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1 hour ago, Dubya_B said:

.

David Chow, the man who started RAG-forum and a leading member of the Roaccutane Action Group, committed suicide last month after 21 long years of suffering severe depression and painful physical complications brought about by Accutane.

Coroner asks for review of acne drug Roaccutane after photographer’s suicide
http://www.eadt.co.uk/news/coroner_asks_for_review_of_acne_drug_roaccutane_after_photographer_s_suicide_1_4337597
 



This is unbelievable sad news. I hope he finds peace now.
 

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http://www.accutaneaction.com/authorties/index.html

http://www.healthy.net/scr/article.aspx?Id=3401
http://www.aquatic-ape-diet.com/blog/hoffmann-la-roche%e2%80%99s-cover-up-of-accutane/

there is so many more links I could post! I remember our first conversation, my first question " was I going to die" that was 9-10 yrs ago! words can't express such sorrow :( 

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1 hour ago, oli girl said:
http://www.accutaneaction.com/authorties/index.html

http://www.healthy.net/scr/article.aspx?Id=3401
http://www.aquatic-ape-diet.com/blog/hoffmann-la-roche%e2%80%99s-cover-up-of-accutane/

there is so many more links I could post! I remember our first conversation, my first question " was I going to die" that was 9-10 yrs ago! words can't express such sorrow :( 

so fucking sad.  i hope all of these roche people burn.

i remember reading this  aquatic-ape site.  its ironic that guitarman brought up being "dried out"   its essentially one of our main problems.  if you read Nathan Carr's site, he mentions TEWL and hyaluronic acid many times.  
 

"Then Matthew found another important link to his other side effects. Accutane, also switches
off the production of hyaluronic acid, the water-holding molecule in the connective tissue
between living cells in the body. Hyaluronic acid is concentrated in the joints, skin, scalp, and
eyes, exactly where all of Matthew’s symptoms were concentrated. Scientific studies appear to
confirm Hamilton’s suspicions regarding hyaluronic acid. The destruction of hyaluronic acid
would explain the universal symptoms of dryness associated with Accutane use, the dry eyes,
hair, skin, and joints.”

“Just as Accutane causes the drying up of secretions from the sebaceous glands, it also inhibits
the secretion from other glands as well. Accutane is not specific to the oil glands in the skin. It
dries out the whole body.”"



Hyaluronic acid is just another GAG.  So why would accutane destroy the ability to make this?!  just another coincidence  .....
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012035685&recNum=100&docAn=JP2011003350&queryString=(IC:C07%2520OR%2520IC:A61K%2520OR%2520IC:C12%2520OR%2520IC:A61P%2520OR%2520IC:A23L)%2520AND%2520LGF:JA&maxRec=36893

A novel composition having strong hyaluronic acid production-promoting capability is provided. The present invention provides a composition for promoting hyaluronic acid production that comprises S-adenosylmethionine and phytic acid. The inventors solved this issue on the basis of the unexpected discovery that a composition comprising S-adenosylmethionine and phytic acid promotes hyaluronic acid production. The inventors confirmed that hyaluronic acid production is promoted by a composition that comprises S-adenosylmethionine and phytic acid, regardless of the fact that none of the components of S-adenosylmethionine and phytic acid promote hyaluronic acid production.

https://patentscope.wipo.int/search/docservicepdf_pct/id00000020667332/ETWOS/WO2012035685.pdf

cyclodextrin is in there too!! lol

So if you want to try this... its SAM-e and the supplement IP6


whoever wrote the above patent is a  moron though... methionine is what all GAGs are started from? 


FUCK!!!! WE HAVE THIS...WE JUST NEED TO FIGURE OUT THIS LAST STEP! Edited by tryingtohelp2014

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I am not sure about the moron...But I do know Mr. Carr and I are close and have meet! He was very important to the old rag forum also,  very important to the Accutane community...has made great accomplishments is doing pretty good! though we must remember that we are all made up of different DNA and what works for one may not work for another!

