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Hey guys, 

So i just wanted to to start off by saying that exactly one year ago from now (june 2017), i was in a horrible position dealing with accutane side effects. I had every single one, from ED, to depression, you name it. I took accutane for a month in October of 2016, so the symptoms had me been bothering me for a few months at this point. I was headed off to college in the upcoming weeks as well, so the added stress of that was almost too much to deal with. I came to a very, very dark point where i was about to give up and considered suicide. I felt like i had no hope. Then one day, i decided that I would muscled through this until i found a way out. 

After trying countless diets, protocols, and lifestyle changes at school, i didnt have much success. Symptoms improved here and there, but nothing major. It wasnt until i came across that video on youtube about bile flow which everyone on this forum knows about. And then i began implementing his tips, and i did begin to see improvement in my symptoms. 

This is where i had a lightning bulb go off in my head though. Essentially, since the day we all started accutane, we have been going through something known as a Herxheimer reaction, or healing reaction. I am very familiar with these, as I grew up with many food intolerances/allergies. 

Essentially, this is what happens during a Herxheimer reaction. The reaction is triggered by a “toxin overload” or something that the immune system sees as an invader. When the body rapidly tries to detox beyond its capabilities, many of these toxins circulate around the body due to an overworked liver. As a response, the body goes into “panic mode”, as it diverts it’s attention strictly to detoxing the toxin. These are commonly seen in lyme disease and candida sufferers if you would like to do some research. 

Now, the severity of the reaction depends exclusively on how much of the toxin is in the body. A small amount of the toxin could trigger just cold or flu like symptoms at most and last a few days, while a large amount of the toxin could produce detrimental symptoms such as endocrine dysfunctional, adrenal dysfunction, and psychiatric symptoms due to the high toxic load. These could last months. 

Now how does this relate to us? Well, the reason i came across this is because i took whey protein just about everyday for a few months as a young teen, and my health began to decline. I was getting sick constantly, had fatigue, weight gain, and some others. It wasn’t until i found out that my body was sensitive to dairy that the symptoms finally stopped once i stopped taking it. It took time, but they gradually dissipated. These symptoms all point to a Herxheimer reaction, as the dairy in the whey was seen as a toxin to my body. I was putting it into my body faster than it could detox, thus initiating this reaction. 

So heres the point....since accutane dumps a tremendous amount of vitamin a in our bodies, our livers cant handle all of it. The excess is seen as a toxin, and since the excess vitamin a in our body is gigantic, the herxheimer reaction is too. 

So that its guys...we are all in just one big herxheimer reaction. Im basically just putting what the guy said in that youtube video in different words. Our body is trying to detox this massive amount of vitamin a, resulting in toxin backup and a major herxheimer reaction. This is why we have hormone disruption, fatigue, digestive disorders, you name it. The body diverts all its attention to detoxing, as it goes into “survival mode”. It comes in waves too, as detoxing will stop occasionally for the body to rest. This is why we have periods of normality. But as time progresses, the reaction will get less and less intense until the toxin is out. 

In terms of my health now, i am doing so much better. Time really is the only answer. Vitamin a leaves the body so slow, so this is why the detox takes so long. Ive been simply avoiding foods with retinol and eating a healthy diet with plenty of exercise. Thats it, and its working but slowly. Also, i only took this drug for 1 month, and its taken me 1.5 years to feel somewhat normal. So its a slow process, but i can guarantee it will resolve with time. just wanted to share this guys. 

Also, If you want to learn more about herxheimers, a quick google search will do the job.  

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54 minutes ago, marshl1 said:

You won't understand his theory if you don't read the ebook but it sounds like you have it all figured out anyway.

Good luck to you if you are making progress.

Thanks

Hang on a second, in his defence why does he even need to read it when he’s getting great results via testosterone treatment??

Until it’s all figured out we need to contrast different theories but by the sound of it Jason3 doesn’t need to look too far into the Vit A theory if he’s doing fine with testosterone yeah....

Correct me if I’m wrong?

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1 hour ago, TrueJustice said:

Hang on a second, in his defence why does he even need to read it when he’s getting great results via testosterone treatment??

Until it’s all figured out we need to contrast different theories but by the sound of it Jason3 doesn’t need to look too far into the Vit A theory if he’s doing fine with testosterone yeah....

Correct me if I’m wrong?

