

Dosage is a factor in severity of long term side effects , no question having said that antibiotics are quite a bit more dangerous especially repeated rounds of anti life biotics cause severe often irreversible damage that WILL shorten your life.

 

A good example would be a Hollywood star who played in “ A few good men “ he was on repeated cycles of antibiotics for acne and thus had his colon removed did isotretinoin play a part in his severe damage maybe but trust me antibiotics were an 80% factor in his demise.

 

By the way the actor sued the manufacturer of Accutane ( Roche) for millions but lost in court. The actors name is James Marshall.

Edited by Gladiatoro

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Those who have sexual side effects. Have you considered it stems from brain damage caused by Accutane?

So we do know tane can mess with frontal lobes yeah. I watched an interview today whereby it was suggested brain damage can cause either hyper or hypo sexual side effects in people. 

I believe Parkinson’s medications can cause this to happen in the brain too again with frontal lobes.

The interview on this subject was with the author of a book called “sex in the brain”. It’s a fascinating field and one that does not get nearly enough attention from what they said.

Just putting this info out there. In my case it’s not sexual issues but depression that stems from these frontal lobe issues. I’m going to look into this next as I’m nearing completion of doing all I can to heal gut.

Edited by TrueJustice

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GUYZ I FIGURED OUT HOW 2 CURE ACCUTANE BRAIN DAMAGE K JUST LISTEN I SWEAR IT WORKS. I LISTEN TO SOLDJA BOI 22.5 HRS/DAY ON REPEAT WHILE FACING THE SUN AND AFTER THE 293RD PLAYBACK I DRINK MY URINE COLLECTED FROM THE FIRST STREAM OF THE MORNING. I EAT GOJI BERRIES AND THEN RUB A MIXTURE OF CASTOR OIL AND MENSTRUAL BLOOD ON MY BELLY BUTTON IN CLOCKWISE DIRECTION PLS TRY IT TRUST ME I'M HEALED!!!

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2 hours ago, rickymartin69 said:

GUYZ I FIGURED OUT HOW 2 CURE ACCUTANE BRAIN DAMAGE K JUST LISTEN I SWEAR IT WORKS. I LISTEN TO SOLDJA BOI 22.5 HRS/DAY ON REPEAT WHILE FACING THE SUN AND AFTER THE 293RD PLAYBACK I DRINK MY URINE COLLECTED FROM THE FIRST STREAM OF THE MORNING. I EAT GOJI BERRIES AND THEN RUB A MIXTURE OF CASTOR OIL AND MENSTRUAL BLOOD ON MY BELLY BUTTON IN CLOCKWISE DIRECTION PLS TRY IT TRUST ME I'M HEALED!!!

Wow , please tell me your joking....

Edited by Gladiatoro

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No, he's totally %100 serious about a %100 recovery by following the "Supaman" protocol. I went counter-clockwise and crashed again. My theory is that counter-clockwise rejuvenates the ambient homeopathic imprinting Accutane left in our bodies, creating a vitamin A pseudo-toxicity.

 

Another 10 sessions of data-based healing with my quantum shaman, and I should be back to baseline.

 

Peace out!

Edited by Dubya_B

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15 hours ago, TrueJustice said:

Those who have sexual side effects. Have you considered it stems from brain damage caused by Accutane?

So we do know tane can mess with frontal lobes yeah. I watched an interview today whereby it was suggested brain damage can cause either hyper or hypo sexual side effects in people. 

I believe Parkinson’s medications can cause this to happen in the brain too again with frontal lobes.

The interview on this subject was with the author of a book called “sex in the brain”. It’s a fascinating field and one that does not get nearly enough attention from what they said.

Just putting this info out there. In my case it’s not sexual issues but depression that stems from these frontal lobe issues. I’m going to look into this next as I’m nearing completion of doing all I can to heal gut.

https://www.dailymail.co.uk/tvshowbiz/article-2123086/Salma-Hayek-talks-depression-hit-big-time.html

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On 9/6/2019 at 11:32 AM, rickymartin69 said:

GUYZ I FIGURED OUT HOW 2 CURE ACCUTANE BRAIN DAMAGE K JUST LISTEN I SWEAR IT WORKS. I LISTEN TO SOLDJA BOI 22.5 HRS/DAY ON REPEAT WHILE FACING THE SUN AND AFTER THE 293RD PLAYBACK I DRINK MY URINE COLLECTED FROM THE FIRST STREAM OF THE MORNING. I EAT GOJI BERRIES AND THEN RUB A MIXTURE OF CASTOR OIL AND MENSTRUAL BLOOD ON MY BELLY BUTTON IN CLOCKWISE DIRECTION PLS TRY IT TRUST ME I'M HEALED!!!