Stay Strong My FRIENDS!!!!!!!

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So can the dryness effects be treated/band aided with a really good hyaluronic acid supplement (or any arthritis supplement) ?

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

Did anyone else tried this ? Or recommend a supplement,at the very least? 

(link to the supplement https://cogentsolutionsgroup.com/products/baxyl)

 

Edited by Francopld

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@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet. 
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

B12 and folate way above range but thats expected considering i take a lot. Potassium low because of folate intake.

All other stuff perfect
57 minutes ago, Francopld said:

So can the dryness effects be treated/band aided with a really good hyaluronic acid supplement (or any arthritis supplement) ?

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

Did anyone else tried this ? Or recommend a supplement,at the very least? 

(link to the supplement https://cogentsolutionsgroup.com/products/baxyl)

 

No.
32 minutes ago, Chloe123 said:

Took my first accutane pill this morning and just came across this log. I don't know what to do anymore I'm so scared now :/ wtf

Quit while you still got the chance, you can get rid of acne with other means

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44 minutes ago, Relentless1k said:
@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet. 
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

B12 and folate way above range but thats expected considering i take a lot. Potassium low because of folate intake.

All other stuff perfect No. Quit while you still got the chance, you can get rid of acne with other means

wow super high testosterone? you're libido is dead? I on the other hand have levels of about 400 and im 21. Doctor doesn't want to do anything about it but i'm miserable. thinking about ordering online. 

and yes I have tried every single possible way to get it up naturally. And the test was first thing in the am on a fasted state. Edited by marlin15

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2 hours ago, Francopld said:


I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

 

taking oral hyaluronic acid doesnt work. many have tried.  your body cant absorb it. medical studies back this up. injections into the joints seem to help.   you have to make it yourself internally.    i just posted how to make your own?
 
1 hour ago, Relentless1k said:
@tryingtohelp2014Just paste the significant parts of the study, not the full thing. 95% of the people reading the thread just has to scroll past it. You can rather have a convo/group message on acne.org inbox with the ppl u want to share the full thing with

i did post the relevant paragraph. .. and im not doing private conversations.  everyone needs to read this.  couldve saved Chloe already.....and if its too long, and they dont want to know every possible thing that might be going wrong with them, they can skip it.  their loss.

did you get a methylmalonic acid test? serum b-12 by itself doesnt confirm anything. Edited by tryingtohelp2014

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7 hours ago, Relentless1k said:

Interestingly enough i just got my blood test results and my serum calcium is high on a low calcium diet. 
Testosterone is way above reference range as well which is really weird since im skinny as hell, its 46 with a 35 max. (40 is 1150ng/dl for you US based people)

You guys talk about Testosterone what about DHT has anyone had the combination of high testosterone low DHT? I read post Tane users have a problem converting this and it could show up as low DHT which is similar to the PROPECIA users that have problems 



BTW high Dose FOLATE or this supplement NADH at 10mgs dried the hell out of me and gave me a limp D*ck(this shit better come back). not sure which one did it yet so a caution to anyone trying these supplements. 
     That being said if it was the FOLATE maybe it antagonised something and this could be looked into as a cause for some of our problems.

Edited by guitarman01

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http://ghr.nlm.nih.gov/gene/NPC2

The NPC2 gene provides instructions for making a protein that is located inside lysosomes, which are compartments in the cell that digest and recycle materials. The NPC2 protein attaches (binds) to cholesterol. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods. Research suggests that the NPC2 protein plays an important role in moving cholesterol and certain other fats (lipids) out of the lysosomes to other parts of the cell.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356423/

Gnmt−/− mice had hyperlipidemia and steatohepatitis.