Of course, nobody needs to read the ebook. I just thought it was extremely important that people know it exists. 

He's doing well, good luck to him
 

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8 hours ago, TrueJustice said:

Jason3 - is the testosterone treatment you have success with working on anything other than just your testosterone levels?

Is it helping repair genome damage for instance or is that completely unrelated?

What do we have to do here? Go to an anti ageing clinic or something to look at repairing cellular damage?


Testosterone won't repair your genome or cellular damage. Nothing can fix someone's genome currently. And testosterone isn't a magic bullet (cream/injection, etc). It will fix low total/free testosterone. Like the other guy said it didn't work for him. Taking for years in high doses is the wrong approach anyway. That causes its own problems. Hormone therapy is more complicated than just injecting something into yourself. Your hormones are akin to a spider web and if you touch one part then the rest move too. It requires a doctor who can help to balance and manage all of your hormones. Broscience will make things so much worse. Guys do not like to hear that, but it's the truth and the way it is. Your body is much more complex than 1 hormone (or supplement or drug) fixing your problems. 

The reason why I've had my own success is that I've methodically been fixing the deficiencies as I find them. Some are "invisible" and can only be brought to light by blood tests. I had sexual dysfunction since taking Accutane. I went to the doctor and testosterone was low and was obvious. So I fixed that, then I looked at other hormones because I wanted to keep finding an incremental "better" than what I was currently feeling. I found DHEA, DHT, Prolactin, Insulin, and lately Thyroid all had problems. Every time I fixed something, I would get blood tests all over again and have to re-balance medications that I was taking. That is a long, slow process, and it is 4 years and counting. It can be expensive for some depending on what tests you need to get. But that is what is necessary and it really is that complicated. You have to fight your way out.

You could go to an anti-aging clinic. In the US, that term is falling out of use because it carries a vain and negative connotation. Sometimes they are called hormone clinics, mens' clinics, or TRT clinics. Look for good reviews. If they try to lock you into contracts for treatments then that is generally a bad sign. If they know what they are doing then they will check more than your testosterone levels. You have to pay for that care and health insurance here won't cover it, but my health and well-being is worth that to my family and I. If I had let these problems go then I could have developed diabetes or heart disease or who knows what else and I would be wishing that my care only cost what I pay now.

As far as your genome, there is the potential and promise of things like CRISPR, but it's too unproven right now in my opinion. There is no scientific proof that it yet works - or worse doesn't cause other problems. You buy a kit online, inject the liquid, and it alters your DNA based on their research of what to alter. But there is no long-term data. It could very well "fix" something that is broken, but then inadvertently do God knows what to other parts of your DNA and then you have even worse problems appear years later. Sound familiar?.I'm not against it, I just think that it needs to be studied a LOT more in order to determine that it is absolutely safe to use. I don't know about you, but my goal is to be healthier long-term, not just hope for the best.

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Good points Jason especially with hormones.   Its  never simple.  I'm wondering, if Clomid was ever suggested to you as a treatment?      And true about these novel treatments, especially messing around with DNA.   Who knows what kind of untoward effects this may have.   

Edited by mikez

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1 hour ago, mikez said:

Good points Jason especially with hormones.   Its  never simple.  I'm wondering, if Clomid was ever suggested to you as a treatment?      And true about these novel treatments, especially messing around with DNA.   Who knows what kind of untoward effects this may have.   


No, I am primary. Clomid is typically tried when a patient has secondary hypogonadism. What happens is that there is a problem with your pituitary or thyroid and the "signals" (primarily Lutenizing Hormone) are not being sent to the testicles telling the Leydig cells to produce testosterone. You would know if you are secondary if your LH and FSH are low.

Primary hypogonadism is simply "testicular failure" - usually injury, infection, TBI, opiate use, SSRIs, or unknown. The signals are being sent but the Leydig cells don't respond or never receive the signals. LH and FSH will be normal or high because your body is trying to overcompensate by sending a stronger signal to the testicles to try to force them into working.

Short-term Clomid can sometimes "reboot" that process for secondary patients but in truth it doesn't work a lot of the time. Part of the problem is that doctors overdose it. And patients generally don't feel that great on it. It also can more than double your estrogens making you really moody, emotional, and bloated.

