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I agree. Need to work on all areas. I forgot to mention that I also do take a b vitamin with the active form of folate because I have the MTHFR gene. I do not have high homocysteine.  Chinese herbalist said you need to continue with the b vitamins for rest of life.  

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4 hours ago, Chris16 said:

I agree. Need to work on all areas. I forgot to mention that I also do take a b vitamin with the active form of folate because I have the MTHFR gene. I do not have high homocysteine.  Chinese herbalist said you need to continue with the b vitamins for rest of life.  

 
Don't take B complexes daily as it can feed infections. They use them as substrate for their metabolism.
I'd take it once a week.
If you eat plenty of raw vegetables, you get loads of B vits.

And food-based forms of supplements are best. The ratios between nutrients, phytonutrients, minerals, trace elements, anti-oxidants, etc.. matters greatly. That's one of the reasons accutane messed us up so bad. It threw our fat-soluble "vitamins" ratio off. We need to get TONS of sunshine now to rebalance the vit A to D. Also, eat plenty of vit K2 containing foods. Sauerkraut with Mercola's Kinetic culture probiotic is best.

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1 hour ago, yetanotheraccutanevictim said:
Don't take B complexes daily as it can feed infections. They use them as substrate for their metabolism.
I'd take it once a week.
If you eat plenty of raw vegetables, you get loads of B vits.

The problem is that the form of B vitamins found in foods can be counterproductive for those of us with MTHFR mutations. The body cannot convert the vitamins properly no matter how healthy one's diet is. That being said, as someone with MTHFR mutations, I noticed no digestive or cognitive changes after supplementing with the active form of folate and B12 for two months. Perhaps I'll give it another go later.

Those well-versed in MTHFR mutation research seem to give highly specific advice based on each individual, genetic mutation. I should probably look into more. If I could pay someone to make sense of all of my mutations related to vitamin metabolism, I'd do it. Some of the advice attached to each mutation directly contradict what I should do in regards to another mutation. I don't know what to believe. Edited by ACCUiTy_drANE

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4 hours ago, ACCUiTy_drANE said:

The problem is that the form of B vitamins found in foods can be counterproductive for those of us with MTHFR mutations. The body cannot convert the vitamins properly no matter how healthy one's diet is. That being said, as someone with MTHFR mutations, I noticed no digestive or cognitive changes after supplementing with the active form of folate and B12 for two months. Perhaps I'll give it another go later.

Those well-versed in MTHFR mutation research seem to give highly specific advice based on each individual, genetic mutation. I should probably look into more. If I could pay someone to make sense of all of my mutations related to vitamin metabolism, I'd do it. Some of the advice attached to each mutation directly contradict what I should do in regards to another mutation. I don't know what to believe.
 
MTHFR is overhyped. Biochemical polymorphisms are useless compared to epigenetic influences. Physics is the answer. Biochemistry / Biology is not a fundamental science. Physics explains why the chemicals of life do the things they do at the most microscopic levels.

It's about the environment primarily, not your genes.

Again, if someone here is suffering and has not tried MMS, turpentine from diamondgforestproducts, colloidal silver, urine therapy, or zapping, WHAT ARE YOU WAITING FOR? Danny Glass (Sun Fruit Dan youtube channel) actually has a lot of decent videos where he gives quick overviews of some of these therapies. Will save you the long route of researching them yourself.
 

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Positive for SIBO, not just candida.  REally going HAM on this with enteric coated peppermint oil, SF722 formula, bone broth, glutamine, etc. I'm already more hydrated on a daily basis.  CBN night oil is putting me to sleep, and CBD is helping saturate my tissues and joints.  FEeling better little by little.  Very slow progress, but noticeable.  Been doing methylation now for almost 8-9 months. It helps with mental clarity and joint pain. I'm doing other things as well but am just too lazy to detail everything. Taking LDN for past 2-3 years. Anyone else have SIBO Dx? I've been slacking on liver flushes, did 10 and was still passing things, so I genuinely believe I'm still very congested still.