Wow, that's so clever man. Created a whole account just to post that. Thinks he's the first one on a forum of 10+ years to troll.

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About the sexual side effects: depression happened for me, too, and for years I struggled with it. I estimate that 3, 4 years after my 2011 treatment I was still affected, I remember 1 year after the way I behaved was totally out of character (and I never felt that bad out of sudden EVER). 

The problem with that theory is that once you get over this (I mean: once the damage that caused the depression in the first place) is completely gone (and for me I am 99.9% sure it is) then there's no reason why your body should remain the same way. And in my case I have NO OTHER permanent disease or health problem caused by Accutane.

I mean, if depression/stress killed your libido (also lowering your testosterone) then why mine is still low (and it has decreased over time) after the depression was long gone? I can think of many reasons as to why my T is low, and one of them are my views about women. But I can't disguise the fact I had a much higher libido before the treatment. What Accutane does is more pervasive than a long-lasting depression:


https://inews.co.uk/news/health/roaccutane-acne-drug-poisoned-fitness-fan/
https://www.madinamerica.com/2018/06/citizens-petition-calls-sexual-side-effect-warnings-antidepressants/

https://www.drugs.com/answers/cure-sexual-dysfunction-long-term-suicidal-3480346.html (this link says there is no known cure for the sexual dysfunction)

https://www.theyworkforyou.com/whall/?id=2018-03-07a.181.1

In the book "The Science of Sex" written by Kevin Pezzi it is said the following:

************************************************
The mechanism by which Accutane causes sexual dysfunction is not known, but I suspect that it has multiple modes of action.

I think it interferes with the proper functioning of some sensory peripheral nerves, or their receptors, or the brain’s response to the nerve data, thus greatly distorting tactile fidelity (a subject I will discuss in detail later in this chapter). This disturbance of fidelity is not necessarily confined to the genitals; Accutane has been associated with a dysesthetic ** tingling on nongenital skin, the course and intensity of which seems to parallel the unpleasant sexual “hit your funny bone” tingling. These dysesthesias may persist for a few seconds after the inciting stimulus is removed. If you lightly touch your skin, for example, the sensation usually ends when the contact ceases. In contrast, Accutane- induced dysesthesias may take seconds to fade away.


I think that Accutane decreases responsiveness to testosterone, at least in those areas of the brain that control libido. (Perene's note: it has been reported and I have posted test results showing that my prolactin is high and T levels are very low; and like I said my libido is the lowest EVER).

** A dysesthesia (dis-es-THEE-zee-uh) is an unpleasant abnormal sensation, whether spontaneous or evoked. Many authors and physicians use dysesthesia interchangeably with paresthesia, which is an abnormal sensation that is not unpleasant. Dictionaries often muddy the issue by defining paresthesia as a burning, prickling, itching, or tingling skin sensation— most of which are unpleasant.

>>>>> What is the treatment?

- Discontinue Accutane now. I understand that it can be a difficult decision to choose between clear skin or a satisfying sex life. I cannot make this decision for you, but I can tell you what I would do: stop the Accutane. Physicians have many other ways to treat acne besides Accutane. I would rather use a less powerful therapy and spare my sex life. Every year, I hear from many patients who wish they’d done the same thing.

- Try relatively high-dose supplemental vitamin B 6 (but avoid excessive doses that may induce a peripheral neuropathy; see the vitamin B 6 section for more information).

- Try other supplements, herbs, and drugs, as discussed elsewhere in this book.

- Stringently avoid other things that may decrease the testosterone level or effect (such as phytoestrogens and antiandrogens). 

- Consider using supplemental testosterone. It is useless to use your blood testosterone level to gauge whether or not this is necessary. Judging from tests conducted on people with Accutane-induced sexual dysfunction, Accutane does not seem to appreciably lower the blood testosterone level. What it apparently does is partially block some of the effects of testosterone. This decreased responsiveness is analogous to someone who is hard of hearing. To some extent, you can compensate for their disability by speaking louder. A partially deaf ear needs more sound, and someone who is less responsive to testosterone needs more testosterone. Of course, there are drawbacks to the use of supplemental testosterone. Because the testosterone susceptibility of most areas of the body is not affected, increasing the testosterone level enough to restore libido and sexual sensation may trigger unwanted changes elsewhere, such as alopecia and acne.

