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17 hours ago, guitarman01 said:
On 4/18/2016 at 7:03 AM, tryingtohelp2014 said:

i call bullshit on anyone who doesnt post scans.

I call bullshit on your bullshit. You have been leading people astray since day one and not coming clean about any of it.The vets on here know what im talking about. So now you think people are just making up blood test results if they dont support your theories? that is some lame ass shit. you havent been tryingtohelp anyone but yourself. where do you think your going anyway? your the copper man remember? its 100 percent the copper doing it right? you tell people on here what kind of copper supplement you were taking?(you know the one that had 10 other vitamins in it?)like the time you said sam-e was giving you more energy when you were also drinking red bulls for breakfast. il post some scans i do have when i get the time, but it sure as hell wont be to appease you. i have zero respect. So now we are sliding into Vitamin D, thats great I think it might be vitamin d too.


you are the craziest person ive ever seen post on a msg board. i think you might be a paid troll.   im leading people astray now???  DO YOU THINK I OWE YOU A CURE???  Everything ive posted has a clear and defined link back to 13-cis retinoic acid   methyl groups=SAM-E , so yes i still believe in this.   there is a  link between methylation and copper deficiency (which i tested deficient for, AND EVERYONE ELSE WHO POSTED DID AS WELL)    WHAT WERE THE LEVELS OF YOUR TESTS?  you never even had a serum copper test.   you had a ceruloplasmin test AFTER taking copper.  so yeah, i call bullshit on your "normal"  post your scan.

and as far as "sliding into Vitamin D"  UM YEAH!!! i tested 9!!!  on a scale of 30-100.  is that low enough for you professor?  
so yeah im going to "slide" into vitamin D.

 
dont worry guitarman... ill keep doing work for you.


 http://www.jimmunol.org/content/194/1_Supplement/123.12

As the prevalence of allergic diseases such as allergic asthma and rhinitis continues to increase, there is growing interest in novel approaches to blunt the inflammatory processes. IgE-mediated mast cell activation results in the release of histamine and other inflammatory mediators. Vitamin D has been linked to allergic disease, with vitamin D deficiency being linked to increased risk for development and severity of allergic disease. We assessed the effects of the Vitamin D metabolite 1a,25-dihydroxyvitamin D3 (1,25D3) on IgE-mediated mast cell activation in vitro. We find that 1,25D3 suppresses IgE-mediated inflammatory cytokine and chemokine production. Surprisingly, these effects do not require expression of the canonical receptor for 1,25D3 (VDR), as wild type and VDR KO mast cells are similarly suppressed by 1,25D3. Additionally, these effects appear to be somewhat stimulus-specific, as IL-33-mediated mast cell activation s not inhibited by 1,25D3. We postulate that the chaperone protein Pdia3, an alternative plasma membrane-associated receptor for 1,25D3, may be responsible for the VDR-independent, anti-inflammatory effects on IgE-mediated mast cell activation. Our data depict novel evidence that 1,25D3 can attenuate the pro-inflammatory mast cell response, and emphasize the possible utility of vitamin D supplementation for treatment of allergic and inflammatory diseases.

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On 16 April 2016 at 1:50 AM, sanadai said:

Anyways, have anyone else here ever had successes with fermented foods (kefir and kombucha specifically)? What were your experiences with it and how did you prepare it? Also, why are we just ignoring that guy's awesome testimonial?


I'm on my 3rd batch of sauerkraut (single batch made from a medium cabbage lasts me about 2 weeks), and also drinking home made kefir milk. Introducing each I got a die-off effect resulting in headaches for a couple of days, but fine after that, I felt the milk kefir resulted in a marked improvement in mental clarify, however I decided to try coconut kefir instead after a couple of weeks, and haven't got much from that, so I've switched back to milk kefir this week (each use a different sort of 'starter culture' grain).

Sauerkraut is obviously an excellent source of probiotics, but in addition is a good source of vitamin C, K, B6 and folate. It also has a decent amount of iron and manganese. 