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2 hours ago, Jason3 said:

No, I am primary. Clomid is typically tried when a patient has secondary hypogonadism. What happens is that there is a problem with your pituitary or thyroid and the "signals" (primarily Lutenizing Hormone) are not being sent to the testicles telling the Leydig cells to produce testosterone. You would know if you are secondary if your LH and FSH are low.

Primary hypogonadism is simply "testicular failure" - usually injury, infection, TBI, opiate use, SSRIs, or unknown. The signals are being sent but the Leydig cells don't respond or never receive the signals. LH and FSH will be normal or high because your body is trying to overcompensate by sending a stronger signal to the testicles to try to force them into working.

Short-term Clomid can sometimes "reboot" that process for secondary patients but in truth it doesn't work a lot of the time. Part of the problem is that doctors overdose it. And patients generally don't feel that great on it. It also can more than double your estrogens making you really moody, emotional, and bloated.

Oh I didn't know you were primary.   You likely stated your LH levels were high before and I missed that.. my bad.

Yes, with Clomid I actually meant as a long term treatment in lower doses (e.g. 12.5mg  E3D),  but given you're primary,  that of course explains why it isn't suitable.  

Thanks for the response.   
  Edited by mikez

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23 hours ago, marshl1 said:

I think that's a great idea. How are you finding the zero vitamin A diet? It's difficult isn't it
Well mine as yet is not so extreme as in the book. I started about 2-3 weeks ago and I consume, at home, rice, corned beef, steak, cauliflower, bread, coffee, olive oil. Planning to stop bread (I eat more of it now than before). At work I have less control as I eat prepared food, but I try to limit it to rice, bread and beef or pork.
I don't find it that hard, also my stomach didn' t ache since the start of the diet, while it happened quite often before.

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Question for Jason3

what are your thoughts on the video “8 tips to reversing Accutane side effects”?

Do you think it could work, some of it is good, none of it is good?

Is it even too late to attempt the protocol if you’re 20 years after taking Accutane?

The big question - if you’ve got genome or cellular damage no amount of “detoxing” is going to help at this stage?

please share your thoughts 

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@Dubya_B
@ACCUiTy_drANE
Maybe it wasnt bacteria. This is what I mean, or have been looking at.
Could be wrong though.
 

Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study

antifungal medication during pregnancy may affect the masculinization of male offspring. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480178/

 

Endocrine disrupting effects in vitro of conazole antifungals used as ...

by MB Kjærstad - ‎2010 - ‎Cited by 88 - ‎Related articles
Aug 11, 2010 - Widely used conazole antifungals were tested for endocrine disruptive effects ...Androgen Receptor Antagonists/toxicity; Animals; Antifungal ...
Like all azole antifungal agents, ketoconazole works principally by inhibition of .... Ketoconazole is anantifungal imidazole that inhibits androgen biosynthesis at ...



Fungistatic activity of all-trans retinoic acid against ... - NCBI - NIH

by E Campione - ‎2016 - ‎Related articles
Apr 29, 2016 - Recent reports hypothesize that the antifungal efficacy of all-trans retinoic acid (ATRA) is mainly related to its strong capacity to stimulate ...
Purpose · ‎Conclusion · ‎Introduction · ‎Results
 
This is the first evidence of a direct and strong fungistatic activity of ATRA 


  Edited by guitarman01

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12 hours ago, TrueJustice said:

Question for Jason3

what are your thoughts on the video “8 tips to reversing Accutane side effects”?

Do you think it could work, some of it is good, none of it is good?

Is it even too late to attempt the protocol if you’re 20 years after taking Accutane?

The big question - if you’ve got genome or cellular damage no amount of “detoxing” is going to help at this stage?

please share your thoughts 


If 20 years don’t helped, than some plant extracts won’t help, too.

Or is here someone who tried this 8 tips & it had helped? Edited by Kolonie

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10 minutes ago, Kolonie said:

If 20 years don’t helped, than some plant extracts won’t help, too.

Or is here someone who tried this 8 tips & it had helped?

I agree with your logic. I have not seen the video, but I’m skeptical of results. Natural remedies can help with minor problems - but they can only do so much. 

First you need to determine if you have a deficiency. Blood tests. Then look for the cause. More tests and reading (both, not just guessing from reading). Then you try to correct it. 

TrueJustice,
Detoxing works - look at what NAC does to your liver. It’s a miracle-worker. Highly recommend NAC just for general health BTW - Jarrow NAC Sustain. 