- If you are a man, avoid things that increase your estrogen level.

- Avoid things that increase sex hormone binding globulin. 

- Experiment with other ways to achieve orgasm. You probably will not want to forgo coitus even if your sensation is affected, because intercourse can be emotionally very satisfying. However, if you aren’t in a relationship and having intercourse, by trying various ways of masturbation, you will likely find that some ways provide less noxious sensations and more pleasant ones. Everyone who has masturbated knows that different techniques produce different sensations. As you will realize once you read the section on sensory fidelity, different techniques of masturbation produce different neural data streams. Accutane effectively distorts this data, which reduces sexual pleasure. However, since neural data streams differ depending on the method of masturbation, some of these will be closer to the ideal that gives optimum pleasure. Your goal is to find one that, once layered on the Accutane-induced distortion, gives a reasonably satisfying experience.

-  See a knowledgeable physician to exclude other causes of dysesthesias and reduced sensation. There are numerous possible causes, such as vitamin B 12 deficiency, multiple sclerosis, brain tumors, strokes, transient ischemic attacks (TIAs), arteriovenous malformations, transverse myelitis, encephalitis, trauma, and peripheral neuropathies secondary to diabetes, alcoholism, hypothyroidism, hereditary conditions (Charcot- Marie-Tooth disease, Denny-Brown's syndrome, familial amyloidotic polyneuropathy), malignancy, uremia, connective tissue disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus, polyarteritis nodosa, autoimmune vasculitis, systemic sclerosis, and Sjögren's syndrome), inflammation (acute idiopathic polyneuritis and chronic relapsing polyneuropathy), chronic overdosage of vitamin B 6 , some chemotherapy, heavy metal toxicity (e.g., lead, arsenic, or mercury), some industrial exposures (e.g., solvents), certain medications, sarcoidosis, porphyria, Lyme disease, and leprosy. Believe it or not, but this is just the tip of the iceberg.

Physicians should keep in mind that it is possible to have symptoms of dysesthesias or paresthesias without measurable neurologic deficits of pain, touch, vibration, joint position, or thermal sensation.

- As a last resort, consider trying one of the drugs used to treat dysesthesias and paresthesias, such as carbamazepine (Tegretol ® ), mexiletine (Mexitil ® ), gabapentin (Neurontin ® ), and tricyclic antidepressants (e.g., imipramine [Tofranil ® ] and amitriptyline [Elavil ® ]). 

Neurologists believe that paresthesias and dysesthesias represent abnormal showers of neural impulses generated from abnormalities anywhere along the sensory pathway, from the peripheral nerves to the sensory cortex of the brain. The aforementioned drugs may reduce the excitability of neurons and therefore mitigate Accutane-induced dysesthesias, especially the unpleasant tingling that persists after skin contact. However, these drugs will not restore sexual sensitivity. 

- Be patient. The dysesthesias tend to diminish in time, although it may take years. Your perception of sexual pleasure will likely increase, too, although it may not return to your pre-Accutane zenith. The elimination half-life (that is, the time it takes for half of an administered drug to be excreted) suggests that Accutane does not persist in the body for a long time. The drug may not stick around for long, but its effects do. It is as if Accutane flips some switches in the body. This is true for its intended effect (the long-term suppression of acne), and its sexual side effects. 

Once flipped, those effects are permanent, or at least very long lasting. Hence, you should think twice before using Accutane. There is no way to know in advance if your use of Accutane will trigger dysesthesias and reduced sensation. You may take it for a while without any problems, and then wake up with enough sensory abnormalities to make you wonder if your spinal cord was mashed in a vice while you slept. Being cheated out of life’s greatest pleasure is a terrible fate. Are you willing to take that risk?
************************************************

My personal opinion:

It is permanent (at least from what I have seen until now) and all these tips are not going to help much, if AT ALL.

I mean, perhaps some will (however be careful - never try anything without some serious medical advice), but this is all just to mitigate, not to fix the issue for good. 

We need to focuse on everything that can increase testosterone levels and decrease prolactin, because if prolactin is high then the libido is low (mine always measures 19-20, and for men the max range should be 13. So it's not very high, but it is high).

What is funny is that we need to be more healthy than SUPERMAN, we need to improve our lifestyle more than before we started the Accutane treatment, just to reduce the damage caused by this poison that should have been banned everywhere.