Kefir is also an excellent source of probiotics as well as a good source of B vitamins, especially B12 and also folate, as well as vitamin D and magnesium. 

Interestingly the folate in kefir is approx 20% tetrahydrofolate (http://kefir.ilbello.com/articoli/k2.pdf), and I've just got my 23andme results back which show I have the MTHFR gene mutation (heterozygous, i.e. only from one parent). This means I will have trouble converting 5-methylfolate into tetrahydrofolate, so supplementing tetrahydrofolate directly from the kefir may be why I've noticed some benefit, but the B12 could be a factor as well. From my Genetic Genie 23andme results analysis (I have all these mutations heterozygously);
 

MTHFR A1298C

MTHFR A1298C is involved in converting 5-methylfolate (5MTHF) to tetrahydrofolate (THF). Unlike MTHFR C677T, the A1298C mutation does not lead to elevated homocysteine levels. This reaction helps generate BH4. BH4 is important for the detoxification of ammonia. The gene is compromised about 70% in MTHFR A1298C (+/+) individuals, and about 30% in people with a heterozygous (+/-) mutation.

BH4 acts as a rate limiting factor for the production of neurotransmitters and catecholamines including serotonin, melatonin, dopamine, norepinephrine, and epinephrine. A MTHFR A1298C + status may cause a decrease in any of these neurotransmitters or catecholamines. BH4 is also a cofactor in the production of nitric oxide. A dysfunctional BH4 enzyme may lead to mental/emotional and/or physical symptoms. Mercury, lead, and aluminum may act as a drain on BH4. 

 

MTHFR C677T

One function of MTHFR (Methylenetetrahydrofolate reductase) is to help convert homocysteine to methionine. A MTHFR C677T mutation means that the MTHFR enzyme may have trouble performing its task leading to high levels of homocysteine. According to Dr. Ben Lynch, impaired function of the enzyme can cause or contribute to conditions such as Autism, Chronic Fatigue Syndrome, Fibromyalgia, Miscarriages, IBS, many birth defects, Multiple Sclerosis, Alzheimer's, Bipolar Disorder, blood clots, Stroke, Chemical Sensitivity, and many other conditions. 

 

MTR/MTRR Mutations

MTRR (Methionine synthase reductase) helps recycle B12. The combination of MTR and MTRR mutations can deplete methyl B12. MTR A2756G, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR S257T, and MTRR A664A all work together to convert homocysteine to methionine.

MTR (5-methyltetrahydrofolate-homocysteine methyltransferase) provides instructions for making the enzyme methionine synthase. Methionine synthase helps convert the amino acid homocysteine to methionine. To work properly, methionine synthase requires B12 (specifically in the form of methylcobalamin). An MTR A2756G mutation increases the activity of the MTR gene causing a greater need for B12 since the enzyme causes B12 to deplete since it is using it up at a faster rate. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency. Megaloblastic anemia can occur as a consequence of reduce methionine synthase activity.

A homozygous mutation of MTR A2756G is not very common (<1% of CEU population). Some studies have demonstrated that people with a combination of MTHFR C677T and MTR A2756G have persistently high homocysteine levels unless they are treated with both B12 and folate. 




  Edited by tanedout

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Hi all!

I finished roaccutane 8 months ago. My problem is skin based. It has become very wrinkled (with very visible pores) since the end of roaccutane. Pic included of my forehead.

Hoping it can recover. My old skin wasnt perfect but way better than this and fairly flat/smooth. I am still shocked and I did tell the nurse that it was getting 'rough' halfway during treatment but i was told it would go away.  Now i am always stressed night and morning. Had mixed opinions from doctors, with several saying it should improve but requires patience as its a rare problem that happens to people? My skin is quite dry and tight feeling often but also more acne prone now than before treatment...

Whole thing is a nightmare.

Best wishes to all!

IMG_0716.JPG

Edited by Worriedscared1

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Has anyone attempted to understand the relationship of Accutane with dopamine and its receptors? 