....Confocal microscopy demonstrated that when cells were treated with low-density lipoprotein, NPC2 was released from lysosomes and interacts with GNMT in the cytosol. Overexpression of GNMT doubled the half-lives of both NPC2 isoforms and reduced cholesterol accumulation in cells.

https://en.wikipedia.org/wiki/Steatohepatitis

 

Steatohepatitis (also known as fatty liver disease) is a type of liver disease, characterized by inflammation of the liver with concurrent fat accumulation in liver . More deposition of fat in the liver is termed steatosis, and together these constitute fatty liver changes.…. When not associated with excessive alcohol intake, it is referred to as nonalcoholic steatohepatitis (NASH),

….. NASH is also associated with lysosomal acid lipase deficiency
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284162/
The sterol in these particles is processed in the late endosomal/lysosomal (E/L) compartment of cells by the sequential action of at least three proteins, lysosomal acid lipase (LAL) (3), Niemann-Pick C2 (NPC2) (4), and Niemann-Pick C1 (NPC1) (5), before being exported into the cytosolic compartment.

https://en.wikipedia.org/wiki/Lysosomal_acid_lipase_deficiency
...Lysosomal acid lipase deficiency (or LAL deficiency) happens when the body does not produce enough active lysosomal acid lipase (LAL or LIPA) enzyme. This enzyme plays an important role in breaking down fatty material (cholesteryl esters and triglycerides) in the body
...Lysosomes are found in the body’s cells and play an important role in digesting nutrients and other materials. Lysosomal Storage Disorders (LSDs) are inherited conditions in which one or more of the enzymes in lysosomes is missing or not functioning effectively. When this happens, materials that would normally be broken down by the lysosome accumulate and this disturbs normal cell function.

https://en.wikipedia.org/wiki/Lysosomal_storage_disease
Lysosomal storage disorders are caused by lysosomal dysfunction usually as a consequence of deficiency of a single enzyme required for the metabolism of lipids, glycoproteins (sugar containing proteins) or so-called mucopolysaccharides.
https://en.wikipedia.org/wiki/Glycosaminoglycan
Glycosaminoglycans[1] (GAGs) or mucopolysaccharides[2] are long unbranched polysaccharides consisting of a repeating disaccharide unit. The repeating unit (except for keratan) consists of an amino sugar (N-acetylglucosamine or N-acetylgalactosamine) along with a uronic sugar (glucuronic acid or iduronic acid) or galactose.[3] Glycosaminoglycans are highly polar and attract water. They are therefore useful to the body as a lubricant or as a shock absorber.
Mucopolysaccharidoses are a group of metabolic disorders in which abnormal accumulations of glycosaminoglycans occur because of enzyme deficiencies.
....The fourth class of GAG, hyaluronic acid, is not synthesized by the Golgi, but rather by integral membrane synthases which immediately secrete the dynamically elongated disaccharide chain.
https://en.wikipedia.org/wiki/Mucopolysaccharidosis

''Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans. These long chains of sugar carbohydrates occur in each of our cells that help build bone, cartilage, tendons, corneas, skin and connective tissue. Glycosaminoglycans (formerly called mucopolysaccharides) are also found in the fluid that lubricates our joints.

People with a mucopolysaccharidosis either do not produce enough of one of the 11 enzymes required to break down these sugar chains into simpler molecules, or they produce enzymes that do not work properly. Over time, these glycosaminoglycans collect in the cells, blood and connective tissues. The result is permanent, progressive cellular damage which affects appearance, physical abilities, organ and system functioning, and, in most cases, mental development.

The mucopolysaccharidoses are part of the lysosomal storage disease family, a group of more than 40 genetic disorders that result when a specific organelle in our bodies' cells – the lysosome – malfunctions. The lysosome is commonly referred to as the cell’s recycling center because it processes unwanted material into substances that the cell can utilize. Lysosomes break down this unwanted matter via enzymes, highly specialized proteins essential for survival. Lysosomal disorders like mucopolysaccharidosis are triggered when a particular enzyme exists in too small an amount or is missing altogether.''

posted this for the record for future conections maybe

Edited by Modeaa

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32 minutes ago, guitarman01 said:
You guys talk about Testosterone what about DHT has anyone had the combination of high testosterone low DHT? I read post Tane users have a problem converting this and it could show up as low DHT which is similar to the PROPECIA users that have problems 

 


My free testosterone is low-ish, but DHT is quite high, near the top of the reference range. Some others have seen the same. 