Edited by Perene

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How do you know the damage is gone??

Id suggest it’s still there in some of us and is responsible for sexual sides, depression or both.

Great that you feel better but underlying brain damage to some degree could still be present yeah... why would it have just disappeared is the question I’m asking if not properly addressed?

Not that I know much about addressing it.....

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9 hours ago, TrueJustice said:

How do you know the damage is gone??

Id suggest it’s still there in some of us and is responsible for sexual sides, depression or both.

Great that you feel better but underlying brain damage to some degree could still be present yeah... why would it have just disappeared is the question I’m asking if not properly addressed?

Not that I know much about addressing it.....

You would know if you had any of these symptoms that affect those that have low T:
https://www.medicalnewstoday.com/articles/322647.php

Since Accutane reduces testosterone and at at the same time decreases libido, then it must be something else going on besides mere depression, which I don't have anymore.

I don't have hypogonadism too, since my testosterone levels were higher years ago, and no doctor says you have it if you can go beyond the 300 ng/DL which I think it's very likely to happen for me (still very low in my opinion, since the max is 800's - I hoped mine were at least 500 ng/DL, which is twice the current levels). One thing caught my attention in this link:
https://inews.co.uk/news/health/roaccutane-acne-drug-poisoned-fitness-fan/

Among all the symptoms this guy has, he says his vitamin-D levels were incredibly low. Mine were too, and once I started taking D-3 pills my vit-D and testosterone levels increased (these are both related). I don't need to be measured right now (however I will soon) to find out they have been reduced again, since I stopped taking vitamin D-3 pills more than a year ago. He said that spent some time outside/exposed to the Sun, something I never do, and I am starting to do now.

Still, it makes me think: since we are always told to never expose our skin to the Sun during all the months of the Accutane treatment, could this mean the testosterone levels are reduced due to depletion of vitamin D in our bodies? So the answer would be to increase our D-3 levels?

Look at this bit from the guy's report:

**************
“I realised fairly recently that one of the main causes of my problems was impaired liver function, due to damage caused, in my opinion, by the Roaccutane,” Tom said. “I was left with very low bile production, resulting in chronic toxicity. The lack of bile also meant I wasn’t able to digest fats properly, hence the vitamin D deficiency, as it is a fat soluble vitamin.
**************

He claims to have had other health issues that my previous tests already proved are not my case. My health is 100% OK except for the low T, high prolactin and low vitamin D.

Edited by Perene

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They are all valid points and yes I’m also low in Vit D on last test. I’m currently supplementing. Low testosterone is definitely worth addressing 

But, what of the potential brain damage associated with Accutane?

This area has yet to be fully understood but absolutely has been documented by several people.

Frontal lobe brain issues post tane 

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4 hours ago, TrueJustice said:

They are all valid points and yes I’m also low in Vit D on last test. I’m currently supplementing. Low testosterone is definitely worth addressing 

But, what of the potential brain damage associated with Accutane?

This area has yet to be fully understood but absolutely has been documented by several people.

Frontal lobe brain issues post tane 

Have you all read reports such as these? I think they are clear enough in how they demonstrate what isotretinoin does to the brain:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637283/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473493/

https://drive.google.com/open?id=1GXj82g6QuDO4swu0B8jM1v84N0A8iCDq

https://drive.google.com/open?id=12wWvskpzXjSUfyKCJl2Lm4R0NC5dUVE6

What Accutane does to cause depression may not be fully understood, yet we have a pretty good idea.

What I don't think is that my brain still suffers from the same depression I had in the first years. And of course that can't be the only reason my libido/testosterone are low.

In my case I noticed a 35% increase in testosterone levels once I took vitamin D-3 pills, 7000 UI, two of them, once a week, for 3 months. I took two blood tests. The first showed for D-3 26 ng/mL (that is very low). Once I started taking, then it raised to 40 ng/mL (this is still low - it's just higher than what your normal levels should be).

Even after I reduced to 1 pill as instructed by the doctor (so 7000 UI in each entire week) it was still in the 40's (ng/mL) in another blood test. Without a doubt if I started exposing myself to the Sun, too, the levels would have been raised even higher.

But... even if my current testosterone levels increased 35% now they would still be very low, from 240 to 325. I said before the range for male adults is 241 to 827 ng/dL.