I understand there have been some studies conducted in the way of its affects on dopamine receptors but they seem to be inconclusive.

Adding on here, and with reference to @tryingtohelp2014 's recent study of vitamin D, there have been a few posts on multiple forums discussing the relation to brain fog - vitamin D and Accutane.

______________________________________________________

Earlier in the thread I also mentioned the importance of vitamin D levels as accutane is shown to permanently damage VitD receptors.

 

VitD is levels are linked to dopamine release (higher vitD results in higher dopamine release)

http://www.ncbi.nlm.nih.gov/pubmed/17105922
http://www.springerlink.com/content/p888671163495l77/
http://www.sciencedirect.com/science/article/pii/S0924933809705528
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950608/

 

VitD directly related to androgen levels:

 http://www.ncbi.nlm.nih.gov/pubmed/20050857

 

So we can see that VitD affects dopamine and also androgen levels. So the tane effects of lowerVitD and Lower DHT are linked to lower dopamine:

 

Low vitD = Low dopamine

 

Low vitD = Low androgen = Low dopamine

 

Low DHT = Low androgen = Low dopamine

 

Low DHT = High Prolactin = Low dopamine

 

Low DHT = High T binding to albumin and SHBG = lower freeT = Low dopamine

 


Im all for Tryingtohelp looking into whatever he thinks may be of interest. Thats literally the premise of any good research. 

Ive got the day off tomorrow so will go have a VIt D test taken. 

Edited by Iamme.

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2 hours ago, Iamme. said:

Has anyone attempted to understand the relationship of Accutane with dopamine and its receptors? 

I understand there have been some studies conducted in the way of its affects on dopamine receptors but they seem to be inconclusive.

Adding on here, and with reference to @tryingtohelp2014 's recent study of vitamin D, there have been a few posts on multiple forums discussing the relation to brain fog - vitamin D and Accutane.

______________________________________________________

Earlier in the thread I also mentioned the importance of vitamin D levels as accutane is shown to permanently damage VitD receptors.

 

VitD is levels are linked to dopamine release (higher vitD results in higher dopamine release)

http://www.ncbi.nlm.nih.gov/pubmed/17105922
http://www.springerlink.com/content/p888671163495l77/
http://www.sciencedirect.com/science/article/pii/S0924933809705528
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950608/

 

VitD directly related to androgen levels:

 http://www.ncbi.nlm.nih.gov/pubmed/20050857

 

So we can see that VitD affects dopamine and also androgen levels. So the tane effects of lowerVitD and Lower DHT are linked to lower dopamine:

 

Low vitD = Low dopamine

 

Low vitD = Low androgen = Low dopamine

 

Low DHT = Low androgen = Low dopamine

 

Low DHT = High Prolactin = Low dopamine

 

Low DHT = High T binding to albumin and SHBG = lower freeT = Low dopamine

 


Im all for Tryingtohelp looking into whatever he thinks may be of interest. Thats literally the premise of any good research. 

Ive got the day off tomorrow so will go have a VIt D test taken. 


Good post about Vit D. Sounds like you can supplement all you want with D, if the receptors are stuffed though how are we to see any benefit??

The bigger question is, how do we fix the receptors??

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1 hour ago, TrueJustice said:

Good post about Vit D. Sounds like you can supplement all you want with D, if the receptors are stuffed though how are we to see any benefit??

The bigger question is, how do we fix the receptors??