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1 hour ago, yetanotheraccutanevictim said:
MTHFR is overhyped. Biochemical polymorphisms are useless compared to epigenetic influences. Physics is the answer. Biochemistry / Biology is not a fundamental science. Physics explains why the chemicals of life do the things they do at the most microscopic levels.

It's about the environment primarily, not your genes.

Again, if someone here is suffering and has not tried MMS, turpentine from diamondgforestproducts, colloidal silver, urine therapy, or zapping, WHAT ARE YOU WAITING FOR? Danny Glass (Sun Fruit Dan youtube channel) actually has a lot of decent videos where he gives quick overviews of some of these therapies. Will save you the long route of researching them yourself.
 

I just need to ask, how have you concluded that you need to take all these things to get results??
Why not just the MMS alone?

Thats what is confusing about this forum, everyone is quick to say take this and do that but how do you know what to eliminate along the way?

Ive tried colloidal silver - by itself nothing happened.

Like the post about Xiao Yao San and it helping the liver. Why isn't that alone good enough to work on liver? Who concluded you also need to take milk thistle and Solomon's seal etc??

Its all hit and miss as far as I'm concerned.

 

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Hey everyone. Good stuff. Lots of good ideas being thrown out. We just need some people to start improving and seeing some success. Does anyone else have an extremely dry face still? I've been off accutane for 2 years and the worst part now is my extreme facial blushing and flushing that actually seems to be getting worse. Anyone else have a problem with that? Anyone do anything to fix or improve it? Any experience or help or advice would be greatly appreciated!

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3 hours ago, helpmeoutbuddies11 said:

Hey everyone. Good stuff. Lots of good ideas being thrown out. We just need some people to start improving and seeing some success. Does anyone else have an extremely dry face still? I've been off accutane for 2 years and the worst part now is my extreme facial blushing and flushing that actually seems to be getting worse. Anyone else have a problem with that? Anyone do anything to fix or improve it? Any experience or help or advice would be greatly appreciated!



Yes I still have this problem after 15 years. I have no clue how to fix this. 

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On 9/23/2016 at 1:15 PM, yetanotheraccutanevictim said:
On 9/23/2016 at 0:28 PM, TrueJustice said:
One thing I do believe I'm right about though is that we all must work on problems similataneaosly, we know that tane potentially messed up the whole body. So in turn you must work on gut whilst working on liver whilst working on methylation etc etc, can't just concentrate on one area.
4
Working on the liver is the key to restoring ANY area in the body. If you improve liver health, you improve gut health, brain health, eye health, toenail health, etc.. EVERYTHING. Please listen to my advice and focus all your attention on the liver, detoxification, and killing pathogens
yetanotheraccutanevictim  - Hey, how did you conclude liver level?    Bilirubin 4 umol/L (range 3 -20) serum ALT 23 IU/L (range5 -55) 
Are you saying these numbers indicate a problem.

interestingly Albumin 48 (range 35 -50g/L)

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13 hours ago, TrueJustice said:

I just need to ask, how have you concluded that you need to take all these things to get results??
Why not just the MMS alone?

Thats what is confusing about this forum, everyone is quick to say take this and do that but how do you know what to eliminate along the way?

Ive tried colloidal silver - by itself nothing happened.

Like the post about Xiao Yao San and it helping the liver. Why isn't that alone good enough to work on liver? Who concluded you also need to take milk thistle and Solomon's seal etc??

Its all hit and miss as far as I'm concerned.

 
 

Each one of the remedies I shared has the potential to heal us completely by itself. However, EVERYONE here should be doing coffee enemas and liver-gallbladder flushes in addition to one other SUPER powerful therapy like turpentine or MMS, etc..
And colloidal silver is probably the weakest of the things I've shared but it's still excellent. Brand matters.
It's not hit or miss tactics. Just do as many things as possible. Don't do ONE single thing like colloidal silver and hope to get well.