That suggests a lot more things need to be taken into account, from my diet to workout routine, sleep, and of course possibly other supplements, such as vitamin B-6, vitamin E, omega-3 (fish oil), zinc, magnesium... nothing can be left out. I don't want a mere 35, what I need is a 100-150% increase.

And of course a decrease in prolactin, I believe I measured this 4 or 5 times and it has never been reduced from 20 ng/ML. That is the ultimate confirmation you have low libido/impotence. For men the normal range is between 2.6 to 13.1.

If it's irrealistic to increase my testosterone 100% then I can thank my old Accutane treatment to this. Look at what this link says (a little late for that, uh?):
https://www.gov.uk/drug-safety-update/isotretinoin-roaccutane-rare-reports-of-erectile-dysfunction-and-decreased-libido

Sexual dysfunction

A routine EU review showed that some patients taking isotretinoin had reported sexual dysfunction adverse effects, including erectile dysfunction and decreased libido. One possible mechanism for this effect may be through a reduction in plasma testosterone levels.

The review recommended that sexual dysfunction including erectile dysfunction and decreased libido should be added to the list of side effects in the product information. The package leaflet for patients will include “Problems getting or maintaining an erection and lower libido” as possible side effects.

In the UK, we have received 14 Yellow Card reports of sexual dysfunction associated isotretinoin between the beginning of 1985 and 7 September 2017. In the same time period, there have been 49 reports of erectile or ejaculation dysfunction, and 23 reports of decreased or loss of libido associated with isotretinoin. We estimate that over the past few years, around 30,000 patients (male and female) per year have been treated with isotretinoin (see 2014 Public Assessment Report).1

 

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A guy on YouTube said he took dosages upto 240 mg for over a year.  How is that even possible without massive long-term side effects?

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As for dosages, this link suggests
http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf


- 25 mg/day for vitamin B-6, which is said to decrease prolactin and boost libido. Read this thread and you'll see some members had good results with it:
https://www.nofap.com/forum/index.php?threads/vitamin-b6-to-support-your-recovery-long-post-but-tl-dr-at-bottom.135163/


- The same 25 mg/day for zinc;
- 50 ug or 2000 UI/day for vitamin D-3. That is the exact dose I took for the first time, when my testosterone increased 35%.
- 300 mg/day for vitamin-E.

I think it would be wise to start taking at least D-3 and B-6 for a couple of months and then get tested again. I promised to do that years ago and ended up not doing it, because I always disliked the idea of taking suplements forever. The issue is not just how much they cost, it's the need to remember taking them, being forced to incorporate this into your lifestyle. I thought taking a vitamin was like taking a medicine, something you remember that needs to, yet you can't wait until it's over and you are fine again.

Of course we would all love to be 100% healthy without any new drug/workaround/supplement, but if that is NEVER going to happen, so be it... treat it as a some food you need to keep ingesting to stay in a good shape. Of course lots of things are important, including diet (and perhaps my low T is also a result of recent indulgences I made, by eating some junk food, which is also known to be detrimental - my current diet was devised by a sports nutritionist, and doesn't include among other things sugar).

However all of the good lifestyle changes combined are not going to be enough to restore how we felt before the treatment. The vitamins, I hope, will do the trick. I think I should be thankful for not suffering from the other side effects from low testosterone, only low libido, or my tests showing a very high prolactin that would need a drug like Cabergoline. It could have been a lot worse.

Edited by Perene

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Is prolactin only ever high when testosterone is low in males?

Can one have normal healthy testosterone levels but also have high prolactin?

what I’m getting at is, it’s pointless surely to try lowering prolactin whilst ever there’s low testosterone. You’d be better just trying to improve testosterone levels yeah?

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8 hours ago, TrueJustice said:

Is prolactin only ever high when testosterone is low in males?

Can one have normal healthy testosterone levels but also have high prolactin?

what I’m getting at is, it’s pointless surely to try lowering prolactin whilst ever there’s low testosterone. You’d be better just trying to improve testosterone levels yeah?

If the prolactin is too low then you have the same sexual dysfunction.

Here’s what a study said:

“Men who had higher body mass indexes and higher glucose levels tended to have lower levels of prolactin. In addition, men who engaged in less physical activity and reported feeling unhealthier also had lower prolactin levels.

Lower prolactin, even within the normal range, was associated with more sexual issues, especially the ability to enjoy orgasm. Depression was also associated with low prolactin.

The results contrast with previous studies, which showed that high prolactin levels interfered with sexual function.”