Natural Ways to Increase Calcitrol and Vitamin D Receptor Gene Expression

  • Exercise (R)- increases calcitriol, but not aerobic exercise (R).
  • RXR ( and retinol) is needed to produce proteins with the VDR (R).  1,25D3 binds to the VDR, which then combines with RXR to activate gene expression.  (Not all VDR dependent genes need RXR.)
  • Parathyroid hormone (PTH) – increases Calcitriol/1,25 D3 (R),
  • PTH-related peptide (R),
  • SIRT1 -potentiates VDR (RR2) – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
  • PGC-1a (R) – potentiates VDR.  It is a coactivator of the VDR, but it still needs 1,25D3.
  • Dopamine (R) –Mucuna (AMZN) or Mucuna (IHERB)
  • Bile – specifically Lithocholic acid or LCA (R),
    The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitates disposal from the cell via the ABC efflux transporter (R).
  • Omega-3:DHA, EPA (R), – Fish oil/DHA (AMZN) or Fish Oil/DHA (IHERB)
  • Omega-6:Linolenic acid, Arachidonic acid (R),
  • Curcumin (R) – Curcumin is more active than LCA/Bile in driving VDR-mediated
    transcription and that it binds to VDR with approximately the same affinity as LCA.
  • Resveratrol (R) – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
  • Forskolin (AMZN) (95%) or Forskolin (IHERB) (R), – increases 1,25D3 from 25D3 in-vitro.
  • Gamma Tocotrienol (R)- Tocotrienols or Tocopherols (IHERB)
  • Vitamin E/alpha-tocopherol (R)- doesn’t compete with calcitriol for the VDR.
  • Dexamethasone (R) – doesn’t compete with 1,25
  • Interferon gamma -IFN-γ treatment inhibited 1,25D3 induction of 24-hydroxylase, the enzyme that breaks down 1,25 D3.  This means 1,25D3 increased. (Technical: IFNy did not change the base level activity of the promoter, or change 1,25D binding to the VDR or nuclear VDR levels. IFN-γ impairs VDR-RXR binding to VDRE through a Stat1-mediated mechanism) (R),
  • Estradiol – increases VDR expression (R, R2),
  • Phytoestrogens (R),
  • Testosterone (R),
  • Prostaglandins (R),
  • Bisphosphonates (R),
______________________________________________________________________________________________

Not so much a fan of boom, copy pasta but there it is. At least if there is a movement towards Vitamin D it can be hopefully grounded with academic research. 

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1 hour ago, Ruvik said:

androgen receptor

is the key

This connection between testosterone levels and vitamin D is not only clear, as apparently a connection with the sex hormone binding globulin (SHBG) also exists.10 As it is generally recognized, approximately 98% of testosterone is not available for interacting with target cells since it is mostly inactivated by binding to serum albumin and SHBG. It is believed that optimum levels of vitamin D, may reduce the amount of SHBG, thus enabling higher free testosterone.10 This may explain the anabolic properties of vitamin D.

Since vitamin D depends mostly from exposure to solar radiation, it was showed that there is a strong relationship between the season of the year and levels of vitamin D and testosterone.10 In the summer, there are obviously higher levels of Vitamin D and testosterone, by increased exposure to solar radiation. In the winter the situation is the opposite, leading us to a situation in which our body depends much more on dietary vitamin D.10

If we want to go a bit deeper into this subject, in a press release of the year 2011, one of the leading companies in the research of sarcopenia (decrease of muscle mass) claimed that vitamin D increases the expression of the androgen receptor in myocytes (muscle cells).11 Apparently vitamin D increased the conversion of satellite cells into new muscle fibers and also raised the possibility of administering nandrolone decanoate together with vitamin D to enhance its activity.11 According to this press release, nandrolone decanoate also acts on the VDR.11

 

To resume everything that has been said, vitamin D can:

a) Increase the activity of the androgen receptor and VDR.

b) Reduce the levels of SHBG.

c) Reduce the androgenic activity of testosterone and similar hormones.

We know that both the activity of the androgen receptor and free testosterone levels, are critical in protein synthesis and muscle hypertrophy.13

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vitamin D has no effect on me

In desperate times, desperate measures

I want to try a super cocktails , for libido, erections and muscles
I want to feel Iike a male, another one time in life

tribulus
ginseng
ginko biloba
maca
dhea
taurine


some other idea?

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1 hour ago, Ruvik said:

vitamin D has no effect on me

In desperate times, desperate measures

I want to try a super cocktails , for libido, erections and muscles
I want to feel Iike a male, another one time in life

tribulus
ginseng
ginko biloba
maca
dhea
taurine


some other idea?