But if your genome is damaged then no detoxing is going to fix that because it’s at a much lower level so to speak. It’s the very encoding that determines how your body assembles itself. Damage that, and from then on your body is using bad prices to put itself together when replacing cells. Imagine you are a Lego kit and you are using broken/deformed/incorrect pieces. It is not going to work right. 

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Is there written in the manual that the side effects can be permanent?
I don’t have the manual any more.

And when it’s not, than is it possible to proceed against the manufacturer firm or is it hopeless?
 

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33 minutes ago, Kolonie said:

Is there written in the manual that the side effects can be permanent?
I don’t have the manual any more.

And when it’s not, than is it possible to proceed against the manufacturer firm or is it hopeless?
 


I don't remember any mention of side-effects being permanent, but it was decades ago when I last had a copy.

I think it would be difficult to go after Roche. You would need to get a product insert that was in circulation at the time you took Accutane. I took it 20 years ago so my copy would be different from yours.

Then you have to prove beyond a doubt that you didn't have any of these problems before you took it. The onus would be on us to prove we didn't have a condition beforehand, not that we had it after. Subtle but important difference.That's nearly impossible because it's not like you are checked for sexual dysfunction, IBS, whatever beforehand - it just isn't routine. Some initial wins to patients suffering were reversed because of this.

And there is the statute of limitations. In many states in the US, it's just a few years. So as soon as you start having symptoms (or a new side effect is formally recognized) you only have that long to bring a case and everyone is likely well past that at this point.

I don't mean to be a downer, but drug manufacturers are very, very good at winning cases. They have to be to stay in business and keep releasing poison like this onto the world to turn a profit.

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On 6/15/2018 at 10:11 AM, Jason3 said:

No, I am primary. Clomid is typically tried when a patient has secondary hypogonadism. What happens is that there is a problem with your pituitary or thyroid and the "signals" (primarily Lutenizing Hormone) are not being sent to the testicles telling the Leydig cells to produce testosterone. You would know if you are secondary if your LH and FSH are low.

Primary hypogonadism is simply "testicular failure" - usually injury, infection, TBI, opiate use, SSRIs, or unknown. The signals are being sent but the Leydig cells don't respond or never receive the signals. LH and FSH will be normal or high because your body is trying to overcompensate by sending a stronger signal to the testicles to try to force them into working.

Short-term Clomid can sometimes "reboot" that process for secondary patients but in truth it doesn't work a lot of the time. Part of the problem is that doctors overdose it. And patients generally don't feel that great on it. It also can more than double your estrogens making you really moody, emotional, and bloated.
interesting as FSH was high for me.. LH was normal i believe 

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8 hours ago, Kolonie said:

Is there written in the manual that the side effects can be permanent?
I don’t have the manual any more.

And when it’s not, than is it possible to proceed against the manufacturer firm or is it hopeless?
 


We cant sue for things like:

thinning hair
dry skin
fatigue 
eye floaters
sebum loss
excess sweating
unwanted body hair
lack of bile flow
depression
loss of quality of life

I could go on....

They know about us, make no mistake about it, are they interested in helping even in the slightest? Not to my knowledge- helping would be an admission of guilt anyway!

Unless they had a hand in putting the 8 tips video together.....I’m curious on the background with that video, like how did they come to believe the combination of those supplements actually work? - who’s actually had success doing it, things like that....

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11 hours ago, Jason3 said:

I agree with your logic. I have not seen the video, but I’m skeptical of results. Natural remedies can help with minor problems - but they can only do so much. 

First you need to determine if you have a deficiency. Blood tests. Then look for the cause. More tests and reading (both, not just guessing from reading). Then you try to correct it. 

TrueJustice,
Detoxing works - look at what NAC does to your liver. It’s a miracle-worker. Highly recommend NAC just for general health BTW - Jarrow NAC Sustain. 

But if your genome is damaged then no detoxing is going to fix that because it’s at a much lower level so to speak. It’s the very encoding that determines how your body assembles itself. Damage that, and from then on your body is using bad prices to put itself together when replacing cells. Imagine you are a Lego kit and you are using broken/deformed/incorrect pieces. It is not going to work right. 

Jason3 - would you rate NAC over Tudca for repairing the Liver?

