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VanceAstro

Reducing/reverting isotretinoin side effects with...

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"Researchers in Greece showed that a large group of people who had side effects from isotretinoin got better when taking L-carnitine".

http://www.ncbi.nlm.nih.gov/pubmed/10642057

I wonder if it also applies to brain metabolism, because some studies show that isotretinoin can cause a decrease in orbitofrontal cortical brain metabolism and lead to a "potential" depression. At the same time scientific studies of Acetyl L-Carnitine [better absorbable version of L-carnitine] show that it promotes brain metabolism, memory, cognitive function and reduce depression.

http://www.ncbi.nlm.nih.gov/pubmed/21443422

http://www.ncbi.nlm.nih.gov/pubmed/2205455

http://www.ncbi.nlm.nih.gov/pubmed/2140973

I am not suggesting anything here, but it's simply interesting.

Edited by VanceAstro

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Guest Modestm

Hi VanceAstro, you were stipulating the other day that Acetyl L-Carnitine can be used to suppress sebum and possibly quench acne. I tried searching for it, but could not find this association; if you have research supporting this claim, could you please post, buddy. Thanks in advance.

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Hi VanceAstro, you were stipulating the other day that Acetyl L-Carnitine can be used to suppress sebum and possibly quench acne. I tried searching for it, but could not find this association; if you have research supporting this claim, could you please post, buddy. Thanks in advance.

Vitamin B5 [pantothenic acid] is a well known sebum surpressor. But to make it work you would have to take 10+ grams [which is around 20 pills daily!].

There is a doctor that suggest using vitamin b5 derivative called "pantethine" combined with l-carnitine instead of swallowing 20 pills of pantothenic acid [b5] daily.

http://jeffreydach.com/2008/09/04/pantethe...ey-dach-md.aspx

Study of dr. Leung who first discovered B5 treatment:

http://www.ncbi.nlm.nih.gov/pubmed/7476595?dopt=Abstract

His article in the journal of orthomolecular medicine where he explains possible pathogenesis of acne:

http://www.acne.org/messageboard/post-a19475-.html

Vitamin B5 & acne info website:

http://www.vitaminb5acne.com/

Mega-dose b5 treatment reviews:

http://www.acne.org/vitamin-b5-reviews/52/page1.html

It's not a secret that ridiculous doses of vitamin b5 can clear 100% of acne by significantly surpressing sebum production [very similar to accutane, just in a "natural way"]. But very high doses of b5 [even if it's water soluble vitamin] aren't recommended due to possible side effects [mostly hair Loss and fatigue]. Besides, who on earth will take 20 pills of vitamin b5 daily?!

So instead dr Dach suggest taking pantethine which provides the same ammount of b5 in just 2-3 capsules without side effects seen in ridiculous doses of pantothenic acid. In fact, pantethine have many positive effects on your health.

http://www.ncbi.nlm.nih.gov/pubmed/10468649

http://www.ncbi.nlm.nih.gov/pubmed/11425046

http://www.ncbi.nlm.nih.gov/pubmed/19685700

I am not claiming that it is some kind of "miracle" cure. Do a research on the internet, for many people it works very well, for others not so much. You will never know untill you try. And don't expect more studies B5 and acne. It's cheap, widely available and unpatented, so no one will fund a study on it.

Edited by VanceAstro

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Guest Modestm

Hi Vance, I haven't read through all that information yet (thank-you very much for supplying), but I know about B5. I first used it about 9 years ago; I just didn't like that you had to take so much of it. It is way better than Accutane. I thought what you had mentioned was something new, so sorry.

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Guest Modestm

Yeah, L-carnitine is an amino acid. I was recalling from memory, and I fudged up, sorry. You said:

"Although there are studies that show much safer way to achieve very similar [sebo-surpressive] effect with pantethine & L-carnitine." I thought that L-canitine alone was useful, so I was wrong; sorry again.

Edited by Modestm

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Okay so I'll be done with accutane in 1 or 2 months. It seems that there's a couple things I can do afterwards:

1. Vit A

2. Vit B5 (or pantethine)

3. L-Carnitine/Acetyl L-Carnitine

So I take one of each of the choices, in recommended safe amounts, and I should be good.

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Guest Modestm

More vitamin A after isotretinoin is an extremely bad idea: even at low levels. Vitamin B-5 at doses recommended in the research are also bad news. I would not use B5 at more than 1-2 grams a day - and even that is pushing it in my opinion. L-Carnitine/Acetyl L-Carnitine alone will not keep acne at bay; it is an amino acid. Even seemingly innocuous herbs like saw palmetto which work as mild anti-androgens have sexually decimated some men.

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Okay so I'll be done with accutane in 1 or 2 months. It seems that there's a couple things I can do afterwards:

1. Vit A

2. Vit B5 (or pantethine)

3. L-Carnitine/Acetyl L-Carnitine

So I take one of each of the choices, in recommended safe amounts, and I should be good.

You don't need vitamin A or B5 right now.

Just finish your isotretinoin course and watch the results. Bare in mind that acne can still show up to 2-3 months post-treatment.

On the other hand, taking L-carnitine, Vitamin D [around 1000 IU - prefferably softgels for better absorbtion] and some good fish oil [with high concentration of EPA/DHA] sounds like a reasonable thing to do after isotretinoin course.

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