Some PFS suffers have recovered from cycling testosterone boosting herbs. I've found pine pollen was very effective. Taking 3 tea spoons of it per day for 3-4 weeks made me feel great, really 'alpha male' feeling, like really confident and assertive, but I got symptoms of high e after about 4 weeks. Taking it alongside an aromatase inhibitor like erase pro might help, or reservatrol, broccoli and celery if you want to go down the more natural route. This is something I'll probably try if I get somewhere with the current gut health protocol I'm trying.  @tryingtohelp2014 Great to see you've now a mod - I hope you can use this position to maybe try and get a 'side effects' sub-forum setup where we can have a thread per topic, rather than this single on-going thread! Would be a huge step forward.  Edited by tanedout

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1 hour ago, Ruvik said:

vitamin D has no effect on me

In desperate times, desperate measures

I want to try a super cocktails , for libido, erections and muscles
I want to feel Iike a male, another one time in life

tribulus
ginseng
ginko biloba
maca
dhea
taurine


some other idea?

Have you ever checked your neurotransmitters ? (sertonin, norepinephrine, epinephrine, dopamine)
Especially DOPAMINE is very important for ED issues!!

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2 hours ago, Ruvik said:

vitamin D has no effect on me

In desperate times, desperate measures

I want to try a super cocktails , for libido, erections and muscles
I want to feel Iike a male, another one time in life

tribulus
ginseng
ginko biloba
maca
dhea
taurine


some other idea?



this doesnt help anyone!!!  it just adds more questions

were you tested for vitamin D?
how much did you take?
for how long?
what else did you take with it?
were you retested??

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http://www.acne.org/messageboard/topic/308708-when-can-i-use-tanning-bed-after-accutane-course/

 
Go to the post by "luc_nic"
 
This person states that they think a lot of tanning/sunlight brought back their acne and oily skin after their first accutane course. Might be related to increases in vitamin D metabolism.
Edited by Accustained
too much theorizing

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Here is what has helped me with the problems from accutane damage.  I took Bromelain 2,000GDU/tab or 3,000GDU/tab for the pain,inflammation, and spasms of bowel and joint.  Took 2 tabs three times a day on empty stomach until symptoms subsides (usually took 2 or 3 days) and then decrease dose to 1 or 2 tabs nightly at bedtime as maintenance.  Also take DHEA 25mg time-release (got it from GNC) once a day and L-arginine 1.5gms twice a day.  Now my libido is back to normal.  Also flaxseed oil 1 tablespoon twice a day and coconut 1 tablespoon in morning in smoothie/shake and 1 tablespoon olive oil or an avocado with dinner helps with dry eyes and dry skin.  Aloe vera juice to soothe stomach whenever.  Ginseng w/Royal jelly for energy and helps with brain fog.  Not 100% but alot better than before

Edited by tilex99

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1 hour ago, tilex99 said:

Here is what has helped me with the problems from accutane damage.  I took Bromelain 2,000GDU/tab or 3,000GDU/tab for the pain,inflammation, and spasms of bowel and joint.  Took 2 tabs three times a day on empty stomach until symptoms subsides (usually took 2 or 3 days) and then decrease dose to 1 or 2 tabs nightly at bedtime as maintenance.  Also take DHEA 25mg time-release (got it from GNC) once a day and L-arginine 1.5gms twice a day.  Now my libido is back to normal.  Also flaxseed oil 1 tablespoon twice a day and coconut 1 tablespoon in morning in smoothie/shake and 1 tablespoon olive oil or an avocado with dinner helps with dry eyes and dry skin.  Aloe vera juice to soothe stomach whenever.  Ginseng w/Royal jelly for energy and helps with brain fog.  Not 100% but alot better than before


I am very interested in DHEA , have you noticed any side effects? how long it takes to work and what symptoms ?