Also someone on the ATM forum has posted up the 2 recent finasteride recoveries, both of which are quick recoveries following the same protocol, which is the antibiotic metronidazole, along with a diet excluding sugar. Worth keeping an eye on..

1. Random guy recovers: "The antibiotics that cured me were metronidazole (500mg 3x a day for 10 days) and paromomycin (1,000mg 3x a day for 5 days). Relief came pretty quickly--I felt 90% on top of the world by day three.”
He also states that he has a zero-sugar diet, took things like HumaWorm and ParaGone and Lactoferrin prior to taking the antibiotics.
http://www.curezone.org/forums/am.asp?i=2276109

2. Another guy replicated this recovery: "This person says he took - metronidazole (500mg 3x a day for 10 days) and paromomycin (1,000mg 3x a day for 5 days) and was cured. So I went to my doctor and requested to be put on this same treatment, and sure enough, just like the poster I felt completely cured physically, sexually and mentally, night and day difference. I did the exact dosing as above and didn't start the paromomycin until the 7th day. So metroni (flagyl) 500 mg 3x a day for 10 days and on the 7th day I started paromomycin for five days straight and ate NO SUGAR to avoid feeding whatever it is that was in me. I felt better after about day 8 or 9. I should also add I was taking high doses of probiotics of the entire duration and still am, most doctors will recommend this with antibiotic treatment.”

He also states the he took tons of probiotics like PrescriptAssist and VSL3 during and after as well as a low-sugar diet.
http://solvepfs.com/viewtopic.php?f=11&t=930

[/QUOTE]



Link to the atm forum;



http://www.allthingsmale.com/community/threads/2-new-recoveries-w-same-protocol.26219/

 

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5 hours ago, alihassanbhatti said:

Two years after accutane. 135mg/kg. No pimple. No marks. Not a single pimple since.


And yet still no friends or a girlfriend. This is a specific thread; you are free to make your own thread, and post whatever you want. Several years as an objective adult on this earth has taught me a lot. I would err on the side of bragging when seemingly ahead of the curve as the universe has a unique way of balancing out in the end. Just some advice.
 
11 hours ago, Francopld said:

So can the dryness effects be treated/band aided with a really good hyaluronic acid supplement (or any arthritis supplement) ?

I remember a guy here trying a supplement callad "baxyl",that is like a liquid form of hyaluronic acid or something like that, and having succes with it,or at least some relief.

Did anyone else tried this ? Or recommend a supplement,at the very least?

 


Why don't you ask your doctor, friends, and family? Remember, "don't believe any of the wash you read on the internet..do not believe anything you read on an online forum." You said that right? Edited by macleod

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15 hours ago, oli girl said:
I am not sure about the moron...But I do know Mr. Carr and I are close and have meet! He was very important to the old rag forum also,  very important to the Accutane community...has made great accomplishments is doing pretty good! though we must remember that we are all made up of different DNA and what works for one may not work for another!

Stay Strong My FRIENDS!!!!!!!
So are Nathan Carr's theories on Accutane Side effects still the same as they were back then? 
Does he have anything to recommended as far as supplements, tests, or any insights that may be of help to us? Edited by guitarman01

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I've decided I'm going to make some effort in getting some testing done along the lines of DNA analysis, gut flora, parasites etc. Obviously like many others I've had all the usual blood tests/liver panels/urine tests/ultrasounds done and of course these are coming back pretty normal with no glaringly obvious issues.