I think I’ve used NAC before, no that I’m adverse to using again. I’m very much interested in Tudca though as it’s listed in the 8 tips Accutane detox video!!

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21 hours ago, TrueJustice said:

We cant sue for things like:

thinning hair
dry skin
fatigue 
eye floaters
sebum loss
excess sweating
unwanted body hair
lack of bile flow
depression
loss of quality of life

I could go on....

They know about us, make no mistake about it, are they interested in helping even in the slightest? Not to my knowledge- helping would be an admission of guilt anyway!

Unless they had a hand in putting the 8 tips video together.....I’m curious on the background with that video, like how did they come to believe the combination of those supplements actually work? - who’s actually had success doing it, things like that....
Have you ever considered that these things might not be due to Roaccutane?

Do you know how the MMR vaccine got linked to Autism? 

Answer: The symptoms of autism first become apparent at around the age of 1-2. Which is the same age as the MMR vaccine is given. This is how people concluded that the MMR vaccine was giving children autism. We know now that this almost cerrtainly isn’t true.

People generally take Roaccutane between 16-21. Depression usually starts after 16. Depression is phenomenally rare in children. 16-21 is particularly a high risk age for depression. Similarly you are a young man. Thinning head hair and unwanted body hair is something that will again begin after 16 and is part of being male.

I would advise you to start treating these conditions in conventional ways, rather than reading crackpot theories (which almost certainly arn’t true) and implementing their drastic interventions to no avail.

Reflect on this. Have any of these theories you’ve read on the internet ever properly worked or have they just given you false hope? 

I’m really not trying to be nasty. I’m trying to help you. Please think about what i’ve said.

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Mate - we should sue them for eye floaters and thinning hair alone!! - undoubtably occurred while taking Accutane and certainly not presented to me as something I’d have to endure 20 years later!!

Sorry, that’s all I’ll say - don’t wish to derail current subject matter!!

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4 hours ago, Benjamin94 said:
I would advise you to start treating these conditions in conventional ways, rather than reading crackpot theories (which almost certainly arn’t true) and implementing their drastic interventions to no avail.

It has been a long weekend with little sleep so I am feeling a little salty, but here goes:

This is what needs to be done. It's what I did to recover my well-being from my own symptoms. The simple truth is that no one is riding in to rescue anyone suffering from symptoms. WE have to take agency over OUR own health. That applies to ALL areas of your health. There are so many theories - I like to call it "broscience". Learn how your body works. It takes a lot of reading, but really isn't difficult and it is so worth it.

I watched about half of that 8 tips video. You know, if you try those things and they work for you then great. But learn on your own why they work, don't rely on a YouTube expert. It's sensationalist to me. That guy is saying that Accutane gives you Cholestasis for God's sake. If you really had that, it's a life-threatening condition, and you would know it. My wife had it while pregnant. She was bed-ridden in a hospital for 3 weeks while they tried to keep her liver from failing and her from dying. And she itched all over day and night without relief. It's just spreading fear and misinformation casually mentioning something like that in a video and sharing it around. Hypervitaminosis A. You would know it. It comes on fast and then goes away within weeks of the Vitamin A source being removed. Hallucinations, double vision, bone swelling, vomiting. If you suspect it with those symptoms, then get your liver and Retinol tested along with some bone x-rays. It's irresponsible to just tell people that Accutane causes it and by the way here is a tip to deal with it. And I stopped watching after he said a bunch of this Accutane gets stored in your fat. Your body can store substances in fat if the liver is overwhelmed, but the research on this and how it works is incomplete at best. 80-90% of retinoic acid is stored in your liver. It's why the drug is so toxic to your liver. Again, you have to confirm with tests showing stress on your liver. Don't just assume that you have half or whatever of your Accutane treatment locked up in fat cells for a lifetime, because you don't.

There are a lot of theories about Accutane's effects, but they are likely to stay just that - theories - because in order for there to be some real progress made there have to be studies and documentation that this is all linked together and real. And the sad fact is that Roche certainly isn't going to prove that they made some kind of poison. And there isn't any money in other researchers doing the work either. Try what you can, but learn about it first from several sources so you don't inadvertently make something worse. And test, test, test - it's the only way you can be sure. Before, during, after trying something.