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http://www.vega-licious.com/is-cleanliness-next-to-health-what-you-need-to-know-about-vitamin-d/

 
sourced article that gives further argument for getting vitamin D from direct sunlight, not from supplementation.
 
photosensitive people, start slow with sunbathing, build up more over time. Since we have less sebum/oils in our skin after accutane it may require some patience to reach adequate levels of vit D. I started yesterday, will update in some time. Also don't use soap on parts of skin exposed to sunlight because it washes away the essential oils for vit D conversion. I think that was mentioned in another article posted recently, but needs repeating.
 
And keep eating that spinach!! (beta carotene, vitamin C & K2, calcium, iron, magnesium, folate, copper, iodine, potassium)
Edited by Accustained

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5 hours ago, Accustained said:

http://www.vega-licious.com/is-cleanliness-next-to-health-what-you-need-to-know-about-vitamin-d/

 
sourced article that gives further argument for getting vitamin D from direct sunlight, not from supplementation.
 
photosensitive people, start slow with sunbathing, build up more over time. Since we have less sebum/oils in our skin after accutane it may require some patience to reach adequate levels of vit D. I started yesterday, will update in some time. Also don't use soap on parts of skin exposed to sunlight because it washes away the essential oils for vit D conversion. I think that was mentioned in another article posted recently, but needs repeating.
 
And keep eating that spinach!! (beta carotene, vitamin C & K2, calcium, iron, magnesium, folate, copper, iodine, potassium)

if we dont have the oils in the skin (squalene) its hard for us to make Vitamin D.   could be part of the endless loop.

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On 4/19/2016 at 2:45 AM, TrueJustice said:

Are we needing to supplement with K2 because of accutane or just because it works well when taking Vit D & magnesium??

I think I might benefit from K2 but don't want to add to current regime if it's not going to do much!?

Ive felt a little less stiff in recent days after hitting the Vit D/Magnesium in last week or so. My back feels better!

A while ago I've read on this forum about people being almost 20 years off accutane who have undergone a surgery for their tendons/soft tissue calcification. Without Vitamin K2, the body cannot direct calcium to the bones where it's needed; instead, the calcium resides in soft tissue (eg. arteries) leading to a combination of osteoporosis and atherosclerosis. I'm not sure whether the soft tissue calcification is caused by accutane though, but it sounds like it in the 2 cases I've read about here.

I have lots of right abdominal pain at the moment, front, side and back, and my blood work shows high levels of potassium. I worry it's the kidney not removing the potassium from the blood properly (seeing a doctor soon). High levels of phosphorus and/or potassium can cause unhealthy nerve function, heart disease and calcium to be pulled from bones and go into circulation. This can lead to calcification of coronary arteries and other soft tissues, and is associated with serious heart problems. Again, K2...

Check your potassium levels.
  Edited by HaniaD

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Hey guys,

Quick questions for all who have ED.

1) Can you masturbate with an erect penis? 2) Is ED experienced only when with other women?  3) Has it gotten worse over the years?.. Or has it been consistent since ending Accutane?

I have been making progress but I need some more time; just wanna see if I am fixing the same problems as everyone else. 

Edited by Accutazed

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How Vitamin D3 works:Vitamin D.jpg

Almost everyone accutane victim has a vitamin D3 deficiency.
I'm going to check my blood tomorrow....i will post my results soon.

I hope I can also check my DHEA.

DHEA.jpg

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8 hours ago, HaniaD said:

A while ago I've read on this forum about people being almost 20 years off accutane who have undergone a surgery for their tendons/soft tissue calcification. Without Vitamin K2, the body cannot direct calcium to the bones where it's needed; instead, the calcium resides in soft tissue (eg. arteries) leading to a combination of osteoporosis and atherosclerosis. I'm not sure whether the soft tissue calcification is caused by accutane though, but it sounds like it in the 2 cases I've read about here.

I have lots of right abdominal pain at the moment, front, side and back, and my blood work shows high levels of potassium. I worry it's the kidney not removing the potassium from the blood properly (seeing a doctor soon). High levels of phosphorus and/or potassium can cause unhealthy nerve function, heart disease and calcium to be pulled from bones and go into circulation. This can lead to calcification of coronary arteries and other soft tissues, and is associated with serious heart problems. Again, K2...