There has been quite a bit of talk about possible issues due the effects of accutanes damage on gut flora numerous times, with Otto who recovered from using RSO oil also taking a medical grade probiotic (potentially a factor), Annony claims to have recovered at least in part from eating healthy and eating lots of fermented foods for 'good bacteria', some of the propecia guys claiming to have parasites (they then followed the specific treatment for that specific parasite), however what seems to happen on here is most people will then jump on the bandwagon of a good theory/positive personal report for a bit (me included) and follow the suggested protocol route without actually getting any tests done. Getting the tests done will at least show if there is an issue, then specifically what the issue is (i.e. a certain parasite etc), then it can be treated specifically with the best methods, not just a stab in the dark 'take some probiotics and hope' sort of approach.

I've just sent off my 23andme test analysis today, so should have the results in a month or so, so that will show if I'm positive for the MTHFR gene mutation for example, along with many other things, and discussing the results with other people post tane might show some trends. 

Testing can also be done pretty easily, and from home, for gut flora, candida, parasites etc - Genova Diagnostics seem to offer pretty comprehensive testing https://www.gdx.net most of which can be done from home/post samples for analysis. We really need some hard evidence to backup/disprove some of these theories! I'm aware of course that many things that would be useful to know can't easily be tested for, but there are still plenty that can.

Edited by tanedout

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what about and ige type blood test that would maybe show something related to   allergy? someone else here said they tested high.
anyone have this test that came back negative or normal?
 

The Pfeiffer Treatment Center identifies two different supplement regimes depending on if you are an "over-methylator" or an "under- methylator." These are VERY rough estimations and nothing concrete...they may not be accurate either; further research is needed.

Q: How can you find out if you are over or under?
A: Histamine levels may be a good indicator of whether someone is an over or under-methylator.

Low histamine points to over-methylator: If your histamine level is low you are probably an over-methylator (according to Pfeiffer research). This means that many supplements would be detrimental to him (those containing methyl). These would include taurine, GABA [both precursors to methyl activity in the brain], folic acid, B12, B6, DMG, TMG (and SAMe) - to name a few.

Q: What test checks histamine levels?
A: There is a blood test to measure histamine. Your pediatrician can do it.

Have we looked at the other end of the spectrum? 

Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). It is very active in the brain, and too much leads to “too much of a good thing.” This causes an overproduction of serotonin, norepinephrine, and dopamine in the brain.  In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido, weight gain, and confusion.

This is what I was talking about earlier and maybe why it was the Folate that possibly gave me a limp di*k

Edited by guitarman01

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22 minutes ago, guitarman01 said:

what about and ige type blood test that would maybe show something related to   allergy? someone else here said they tested high.
anyone have this test that came back negative or normal?
 

The Pfeiffer Treatment Center identifies two different supplement regimes depending on if you are an "over-methylator" or an "under- methylator." These are VERY rough estimations and nothing concrete...they may not be accurate either; further research is needed.

Q: How can you find out if you are over or under?
A: Histamine levels may be a good indicator of whether someone is an over or under-methylator.

Low histamine points to over-methylator: If your histamine level is low you are probably an over-methylator (according to Pfeiffer research). This means that many supplements would be detrimental to him (those containing methyl). These would include taurine, GABA [both precursors to methyl activity in the brain], folic acid, B12, B6, DMG, TMG (and SAMe) - to name a few.

Q: What test checks histamine levels?
A: There is a blood test to measure histamine. Your pediatrician can do it.

Have we looked at the other end of the spectrum? 

Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). It is very active in the brain, and too much leads to “too much of a good thing.” This causes an overproduction of serotonin, norepinephrine, and dopamine in the brain.  In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido, weight gain, and confusion.

This is what I was talking about earlier and maybe why it was the Folate that possibly gave me a limp di*k

why would we have too many methyl groups after taking accutane?  about 100 studies say accutane drains methyl groups??

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idk man thats why your here to tell me this

BAM!
Therefore, if there is a mutation in the MTR or MTRR genes, they will potentially be unable to correctly synthesise methionine, which we need to utilise up the methyl-groups we create and supplement.

Therefore, supplementing with methylfolate without first supporting your patients MTR and MTRR genes could do more harm than good, as their body will be unable to create the methionine needed to use the methyl-portion of their supplemented methyl-folate.