If you are just above the 300 ng/DL you are not in need of testosterone therapy (which should be the last resort anyway, due to bad side effects) and in the absence of other symptoms and tests showing something wrong (not just blood, CT scan test as well) then you don’t have hypogonadism or some other debilitating condition. A sperm analysis also showed I am OK.

The problem is that most doctors will tell that having 300s is normal and you are totally fine, but the truth is that if were not for the Accutane treatment then I am sure my results would be in the 500s and what these doctors consider “fine” seems to me being a mollycoddle, a “soy-boy”, instead of a masculine man in all its potential. Low testosterone not only affects libido, cognitive impairment is among the side effects, too.

That’s why I am going to take a few of these vitamins regardless of what these doctors tell me, most of them are idiots that can only read numbers and don’t interpret what’s behind them. Oh, and of course they don’t believe or know more about the deleterious effects of the isotretinoin treatment.

Edited by Perene

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Thx Perene - appreciate the info.

I know you’re taking Vit D, what else you taking?

What are your thoughts on supplementing Vit E? What do you notice in particular with this?

Also, how dry is your skin? mine is fucked.....so bloody dry....

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On 9/10/2019 at 8:58 AM, TrueJustice said:

Thx Perene - appreciate the info.

I know you’re taking Vit D, what else you taking?

What are your thoughts on supplementing Vit E? What do you notice in particular with this?

Also, how dry is your skin? mine is fucked.....so bloody dry....

I am going to take 25 mg of B6 (daily - and, the Pyridoxal 5 Phosphate (P5P)). Plus 2000 UI of D-3 + 200 UI of vitamin E combined. After at least 60 days of this I'll do another testosterone and vitamin D test. And this time i'll also hire someone to help with my workout routine.

P.S. I'll also add omega 3 fish oil, 1000 mg (180/120, 3 pills a day), which was recommended to me along with the D-3+E in the first appointment with a nutritionist I had, and following what this guy said about how he doubled his T levels: https://www.artofmanliness.com/articles/how-to-increase-testosterone-naturally/

As for the skin being too dry I haven't noticed anything unusual, I also don't use anything for the lips. I think after years there's no unusual dryness.

This is worse depending on the weather and if you take hot baths (I don't do the latter anymore). Also be careful of what kind of soap and shampoo you are using. I believe my penis had this problem for a while, perhaps it had something to do with what I applied to it everyday. This is something most people don't consider important, but it really is and a dermatologist will tell you, for example, that a liquid soap instead of bar is better for your face. That's because they are less harsh on your skin and their pH is closer to your skin's normal pH level.

If you prefer a bar soap to liquid, at least look for one that's really gentle. If your skin is sensitive or easily gets red and itchy, try to avoid sodium lauryl sulfate, a common skin irritant. I purchased a natural soap without this ingredient and I believe that was the reason over time the skin of my penis improved and stopped being irritated easily.

Edited by Perene

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22 hours ago, Calcified said:

A guy on YouTube said he took dosages upto 240 mg for over a year.  How is that even possible without massive long-term side effects?

It’s not.

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1 hour ago, Gladiatoro said:

It’s not.

Yeah it's a time game isn't it.

I don't get how people on YouTube don't have much peeling skin.  My dose was high 26 years ago, but im starting to think it's a little more watered down these days.  My skin was peeling off almost in sheets. Moisturisers were useless.

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On 9/9/2019 at 1:07 PM, Calcified said:

A guy on YouTube said he took dosages upto 240 mg for over a year.  How is that even possible without massive long-term side effects?

Because some people can take high doses for a long time without much trouble and some of us react very very badly, even to low doses. There is some genetic susceptibility or other confounding factor involved in Accutane causing severe and permanent side effects in only a small percentage.

For example, two of the members here, @Crank92 and @mes6890 had very low cumulative dosages and were left with persistent sexual side effects. Crank took a trial dose of 20mg daily for a few weeks, and mes took it for less than a week. Mes also has skin thinning and neurological symptoms.

 

 

Edited by Dubya_B

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Stomach issues or ibs seems common with accutaners has it ever progressed to colon cancer or are we now tuned to never get colon cancer? 

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Yes, as I've posted a while ago on this very thread, those that are able to tolerate high doses of retinoid in their diet's are those of Scandinavian descent.  Something to do with the cold weathe, diet, and vitamin A going back thousands of years. It's a fairly reasonable probability that Roche used Swiss nationals to carry out their clinical trials. Some can handle it, others not so much.

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