Check your potassium levels.
 

there was a guy on here chung pao.... and i found him on a reddit board.    he solved a vitamin A toxicity problem with Vitamin D , vitamin K2 MK4 version, and Magnesium.   he specifically took the Mk4 version to remove calcium deposits while taking the Vitamin D

accutane causes an induction of the CYP3A4 enzyme.  this by itself depletes the body of Vitamin D.   Vitamin D and vitamin K2 also stimulate the CYP3A4 enzyme, and his theory was this could speed the detoxifcation process.


my theory also would include copper... because accutane upregulates three different pathways to remove copper from your cells and liver.   copper and vitamin A have an inverse relationship with liver storage.

so once path could be to have copper induce vitamin A to be removed from the liver to the bloodstream....and then have Taurine conjugate with it for removal.   would be an a.m. /p.m. dosage.    copper and taurine are antagonistic with each other.

and the second path could include a vitamin D / K2 / Mag  .    CYP3A4 induction.   D is obviously antagositc with A.  and so is K2.    D and K2 stimulate CYP3A4

it will never be just one thing.   

@yetanotheraccutanevictim  all you can do is get tested.

another anecdote... day 5 of 5000iu D3  with K2 and mag.     ive had serious muscle cramps from working out for years.  mainly in my toes and calves.  if i would flex my calves or curl my toes, i would get just painful cramps.  if i turn to the side too much, i would get a stitch there as well.   well, after 5 days my cramps are TOTALLY GONE.  its unbelievable.
it almost 100% has to do with the D helping regulate the calcium to the muscles
.


https://www.urmc.rochester.edu/news/story/2923/amid-the-murk-of-gut-flora-vitamin-d-receptor-emerges-as-a-key-player.aspx

http://paleoleap.com/you-and-your-gut-flora/
the first three things mentioned are D K2 and Mag

 

 


 

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@HaniaD 
@tryingtohelp2014


Hania, if you ever discover these stories, be sure to send them to me. I'd appreciate it.

I have what appears to be hypercalcemia throughout my entire body. I have extreme pain. I don't think it's from calcium leaching from bones & teeth into the soft tissues, though. I think it has something to do with oxalates depositing in my tissues. Still haven't figured out if they're from my diet or infection but I'm working on it. I excrete these via my stool daily. Looks like sharp white crystals.

Btw, for those of you who do not know, oxalates are the same thing that kidney stones & tonsil stones are comprised of: calcium oxalate or oxalic acid. This may be something to look into if you have systemic pain or cracking, creaking joints. Low oxalate diet & attacking certain microbes will alleviate this issue most of the time. Parasites are well known to produce oxalates as protective biofilm. Most autistic kids have parasites and thus have very high oxalate levels. Taking an herb known as stone breaker or chanca piedra can help with this as well.

I'd steer clear of taking any single compound in high doses like vitamin D as that can majorly calcify the tissues.

Some useful studies I pulled together regarding hypercalcemia:
LINK

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Some good posts about Vit D & K2. I'm going to continue to take them and see what happens.

I may get my levels checked, I worry though that our situation is unique, we produce NO OIL anymore and the body just doesn't take up Vit D like it should. Once I see some oil return maybe then I'll know something is working.

I'm also still concerned with gut health - my instincts tell me that there is some infection going on that I need to address - good thing that I'm seeing an endocrinologist next month, maybe he'll shed some light on things and do some real tests!?

I may start taking copper again....the guessing game continues....

PS - Why are people posting about accutane problems from taking it just 8 months ago!? It's offensive to me that you'd take it given what's been said about this hideous drug. If I had the knowledge back in 1998 like we do now when I was introduced to it, do you really think I'd of taken it.
I'm sure long-term sufferers would agree.

Unless you've had your head in the sand or you just want to ignore shit, taking accutane in this day and age is nothing short of mental!!!

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