This will typically show as classic symptoms of over-methylating, as the methyl folate will be unable to be given to methionine by MTR and MTRR due to their underfunctioning.
http://www.mthfrsupport.com.au/mtr-mtrr/
 

Edited by guitarman01

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1 hour ago, thedayacneceased said:

So basically, I shouldn't try Accutane even after the Acne.org regiment and home remedies have failed me because it'll likely ruin my life with side-effects.

uh C correcto.   I wouldnt say my life is ruined, but I picture my other self who never took accutane and he's better then me. Edited by guitarman01

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Hey, i want to help with a testimonial of an very rare accutane side effect that i have in 2011.
and for the record i ended my second course in december 2015,

my first contact with accutane was in 2011 when my face exploded with severe cystic acne and nothing worked 1 month before the accutane i was taking tetracycline which only worsened my acne
after 2 weeks i god a persistent headache and my vision was blurry so i was diagnosed with pseudo tumor cerebri, i got a papiledema in my eyes and i was experiencing a high pressure of liquor in my head, i stopped accutane right after that.
the doctors said that couldve be a tumor in my brain so my family and me was desperated i do remember like it was yesterday i experiencing a nightmare
2011 was a hell to me, after being affected with acne i got this rare side effect of accutane so i passed all 2011 taking drugs to relieve the pressure in my head, i dod alot of x-rays, ressonances etc and nothing was found, and i take a drug called diamox for around 4 months
the side effects of diamox was terrible my head was pricking my arms and legs was pricking and i was very weak
in 2012 my head was doing okay and i went to a new dermatologist and she said that this head pressure side effect was due to the hypervitaminosis caused by accutane and te tetracycline that wasnt full out of my system  and she said that she was able to manage to put me in accutane again in low doses(20mg day) and she guaranteed that this time i would not go pass to this again and i accepted, let me say something before you judge me
i was about to kill myself i wasnt eating, i wasnt doing anything, i was paralyzed by depression due to my state, i accepted because i was nihilist enough to just give up everything and end my life.
i take 20mg accutane from jan 2012 to 2013.  I got no harsh side effects beside dry lips, hair and skin
in beggin of 2015 my face exploded again and my derm put me in accutane again but in 40mg this time, i ended the course december 2015
i got no internal side effects again except by a very itchy scalp and a mild hair loss with a baldspot that she diagnosed as alopecia areata but she said that it wasnt because accutane which i doubt because it started after 1 month on accutane.
my hair loss is stabilishing right now and for the moment i didnt experienced longterm side effects

this is a true and sincerely testimonial and i only recommend accutane if your acne isnt deable and very severe to the point of destroying your life 
 

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20 hours ago, thedayacneceased said:

So basically, I shouldn't try Accutane even after the Acne.org regiment and home remedies have failed me because it'll likely ruin my life with side-effects.


Permanent debilitating side effects are rare, so I don't know how you can deduce that you will "likely" ruin your life with side effects...You are *unlikely to ruin your life, and the odds are in your favor as millions have taken this drug, but odds nonetheless. If you have severe acne, and are old enough to walk into a casino and gamble, then you are old enough to understand the potential risks of taking Accutane, and cleared for treatment under the supervision of a dermatologist in my opinion.  However, be aware that nary a dermatologist, nor physician, understands this drug or its mechanisms of action intrinsically on a chemical level.

...

Just talking to some of these kids man...such a waste of time.

Really a shame how they can market and solicit this stuff to teenagers and young adults who have no capacity of situational awareness or how the world works around them.  And the parents just go along with whatever, because well, they were raised in an era where preventative medicine (vaccines) in the 50's and 60's saved so many lives, so they just inherently trust whatever a doctor tells them or gives them. I hate how we are perceived as if we are against allopathic medicine as a whole, which is not the case...and its so disheartening that the common sense in people can't see that  currently the whole industry is just so saturated and perverse imo. Edited by macleod

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i just remembered that choline is needed for folate activity or something like that, don't remember where i read it. maube here.

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