1 hour ago, hatetane said:
yetanotheraccutanevictim  - Hey, how did you conclude liver level?    Bilirubin 4 umol/L (range 3 -20) serum ALT 23 IU/L (range5 -55) 
Are you saying these numbers indicate a problem.

interestingly Albumin 48 (range 35 -50g/L)
 
A few hundred hours of research. Yes, your liver is under stress and most likely congested. My numbers are lower than yours and my liver is almost completely clogged.

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I really need some suggestions! I have been on Accutane for two months now and now am getting joint pains. Some people are suggesting omega 3 some are suggesting glucosamine. Can someone give me some suggestions on it?
 

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2 hours ago, Sincere1212 said:

I really need some suggestions! I have been on Accutane for two months now and now am getting joint pains. Some people are suggesting omega 3 some are suggesting glucosamine. Can someone give me some suggestions on it?
 


Stop taking it is my best suggestion for you.

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I have a dry face as well, and dry body, etc.  I don't get the flushing that everyone talks about though which is weird.  I get the opposite, lack of blood flow to the face.  I literally have to hang upside down to get blood into my head, face, and scalp.  Worst circulation goes to ME! :)

It's been much  better with exercise and CBD oil

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6 hours ago, MovingOnMusicGal said:

I have a dry face as well, and dry body, etc.  I don't get the flushing that everyone talks about though which is weird.  I get the opposite, lack of blood flow to the face.  I literally have to hang upside down to get blood into my head, face, and scalp.  Worst circulation goes to ME! :)

It's been much  better with exercise and CBD oil


Where do you get CBD oil from?
Any brands you can recommend?

In relation to your dry face - do you put CBD oil on it? or do you use it just on the body?

My circulation is horrendous too, plus I have bad varicose veins. On top of the eye floaters and all that crap, I'd say it's all related.

Is it from a clogged liver??

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On 02.03.2016 at 10:57 PM, MrErdem said:

2 years passed since my last pill. I took 40mg/day for two months in 2014 Jan/Feb..
This is the list of my problems:
-ED: Still no connection between penis and brain. Improved maybe %40 where I can achieve an erection but sensation got worse. I used to be very horny, now I am half the man I used to be (good song btw). My flaccid state is horrible. My orgasms got worse where I dont feel anything during ejaculation. 
- Tinnitus: still there
- Vision problems: floaters are gone by 90%. But I am still night blinded and have some visual snow and double vision. Not a big deal, can live with these.
- Tremors: gone by 99%
- Weak urine: still bothering me but ok.
- Hair: still thin and dry and I lost lots of hair, but I am still not bald and it stopped.
- Dry eyes, nose, mouth: I never had these, it is interesting that some sympthoms are not the same.
- Panic attacks, anxiety, suicidal state: gone, I feel depressed sometimes but mental I am pre-accutane
- Energy: Better %70
- Flexibility: I feel like an old man, I dont prefer to yawn. It hurts. But improved %40
- Stomach: my new problem, reflux and gastrit started 6-7 months ago.

Overall I am Ok. Soon I will start gym, I feel I can do it : )
But my biggest problem is the absence of libido. I just dont have it. When I see an attractive woman, i know that she is hot but I don't feel it. I want to feel like a man again. I think I will try Clomid and see if it works.

 


Ok, now it has been 6 months since I started gym. The best thing ever. I encourage everybody start moving. Just do it! 
But:
No matter hard I try, no matter I go every other day to gym, or everday, or sleep or nutrition.. I can not get in shape!
Nobody believes me that I go to gym. I think the androgen insensitivity theory fits to me. I checked my hormonal panel many times, levels are within ranges but on the low side. I tried tamoxifen (only a couple of pills cause I am scared) , tribulus tettretis, zinc, NO boosters, they wont help.  
This is my body shape still after 6 months: 

bf.jpg

And this is my case, especialy two boxes on the bottom..