You have to treat the symptoms and problems as they are for you. It's no longer Accutane, it's what Accutane caused, so the "Accutane angle" just isn't going to help much at this point. Especially those of us who are years or decades out from it. If you have ED, IBS, hypogonadism, you have to treat those things. Learn all you can so that you can have an informed conversation with your doctor. And it your doctor doesn't care or won't listen then fire your doctor and get another just like you would with a plumber or mechanic. 

 

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On 6/14/2018 at 9:15 AM, marshl1 said:

Quite ironically, I am now totally convinced that acne is the result of the over-accumulation of VA in the sebaceous glands in the first place.

 

How an over-accumulation of vitamin A could be the cause of acne and prevent acne (Accutane)? Aren’t those two affirmations contradictory?

 

On 6/14/2018 at 9:15 AM, marshl1 said:

I don't think I had specifically stated that RA can be stored in the liver for a long period of time. But, it definitely persists in the skin lipids for long periods of time.

 

I suppose a blood test measures the quantity of VA in the blood? But is there a way to measure VA/RA “in the skin lipids”?

Edited by Ákos

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6 hours ago, Jason3 said:

It has been a long weekend with little sleep so I am feeling a little salty, but here goes:

This is what needs to be done. It's what I did to recover my well-being from my own symptoms. The simple truth is that no one is riding in to rescue anyone suffering from symptoms. WE have to take agency over OUR own health. That applies to ALL areas of your health. There are so many theories - I like to call it "broscience". Learn how your body works. It takes a lot of reading, but really isn't difficult and it is so worth it.

I watched about half of that 8 tips video. You know, if you try those things and they work for you then great. But learn on your own why they work, don't rely on a YouTube expert. It's sensationalist to me. That guy is saying that Accutane gives you Cholestasis for God's sake. If you really had that, it's a life-threatening condition, and you would know it. My wife had it while pregnant. She was bed-ridden in a hospital for 3 weeks while they tried to keep her liver from failing and her from dying. And she itched all over day and night without relief. It's just spreading fear and misinformation casually mentioning something like that in a video and sharing it around. Hypervitaminosis A. You would know it. It comes on fast and then goes away within weeks of the Vitamin A source being removed. Hallucinations, double vision, bone swelling, vomiting. If you suspect it with those symptoms, then get your liver and Retinol tested along with some bone x-rays. It's irresponsible to just tell people that Accutane causes it and by the way here is a tip to deal with it. And I stopped watching after he said a bunch of this Accutane gets stored in your fat. Your body can store substances in fat if the liver is overwhelmed, but the research on this and how it works is incomplete at best. 80-90% of retinoic acid is stored in your liver. It's why the drug is so toxic to your liver. Again, you have to confirm with tests showing stress on your liver. Don't just assume that you have half or whatever of your Accutane treatment locked up in fat cells for a lifetime, because you don't.

There are a lot of theories about Accutane's effects, but they are likely to stay just that - theories - because in order for there to be some real progress made there have to be studies and documentation that this is all linked together and real. And the sad fact is that Roche certainly isn't going to prove that they made some kind of poison. And there isn't any money in other researchers doing the work either. Try what you can, but learn about it first from several sources so you don't inadvertently make something worse. And test, test, test - it's the only way you can be sure. Before, during, after trying something.

You have to treat the symptoms and problems as they are for you. It's no longer Accutane, it's what Accutane caused, so the "Accutane angle" just isn't going to help much at this point. Especially those of us who are years or decades out from it. If you have ED, IBS, hypogonadism, you have to treat those things. Learn all you can so that you can have an informed conversation with your doctor. And it your doctor doesn't care or won't listen then fire your doctor and get another just like you would with a plumber or mechanic. 

 


Hypervitaminosis A can be chronic and it's treated by removing any supplements containing Vitamin A but also a vitamin A depletion diet or low vitamin A diet. 
Why couldn't Accutane cause chronic hypervitaminosis A? The doses are massive and taken over a very long period of time to 'work'. People suffer from chronic hypervitaminosis A after consuming less Vitamin A (which is converted to retinoic acid in the body) than the extremely high doses of retinoic acid in accutane. 
I personally don't believe the projected half life of of accutane. I prefer to believe it's probably something made up by Roche, my opinion obviously.
Anyway it makes logical sense that this massive dose taken over a long duration is going to take a long time to leave the lipids especially if the person is continuing to consume Vitamin A which is being converted to retinoic acid and maintaining the toxicity.

 

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