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lotion at night before epiduo?

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I've had acne for about 4 or 5 years now but about a year and a half ago i was pretty much clear for 5 or so months. I took minocyclin and was using epiduo at night. For a while I wasn't doing either and just tried other products but it came back and almost as bad as before. I'm now trying out the doxycycline and got the epiduo back but I have a question about the best way to use it. Sometimes I'll wash my face then shave and then put on the epiduo and just go to bed, my skin gets very dry when i do this, or sometimes i'll put lotion on then 20-30 minutes later put on the epiduo. So my questions are: Is it bad to leave the skin dry over night? and will epiduo work as well when i put it on after lotion? It's non-condogemic aveno ultra calming lotion or something like that. I have very fair skin btw.

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