low-testosterone1.jpg

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8 hours ago, MrErdem said:

Ok, now it has been 6 months since I started gym. The best thing ever. I encourage everybody start moving. Just do it! 
But:
No matter hard I try, no matter I go every other day to gym, or everday, or sleep or nutrition.. I can not get in shape!
Nobody believes me that I go to gym. I think the androgen insensitivity theory fits to me. I checked my hormonal panel many times, levels are within ranges but on the low side. I tried tamoxifen (only a couple of pills cause I am scared) , tribulus tettretis, zinc, NO boosters, they wont help.  
This is my body shape still after 6 months: 

bf.jpg

And this is my case, especialy two boxes on the bottom..

low-testosterone1.jpg

What hormone panel did you get.. and what are the numbers?

Estrogen dominance mimic  the same EXACT  symptoms.    many people on here have had their testosterone numbers tested... soe come back high

its a specific test... im having a complete hormone panel... but you have to order a total estrogen count... not just the male estrodial number.  (you have to get a womens test.)   it would fit with the low libido, SIBO, Candida.

google candida and estrogen dominance (think eye floaters)
SIBO and estrogen dominance

calcium D glucarate    .. our livers are so backed up, that we cant eliminate estrogens the correct way anymore?  Gilberts disease would make it worse.

many people on these forums take DIM and calcium D glucarate for acne.  its mostly women... but the results are astounding.

I3C  indole 3 Carbinol or Zinc would do the same thing.... clear excess androgens and estrogens.


Estrogen and Cholestasis.....  i know we keep going to in circles about glucuronides of accutane being stuck.. but what about Estrogen not being able to be detoxified due to the drug as well?   causing a loop?  

Read these two paragraphs below...  is this why Calcium D Glucarate and UDCA are recommended in the solving the accutance problem video?


Estrogens
[edit]

Estrogens, and particularly glucuronides such as estradiol-17β-D-glucuronide, have been shown to cause cholestasis in animal studies, by reducing bile acid uptake by hepatocytes.[7]

Treatment[edit]

Upon diagnosis, many providers will prescribe Ursodeoxycholic Acid. While there is no cure for ICP, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of Ursodeoxycholic Acid, whereas Cholestyramine appears to only relieve itching.[7]

If additional blood tests to check clotting function identify a problem, giving Vitamin K may help avoid the risk of hemorrhage at delivery.

Delivery by 35–37 completed weeks may be important to fetal outcome as a recent study demonstrated that in severe ICP (defined as bile acids greater than 40 umol/L) the risk of stillbirth was 1.5% compared to 0.5% of uncomplicated pregnancies. This risk rose further if bile acids doubled,[12]


Since estrogen is detoxified the same way as accutane... maybe accutane caused a block here...

http://onlinelibrary.wiley.com/doi/10.1002/hep.1840030422/abstract

So maybe  get a total estrogen test ... even a progesterone test as well.  i know these are for women...but maybe it will show something. (all 3, not just the one   E1 E2  E3) ...


then a treatment of:

Calcium D glucarate
DIM 
Indole 3 Carbinol
TUDCA



 

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Retinoic acid regulates several genes in bile acid and lipid metabolism via upregulation of small heterodimer partner in hepatocytes.

Abstract

Retinoic acid (RA) affects multiple aspects of development, embryogenesis and cell differentiation processes. The liver is a major organ that stores RA suggesting that retinoids play an important role in the function of hepatocytes. In our previous studies, we have demonstrated the involvement of small heterodimer partner (SHP) in RA-induced signaling in a non-transformed hepatic cell line AML 12. In the present study, we have identified several critical genes in lipid homeostasis (Apoa1, Apoa2 and ApoF) that are repressed by RA-treatment in a SHP dependent manner, in vitro and also in vivo with the use of the SHP null mice. In a similar manner, RA also represses several critical genes involved in bile acid metabolism (Cyp7a1, Cyp8b1, Mdr2, Bsep, Baat and Ntcp) via upregulation of SHP. Collectively our data suggest that SHP plays a major role in RA-induced potential changes in pathophysiology of metabolic disorders in the liver.

Copyright © 2014. Published by Elsevier B.V.



so retinoic acid causes problems with the bile acid formation. via upregulation of SHP.  Estrogens do the same thing. Interestingly the  CYP26 family the regulates retinoic acid also is affected negatively.

 

Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.

Abstract

Cholestasis activates bile acid receptor farnesoid X receptor (FXR) and subsequently enhances hepatic expression of small heterodimer partner (SHP). We previously demonstrated that SHP represses the transactivation of cytochrome P450 2D6 (CYP2D6) promoter by hepatocyte nuclear factor (HNF) 4α. In this study, we investigated the effects of estrogen-induced cholestasis on CYP2D6 expression. Estrogen-induced cholestasis occurs in subjects receiving estrogen for contraception or hormone replacement, or in susceptible women during pregnancy. In CYP2D6-humanized transgenic (Tg-CYP2D6) mice, cholestasis triggered by administration of 17α-ethinylestradiol (EE2) at a high dose led to 2- to 3-fold decreases in CYP2D6 expression. This was accompanied by increased hepatic SHP expression and subsequent decreases in the recruitment of HNF4α to CYP2D6 promoter. Interestingly, estrogen-induced cholestasis also led to increased recruitment of estrogen receptor (ER) α, but not that of FXR, to Shp promoter, suggesting a predominant role of ERα in transcriptional regulation of SHP in estrogen-induced cholestasis. EE2 at a low dose (that does not cause cholestasis) also increased SHP (by ∼ 50%) and decreased CYP2D6 expression (by 1.5-fold) in Tg-CYP2D6 mice, the magnitude of differences being much smaller than that shown in EE2-induced cholestasis. Taken together, our data indicate that EE2-induced cholestasis increases SHP and represses CYP2D6 expression in Tg-CYP2D6 mice in part through ERα transactivation of Shp promoter.

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.

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Guys listen !! its not going to work like this. We are so many , we are talking for 10 years in forums. Nothing solved.

Why dont we start a lawsuit against Roche ? or make a contact to a known medical university ALL TOGETHER ? we will never going to fix our problem like this. We need professional medical help !

Isnt there anybody who pressed a charge against Roche ? cant we prove it , cmon..

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1 hour ago, SaffronAide said:

Guys listen !! its not going to work like this. We are so many , we are talking for 10 years in forums. Nothing solved.

Why dont we start a lawsuit against Roche ? or make a contact to a known medical university ALL TOGETHER ? we will never going to fix our problem like this. We need professional medical help !

Isnt there anybody who pressed a charge against Roche ? cant we prove it , cmon..


There are hundreds of lawsuits filed every year against hoffman-la-roche, accutane side effects in particular, the dockets list thousands of names in district court of New Jersey alone. It's public information. Their lawyers fight cases year round.

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12 hours ago, macleod said:

There are hundreds of lawsuits filed every year against hoffman-la-roche, accutane side effects in particular, the dockets list thousands of names in district court of New Jersey alone. It's public information. Their lawyers fight cases year round.

So how in the fuck it can still be legal to sell isotretinoin? What needs to happen so it gets banned?

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I'll review the document, though this side of my detox profile is not in the red so if indeed it is an issue, then I wonder what the cause is. As a side note, and I'll make a detailed post upon completing my trial, Calcium D Glucarate has done me great. I've only dosed 40g total this month and I'm taking a little break right now to review how I feel, but I'm definitely at my very best.

Gene & Variation

rsID

Alleles

Result

CYP1A1*2C A4889G

rs1048943

TT

-/-

CYP1A1 m3 T3205C

rs4986883

TT

-/-

CYP1A1 C2453A

rs1799814

GG

-/-

CYP1A2 164A>C

rs762551

AC

+/-

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